KEGG   PATHWAY: dre00280
Entry
dre00280                    Pathway                                
Name
Valine, leucine and isoleucine degradation - Danio rerio (zebrafish)
Class
Metabolism; Amino acid metabolism
Pathway map
dre00280  Valine, leucine and isoleucine degradation
dre00280

Module
dre_M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:dre00280]
dre_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:dre00280]
Other DBs
GO: 0006550 0006552 0006574
Organism
Danio rerio (zebrafish) [GN:dre]
Gene
100000026  aldh3a1; aldehyde dehydrogenase family 3 member A2 [KO:K00128] [EC:1.2.1.3]
100000859  ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
100004018  [KO:K01969] [EC:6.4.1.4]
100005587  aldh9a1a.1; 4-trimethylaminobutyraldehyde dehydrogenase A [KO:K00149] [EC:1.2.1.47 1.2.1.3]
100006238  aldh9a1a.2; aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 2 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
110437777  acadsb; short/branched chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K09478] [EC:1.3.8.5]
30643  acat2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
323653  aldh3a2a; aldehyde dehydrogenase family 3 member A2a [KO:K00128] [EC:1.2.1.3]
334197  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
336606  hadhb; trifunctional enzyme subunit beta, mitochondrial [KO:K07509] [EC:2.3.1.16]
337166  il4i1; L-amino-acid oxidase isoform X2 [KO:K03334] [EC:1.4.3.2]
337412  bcat1; branched-chain-amino-acid aminotransferase, cytosolic [KO:K00826] [EC:2.6.1.42]
368239  aldh2.2; aldehyde dehydrogenase 2 family member, tandem duplicate 2 [KO:K00128] [EC:1.2.1.3]
368775  ivd; isovaleryl-CoA dehydrogenase, mitochondrial [KO:K00253] [EC:1.3.8.4]
368912  echs1; enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
378968  abaT; 4-aminobutyrate aminotransferase, mitochondrial isoform X1 [KO:K13524] [EC:2.6.1.19 2.6.1.22]
393462  aldh2.1; aldehyde dehydrogenase 2 family member, tandem duplicate 1 [KO:K00128] [EC:1.2.1.3]
393984  aacS; acetoacetyl-CoA synthetase [KO:K01907] [EC:6.2.1.16]
394060  hmgcs1; hydroxymethylglutaryl-CoA synthase, cytoplasmic [KO:K01641] [EC:2.3.3.10]
394130  acad8; isobutyryl-CoA dehydrogenase, mitochondrial [KO:K11538] [EC:1.3.99.-]
394135  [KO:K00020] [EC:1.1.1.31]
394190  hmgcl; hydroxymethylglutaryl-CoA lyase, mitochondrial [KO:K01640] [EC:4.1.3.4]
399479  dld; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
399481  aldh9a1b; 4-trimethylaminobutyraldehyde dehydrogenase B isoform X1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
405861  pccB; propionyl-CoA carboxylase beta chain, mitochondrial [KO:K01966] [EC:6.4.1.3 2.1.3.15]
405863  mccc2; methylcrotonoyl-CoA carboxylase beta chain, mitochondrial [KO:K01969] [EC:6.4.1.4]
406283  acadm; medium-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00249] [EC:1.3.8.7]
406325  acaa2; 3-ketoacyl-CoA thiolase, mitochondrial [KO:K07508] [EC:2.3.1.16]
431754  acaa1; 3-ketoacyl-CoA thiolase, peroxisomal [KO:K07513] [EC:2.3.1.16]
436647  aldh6a1; methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial [KO:K00140] [EC:1.2.1.18 1.2.1.27]
436949  bcat2; branched-chain-amino-acid aminotransferase, mitochondrial isoform 1 precursor [KO:K00826] [EC:2.6.1.42]
437019  pccA; propionyl-CoA carboxylase alpha chain, mitochondrial [KO:K01965] [EC:6.4.1.3]
442923  oxct1a; succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial [KO:K01027] [EC:2.8.3.5]
445121  hadH; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
