KEGG   PATHWAY: cfa04120
Entry
cfa04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Canis lupus familiaris (dog)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
cfa04120  Ubiquitin mediated proteolysis
cfa04120

Other DBs
GO: 0016567
Organism
Canis lupus familiaris (dog) [GN:cfa]
Gene
100684029  [KO:K10580] [EC:2.3.2.23]
100684685  UBOX5; RING finger protein 37 isoform X1 [KO:K10600]
100685242  UBE2G1; ubiquitin-conjugating enzyme E2 G1 isoform X1 [KO:K10575] [EC:2.3.2.23]
100685549  [KO:K12456]
100688110  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100688162  KLHL9; kelch-like protein 9 [KO:K10447]
100688676  UBE2Q1; ubiquitin-conjugating enzyme E2 Q1 [KO:K10582] [EC:2.3.2.23]
100855774  CDC20; cell division cycle protein 20 homolog [KO:K03363]
100856010  [KO:K10574] [EC:2.3.2.23]
100856331  RHOBTB2; rho-related BTB domain-containing protein 2 isoform X3 [KO:K07868]
100856496  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
100856557  FBXO4; F-box only protein 4 isoform X1 [KO:K10291]
100856769  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X4 [KO:K05633] [EC:2.3.2.26]
102151129  [KO:K02927]
102152434  TRIM32; E3 ubiquitin-protein ligase TRIM32 [KO:K10607] [EC:2.3.2.27]
102155320  [KO:K02207] [EC:2.3.2.23]
102155658  [KO:K04552] [EC:2.3.2.23]
102156563  [KO:K12456]
106557459  RNF7; RING-box protein 2 isoform X1 [KO:K10611]
106557503  FBXW8; F-box/WD repeat-containing protein 8 [KO:K10264]
106558148  [KO:K10580] [EC:2.3.2.23]
111090648  [KO:K03094]
111094434  [KO:K10580] [EC:2.3.2.23]
119863875  [KO:K10580] [EC:2.3.2.23]
119866339  [KO:K03872]
119870395  [KO:K10573] [EC:2.3.2.23]
119870849  [KO:K03872]
403437  BRCA1; breast cancer type 1 susceptibility protein homolog [KO:K10605] [EC:2.3.2.27]
403671  UBE2S; ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
403693  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
403722  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
442949  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
442989  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
474161  NHLRC1; E3 ubiquitin-protein ligase NHLRC1 [KO:K10602] [EC:2.3.2.27]
474494  RBX1; E3 ubiquitin-protein ligase RBX1 isoform X2 [KO:K03868] [EC:2.3.2.32]
474599  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
474682  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
474683  UBE2B; ubiquitin-conjugating enzyme E2 B [KO:K10574] [EC:2.3.2.23]
474993  UBE2J1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
475055  UBR5; E3 ubiquitin-protein ligase UBR5 isoform X5 [KO:K10593] [EC:2.3.2.26]
475160  UBA6; ubiquitin-like modifier-activating enzyme 6 isoform X2 [KO:K10699] [EC:6.2.1.45]
475453  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
475465  FBXW7; F-box/WD repeat-containing protein 7 isoform X4 [KO:K10260]
475512  CUL1; cullin-1 [KO:K03347]
475563  [KO:K20217] [EC:2.3.2.23]
475718  BIRC6; baculoviral IAP repeat-containing protein 6 isoform X47 [KO:K10586] [EC:2.3.2.23]
475750  ANAPC1; anaphase-promoting complex subunit 1 isoform X12 [KO:K03348]
475967  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X2 [KO:K04553] [EC:2.3.2.23]
476067  DDB1; DNA damage-binding protein 1 [KO:K10610]
476189  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X16 [KO:K13305] [EC:2.3.2.26]
476425  SAE1; SUMO-activating enzyme subunit 1 isoform X4 [KO:K10684] [EC:6.2.1.45]
476490  UBA2; SUMO-activating enzyme subunit 2 isoform X3 [KO:K10685] [EC:6.2.1.45]
476560  UBA3; NEDD8-activating enzyme E1 catalytic subunit isoform X3 [KO:K10686] [EC:6.2.1.64]
476713  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
476759  CDC34; ubiquitin-conjugating enzyme E2 R1 [KO:K02207] [EC:2.3.2.23]
476784  [KO:K10580] [EC:2.3.2.23]
476817  ANAPC15; anaphase-promoting complex subunit 15 isoform X2 [KO:K25228]
