KEGG   PATHWAY: cgob04144
Entry
cgob04144                   Pathway                                
Name
Endocytosis - Cottoperca gobio
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
cgob04144  Endocytosis
cgob04144

Other DBs
GO: 0006897
Organism
Cottoperca gobio [GN:cgob]
Gene
115003445  [KO:K07941]
115003505  [KO:K12476]
115003814  [KO:K12474]
115003887  igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564]
115004580  [KO:K18584]
115004665  vps45; vacuolar protein sorting-associated protein 45 [KO:K12479]
115004776  arf5; ADP-ribosylation factor 5 [KO:K07939]
115004824  [KO:K12495]
115004848  [KO:K10396] [EC:5.6.1.3]
115004882  [KO:K12494]
115004957  [KO:K12562]
115005005  [KO:K12185]
115005033  amph; amphiphysin [KO:K12562]
115005330  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
115005484  [KO:K05069]
115005566  [KO:K01528] [EC:3.6.5.5]
115005681  [KO:K23605]
115005781  [KO:K04388] [EC:2.7.11.30]
115005886  [KO:K04388] [EC:2.7.11.30]
115005929  arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
115006097  [KO:K03283]
115006131  [KO:K18441]
115006236  wipf2; WAS/WASL-interacting protein family member 2 isoform X1 [KO:K19475]
115006326  spg21; maspardin [KO:K19367]
115006335  ist1; IST1 homolog isoform X1 [KO:K19476]
115006567  [KO:K12196]
115006641  pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
115006645  acap2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
115006742  pdgfra; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
115006757  eps15; epidermal growth factor receptor substrate 15 [KO:K12472]
115006776  dnm3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
115006801  [KO:K07905]
115006856  [KO:K04679]
115006911  [KO:K12472]
115007144  [KO:K11247]
115007172  dnajc6; LOW QUALITY PROTEIN: putative tyrosine-protein phosphatase auxilin [KO:K09526]
115007248  rab8a; ras-related protein Rab-8A [KO:K07901]
115007421  arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
115007706  [KO:K17920]
115007725  [KO:K05757]
115007835  [KO:K07897]
115007901  [KO:K12194]
115007950  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
115007964  [KO:K12495]
115007984  [KO:K05704] [EC:2.7.10.2]
115007997  [KO:K12488]
115008046  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
115008052  [KO:K04513]
115008074  [KO:K07938]
115008106  [KO:K07891]
115008135  [KO:K05632] [EC:2.3.2.26]
115008141  kif5a; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
115008187  [KO:K12958]
115008229  [KO:K17848]
115008237  [KO:K10364]
115008238  [KO:K04513]
115008278  [KO:K05755]
115008284  [KO:K12485]
115008354  cav3; caveolin-3 [KO:K12959]
115008492  [KO:K12489]
115008553  [KO:K07897]
115008700  [KO:K12958]
115008730  [KO:K07897]
115008776  [KO:K05755]
115008836  [KO:K04393]
115009156  cav2; caveolin-2 [KO:K12958]
115009210  [KO:K23612]
115009466  eea1; early endosome antigen 1 [KO:K12478]
115009481  [KO:K12196]
115009500  [KO:K17917]
115009507  washc4; WASH complex subunit 4 isoform X1 [KO:K18465]
115009523  washc1; WASH complex subunit 1 [KO:K18461]
115009532  tsg101; tumor susceptibility gene 101 protein [KO:K12183]
115009535  hras; GTPase HRas [KO:K02833]
115009816  igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
115009828  [KO:K07939]
115009849  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
115009939  capza2; F-actin-capping protein subunit alpha-2 isoform X1 [KO:K10364]
115009978  chmp1a; charged multivesicular body protein 1a [KO:K12197]
115009980  [KO:K12194]
115009981  [KO:K06093]
115010103  [KO:K04678] [EC:2.3.2.26]
115010118  [KO:K12495]
115010224  clta; clathrin light chain A isoform X1 [KO:K04644]
115010234  cav1; caveolin-1 [KO:K06278]
115010449  [KO:K04393]
115010466  [KO:K10364]
115010493  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
115010496  [KO:K03283]
115010547  [KO:K12495]
115010595  mvb12a; multivesicular body subunit 12A [KO:K12186]
115010661  arf3; ADP-ribosylation factor 3 [KO:K07938]
115010684  [KO:K05704] [EC:2.7.10.2]
115010688  [KO:K04513]
115010789  [KO:K04513]
115010790  [KO:K04513]
115010823  [KO:K05632] [EC:2.3.2.26]
115010847  [KO:K17848]
115010863  [KO:K18442]
115010866  [KO:K12489]
115010897  rbsn; rabenosyn-5 [KO:K12481]
115010940  [KO:K10396] [EC:5.6.1.3]
115010941  [KO:K12495]
115011083  pard6b; partitioning defective 6 homolog beta [KO:K06093]
115011086  [KO:K12958]
115011265  [KO:K12194]
115011325  [KO:K12495]
115011422  [KO:K12473]
115011671  [KO:K23484]
115011822  ap2a1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
115011894  [KO:K18441]
115011926  [KO:K07876]
115011997  rab5c; ras-related protein Rab-5C [KO:K07889]
115012006  epn2; epsin-2 isoform X1 [KO:K12471]
115012055  [KO:K04678] [EC:2.3.2.26]
115012066  sh3gl2; endophilin-A1 isoform X1 [KO:K11247]
