KEGG   PATHWAY: bbuf00230
Entry
bbuf00230                   Pathway                                
Name
Purine metabolism - Bufo bufo (common toad)
Class
Metabolism; Nucleotide metabolism
Pathway map
bbuf00230  Purine metabolism
bbuf00230

Module
bbuf_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:bbuf00230]
bbuf_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:bbuf00230]
bbuf_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:bbuf00230]
bbuf_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:bbuf00230]
bbuf_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:bbuf00230]
bbuf_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:bbuf00230]
bbuf_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:bbuf00230]
Other DBs
GO: 0006163 0042278
Organism
Bufo bufo (common toad) [GN:bbuf]
Gene
121007532  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
121004707  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
121005235  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase-like [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
120983630  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
120978527  PGM1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
120990280  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
120977668  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
120995639  PRPS2; ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
120990190  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
120997670  trifunctional purine biosynthetic protein adenosine-3-like isoform X1 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
120994518  trifunctional purine biosynthetic protein adenosine-3-like [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
120994519  trifunctional purine biosynthetic protein adenosine-3-like [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
120984420  PFAS; phosphoribosylformylglycinamidine synthase isoform X1 [KO:K01952] [EC:6.3.5.3]
120990191  PAICS; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
120990192  uncharacterized protein LOC120990192 isoform X1 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
120979171  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
121008315  ATIC; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
120980191  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
120997325  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
121005329  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
121009040  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
120986196  cytosolic purine 5'-nucleotidase-like isoform X1 [KO:K01081] [EC:3.1.3.5]
120995435  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
120998162  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
121004680  purine nucleoside phosphorylase-like [KO:K03783] [EC:2.4.2.1]
120988968  purine nucleoside phosphorylase isoform X1 [KO:K03783] [EC:2.4.2.1]
120993526  LACC1; purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
121009563  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
120979730  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
120985539  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
121007406  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
121007468  nucleoside diphosphate kinase A1 isoform X1 [KO:K00940] [EC:2.7.4.6]
121007887  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
120985555  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
120994938  NME7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
120998255  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
121001222  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
120977389  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
120977413  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
121004358  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
121003821  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
120986157  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
120998808  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
120982290  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 isoform X1 [KO:K01511] [EC:3.6.1.6]
120977180  U8 snoRNA-decapping enzyme-like [KO:K16855] [EC:3.6.1.62 3.6.1.64]
120978874  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
120999630  XDH; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120992298  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
120997829  GMPS; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
121001781  GMPR; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
120989063  GMPR2; GMP reductase 2 [KO:K00364] [EC:1.7.1.7]
120989157  GDA; guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
121000924  GUK1; guanylate kinase [KO:K00942] [EC:2.7.4.8]
120996630  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
120997400  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
121001298  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
120998465  HDDC2; 5'-deoxynucleotidase HDDC2 [KO:K07023] [EC:3.1.3.89]
120987074  deoxyguanosine kinase, mitochondrial-like [KO:K00904] [EC:2.7.1.113]
120989686  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
121003868  deoxycytidine kinase 2 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
120985907  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
120981744  PRUNE1; exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
121001993  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
120997161  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
120988965  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
121007372  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
120995950  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
120981193  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
121001129  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
121008967  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
120990065  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X1 [KO:K12318] [EC:4.6.1.2]
120996387  GUCY1A2; LOW QUALITY PROTEIN: guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
120990066  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
120999071  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
120993971  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
120979823  GUCY2C; LOW QUALITY PROTEIN: heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
120987271  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
120994037  retinal guanylyl cyclase 2-like [KO:K12322] [EC:4.6.1.2]
120978090  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
120981640  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
120979859  atrial natriuretic peptide receptor 1-like [KO:K12324] [EC:4.6.1.2]
120990897  atrial natriuretic peptide receptor 1-like [KO:K12324] [EC:4.6.1.2]
120991911  NPR2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
121008354  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
121002879  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C-like isoform X1 [KO:K13755] [EC:3.1.4.17]
120996132  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
121003550  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
120980987  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
120989883  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase [KO:K13762] [EC:3.1.4.35]
120987052  PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [KO:K08718] [EC:3.1.4.35]
120990963  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta-like [KO:K13756] [EC:3.1.4.35]
121003904  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
120998018  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
121004441  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
120978843  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
120997498  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A-like [KO:K13761] [EC:3.1.4.35]
120993144  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
120998581  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
121008308  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
120998670  ADSS2; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
120982545  ADSS1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
120980962  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
120994995  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
120995086  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
121003138  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
121003864  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
121004194  adenosine deaminase-like [KO:K01488] [EC:3.5.4.4]
121004520  ADA2; adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
120979637  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
120981879  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
121009565  AK8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
120977173  adenylate kinase isoenzyme 5-like [KO:K00939] [EC:2.7.4.3]
120977174  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
120995416  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
120978560  AK5; adenylate kinase isoenzyme 5 isoform X1 [KO:K00939] [EC:2.7.4.3]
120992481  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
120989195  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
120977089  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
120999722  cancer-related nucleoside-triphosphatase homolog [KO:K06928] [EC:3.6.1.15]
120999723  cancer-related nucleoside-triphosphatase homolog [KO:K06928] [EC:3.6.1.15]
120998498  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
120999217  ENPP3; LOW QUALITY PROTEIN: ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
120979589  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
120989602  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
120992369  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
120986394  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
120998518  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
121001614  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
120992422  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
120985855  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A-like isoform X1 [KO:K18437] [EC:3.1.4.53]
120979483  FHIT; LOW QUALITY PROTEIN: bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
120997272  bis(5'-adenosyl)-triphosphatase enpp4-like isoform X1 [KO:K18424] [EC:3.6.1.29]
120997273  bis(5'-adenosyl)-triphosphatase enpp4-like [KO:K18424] [EC:3.6.1.29]
121004942  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
120989882  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
120979288  uricase-like isoform X1 [KO:K00365] [EC:1.7.3.3]
120994160  URAD; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
120997692  LOW QUALITY PROTEIN: allantoinase, mitochondrial-like [KO:K01466] [EC:3.5.2.5]
120997465  ALLC; probable allantoicase isoform X1 [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
bbuf00030  Pentose phosphate pathway
bbuf00220  Arginine biosynthesis
bbuf00250  Alanine, aspartate and glutamate metabolism
bbuf00260  Glycine, serine and threonine metabolism
bbuf00340  Histidine metabolism
bbuf00630  Glyoxylate and dicarboxylate metabolism
bbuf00730  Thiamine metabolism
bbuf00740  Riboflavin metabolism
bbuf00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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