477048  UBE2E1; ubiquitin-conjugating enzyme E2 E1 isoform X1 [KO:K20217] [EC:2.3.2.23]
477199  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X2 [KO:K05632] [EC:2.3.2.26]
477392  CUL3; cullin-3 isoform X5 [KO:K03869]
477400  TRIP12; E3 ubiquitin-protein ligase TRIP12 isoform X1 [KO:K10590] [EC:2.3.2.26]
477421  UBE2F; NEDD8-conjugating enzyme UBE2F isoform X1 [KO:K10687] [EC:2.3.2.34]
477471  ANAPC5; anaphase-promoting complex subunit 5 isoform X2 [KO:K03352]
477572  UBE2L3; ubiquitin-conjugating enzyme E2 L3 isoform X2 [KO:K04552] [EC:2.3.2.23]
477573  PPIL2; RING-type E3 ubiquitin-protein ligase PPIL2 isoform X1 [KO:K10598] [EC:5.2.1.8]
477914  ELOC; elongin-C [KO:K03872]
477952  CUL2; cullin-2 isoform X1 [KO:K03870]
478061  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
478231  FBXO2; F-box only protein 2 isoform X1 [KO:K10099]
478350  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X2 [KO:K04706] [EC:2.3.2.-]
478374  UBE2Q2; ubiquitin-conjugating enzyme E2 Q2 isoform X2 [KO:K10582] [EC:2.3.2.23]
478475  HERC3; probable E3 ubiquitin-protein ligase HERC3 isoform X1 [KO:K10614] [EC:2.3.2.26]
478495  UBE2D3; ubiquitin-conjugating enzyme E2 D3 isoform X2 [KO:K06689] [EC:2.3.2.23]
479005  HERC2; E3 ubiquitin-protein ligase HERC2 isoform X2 [KO:K10595] [EC:2.3.2.26]
479010  UBE3A; ubiquitin-protein ligase E3A isoform X3 [KO:K10587] [EC:2.3.2.26]
479036  DET1; DET1 homolog isoform X2 [KO:K10571]
479123  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
479225  HERC4; probable E3 ubiquitin-protein ligase HERC4 isoform X5 [KO:K10615] [EC:2.3.2.26]
479291  FBXW11; F-box/WD repeat-containing protein 11 isoform X5 [KO:K03362]
479418  UBE4A; ubiquitin conjugation factor E4 A [KO:K10596] [EC:2.3.2.27]
479464  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
479513  UBB; polyubiquitin-B [KO:K04551]
479603  UBE4B; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
479672  WWP2; NEDD4-like E3 ubiquitin-protein ligase WWP2 [KO:K05630] [EC:2.3.2.26]
479863  MGRN1; E3 ubiquitin-protein ligase MGRN1 isoform X8 [KO:K10604] [EC:2.3.2.27]
479873  ELOB; elongin-B isoform X1 [KO:K03873]
479892  STUB1; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
479932  [KO:K10580] [EC:2.3.2.23]
480060  COP1; E3 ubiquitin-protein ligase COP1 isoform X6 [KO:K10143] [EC:2.3.2.27]
480147  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X3 [KO:K16063] [EC:2.3.2.-]
480470  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
480575  TRIM37; E3 ubiquitin-protein ligase TRIM37 isoform X8 [KO:K10608] [EC:2.3.2.27]
480896  UBA1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
480931  HUWE1; E3 ubiquitin-protein ligase HUWE1 isoform X7 [KO:K10592] [EC:2.3.2.26]
481325  [KO:K06688] [EC:2.3.2.23]
481526  CDC23; cell division cycle protein 23 homolog isoform X2 [KO:K03355]
481679  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
481807  CUL7; cullin-7 isoform X1 [KO:K10613]
482822  UBE3C; ubiquitin-protein ligase E3C isoform X4 [KO:K10589] [EC:2.3.2.26]
483160  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X2 [KO:K16064] [EC:2.3.2.-]
483330  UBE2O; (E3-independent) E2 ubiquitin-conjugating enzyme isoform X2 [KO:K10581] [EC:2.3.2.24]
483370  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
483626  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
483746  SYVN1; E3 ubiquitin-protein ligase synoviolin isoform X2 [KO:K10601] [EC:2.3.2.27]
484221  UBE2M; NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
485049  PIAS4; E3 SUMO-protein ligase PIAS4 isoform X3 [KO:K16065] [EC:2.3.2.27]
485059  FZR1; fizzy-related protein homolog isoform X1 [KO:K03364]
485898  UBE2C; ubiquitin-conjugating enzyme E2 C isoform X1 [KO:K06688] [EC:2.3.2.23]
485969  BIRC7; baculoviral IAP repeat-containing protein 7 [KO:K16061]
486264  ANAPC7; anaphase-promoting complex subunit 7 isoform X3 [KO:K03354]