115012188  epn3; epsin-3 isoform X1 [KO:K12471]
115012201  [KO:K18441]
115012205  [KO:K07937]
115012230  [KO:K18441]
115012308  [KO:K05757]
115012352  [KO:K12485]
115012462  [KO:K12195]
115012519  ldlr; low-density lipoprotein receptor [KO:K12473]
115012699  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
115012720  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
115012725  [KO:K05069]
115012925  [KO:K21269]
115012936  [KO:K13712] [EC:2.7.1.68]
115013027  chmp7; charged multivesicular body protein 7 [KO:K15053]
115013191  [KO:K08291] [EC:2.7.11.16]
115013192  [KO:K04646]
115013252  [KO:K05757]
115013311  [KO:K12484]
115013365  git2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
115013378  [KO:K00889] [EC:2.7.1.68]
115013818  mvb12b; multivesicular body subunit 12B [KO:K12186]
115013923  snx2; sorting nexin-2 [KO:K17917]
115013998  stambp; STAM-binding protein isoform X1 [KO:K11866] [EC:3.4.19.12]
115014025  vps37b; vacuolar protein sorting-associated protein 37B [KO:K12185]
115014050  [KO:K04500]
115014051  [KO:K04500]
115014073  rab35; ras-related protein Rab-35 isoform X1 [KO:K07876]
115014215  zfyve27; protrudin isoform X1 [KO:K19368]
115014322  cltb; clathrin light chain B isoform X1 [KO:K04645]
115014526  psd2; PH and SEC7 domain-containing protein 2 isoform X1 [KO:K12494]
115014729  [KO:K12483]
115014915  [KO:K12471]
115015121  [KO:K12484]
115015185  rufy1; RUN and FYVE domain-containing protein 1 [KO:K12482]
115015367  [KO:K04393]
115015440  [KO:K00889] [EC:2.7.1.68]
115015457  tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
115015535  [KO:K12486]
115015778  pdcd6ip; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
115015824  [KO:K12486]
115015924  [KO:K06751]
115016072  wipf3; WAS/WASL-interacting protein family member 3 isoform X1 [KO:K19475]
115016192  [KO:K12474]
115016195  [KO:K06751]
115016254  vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
115016257  [KO:K07887]
115016276  [KO:K06093]
115016394  [KO:K04679]
115016432  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
115016456  [KO:K12494]
115016473  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
115016508  [KO:K21269]
115016510  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
115016579  [KO:K12487]
115016729  [KO:K08291] [EC:2.7.11.16]
115016732  [KO:K17260]
115016817  pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
115016835  dnm1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
115016976  dab2; disabled homolog 2 isoform X1 [KO:K12475]
115017167  [KO:K00889] [EC:2.7.1.68]
115017198  [KO:K12484]
115017239  agap1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
115017313  [KO:K04646]
115017385  arap1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
115017399  [KO:K00909] [EC:2.7.11.14]
115017446  vps26b; vacuolar protein sorting-associated protein 26B [KO:K18466]
115017520  [KO:K13649]
115017523  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
115017526  [KO:K04513]
115017571  [KO:K03283]
115017572  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
115017575  ap2s1; AP-2 complex subunit sigma [KO:K11827]
115017856  [KO:K05093] [EC:2.7.10.1]
115017933  [KO:K05093] [EC:2.7.10.1]
115018065  [KO:K12469]
115018066  arrb1; beta-arrestin-1 [KO:K04439]
115018092  [KO:K12185]
115018132  ehd2; EH domain-containing protein 2 isoform X1 [KO:K12469]
115018207  [KO:K11826]
115018217  [KO:K19366]
115018425  vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
115018518  cblb; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
115018552  [KO:K04439]
115018623  [KO:K05070]
115018624  snx12; sorting nexin-12 isoform X1 [KO:K17918]
115018681  grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
115018698  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
115018699  [KO:K11825]
115018734  chmp1b; charged multivesicular body protein 1b [KO:K12197]
115018739  [KO:K18584]
115018877  [KO:K04707] [EC:2.3.2.27]
115018984  spart; spartin isoform X1 [KO:K19366]
115018990  [KO:K00909] [EC:2.7.11.14]
115018997  [KO:K18466]
115019023  [KO:K18440]
115019056  [KO:K05050]
115019070  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
115019083  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
115019162  [KO:K01115] [EC:3.1.4.4]
115019469  cltc; clathrin heavy chain 1 isoform X1 [KO:K04646]
115019690  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
115019713  gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 [KO:K18443]
115019891  rab11fip2; LOW QUALITY PROTEIN: rab11 family-interacting protein 2 [KO:K12484]
115019932  snx5; sorting nexin-5 isoform X1 [KO:K17920]
115020148  [KO:K12486]
115020205  [KO:K18462]
115020461  wipf1; WAS/WASL-interacting protein family member 1 isoform X1 [KO:K19475]
