KEGG   PATHWAY: lcat00380
Entry
lcat00380                   Pathway                                
Name
Tryptophan metabolism - Lemur catta (Ring-tailed lemur)
Class
Metabolism; Amino acid metabolism
Pathway map
lcat00380  Tryptophan metabolism
lcat00380

Module
lcat_M00037  Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin [PATH:lcat00380]
lcat_M00038  Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate [PATH:lcat00380]
lcat_M00912  NAD biosynthesis, tryptophan => quinolinate => NAD [PATH:lcat00380]
Other DBs
GO: 0006568 0009851
Organism
Lemur catta (Ring-tailed lemur) [GN:lcat]
Gene
123620487  AANAT; serotonin N-acetyltransferase [KO:K00669] [EC:2.3.1.87]
123623795  IL4I1; L-amino-acid oxidase isoform X1 [KO:K03334] [EC:1.4.3.2]
123624369  [KO:K07408] [EC:1.14.14.1]
123624379  [KO:K07409] [EC:1.14.14.1]
123626041  ALDH2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
123626627  IDO2; indoleamine 2,3-dioxygenase 2 [KO:K00463] [EC:1.13.11.52]
123626628  IDO1; indoleamine 2,3-dioxygenase 1 [KO:K00463] [EC:1.13.11.52]
123626697  DHTKD1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial isoform X1 [KO:K15791] [EC:1.2.4.-]
123627430  KMO; kynurenine 3-monooxygenase [KO:K00486] [EC:1.14.13.9]
123627735  HADH; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
123628068  ASMT; LOW QUALITY PROTEIN: acetylserotonin O-methyltransferase [KO:K00543] [EC:2.1.1.4]
123630345  EHHADH; peroxisomal bifunctional enzyme isoform X1 [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
123633294  ALDH8A1; 2-aminomuconic semialdehyde dehydrogenase [KO:K23234]
123633426  ACAT2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
123634927  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
123635430  KYAT3; kynurenine--oxoglutarate transaminase 3 isoform X1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
123636688  HADHA; trifunctional enzyme subunit alpha, mitochondrial isoform X1 [KO:K07515] [EC:4.2.1.17 1.1.1.211]
123636812  [KO:K07410] [EC:1.14.14.1]
123636845  HAAO; 3-hydroxyanthranilate 3,4-dioxygenase [KO:K00452] [EC:1.13.11.6]
123637266  GCDH; glutaryl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K00252] [EC:1.3.8.6]
123637477  [KO:K00274] [EC:1.4.3.4]
123638512  TDO2; tryptophan 2,3-dioxygenase [KO:K00453] [EC:1.13.11.11]
123638697  [KO:K00825] [EC:2.6.1.7 2.6.1.39]
123638698  [KO:K00825] [EC:2.6.1.7 2.6.1.39]
123638699  [KO:K00825] [EC:2.6.1.7 2.6.1.39]
123640652  TPH2; tryptophan 5-hydroxylase 2 [KO:K00502] [EC:1.14.16.4]
123641739  ACAT1; acetyl-CoA acetyltransferase, mitochondrial [KO:K00626] [EC:2.3.1.9]
123642496  TPH1; tryptophan 5-hydroxylase 1 [KO:K00502] [EC:1.14.16.4]
123642582  CAT; catalase [KO:K03781] [EC:1.11.1.6]
123643282  [KO:K00274] [EC:1.4.3.4]
123643320  [KO:K00157] [EC:1.2.3.1]
123643381  KYNU; kynureninase isoform X1 [KO:K01556] [EC:3.7.1.3]
123643621  [KO:K00157] [EC:1.2.3.1]
123643919  [KO:K00157] [EC:1.2.3.1]
123644025  ACMSD; 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase isoform X1 [KO:K03392] [EC:4.1.1.45]
123645957  ALDH1B1; aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
123646385  KYAT1; kynurenine--oxoglutarate transaminase 1 isoform X1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
123646634  DLST; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [KO:K00658] [EC:2.3.1.61]
123646987  INMT; LOW QUALITY PROTEIN: indolethylamine N-methyltransferase [KO:K00562] [EC:2.1.1.49 2.1.1.96]
123647351  DDC; aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
123647521  AOC1; amiloride-sensitive amine oxidase [copper-containing] [KO:K11182] [EC:1.4.3.22]
