KEGG   PATHWAY: bta04810
Entry
bta04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Bos taurus (cow)
Class
Cellular Processes; Cell motility
Pathway map
bta04810  Regulation of actin cytoskeleton
bta04810

Other DBs
GO: 0030036
Organism
Bos taurus (cow) [GN:bta]
Gene
100124501  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
100125224  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
100137872  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100138040  SOS2; son of sevenless homolog 2 [KO:K03099]
100140050  ITGAE; integrin alpha-E [KO:K06524]
100141021  CYFIP1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
100298939  HRAS; GTPase HRas isoform 1 [KO:K02833]
100300257  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100847184  [KO:K02833]
101904063  [KO:K06462]
101905399  [KO:K04368] [EC:2.7.12.2]
101906565  [KO:K05764]
101907541  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
104968536  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
107131237  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
112441594  [KO:K05764]
132344337  [KO:K05764]
280685  F2; prothrombin precursor [KO:K01313] [EC:3.4.21.5]
280794  FN1; fibronectin precursor [KO:K05717]
280829  INS; insulin preproprotein [KO:K04526]
280833  KNG1; kininogen-1 isoform II precursor [KO:K03898]
280979  ACTB; actin, cytoplasmic 1 [KO:K05692]
280991  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
281136  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
281160  FGF1; fibroblast growth factor 1 [KO:K18496]
281161  FGF2; fibroblast growth factor 2 precursor [KO:K18497]
281440  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
281478  SCIN; scinderin [KO:K05768]
281574  EZR; ezrin [KO:K08007]
281577  WASL; actin nucleation-promoting factor WASL [KO:K23612]
281597  ACTR3; actin-related protein 3 [KO:K18584]
281684  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
281685  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
281686  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
281736  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
281768  FGFR1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
281769  FGFR3; fibroblast growth factor receptor 3 precursor [KO:K05094] [EC:2.7.10.1]
281872  ITGA2; integrin alpha-2 precursor [KO:K06481]
281873  ITGA5; integrin alpha-5 [KO:K06484]
281874  ITGAL; integrin alpha-L precursor [KO:K05718]
281875  ITGAV; integrin alpha-V precursor [KO:K06487]
281876  ITGB1; integrin beta-1 precursor [KO:K05719]
281877  ITGB2; integrin beta-2 precursor [KO:K06464]
282041  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
282301  PDGFRA; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
282306  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
282307  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
282308  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
282318  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
282386  TMSB4X; thymosin beta-4 [KO:K05764]
282564  ITGB5; integrin beta-5 precursor [KO:K06588]
282642  ITGB3; integrin beta-3 precursor [KO:K06493]
282644  ITGB6; integrin beta-6 precursor [KO:K06589]
282882  ITGA4; integrin alpha-4 precursor [KO:K06483]
286850  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
286865  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
317654  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
317655  MYH10; myosin-10 [KO:K10352]
317696  FGFR4; fibroblast growth factor receptor 4 precursor [KO:K05095] [EC:2.7.10.1]
326284  FGF8; fibroblast growth factor 8 precursor [KO:K04358]
326285  FGF10; fibroblast growth factor 10 precursor [KO:K04358]
326600  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
327671  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
327672  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
338037  MYLK; myosin light chain kinase, smooth muscle isoform 1 [KO:K00907] [EC:2.7.11.18]
338049  RHOA; transforming protein RhoA [KO:K04513]
404108  MYH9; myosin-9 [KO:K10352]
404122  ACTG1; actin, cytoplasmic 2 [KO:K05692]
404193  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
407124  ITGAM; integrin alpha-M precursor [KO:K06461]
407217  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
444869  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
503575  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
504482  WASF2; actin-binding protein WASF2 [KO:K05748]
504531  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
504763  CYRIA; CYFIP-related Rac1 interactor A [KO:K27976]
505519  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
505611  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
505852  ARHGEF4; rho guanine nucleotide exchange factor 4 [KO:K05769]
505886  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
505908  PDGFA; platelet-derived growth factor subunit A precursor [KO:K04359]
505964  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
506270  PTK2; PTK2 protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
506322  NRAS; GTPase NRas [KO:K07828]
506526  ITGA10; integrin alpha-10 precursor [KO:K06586]
506596  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
506953  ITGA7; integrin alpha-7 [KO:K06583]
506995  ITGB4; integrin beta-4 precursor [KO:K06525]
507339  C7; complement component C7 precursor [KO:K03996]
507598  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
507749  C6; complement component C6 precursor [KO:K03995]
507837  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 [KO:K05627]
508257  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
508402  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
508490  ITGA3; integrin alpha-3 precursor [KO:K06482]
508819  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
508874  PFN4; profilin-4 [KO:K05759]
509748  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
510019  CYRIB; CYFIP-related Rac1 interactor B [KO:K27976]
510434  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
511976  ITGA8; integrin alpha-8 [KO:K06584]
512045  C5; complement C5a anaphylatoxin precursor [KO:K03994]
512431  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
512652  SSH2; protein phosphatase Slingshot homolog 2 isoform X5 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
512841  CRK; adapter molecule crk [KO:K04438]
512928  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
512950  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
513095  ENAH; protein enabled homolog isoform X12 [KO:K05746]
513217  C8B; complement component C8 beta chain precursor [KO:K03998]
513377  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
513432  PAK5; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
513539  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
513641  NCKAP1L; nck-associated protein 1-like [KO:K05750]
513673  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
513895  PFN1; profilin-1 [KO:K05759]
514031  ITGB7; integrin beta-7 precursor [KO:K06590]
514056  ITGAD; integrin alpha-D precursor [KO:K06594]