115020477  actr2; actin-related protein 2 isoform X1 [KO:K17260]
115020751  [KO:K04393]
115020784  [KO:K22518] [EC:2.3.2.27]
115020893  [KO:K08291] [EC:2.7.11.16]
115020950  [KO:K07904]
115021072  [KO:K12471]
115021104  [KO:K04393]
115021117  [KO:K03283]
115021224  [KO:K00889] [EC:2.7.1.68]
115021300  [KO:K23484]
115021317  washc5; WASH complex subunit 5 [KO:K18464]
115021364  rab5a; ras-related protein Rab-5A [KO:K07887]
115021449  [KO:K04180]
115021823  [KO:K10396] [EC:5.6.1.3]
115021876  cyth2; cytohesin-2 [KO:K18441]
115021986  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
115022037  [KO:K11247]
115022064  [KO:K12472]
115022085  zfyve9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
115022094  [KO:K05754]
115022096  [KO:K04237]
115022178  [KO:K07905]
115022205  [KO:K01528] [EC:3.6.5.5]
115022244  [KO:K10396] [EC:5.6.1.3]
115022366  stam; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
115022376  chmp5; charged multivesicular body protein 5 [KO:K12198]
115022485  [KO:K04361] [EC:2.7.10.1]
115022501  [KO:K07901]
115022536  arf1; ADP-ribosylation factor 1 [KO:K07937]
115022559  [KO:K11826]
115022626  [KO:K04189]
115022630  [KO:K12472]
115022688  [KO:K00909] [EC:2.7.11.14]
115022702  tfrc; transferrin receptor protein 1 isoform X1 [KO:K06503]
115022826  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
115022893  [KO:K00889] [EC:2.7.1.68]
115022937  rab31; ras-related protein Rab-31 [KO:K07891]
115023093  agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 [KO:K12491]
115023418  [KO:K17260]
115023434  [KO:K04439]
115023482  acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12489]
115023493  [KO:K12474]
115023551  [KO:K11247]
115023939  arap2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
115024229  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
115024256  chmp6; charged multivesicular body protein 6 [KO:K12195]
115024344  cyth3; cytohesin-3 [KO:K18441]
115024430  [KO:K07937]
115024456  chmp2a; charged multivesicular body protein 2a [KO:K12191]
115024457  rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
115024472  [KO:K18441]
115024484  snf8; vacuolar-sorting protein SNF8 [KO:K12188]
115024527  rab4a; ras-related protein Rab-4A [KO:K07879]
115024607  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
115024996  [KO:K07889]
115025048  [KO:K12494]
115025265  [KO:K24782]
115025292  kif5b; kinesin-1 heavy chain [KO:K10396] [EC:5.6.1.3]
115025321  [KO:K11248]
115025327  asap1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
115025371  [KO:K05633] [EC:2.3.2.26]
115025401  vps37c; vacuolar protein sorting-associated protein 37C [KO:K12185]
115025542  sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
115025564  arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
115025632  [KO:K04237]
115025646  [KO:K12198]
115025660  [KO:K06503]
115025932  cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
115025996  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
115026286  [KO:K00909] [EC:2.7.11.14]
115026324  [KO:K18584]
115026336  rab11a; ras-related protein Rab-11A [KO:K07904]
115026372  [KO:K12562]
115026402  [KO:K05050]
115026491  [KO:K05050]
115026716  [KO:K07888]
115026722  chmp2b; charged multivesicular body protein 2b [KO:K12192]
115026760  [KO:K17919]
115026853  nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
115026967  chmp3; charged multivesicular body protein 3 [KO:K12193]
115026979  [KO:K12484]
115027074  [KO:K07941]
115027139  [KO:K05094] [EC:2.7.10.1]
115027175  [KO:K11248]
115027280  [KO:K12488]
115027282  asap2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [KO:K12488]
115027444  usp8; ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
115027468  [KO:K11247]
115027470  [KO:K12477]
115027477  [KO:K01115] [EC:3.1.4.4]
115027802  vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
115027896  ldlrap1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
115028104  [KO:K17919]
115028266  iqsec3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
115028324  wasl; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
115028540  washc3; WASH complex subunit 3 [KO:K18463]
115028571  grk1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
115028600  arfgap3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
115028822  vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
115028946  [KO:K11824]
115028959  snx3; sorting nexin-3 [KO:K17918]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
cgob04060  Cytokine-cytokine receptor interaction
cgob04070  Phosphatidylinositol signaling system
cgob04130  SNARE interactions in vesicular transport
cgob04142  Lysosome biogenesis
cgob04350  TGF-beta signaling pathway
KO pathway
ko04144   

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