KEGG   PATHWAY: hgl00310
Entry
hgl00310                    Pathway                                
Name
Lysine degradation - Heterocephalus glaber (naked mole-rat)
Class
Metabolism; Amino acid metabolism
Pathway map
hgl00310  Lysine degradation
hgl00310

Module
hgl_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:hgl00310]
Other DBs
GO: 0006554
Organism
Heterocephalus glaber (naked mole-rat) [GN:hgl]
Gene
101707268  Aass; aminoadipate-semialdehyde synthase [KO:K14157] [EC:1.5.1.8 1.5.1.9]
101711696  Aldh7a1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
101707012  Aadat; aminoadipate aminotransferase [KO:K00825] [EC:2.6.1.7 2.6.1.39]
101721202  Dhtkd1; dehydrogenase E1 and transketolase domain containing 1 [KO:K15791] [EC:1.2.4.-]
101696795  Dlst; dihydrolipoamide S-succinyltransferase [KO:K00658] [EC:2.3.1.61]
101699518  Dld; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
101718348  Gcdh; glutaryl-CoA dehydrogenase [KO:K00252] [EC:1.3.8.6]
101724137  Hadha; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [KO:K07515] [EC:4.2.1.17 1.1.1.211]
101699730  Ehhadh; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
101697414  Echs1; enoyl-CoA hydratase, short chain 1 [KO:K07511] [EC:4.2.1.17]
101712136  Hadh; hydroxyacyl-CoA dehydrogenase [KO:K00022] [EC:1.1.1.35]
101709659  Acat1; acetyl-CoA acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]
101712256  Acat2; acetyl-CoA acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
101702212  Hykk; hydroxylysine kinase [KO:K18201] [EC:2.7.1.81]
101713270  Phykpl; 5-phosphohydroxy-L-lysine phospho-lyase [KO:K18202] [EC:4.2.3.134]
101724480  Pipox; pipecolic acid and sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
101725603  Camkmt; calmodulin-lysine N-methyltransferase [KO:K18826] [EC:2.1.1.60]
101716671  Kmt2a; lysine methyltransferase 2A [KO:K09186] [EC:2.1.1.354]
101718411  Kmt2d; lysine methyltransferase 2D [KO:K09187] [EC:2.1.1.354]
101698170  Kmt2c; lysine methyltransferase 2C [KO:K09188] [EC:2.1.1.354]
101699273  Kmt2b; lysine methyltransferase 2B [KO:K14959] [EC:2.1.1.354]
101712321  Kmt2e; lysine methyltransferase 2E [KO:K09189] [EC:2.1.1.354]
101702850  Setd1b; SET domain containing 1B [KO:K11422] [EC:2.1.1.354]
101709197  Setd1a; SET domain containing 1A [KO:K11422] [EC:2.1.1.354]
101715832  Setd7; SET domain containing lysine methyltransferase 7 [KO:K11431] [EC:2.1.1.364]
101701112  histone-lysine N-methyltransferase PRDM9 [KO:K20796] [EC:2.1.1.354]
101723836  Ash1l; ASH1 like histone lysine methyltransferase [KO:K06101] [EC:2.1.1.354]
101718535  Smyd1; SET and MYND domain containing 1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
101720447  Smyd2; SET and MYND domain containing 2 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
101722574  Smyd3; SET and MYND domain containing 3 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
101701917  Suv39h2; suppressor of variegation 3-9 homolog 2 [KO:K11419] [EC:2.1.1.355]
101706867  Suv39h1; suppressor of variegation 3-9 homolog 1 [KO:K11419] [EC:2.1.1.355]
101697232  Ehmt2; euchromatic histone lysine methyltransferase 2 [KO:K11420] [EC:2.1.1.355]
101699104  Ehmt1; euchromatic histone lysine methyltransferase 1 [KO:K11420] [EC:2.1.1.355]
101715248  Setdb1; SET domain bifurcated 1 [KO:K11421] [EC:2.1.1.366]
101696702  Setdb2; SET domain bifurcated 2 [KO:K18494] [EC:2.1.1.355]
101699822  Prdm2; PR/SET domain 2 [KO:K11432] [EC:2.1.1.355]
101723063  Ezh1; enhancer of zeste 1 polycomb repressive complex 2 subunit [KO:K17451] [EC:2.1.1.356]
101702710  Ezh2; enhancer of zeste 2 polycomb repressive complex 2 subunit [KO:K11430] [EC:2.1.1.356]
101704237  Setmar; histone-lysine N-methyltransferase SETMAR [KO:K11433] [EC:2.1.1.357]
101698401  Nsd1; nuclear receptor binding SET domain protein 1 [KO:K15588] [EC:2.1.1.357]