445182  auh; methylglutaconyl-CoA hydratase, mitochondrial [KO:K05607] [EC:4.2.1.18]
445252  [KO:K00020] [EC:1.1.1.31]
445288  acads; short-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00248] [EC:1.3.8.1]
445290  acat1; acetyl-CoA acetyltransferase, mitochondrial precursor [KO:K00626] [EC:2.3.1.9]
447920  aldh3a2b; aldehyde dehydrogenase family 3 member A2b [KO:K00128] [EC:1.2.1.3]
450078  hsd17b10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
492710  aldh16a1; aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
541388  dbt; lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial [KO:K09699] [EC:2.3.1.168]
553401  hadhaa; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha A [KO:K07515] [EC:4.2.1.17 1.1.1.211]
553804  mceE; methylmalonyl-CoA epimerase, mitochondrial [KO:K05606] [EC:5.1.99.1]
554124  bckdha; 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial [KO:K00166] [EC:1.2.4.4]
560273  oxct1b; 3-oxoacid CoA transferase 1b [KO:K01027] [EC:2.8.3.5]
562292  acsf3; malonate--CoA ligase ACSF3, mitochondrial [KO:K18660] [EC:6.2.1.76 6.2.1.-]
569581  mmuT; methylmalonyl-CoA mutase, mitochondrial isoform X1 [KO:K01847] [EC:5.4.99.2]
569980  bckdhb; 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial [KO:K00167] [EC:1.2.4.4]
570457  aox6; aldehyde oxidase 6 [KO:K00157] [EC:1.2.3.1]
571388  hmgcll1; 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic [KO:K01640] [EC:4.1.3.4]
619269  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
64265  aox5; aldehyde oxidase 5 [KO:K00157] [EC:1.2.3.1]
777632  mccc1; methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial [KO:K01968] [EC:6.4.1.4]
793834  hadhab; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha B [KO:K07515] [EC:4.2.1.17 1.1.1.211]
798364  hibch; 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial [KO:K05605] [EC:3.1.2.4]
Compound
C00024  Acetyl-CoA
C00068  Thiamin diphosphate
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00164  Acetoacetate
C00183  L-Valine
C00233  4-Methyl-2-oxopentanoate
C00332  Acetoacetyl-CoA
C00349  2-Methyl-3-oxopropanoate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00407  L-Isoleucine
C00630  2-Methylpropanoyl-CoA
C00671  (S)-3-Methyl-2-oxopentanoic acid
C00683  (S)-Methylmalonyl-CoA
C01205  (R)-3-Amino-2-methylpropanoate
C01213  (R)-Methylmalonyl-CoA
C02170  Methylmalonate
C02939  3-Methylbutanoyl-CoA
C03069  3-Methylcrotonyl-CoA
C03231  3-Methylglutaconyl-CoA
C03284  L-3-Aminoisobutanoate
C03344  2-Methylacetoacetyl-CoA
C03345  2-Methylbut-2-enoyl-CoA
C03460  2-Methylprop-2-enoyl-CoA
C04405  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
C05996  Branched chain fatty acid
C05998  3-Hydroxyisovaleryl-CoA
C06000  (S)-3-Hydroxyisobutyryl-CoA
C06001  (S)-3-Hydroxyisobutyrate
C06002  (S)-Methylmalonate semialdehyde
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C15974  3-Methyl-1-hydroxybutyl-ThPP
C15975  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
C15976  2-Methyl-1-hydroxypropyl-ThPP
C15977  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
C15978  2-Methyl-1-hydroxybutyl-ThPP
C15979  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
C15980  (S)-2-Methylbutanoyl-CoA
C20827  3-Hydroxyisovalerate
Related
pathway
dre00020  Citrate cycle (TCA cycle)
dre00240  Pyrimidine metabolism
dre00290  Valine, leucine and isoleucine biosynthesis
dre00640  Propanoate metabolism
dre00900  Terpenoid backbone biosynthesis
KO pathway
ko00280   

DBGET integrated database retrieval system