KEGG   PATHWAY: els04120
Entry
els04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Esox lucius (northern pike)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
els04120  Ubiquitin mediated proteolysis
els04120

Other DBs
GO: 0016567
Organism
Esox lucius (northern pike) [GN:els]
Gene
105015226  polyubiquitin-C [KO:K08770]
105030977  ubc; polyubiquitin-C [KO:K08770]
105024444  ubiquitin-60S ribosomal protein L40 [KO:K02927]
105026211  ubiquitin-60S ribosomal protein L40 [KO:K02927]
105010516  rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
105023702  ubiquitin-like modifier-activating enzyme 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
105006802  uba1; ubiquitin-like modifier-activating enzyme 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
105012732  sae1; SUMO-activating enzyme subunit 1 [KO:K10684] [EC:6.2.1.45]
105018520  uba2; SUMO-activating enzyme subunit 2 isoform X1 [KO:K10685] [EC:6.2.1.45]
105013730  uba3; NEDD8-activating enzyme E1 catalytic subunit isoform X1 [KO:K10686] [EC:6.2.1.64]
105009648  uba6; ubiquitin-like modifier-activating enzyme 6 [KO:K10699] [EC:6.2.1.45]
105016494  ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:2.3.2.23]
105007763  ube2a; ubiquitin-conjugating enzyme E2A [KO:K10573] [EC:2.3.2.23]
105025433  ube2a; ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:2.3.2.23]
105026696  ube2b; ubiquitin-conjugating enzyme E2 B [KO:K10574] [EC:2.3.2.23]
105016710  ube2c; ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
105010549  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
105010898  ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
105015883  ubiquitin-conjugating enzyme E2 D2 isoform X1 [KO:K06689] [EC:2.3.2.23]
105029919  ubiquitin-conjugating enzyme E2 D2 isoform X1 [KO:K06689] [EC:2.3.2.23]
105026292  ube2d1; ubiquitin-conjugating enzyme E2 D1 [KO:K06689] [EC:2.3.2.23]
105014240  ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
105026747  ube2d2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
105021876  ubiquitin-conjugating enzyme E2 E2-like [KO:K20217] [EC:2.3.2.23]
105021877  ubiquitin-conjugating enzyme E2 E1 [KO:K20217] [EC:2.3.2.23]
105012542  ube2e1; ubiquitin-conjugating enzyme E2 E1 [KO:K20217] [EC:2.3.2.23]
105016347  ube2e3; ubiquitin-conjugating enzyme E2 E3 [KO:K20217] [EC:2.3.2.23]
106024483  ubiquitin-conjugating enzyme E2 E2 isoform X1 [KO:K20217] [EC:2.3.2.23]
105026253  ube2f; NEDD8-conjugating enzyme UBE2F isoform X2 [KO:K10687] [EC:2.3.2.34]
105014826  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
105025954  ube2g1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
105014186  ubiquitin-conjugating enzyme E2 G1 isoform X1 [KO:K10575] [EC:2.3.2.23]
105008097  ube2g2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
105020346  ube2h; ubiquitin-conjugating enzyme E2 H [KO:K10576] [EC:2.3.2.23]
105022174  ubiquitin-conjugating enzyme E2 H [KO:K10576] [EC:2.3.2.23]
105013396  SUMO-conjugating enzyme UBC9-B [KO:K10577]
105021299  ube2i; SUMO-conjugating enzyme UBC9 [KO:K10577]
105029658  SUMO-conjugating enzyme UBC9 [KO:K10577]
105017866  ube2j1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
105006208  ube2j2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
105009164  ube2k; ubiquitin-conjugating enzyme E2 K [KO:K04649] [EC:2.3.2.23]
105026169  ubiquitin-conjugating enzyme E2 K isoform X1 [KO:K04649] [EC:2.3.2.23]
105014537  ube2l3; ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
105014760  ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
105013286  ube2m; NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
105005930  ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
105022147  ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
105021628  ube2o; (E3-independent) E2 ubiquitin-conjugating enzyme isoform X3 [KO:K10581] [EC:2.3.2.24]
105012405  ube2ql1; ubiquitin-conjugating enzyme E2Q-like protein 1 [KO:K10582] [EC:2.3.2.23]
105015542  ubiquitin-conjugating enzyme E2 Q2 isoform X1 [KO:K10582] [EC:2.3.2.23]
105018371  ubiquitin-conjugating enzyme E2 Q2-like isoform X1 [KO:K10582] [EC:2.3.2.23]
105011597  ubiquitin-conjugating enzyme E2 R1 [KO:K02207] [EC:2.3.2.23]
105020474  ubiquitin-conjugating enzyme E2 R1 [KO:K02207] [EC:2.3.2.23]
105016786  ubiquitin-conjugating enzyme E2 R2 [KO:K02207] [EC:2.3.2.23]
