KEGG   PATHWAY: bta04530
Entry
bta04530                    Pathway                                
Name
Tight junction - Bos taurus (cow)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
bta04530  Tight junction
bta04530

Other DBs
GO: 0005923
Organism
Bos taurus (cow) [GN:bta]
Gene
100125881  RAB8A; ras-related protein Rab-8A [KO:K07901]
100138150  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4 [KO:K03456]
100139484  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
100141266  [KO:K07374]
100295316  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
100295712  [KO:K07374]
100337329  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
100337373  SYMPK; symplekin [KO:K06100]
100847650  CLDN34; claudin-34 [KO:K06087]
100851408  DLG2; disks large homolog 2 isoform X7 [KO:K12075]
101906359  [KO:K06099]
101907895  CLDN20; claudin-20 [KO:K06087]
107131173  WAS; actin nucleation-promoting factor WAS [KO:K05747]
112443216  [KO:K07374]
112444630  [KO:K06087]
112446354  [KO:K06087]
132344360  [KO:K03456]
280831  JUN; transcription factor Jun [KO:K04448]
280979  ACTB; actin, cytoplasmic 1 [KO:K05692]
281067  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
281258  F11R; junctional adhesion molecule A precursor [KO:K06089]
281341  MYL6; myosin light polypeptide 6 [KO:K12751]
281440  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
281574  EZR; ezrin [KO:K08007]
281597  ACTR3; actin-related protein 3 [KO:K18584]
281876  ITGB1; integrin beta-1 precursor [KO:K05719]
282031  RAP1A; ras-related protein Rap-1A [KO:K04353]
282041  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
282184  CLDN16; claudin-16 [KO:K06087]
282320  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
282322  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
282323  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
282324  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
286877  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
317655  MYH10; myosin-10 [KO:K10352]
326600  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
327716  GATA4; transcription factor GATA-4 [KO:K09183]
338049  RHOA; transforming protein RhoA [KO:K04513]
404053  TUBA1A; tubulin alpha-1B chain [KO:K07374]
404089  CLDN2; claudin-2 [KO:K06087]
404108  MYH9; myosin-9 [KO:K10352]
404122  ACTG1; actin, cytoplasmic 2 [KO:K05692]
404153  CLDN3; claudin-3 [KO:K06087]
407100  TJP3; tight junction protein ZO-3 [KO:K06097]
407101  TJP2; tight junction protein ZO-2 [KO:K06098]
407102  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
408013  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
414921  CLDN4; claudin-4 [KO:K06087]
414922  CLDN1; claudin-1 [KO:K06087]
504219  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
504244  TUBA1C; tubulin alpha-1C chain [KO:K07374]
504245  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
504856  AFDN; afadin isoform X6 [KO:K05702]
505242  NHERF1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
505519  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
505709  ERBB2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
505940  ARHGEF2; rho guanine nucleotide exchange factor 2 [KO:K12791]
505964  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
506545  CLDN10; claudin-10 isoform a precursor [KO:K06087]
506596  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
506939  CTTN; src substrate cortactin [KO:K06106]
507041  PRKCE; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
507767  [KO:K06448]
507781  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X2 [KO:K10591] [EC:2.3.2.26]
508045  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
508268  CLDN11; claudin-11 [KO:K06087]
508402  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
508445  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
509004  CD1B; CD1b molecule precursor [KO:K06448]
509005  [KO:K06448]
509290  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
509882  DLG3; disks large homolog 3 [KO:K21098]
510003  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X7 [KO:K13305] [EC:2.3.2.26]
510618  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
510644  MICALL2; MICAL-like protein 2 [KO:K21068]
510810  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
510832  CD1E; T-cell surface glycoprotein CD1e, membrane-associated precursor [KO:K06448]
511318  CLDN6; claudin-6 [KO:K06087]
511460  CLDN18; claudin-18 precursor [KO:K06087]
511594  IGSF5; immunoglobulin superfamily member 5 isoform 1 precursor [KO:K06786]
511961  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform 1 [KO:K07200]
512286  [KO:K06448]
512405  OCLN; occludin [KO:K06088]
512665  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
512703  CLDN17; claudin-17 [KO:K06087]
512975  CLDN7; claudin-7 precursor [KO:K06087]
513034  CLDN19; claudin-19 [KO:K06087]
513412  JAM3; junctional adhesion molecule C precursor [KO:K06785]
514212  MYH14; myosin-14 isoform X1 [KO:K10352]
514541  RAB13; ras-related protein Rab-13 [KO:K06109]