123647713  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
123648287  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
123648852  [KO:K00274] [EC:1.4.3.4]
123650193  ECHS1; enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
123650578  ALDH3A2; aldehyde dehydrogenase family 3 member A2 isoform X1 [KO:K00128] [EC:1.2.1.3]
123650640  AFMID; kynurenine formamidase isoform X1 [KO:K01432] [EC:3.5.1.9]
Compound
C00024  Acetyl-CoA
C00078  L-Tryptophan
C00108  Anthranilate
C00322  2-Oxoadipate
C00328  L-Kynurenine
C00331  Indolepyruvate
C00332  Acetoacetyl-CoA
C00398  Tryptamine
C00463  Indole
C00527  Glutaryl-CoA
C00632  3-Hydroxyanthranilate
C00637  Indole-3-acetaldehyde
C00643  5-Hydroxy-L-tryptophan
C00780  Serotonin
C00877  Crotonoyl-CoA
C00954  Indole-3-acetate
C00955  Indole-3-ethanol
C00978  N-Acetylserotonin
C01111  7,8-Dihydroxykynurenate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01249  7,8-Dihydro-7,8-dihydroxykynurenate
C01252  4-(2-Aminophenyl)-2,4-dioxobutanoate
C01598  Melatonin
C01717  4-Hydroxy-2-quinolinecarboxylic acid
C01987  2-Aminophenol
C02161  2-Aminophenoxazin-3-one
C02172  N-Acetylisatin
C02220  2-Aminomuconate
C02298  N-Acetylindoxyl
C02470  Xanthurenic acid
C02693  (Indol-3-yl)acetamide
C02700  L-Formylkynurenine
C02775  2,3-Dihydroxyindole
C02937  Indole-3-acetaldehyde oxime
C02938  3-Indoleacetonitrile
C03227  3-Hydroxy-L-kynurenine
C03230  (Indol-3-yl)glycolaldehyde
C03453  gamma-Oxalocrotonate
C03574  2-Formylaminobenzaldehyde
C03722  Quinolinate
C03824  2-Aminomuconate semialdehyde
C04409  2-Amino-3-carboxymuconate semialdehyde
C05634  5-Hydroxyindoleacetaldehyde
C05635  5-Hydroxyindoleacetate
C05636  3-Hydroxykynurenamine
C05637  4,8-Dihydroxyquinoline
C05638  5-Hydroxykynurenamine
C05639  4,6-Dihydroxyquinoline
C05640  Cinnavalininate
C05641  5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate
C05642  Formyl-N-acetyl-5-methoxykynurenamine
C05643  6-Hydroxymelatonin
C05644  3-Methylindolepyruvate
C05645  4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
C05646  5-Hydroxyindolepyruvate
C05647  Formyl-5-hydroxykynurenamine
C05648  5-Hydroxy-N-formylkynurenine
C05651  5-Hydroxykynurenine
C05652  4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate
C05653  Formylanthranilate
C05654  5-(2'-Formylethyl)-4,6-dihydroxypicolinate
C05655  5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate
C05656  5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate
C05658  Indoxyl
C05659  5-Methoxytryptamine
C05660  5-Methoxyindoleacetate
C05663  6-Hydroxykynurenate
C05830  8-Methoxykynurenate
C05831  3-Methoxyanthranilate
C05832  5-Hydroxyindoleacetylglycine
C05834  3-Methyldioxyindole
C05835  2-Formaminobenzoylacetate
C05837  Glucobrassicin
C06212  N-Methylserotonin
C06213  N-Methyltryptamine
C08313  Skatole
C10164  Picolinic acid
C16516  Indolylmethylthiohydroximate
C16517  Indolylmethyl-desulfoglucosinolate
C16518  S-(Indolylmethylthiohydroximoyl)-L-cysteine
C17203  N-Hydroxyl-tryptamine
C22006  (R)-(Indol-3-yl)lactate
C22202  2-Oxoindole-3-acetate
C23064  Didemethylasterriquinone D
Reference
PMID:15749753
  Authors
Woodward AW, Bartel B
  Title
Auxin: regulation, action, and interaction.
  Journal
Ann Bot 95:707-35 (2005)
DOI:10.1093/aob/mci083
Related
pathway
lcat00010  Glycolysis / Gluconeogenesis
lcat00400  Phenylalanine, tyrosine and tryptophan biosynthesis
lcat00760  Nicotinate and nicotinamide metabolism
KO pathway
ko00380   

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