105019014  ube2s; ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
105019654  ube2w; ubiquitin-conjugating enzyme E2 W isoform X1 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
105013263  ube2z; ubiquitin-conjugating enzyme E2 Z [KO:K10585] [EC:2.3.2.23]
105023260  birc6; baculoviral IAP repeat-containing protein 6 isoform X2 [KO:K10586] [EC:2.3.2.23]
105019708  ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
105011338  ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
105014438  ube3b; ubiquitin-protein ligase E3B [KO:K10588] [EC:2.3.2.26]
105019365  ube3c; ubiquitin-protein ligase E3C [KO:K10589] [EC:2.3.2.26]
105021636  E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
105009663  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
105013159  E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
105030547  E3 ubiquitin-protein ligase Itchy isoform X1 [KO:K05632] [EC:2.3.2.26]
105022768  E3 ubiquitin-protein ligase Itchy isoform X1 [KO:K05632] [EC:2.3.2.26]
105031534  wwp1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
105018552  wwp2; NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1 [KO:K05630] [EC:2.3.2.26]
105012543  trip12; E3 ubiquitin-protein ligase TRIP12 isoform X1 [KO:K10590] [EC:2.3.2.26]
105016386  nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X3 [KO:K10591] [EC:2.3.2.26]
105006395  E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
105013560  huwe1; E3 ubiquitin-protein ligase HUWE1 isoform X1 [KO:K10592] [EC:2.3.2.26]
105019204  ubr5; E3 ubiquitin-protein ligase UBR5 isoform X1 [KO:K10593] [EC:2.3.2.26]
105021116  herc1; probable E3 ubiquitin-protein ligase HERC1 isoform X10 [KO:K10594] [EC:2.3.2.26]
105029281  probable E3 ubiquitin-protein ligase HERC1 isoform X1 [KO:K10594] [EC:2.3.2.26]
105027381  E3 ubiquitin-protein ligase HERC2 isoform X1 [KO:K10595] [EC:2.3.2.26]
105022848  probable E3 ubiquitin-protein ligase HERC3 [KO:K10614] [EC:2.3.2.26]
105021018  herc3; probable E3 ubiquitin-protein ligase HERC3 isoform X1 [KO:K10614] [EC:2.3.2.26]
105028635  herc4; probable E3 ubiquitin-protein ligase HERC4 isoform X1 [KO:K10615] [EC:2.3.2.26]
105011720  ube4a; ubiquitin conjugation factor E4 A [KO:K10596] [EC:2.3.2.27]
105022962  ube4b; ubiquitin conjugation factor E4 B isoform X2 [KO:K10597] [EC:2.3.2.27]
105007702  STIP1 homology and U box-containing protein 1 isoform X1 [KO:K09561] [EC:2.3.2.27]
105021261  stub1; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
105006511  ppil2; RING-type E3 ubiquitin-protein ligase PPIL2 isoform X1 [KO:K10598] [EC:5.2.1.8]
105029954  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
105022889  prpf19; pre-mRNA-processing factor 19 isoform X1 [KO:K10599] [EC:2.3.2.27]
105023340  ubox5; RING finger protein 37 isoform X1 [KO:K10600]
105017801  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X2 [KO:K06643] [EC:2.3.2.27]
105011087  E3 ubiquitin-protein ligase CBL-like [KO:K04707] [EC:2.3.2.27]
105012434  cbl; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
105028781  cblb; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
105024282  cblc; E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
105025493  prkn; E3 ubiquitin-protein ligase parkin isoform X3 [KO:K04556] [EC:2.3.2.31]
105008390  siah1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
105025313  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
105021721  map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
105007929  cop1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
105014503  rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
105006427  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
105024403  xiap; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
105013948  birc7; baculoviral IAP repeat-containing protein 7 isoform X1 [KO:K16061]
105005843  E3 SUMO-protein ligase PIAS1-like isoform X1 [KO:K04706] [EC:2.3.2.-]
105013624  E3 SUMO-protein ligase PIAS1 isoform X3 [KO:K04706] [EC:2.3.2.-]
105030225  E3 SUMO-protein ligase PIAS2 [KO:K16063] [EC:2.3.2.-]
105011558  E3 SUMO-protein ligase PIAS4-A [KO:K16065] [EC:2.3.2.27]
105005995  syvn1; E3 ubiquitin-protein ligase synoviolin [KO:K10601] [EC:2.3.2.27]
105018766  nhlrc1; E3 ubiquitin-protein ligase NHLRC1 [KO:K10602] [EC:2.3.2.27]
