KEGG ORTHOLOGY: K15185

ORTHOLOGY: K15185

Entry

K15185                      KO

Symbol

AFF4

Name

AF4/FMR2 family member 4

Pathway

map03250

Viral life cycle - HIV-1

Disease

H01569

CHOPS syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09125 Information processing in viruses
   03250 Viral life cycle - HIV-1
    K15185  AFF4; AF4/FMR2 family member 4
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03021 Transcription machinery
    K15185  AFF4; AF4/FMR2 family member 4
Transcription machinery [BR:ko03021]
Eukaryotic type
  RNA polymerase II system
   Other transcription-related factors
    Super elongation complex (SEC)
     K15185  AFF4; AF4/FMR2 family member 4

Genes

HSA:	27125(AFF4)

PTR:	107974861(AFF4)

PPS:	100986081(AFF4)

GGO:	101144943(AFF4)

PON:	100454296(AFF4)

PPYG:

129036381(AFF4)

NLE:	100600223(AFF4)

HMH:	116470415(AFF4)

SSYN:

129493368(AFF4)

MCC:	709137(AFF4)

MCF:	101926415(AFF4)

MTHB:

126955965

MNI:	105467160(AFF4)

CSAB:

103244530(AFF4)

CATY:

105599756(AFF4)

PANU:

100137227(AFF4)

TGE:	112625957(AFF4)

MLEU:

105531377(AFF4)

RRO:	104659824(AFF4)

RBB:	108529572(AFF4)

TFN:	117065876(AFF4)

PTEH:

111529352(AFF4)

CANG:

105518202(AFF4)

CJC:	100403628(AFF4)

SBQ:	101034042(AFF4)

CIMI:

108307156(AFF4)

ANAN:

105710286(AFF4)

CSYR:

103259264(AFF4)

MMUR:

105869958(AFF4)

LCAT:

123637762(AFF4)

PCOQ:

105816037(AFF4)

OGA:	100944774(AFF4)

MMU:	93736(Aff4)

MCAL:

110305894(Aff4)

MPAH:

110332063(Aff4)

RNO:	303132(Aff4)

MCOC:

116078927(Aff4)

ANU:	117711353(Aff4)

ASYL:

127695257(Aff4)

MUN:	110548768(Aff4)

CGE:	100756909(Aff4)

MAUA:

101844448(Aff4)

PROB:

127219292(Aff4)

PLEU:

114681923(Aff4)

MORG:

121456721(Aff4)

MFOT:

126510988

AAMP:

119812121(Aff4)

NGI:	103747036(Aff4)

HGL:	101710985(Aff4)

CPOC:

100723342(Aff4)

CCAN:

109696607(Aff4)

DORD:

105996717(Aff4)

DSP:	122115364(Aff4)

DMER:

138807903(Aff4) 138808210

PLOP:

125342236(Aff4)

NCAR:

124986594

ITI:	101969512(Aff4)

OCU:	100328920(AFF4)

OPI:	101525996(AFF4)

OCZ:	121150596(AFF4) 121167523

TUP:	102490326(AFF4)

GVR:	103589606(AFF4)

CFA:	474678(AFF4)

CLUD:

112650446(AFF4)

VVP:	112917069(AFF4)

VLG:	121494365(AFF4)

NPO:	129495290(AFF4)

AML:	100484066(AFF4)

UMR:	103663825(AFF4)

UAH:	113261726(AFF4)

UAR:	123790357(AFF4)

ELK:

111140846

LLV:

125099674

MPUF:

101683132(AFF4)

MNP:	132028509(AFF4)

MLK:	131832030(AFF4)

NVS:	122891790(AFF4)

ORO:	101362661(AFF4)

EJU:	114209450(AFF4)

ZCA:	113929929(AFF4)

MLX:	118016629(AFF4)

NSU:	110591134(AFF4)

LWW:	102748161(AFF4)

FCA:	101085687(AFF4)

PYU:	121010688(AFF4)

PCOO:

112860330(AFF4)

PBG:	122487343(AFF4)

PVIV:

125152469(AFF4)

LRUF:

124515558

LGF:	123603621(AFF4)

AJU:

106970705

PTG:	102960270(AFF4)

PPAD:

109250875(AFF4)

PUC:

125935471

PLEZ:

122217653(AFF4)

HHV:	120223321(AFF4)

BTA:	541306(AFF4)

BOM:	102270448(AFF4)

BIU:	109562008(AFF4)

BBUB:

102394419(AFF4)

BBIS:

104991869(AFF4)

CHX:	102171706(AFF4)

OAS:	101121933(AFF4)

BTAX:

128050669(AFF4)