514634  CLDN23; claudin-23 [KO:K06087]
514902  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
514998  CLDN15; claudin-15 [KO:K06087]
515181  RAP2C; ras-related protein Rap-2c [KO:K07839]
515418  [KO:K06448]
515421  MYL6B; myosin light chain 6B [KO:K12751]
515499  PCNA; proliferating cell nuclear antigen [KO:K04802]
515620  TJAP1; tight junction-associated protein 1 [KO:K06105]
516046  CD1D; CD1D antigen, d polypeptide [KO:K06448]
517111  RDX; radixin [KO:K05762]
517509  CGNL1; cingulin-like protein 1 [KO:K21110]
519310  EPB41L4B; band 4.1-like protein 4B isoform X5 [KO:K21111]
521663  CD1B5; CD1b molecule-like precursor [KO:K06448]
522269  ACTN4; alpha-actinin-4 [KO:K05699]
522521  ARHGEF18; rho guanine nucleotide exchange factor 18 isoform X2 [KO:K21066]
522679  CLDN25; putative claudin-25 [KO:K06087]
523962  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
524361  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
524530  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
524653  PARD6A; partitioning defective 6 homolog alpha [KO:K06093]
524770  ACTN1; alpha-actinin-1 [KO:K05699]
527964  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
528109  PALS1; protein PALS1 [KO:K06091]
528478  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
529631  RUNX1; runt-related transcription factor 1 [KO:K08367]
530050  MYH11; myosin-11 [KO:K10352]
531505  MYL12A; myosin regulatory light polypeptide 9 [KO:K12757]
532070  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
532712  CDC42; cell division control protein 42 homolog [KO:K04393]
533131  MARVELD3; MARVEL domain-containing protein 3 [KO:K21099]
533297  YBX3; Y-box-binding protein 3 [KO:K06099]
533531  SYNPO; synaptopodin [KO:K21112]
533725  CGN; cingulin [KO:K06102]
534107  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
534125  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
534900  TUBA3E; tubulin alpha-3 chain [KO:K07374]
535321  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
535509  AMOT; angiomotin [KO:K16819]
535605  TUBA1D; tubulin alpha-1D chain [KO:K07374]
535742  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
536517  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
536558  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
536739  [KO:K06087]
536863  MPDZ; multiple PDZ domain protein [KO:K06095]
536993  PATJ; inaD-like protein [KO:K06092]
537380  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
537631  MAPK10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
538486  ACTR2; actin-related protein 2 [KO:K17260]
538514  AMOTL2; angiomotin-like protein 2 isoform X2 [KO:K06104]
538709  CLDN12; claudin-12 [KO:K06087]
538761  CLDN8; claudin-8 [KO:K06087]
538846  JAM2; junctional adhesion molecule B precursor [KO:K06735]
538954  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
539292  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
539459  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
539545  LLGL2; LLGL scribble cell polarity complex component 2 [KO:K06094]
539687  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
539882  TUBA1B; tubulin alpha-1B chain [KO:K07374]
539941  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
539988  BVES; blood vessel epicardial substance [KO:K21108]
540404  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
540426  MSN; moesin [KO:K05763]
540479  NF2; merlin isoform X2 [KO:K16684]
540838  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
541110  MARVELD2; MARVEL domain-containing protein 2 [KO:K17291]
541209  AMOTL1; angiomotin-like protein 1 isoform X4 [KO:K06104]
613421  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
614055  MYL12B; myosin regulatory light chain 12B [KO:K12757]
614242  RAB8B; ras-related protein Rab-8B [KO:K07902]
614345  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
616404  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
616695  [KO:K03456]
617449  CLDN9; claudin-9 [KO:K06087]
617453  CLDN5; claudin-5 [KO:K06087]
768036  TUBA8; tubulin alpha-8 chain [KO:K07374]
777775  TUBA4A; tubulin alpha-4A chain [KO:K07374]
781011  CD1A; T-cell surface glycoprotein CD1a isoform 1 precursor [KO:K06448]
781726  [KO:K06448]
781865  LLGL1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
782110  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
782367  [KO:K06448]
782966  [KO:K07374]
783180  CLDN14; claudin-14 [KO:K06087]
783484  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X23 [KO:K05631]
785291  DLG1; disks large homolog 1 isoform X3 [KO:K12076]
785911  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
787278  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
787466  CRB3; protein crumbs homolog 3 precursor [KO:K06090]
788175  [KO:K06448]
789597  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X2 [KO:K08020]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
bta04520  Adherens junction
bta04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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