105028808  aire; autoimmune regulator [KO:K10603]
105030602  brca1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
105030345  fancl; E3 ubiquitin-protein ligase FANCL isoform X1 [KO:K10606] [EC:2.3.2.27]
105020024  E3 ubiquitin-protein ligase Midline-1 isoform X1 [KO:K08285] [EC:2.3.2.27]
105018783  E3 ubiquitin-protein ligase Midline-1 isoform X1 [KO:K08285] [EC:2.3.2.27]
105014996  trim32; E3 ubiquitin-protein ligase TRIM32 [KO:K10607] [EC:2.3.2.27]
105011106  trim37; E3 ubiquitin-protein ligase TRIM37 isoform X1 [KO:K10608] [EC:2.3.2.27]
105025789  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
105022041  cul1; cullin-1 [KO:K03347]
105024245  cullin-1 [KO:K03347]
105026694  skp1; S-phase kinase-associated protein 1 [KO:K03094]
105029256  F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
105026178  F-box/WD repeat-containing protein 11 isoform X3 [KO:K03362]
105025175  skp2; S-phase kinase-associated protein 2 [KO:K03875]
105006500  F-box/WD repeat-containing protein 7 isoform X1 [KO:K10260]
105020919  fbxw7; F-box/WD repeat-containing protein 7 isoform X3 [KO:K10260]
105011174  F-box only protein 6-like isoform X2 [KO:K10099]
105025461  F-box only protein 2 [KO:K10099]
105030528  uncharacterized protein LOC105030528 [KO:K10099]
105023335  fbxo4; F-box only protein 4 isoform X1 [KO:K10291]
105019434  cul2; cullin-2 isoform X1 [KO:K03870]
105019655  eloc; transcription elongation factor B polypeptide 1 [KO:K03872]
105012960  elongin-B isoform X1 [KO:K03873]
105030139  elongin-B [KO:K03873]
105017201  vhl; von Hippel-Lindau disease tumor suppressor isoform X1 [KO:K03871]
105027074  von Hippel-Lindau disease tumor suppressor-like [KO:K03871]
105011392  cullin-3 isoform X1 [KO:K03869]
105024564  cullin-3 [KO:K03869]
105012141  keap1; kelch-like ECH-associated protein 1 [KO:K10456]
105019872  kelch-like ECH-associated protein 1 [KO:K10456]
105027846  kelch-like protein 13 isoform X1 [KO:K10447]
105016433  kelch-like protein 9 isoform X1 [KO:K10447]
105014033  rhobtb2; rho-related BTB domain-containing protein 2 isoform X1 [KO:K07868]
105026303  rho-related BTB domain-containing protein 1 isoform X1 [KO:K07868]
105031178  rho-related BTB domain-containing protein 1 isoform X1 [KO:K07868]
105020052  cul4a; cullin-4A [KO:K10609]
105025584  cul4b; cullin-4B isoform X1 [KO:K10609]
105025975  ddb1; DNA damage-binding protein 1 [KO:K10610]
105029687  ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
105014117  ercc8; DNA excision repair protein ERCC-8 [KO:K10570]
105018512  det1; DET1 homolog [KO:K10571]
105012598  rnf7; RING-box protein 2 [KO:K10611]
105010654  cullin-5 [KO:K10612]
105011055  cullin-5 isoform X1 [KO:K10612]
105007127  socs1; suppressor of cytokine signaling 1 [KO:K04694]
105009400  suppressor of cytokine signaling 1 isoform X1 [KO:K04694]
105013055  suppressor of cytokine signaling 3 [KO:K04696]
105021322  suppressor of cytokine signaling 3 [KO:K04696]
105024684  fbxw8; F-box/WD repeat-containing protein 8 isoform X1 [KO:K10264]
105021607  anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
105015042  anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
105019168  cdc20; cell division cycle protein 20 homolog [KO:K03363]
105020641  fizzy-related protein homolog isoform X1 [KO:K03364]
105011710  fizzy-related protein homolog [KO:K03364]
105022022  fizzy-related protein homolog [KO:K03364]
105010333  anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
105023365  cdc27; cell division cycle protein 27 homolog [KO:K03350]
105011814  anapc4; anaphase-promoting complex subunit 4 [KO:K03351]
105024853  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
105031344  cdc16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
105014187  anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
105010889  cdc23; cell division cycle protein 23 homolog isoform X2 [KO:K03355]
105007267  anapc10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
105015133  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
105024196  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
105024054  anapc15; anaphase-promoting complex subunit 15 [KO:K25228]
105009056  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
els03050  Proteasome
KO pathway
ko04120   
LinkDB

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