CSUM:

138085389(AFF4)

ODA:	120863670(AFF4)

CCAD:

122439930(AFF4)

MREE:

136156106(AFF4)

OVR:	110139608(AFF4)

MBEZ:

129559503(AFF4)

SSC:	100524487(AFF4)

CFR:	102517357(AFF4)

CBAI:

105082114(AFF4)

CDK:	105090208(AFF4)

VPC:	102539369(AFF4)

BACU:

103013391(AFF4)

BMUS:

118893180(AFF4)

LVE:	103071770(AFF4)

OOR:	101271876(AFF4)

LALB:

132517057(AFF4)

GMF:	115860138(AFF4)

DDP:	132423290(AFF4)

DLE:	111182429(AFF4)

PCAD:

102987951(AFF4)

PSIU:

116752314(AFF4)

PPHC:

136119919(AFF4)

NASI:

112401386(AFF4)

ECB:	100063038(AFF4)

EPZ:	103563099(AFF4)

EAI:	106841007(AFF4)

MYB:	102248417(AFF4)

MYD:	102762616(AFF4)

MMYO:

118658317(AFF4)

MLF:	102434643(AFF4)

MDT:	132235639(AFF4)

MYUM:

139010494(AFF4)

PKL:	118711000(AFF4)

EFUS:

103286788(AFF4)

MNA:	107525403(AFF4)

DRO:	112318185(AFF4)

SHON:

118990093(AFF4)

AJM:	119037643(AFF4)

PDIC:

114509202(AFF4)

PHAS:

123812168(AFF4)

MMF:	118643588(AFF4)

PPAM:

129066692(AFF4)

HAI:	109382598(AFF4)

RFQ:	117017126(AFF4)

PALE:

102888289(AFF4)

PGIG:

120616504(AFF4)

PVP:	105293558(AFF4)

RAY:	107497032(AFF4)

MJV:	108392350(AFF4)

TOD:	119243478(AFF4)

SARA:

101556353(AFF4)

SFUM:

130032728(AFF4)

SETR:

126027804(AFF4)

LAV:	100661683(AFF4)

TMU:

101352816

ETF:	101655799(AFF4)

DNM:	101415373(AFF4)

MDO:	100015863(AFF4)

GAS:	123237624(AFF4)

SHR:	100935345(AFF4)

AFZ:

127549853

PCW:	110211690(AFF4)

TVP:	118841311(AFF4)

PBRV:

138173767(AFF4)

MLAO:

141506444 141506445

OAA:	100079379(AFF4)

TACU:

119919889(AFF4)

GGA:	416337(AFF4)

PCOC:

116232243(AFF4)

MGP:	100548612(AFF4)

TPAI:

128084112(AFF4)

LMUT:

125700484(AFF4)

NMEL:

110405216(AFF4)

APLA:

101797005(AFF4)

ACYG:

106032746(AFF4)

CATA:

118254912(AFF4)

AFUL:

116494692(AFF4)

TGU:	100219524(AFF4)

LSR:	110476389(AFF4)

SCAN:

103817390(AFF4)

PMOA:

120498642(AFF4)

OTC:	121332496(AFF4)

PRUF:

121365576(AFF4)

ATRC:

139597866(AFF4)

GFR:	102036860(AFF4)

FAB:	101812257(AFF4)

OMA:	130258559(AFF4)

PHI:	102102077(AFF4)

PMAJ:

107210663(AFF4)

CCAE:

111935793(AFF4)

CCW:	104689634(AFF4)

CBRC:

103611588(AFF4)

ACOE:

138117924(AFF4)

ETL:	114066910(AFF4)

ZAB:	102070854(AFF4)

ZLE:	135453895(AFF4)

ACHL:

103811461(AFF4)

SVG:	106860459(AFF4)

MMEA:

130583410(AFF4)

HRT:	120759092(AFF4)

SATI:

136367643(AFF4)

CCIC:

134049748(AFF4)

FPG:	101914947(AFF4)

FCH:	102049419(AFF4)

CCRI:

104159988(AFF4)

NNT:	104405866(AFF4)

SHAB:

115615850(AFF4)

ACUN:

113485076(AFF4)

TALA:

104357976(AFF4)

ACHC:

115334158(AFF4)

HALD:

104317352(AFF4)

HLE:	104838834(AFF4)

AGEN:

126051165

HHAR:

128155120(AFF4)

GCL:

127021801

CSTI:

104555254(AFF4)

LDI:	104343909(AFF4)

MNB:	103769028(AFF4)

DPUB:

104301873(AFF4)

PPUS:

135185159(AFF4)

AVIT:

104274001(AFF4)

BRHI:

104501885(AFF4)

EGZ:	104133447(AFF4)

NNI:	104012018(AFF4)

PCRI:

104026961(AFF4)

PCAO:

104044005(AFF4)

PADL:

103923137(AFF4)

AFOR:

103904455(AFF4)

FGA:	104076206(AFF4)

CBOR:

142088793(AFF4)

GSTE:

104260444(AFF4)

CBOY:

140656904(AFF4)

MAME:

142413597(AFF4)

CLV:	102089839(AFF4)

CNIC:

135993747(AFF4)

MUI:	104541500(AFF4)

PGUU:

104468441(AFF4)

PLET:

104627917(AFF4)

EHS:	104514556(AFF4)

CMAC:

104482867(AFF4)

CUCA:

104060608(AFF4)

TEO:	104377335(AFF4)

BREG:

104640463(AFF4)

OHA:	104327492(AFF4)

ACAR:

104528370(AFF4)

CPEA:

104391875(AFF4)

CVF:	104291435(AFF4)

RTD:	128916370(AFF4)

CRID:

134522181(AFF4)

LMIC:

141749941(AFF4)

AAM:	106487220(AFF4)

AROW:

112964844(AFF4)

NPD:	112952826(AFF4)

TGT:	104565772(AFF4)

DNE:	112994051(AFF4)

SCAM:

104146728(AFF4)

ASN:	102370879(AFF4)

AMJ:	102558933(AFF4)

CPOO:

109310062(AFF4)

GGN:	109289985(AFF4)

PSS:	102449460(AFF4)

CIZ:	142021338(AFF4)

CMY:	102933503(AFF4)

CCAY:

125640936(AFF4)

DCC:	119859952(AFF4)

CPIC:

101931323(AFF4)

TST:	117881153(AFF4)

CABI:

116818350(AFF4)

MRV:	120370063(AFF4)

ACS:	100565688(aff4)

ASAO:

132768861(AFF4)

PVT:	110090129(AFF4)

SUND:

121920769(AFF4)

PBI:	103050075(AFF4)

PMUR:

107298306(AFF4)

CTIG:

120311529(AFF4)

TSR:	106543605(AFF4)

PGUT:

117656513(AFF4)

PCAE:

139312493(AFF4)

APRI:

131189970(AFF4)

PTEX:

113433724(AFF4)

NSS:	113425505(AFF4)

VKO:	123035901(AFF4)

PMUA:

114591236(AFF4)

PRAF:

128407841(AFF4)

ZVI:	118080333(AFF4)

HCG:	128342348(AFF4)

GJA:	107125737(AFF4)

STOW:

125428165(AFF4)

EMC:	129329263(AFF4)

XLA:	108712406(aff4.S) 446225(aff4.L)

XTR:	100485382(aff4)

NPR:	108792441(AFF4)

RTEM:

120932318(AFF4)

ACAT:

141132357(AFF4)

BBUF:

120977732(AFF4)

BGAR:

122928222(AFF4)

DTC:	141051601(AFF4)

PWL:	138304564(AFF4)

MUO:	115476304(AFF4)

GSH:	117351568(AFF4)

DRE:	556421(aff4)

SRX:	107715968 107742451

SANH:

107661694(aff4) 107692940

SGH:	107562161(aff4) 107576009

CCAR:

109061327(aff4) 109074655

CAUA:

113038269 113063845

CGIB:

127941549 127985806

PTET:

122326181(aff4)

LROH:

127152136(aff4)

GRF:	141292215(aff4)

OMC:	131528595(aff4)

PPRM:

120473618(aff4)

MAMB:

125253388(aff4)

CIDE:

127503960

CERY:

137013076(aff4)

MASI:

127429333 127430406

TROS:

130570061(aff4)

TDW:	130407972(aff4)

MANU:

129424256(aff4)

PDAB:

135776701(aff4)

IPU:

108279078

IFU:	128622274(aff4)

PHYP:

113541561(aff4)

SMEO:

124397789(aff4)

TFD:	113647537(aff4)

TVC:	132859621(aff4)

CGAR:

128517059(aff4)

NGRA:

132895737(aff4)

TRN:	134330107(aff4)

AMEX:

103047568(aff4)

CMAO:

118819682(aff4)

EEE:

113582630

CHAR:

105900360(aff4)

SPIL:

134080289(aff4)

ASAD:

121708497(aff4)

TRU:	101062415(aff4)

TFS:	130537032(aff4)

LCO:	104917786(aff4)

NCC:	104952450(aff4)

TBEN:

117490247(aff4)

CGOB:

115018693(aff4)

PGEO:

117458680(aff4)

GACU:

117540092(aff4)

EMAC:

134871650(aff4)

ELY:	117266744(aff4)

EFO:	125898075(aff4)

PLEP:

121952123(aff4)

SLUC:

116036965(aff4)

ECRA:

117956160(aff4)

ESP:	116700297(aff4)

PFLV:

114566608(aff4)

GAT:	120822238(aff4)

PPUG:

119215111(aff4)

AFB:	129113368(aff4)

CLUM:

117743240(aff4)

PSWI:

130211823(aff4)

CANA:

137802441(aff4)

CVE:	137876275(aff4)

MSAM:

119894970(aff4)

SCHU:

122888760(aff4)

CUD:	121518496(aff4)

SPUL:

138597463(aff4)

LMIX:

132988050(aff4)

HTC:	141791432(aff4)

ALAT:

119030834(aff4)

ASTR:

137605874(aff4)

MZE:	101486107(aff4)

ONL:	100704525(aff4)

OAU:	116309350(aff4)

OLA:	101169723(aff4)

OML:	112142396(aff4)

CSAI:

133459478(aff4)

XMA:	102227701(aff4)

XCO:	114152549(aff4)

XHE:	116727919(aff4)

PRET:

103475358(aff4)

PFOR:

103144870(aff4)

PLAI:

106948633(aff4)

PMEI:

106925102(aff4)

GAF:	122845383(aff4)

PPRL:

129373629(aff4)

CVG:	107104874(aff4)

CTUL:

119787966(aff4)

GMU:	124876362(aff4)

NFU:	107386770(aff4)

KMR:	108238963(aff4)

ALIM:

106523428(aff4)

NWH:	119420490(aff4)

AOCE:

111579554(aff4)

EJA:	138196203(aff4)

BFRE:

138632575(aff4)

MCEP:

125021017(aff4)

CSEM:

103394949(aff4)

POV:	109635849(aff4)

SSEN:

122779383(aff4)

SSOE:

131458069(aff4)

HHIP:

117774867(aff4)

HSP:	118121800(aff4)

PPLT:

128456615(aff4)

SMAU:

118300532(aff4)

LCF:

108893450

SDU:	111234340(aff4)

SLAL:

111672084(aff4)

XGL:	120802358(aff4)

HCQ:	109517861(aff4)

SSCV:

125982213(aff4)

SBIA:

133491836(aff4)

PEE:	133415576(aff4)

PTAO:

133467282(aff4)

BPEC:

110160398(aff4)

ENY:	140360492(aff4)

MALB:

109959959(aff4)

BSPL:

114869098(aff4)

SJO:	128371361(aff4)

SSCO:

133993673(aff4)

TTY:	137195844(aff4)

GMH:	115546755(aff4)

SASA:

106567500 106603851

STRU:

115148529 115153986

OTW:	112228314 112258119

OMY:	110533355 110537760

OGO:	123999991 124014045

ONE:	115105257 115136209

OKI:	109872743 109892972

OKE:	118373499 118390872

OMM:	135548810 135550975

OCLA:

139418014 139420806

SALP:

111950209 111980376

SNH:	120032149(aff4) 120056881

SFON:

129821187 129868222

CCLU:

121574029 121579207

ELS:	105011247(aff4)

OEP:	134039217(aff4)

SFM:	108934430 108936836(aff4)

PKI:	111833355 111857448(aff4)

AANG:

118236537(aff4)

AROT:

135262719(aff4)

CCOG:

133132379(aff4)

LOC:	102693423(aff4)

PSPA:

121297087 121324011

ARUT:

117413027 117431288

PSEX:

120543000(aff4)

LCM:	102351691(AFF4)

CMK:	103177336(aff4)

RTP:	109926034(aff4)

CPLA:

122556539(aff4)

HOC:	132823450(aff4)

SCAU:

119965362(aff4)

LERI:

129701846(aff4)

HAKA:

140739196(aff4)

BFO:

BBEL:

CIN:

SCLV:

SKO:

SOY:

OTU:

LOA:	LOAG_04938

TSP:

Tsp_05184

LGI:	LOTGIDRAFT_228539

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

MMER:

LAK:

NVE:

EPA:

PDAM:

SPIS:

DGT:

XEN:

HMG:

Reference

PMID:20159561

Authors

Lin C, Smith ER, Takahashi H, Lai KC, Martin-Brown S, Florens L, Washburn MP, Conaway JW, Conaway RC, Shilatifard A

Title

AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.

Journal

Mol Cell 37:429-37 (2010)
DOI:10.1016/j.molcel.2010.01.026

Sequence

[hsa:27125]

LinkDB

DBGET integrated database retrieval system