514106  MYL11; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
514212  MYH14; myosin-14 isoform X1 [KO:K10352]
514643  SSH3; protein phosphatase Slingshot homolog 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
515011  ITGA2B; integrin alpha-IIb [KO:K06476]
515088  GIT1; ARF GTPase-activating protein GIT1 isoform X2 [KO:K05737]
515159  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
515718  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
516175  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
517111  RDX; radixin [KO:K05762]
517356  C8G; complement component C8 gamma chain precursor [KO:K03999]
517456  PXN; paxillin isoform X3 [KO:K05760]
517948  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
518025  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
518180  CRKL; crk-like protein [KO:K04438]
518833  CYFIP2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
519269  RRAS2; ras-related protein R-Ras2 [KO:K07830]
519657  FGF22; fibroblast growth factor 22 precursor [KO:K04358]
521196  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
521379  PFN3; profilin-3 [KO:K05759]
521475  FGF19; fibroblast growth factor 19 [KO:K22603]
521961  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
522170  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
522269  ACTN4; alpha-actinin-4 [KO:K05699]
523755  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
524352  ARHGEF7; rho guanine nucleotide exchange factor 7 [KO:K13710]
524770  ACTN1; alpha-actinin-1 [KO:K05699]
525628  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
525931  PDGFD; platelet-derived growth factor D [KO:K05450]
526379  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
526572  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
526585  F2R; proteinase-activated receptor 1 precursor [KO:K03914]
526766  C9; complement component C9 precursor [KO:K04000]
527165  PDGFRB; platelet-derived growth factor receptor beta precursor [KO:K05089] [EC:2.7.10.1]
527391  C8A; complement component C8 alpha chain precursor [KO:K03997]
527550  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
529425  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
530050  MYH11; myosin-11 [KO:K10352]
530239  FGF23; fibroblast growth factor 23 [KO:K22428]
530315  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
531391  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
531488  WASF1; actin-binding protein WASF1 [KO:K05753]
531505  MYL12A; myosin regulatory light polypeptide 9 [KO:K12757]
532119  BDKRB1; B1 bradykinin receptor [KO:K03915]
532127  ITGA9; integrin alpha-9 precursor [KO:K06585]
532712  CDC42; cell division control protein 42 homolog [KO:K04393]
533199  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
533233  APC; adenomatous polyposis coli protein [KO:K02085]
533289  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
533378  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
533729  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
533823  ARHGEF6; rho guanine nucleotide exchange factor 6 [KO:K05729]
533929  FGF18; fibroblast growth factor 18 precursor [KO:K04358]
534526  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
534553  CFL1; cofilin-1 [KO:K05765]
534923  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
535043  ITGA6; integrin alpha-6 precursor [KO:K06485]
535077  GSN; gelsolin isoform b [KO:K05768]
535225  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
535742  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
535951  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
536051  BRAF; serine/threonine-protein kinase B-raf isoform X9 [KO:K04365] [EC:2.7.11.1]
536286  ITGB8; integrin beta-8 precursor [KO:K06591]
536517  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
536771  FGF5; fibroblast growth factor 5 precursor [KO:K04358]
537203  DOCK1; dedicator of cytokinesis protein 1 isoform X2 [KO:K13708]
537654  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X5 [KO:K00889] [EC:2.7.1.68]
537682  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
537711  ABI2; abl interactor 2 [KO:K05751]
538233  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
538486  ACTR2; actin-related protein 2 [KO:K17260]
538606  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
538829  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
538896  BDKRB2; B2 bradykinin receptor [KO:K03916]
539034  PFN2; profilin-2 [KO:K05759]
539083  FGF20; fibroblast growth factor 20 [KO:K04358]
539211  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
539224  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
539332  CFL2; cofilin-2 [KO:K05765]
539459  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
539738  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
539742  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
540005  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
540092  BRK1; protein BRICK1 [KO:K05752]
540106  PDGFB; platelet-derived growth factor subunit B precursor [KO:K17386]
540310  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
540317  FGF6; fibroblast growth factor 6 [KO:K04358]
540421  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
540426  MSN; moesin [KO:K05763]
540758  FGF16; fibroblast growth factor 16 [KO:K04358]
540803  MRAS; ras-related protein M-Ras [KO:K07831]
540838  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
541140  KRAS; GTPase KRas [KO:K07827]
613421  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
613731  FGF9; fibroblast growth factor 9 [KO:K04358]
613787  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
613811  CXCL12; stromal cell-derived factor 1 precursor [KO:K10031]
614055  MYL12B; myosin regulatory light chain 12B [KO:K12757]
614345  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
614348  RGCC; regulator of cell cycle RGCC [KO:K26108]
616404  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
616503  RRAS; ras-related protein R-Ras [KO:K07829]
616885  FGF7; fibroblast growth factor 7 precursor [KO:K04358]
617345  VAV1; proto-oncogene vav [KO:K05730]
617357  MYL10; myosin regulatory light chain 10 [KO:K12756]
618474  FGF4; fibroblast growth factor 4 precursor [KO:K04358]
618481  FGF3; fibroblast growth factor 3 [KO:K04358]
619066  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
782315  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
783645  VCL; vinculin [KO:K05700]
785576  FGF21; fibroblast growth factor 21 [KO:K22429]
785745  [KO:K05764]
785769  SPATA13; spermatogenesis-associated protein 13 isoform X3 [KO:K05769]
785911  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
786565  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
787068  INSRR; insulin receptor-related protein precursor [KO:K05086] [EC:2.7.10.1]
790873  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
bta04010  MAPK signaling pathway
bta04510  Focal adhesion
bta04520  Adherens junction
KO pathway
ko04810   

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