101709487  Nsd2; nuclear receptor binding SET domain protein 2 [KO:K11424] [EC:2.1.1.357]
101703406  Nsd3; nuclear receptor binding SET domain protein 3 [KO:K11425] [EC:2.1.1.370 2.1.1.371]
101712712  Dot1l; DOT1 like histone lysine methyltransferase [KO:K11427] [EC:2.1.1.360]
101726359  Kmt5a; lysine methyltransferase 5A [KO:K11428] [EC:2.1.1.361]
101720211  Prdm6; PR/SET domain 6 [KO:K20795] [EC:2.1.1.361]
101719039  Kmt5b; lysine methyltransferase 5B [KO:K11429] [EC:2.1.1.362]
101707567  Kmt5c; lysine methyltransferase 5C [KO:K11429] [EC:2.1.1.362]
101718355  Mecom; MDS1 and EVI1 complex locus [KO:K04462] [EC:2.1.1.367]
101721685  Prdm16; PR/SET domain 16 [KO:K22410] [EC:2.1.1.367]
101700950  Tmlhe; trimethyllysine hydroxylase, epsilon [KO:K00474] [EC:1.14.11.8]
101706449  Aldh2; aldehyde dehydrogenase 2 family (mitochondrial) [KO:K00128] [EC:1.2.1.3]
101711406  Aldh3a2; aldehyde dehydrogenase 3 family member A2 [KO:K00128] [EC:1.2.1.3]
101701236  Aldh1b1; aldehyde dehydrogenase 1 family member B1 [KO:K00128] [EC:1.2.1.3]
101700529  Aldh16a1; aldehyde dehydrogenase 16 family member A1 [KO:K00128] [EC:1.2.1.3]
101717741  Aldh9a1; aldehyde dehydrogenase 9 family member A1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
101702765  Bbox1; gamma-butyrobetaine hydroxylase 1 [KO:K00471] [EC:1.14.11.1]
101716463  Plod1; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 [KO:K00473] [EC:1.14.11.4]
101708679  Plod2; procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [KO:K13645] [EC:1.14.11.4]
101701075  Plod3; procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 [KO:K13646] [EC:1.14.11.4 2.4.1.50 2.4.1.66]
101711193  Colgalt1; collagen beta(1-O)galactosyltransferase 1 [KO:K11703] [EC:2.4.1.50]
101713780  Colgalt2; collagen beta(1-O)galactosyltransferase 2 [KO:K11703] [EC:2.4.1.50]
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00042  Succinate
C00047  L-Lysine
C00068  Thiamin diphosphate
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00322  2-Oxoadipate
C00332  Acetoacetyl-CoA
C00408  L-Pipecolate
C00431  5-Aminopentanoate
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  Carnitine
C00489  Glutarate
C00527  Glutaryl-CoA
C00739  D-Lysine
C00877  Crotonoyl-CoA
C00956  L-2-Aminoadipate
C00990  5-Aminopentanamide
C01087  (R)-2-Hydroxyglutarate
C01142  (3S)-3,6-Diaminohexanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01149  4-Trimethylammoniobutanal
C01181  4-Trimethylammoniobutanoate
C01186  (3S,5S)-3,5-Diaminohexanoate
C01211  Procollagen 5-hydroxy-L-lysine
C01259  (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  Cadaverine
C02188  Protein lysine
C02727  N6-Acetyl-L-lysine
C03087  5-Acetamidopentanoate
C03196  (S)-2-Hydroxyglutarate
C03239  6-Amino-2-oxohexanoate
C03273  5-Oxopentanoate
C03366  5-Phosphooxy-L-lysine
C03656  (S)-5-Amino-3-oxohexanoic acid
C03793  N6,N6,N6-Trimethyl-L-lysine
C04020  D-Lysopine
C04076  L-2-Aminoadipate 6-semialdehyde
C04092  Delta1-Piperideine-2-carboxylate
C04487  5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  (2R,5S)-2,5-Diaminohexanoate
C05231  L-3-Aminobutyryl-CoA
C05544  Protein N6-methyl-L-lysine
C05545  Protein N6,N6-dimethyl-L-lysine
C05546  Protein N6,N6,N6-trimethyl-L-lysine
C05548  6-Acetamido-2-oxohexanoate
C05825  2-Amino-5-oxohexanoate
C06157  [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C12455  5-Aminopentanal
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16741  L-Hydroxylysine
C22667  4-Carboxy-1-hydroxybutyryl-ThPP
Reference
PMID:11802770
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
DOI:10.1042/bj3610417
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Related
pathway
hgl00020  Citrate cycle (TCA cycle)
hgl00780  Biotin metabolism
KO pathway
ko00310   
LinkDB

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