486311  UBE3B; ubiquitin-protein ligase E3B isoform X1 [KO:K10588] [EC:2.3.2.26]
486851  BTRC; F-box/WD repeat-containing protein 1A isoform X2 [KO:K03362]
486999  UBE2W; ubiquitin-conjugating enzyme E2 W isoform X1 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
487225  ERCC8; DNA excision repair protein ERCC-8 isoform X3 [KO:K10570]
487592  HERC1; probable E3 ubiquitin-protein ligase HERC1 isoform X1 [KO:K10594] [EC:2.3.2.26]
487641  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
487796  AIRE; autoimmune regulator [KO:K10603]
487965  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
488058  UBE2QL1; ubiquitin-conjugating enzyme E2Q-like protein 1 isoform X1 [KO:K10582] [EC:2.3.2.23]
488998  RHOBTB1; rho-related BTB domain-containing protein 1 isoform X1 [KO:K07868]
489228  SKP2; S-phase kinase-associated protein 2 isoform X5 [KO:K03875]
489369  CBL; E3 ubiquitin-protein ligase CBL isoform X2 [KO:K04707] [EC:2.3.2.27]
489422  CUL5; LOW QUALITY PROTEIN: cullin-5 [KO:K10612]
489433  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
490006  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
490924  CDC27; cell division cycle protein 27 homolog isoform X4 [KO:K03350]
491062  UBE2Z; ubiquitin-conjugating enzyme E2 Z [KO:K10585] [EC:2.3.2.23]
491236  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
491332  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
491737  MID1; E3 ubiquitin-protein ligase Midline-1 isoform X2 [KO:K08285] [EC:2.3.2.27]
492088  KLHL13; kelch-like protein 13 isoform X7 [KO:K10447]
492095  UBE2A; ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:2.3.2.23]
492102  CUL4B; cullin-4B isoform X3 [KO:K10609]
494000  VHL; von Hippel-Lindau disease tumor suppressor [KO:K03871]
606935  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
607100  CDC16; cell division cycle protein 16 homolog isoform X3 [KO:K03353]
607683  CUL4A; cullin-4A isoform X5 [KO:K10609]
607816  UBE2H; ubiquitin-conjugating enzyme E2 H isoform X3 [KO:K10576] [EC:2.3.2.23]
607817  [KO:K10580] [EC:2.3.2.23]
607889  [KO:K10580] [EC:2.3.2.23]
608118  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
608342  ANAPC16; anaphase-promoting complex subunit 16 isoform X1 [KO:K25229]
608578  UBE2D1; ubiquitin-conjugating enzyme E2 D1 [KO:K06689] [EC:2.3.2.23]
608680  [KO:K10580] [EC:2.3.2.23]
608738  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
608821  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
609033  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
609108  [KO:K10580] [EC:2.3.2.23]
609531  UBE2K; ubiquitin-conjugating enzyme E2 K isoform X1 [KO:K04649] [EC:2.3.2.23]
609637  [KO:K10580] [EC:2.3.2.23]
609932  UBE2U; ubiquitin-conjugating enzyme E2 U isoform X1 [KO:K10584] [EC:2.3.2.23]
610187  UBE2E2; ubiquitin-conjugating enzyme E2 E2 isoform X1 [KO:K20217] [EC:2.3.2.23]
610206  [KO:K10580] [EC:2.3.2.23]
611552  PRPF19; pre-mRNA-processing factor 19 isoform X1 [KO:K10599] [EC:2.3.2.27]
611581  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X3 [KO:K04555] [EC:2.3.2.23]
611799  UBE2R2; ubiquitin-conjugating enzyme E2 R2 [KO:K02207] [EC:2.3.2.23]
611801  [KO:K10580] [EC:2.3.2.23]
611865  UBE2N; ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
612161  FANCL; E3 ubiquitin-protein ligase FANCL isoform X5 [KO:K10606] [EC:2.3.2.27]
612316  PRKN; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
612343  CBLC; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
612742  UBE2D2; ubiquitin-conjugating enzyme E2 D2 isoform X1 [KO:K06689] [EC:2.3.2.23]
612746  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X7 [KO:K10144] [EC:2.3.2.27]
612823  UBE2E3; ubiquitin-conjugating enzyme E2 E3 isoform X1 [KO:K20217] [EC:2.3.2.23]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
cfa03050  Proteasome
KO pathway
ko04120   

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