Entry Name mTOR signaling pathway - Macaca mulatta (rhesus monkey)
Description The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Organism Macaca mulatta (rhesus monkey) [GN:
mcc ]
Gene 100423838 DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353 ]
107000642 CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080 ]
641449 STRADB; STE20-related kinase adapter protein beta [KO:K17532 ]
693323 ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144 ]
693840 ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148 ]
694786 GRB10; growth factor receptor-bound protein 10 [KO:K20064 ]
694915 RICTOR; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267 ]
695558 PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198 ] [EC:2.7.11.31 ]
695650 MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266 ]
695843 LRP6; low-density lipoprotein receptor-related protein 6 precursor [KO:K03068 ]
695886 SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780 ]
698444 IGF1; insulin-like growth factor I precursor [KO:K05459 ]
698996 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
699930 TTI1; TELO2-interacting protein 1 homolog [KO:K20403 ]
700617 SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875 ]
700688 EIF4B; eukaryotic translation initiation factor 4B [KO:K03258 ]
701645 LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344 ]
701679 TELO2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137 ]
701924 NPRL2; GATOR complex protein NPRL2 isoform X2 [KO:K20405 ]
702041 GRB2; growth factor receptor-bound protein 2 [KO:K04364 ]
702137 CLIP1; CAP-Gly domain-containing linker protein 1 isoform X3 [KO:K10421 ]
702599 MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410 ]
702649 DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402 ]
703628 EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205 ]
703646 ATP6V1B1; V-type proton ATPase subunit B, kidney isoform isoform X1 [KO:K02147 ]
703655 ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152 ]
703732 EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259 ]
705605 ATP6V1B2; LOW QUALITY PROTEIN: V-type proton ATPase subunit B, brain isoform [KO:K02147 ]
705864 DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353 ]
706015 TBC1D7; TBC1 domain family member 7 isoform X1 [KO:K20396 ]
706066 CAB39L; calcium-binding protein 39-like isoform X1 [KO:K08272 ]
706673 ATP6V1C2; V-type proton ATPase subunit C 2 isoform X3 [KO:K02148 ]
706751 EIF4E; eukaryotic translation initiation factor 4E [KO:K03259 ]
706752 SLC38A9; sodium-coupled neutral amino acid transporter 9 [KO:K14995 ]
707310 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
709133 LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370 ]
709511 CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3 [KO:K04467 ] [EC:2.7.11.10 ]
709739 ATP6V1E1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150 ]
709959 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
710372 ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152 ]
710552 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
710576 WDR59; GATOR complex protein WDR59 isoform X2 [KO:K20409 ]
712848 RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204 ]
713487 EIF4E2; eukaryotic translation initiation factor 4E type 2 [KO:K03259 ]
713777 SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099 ]
714381 DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353 ]
714746 ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150 ]
715307 DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270 ]
715331 ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152 ]
716098 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
717927 STRADA; STE20-related kinase adapter protein alpha isoform X7 [KO:K08271 ]
718110 LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398 ]
718249 LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397 ]
718522 DEPDC5; GATOR complex protein DEPDC5 isoform X2 [KO:K20404 ]
719101 AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184 ]
719122 LAMTOR4; ragulator complex protein LAMTOR4 isoform X1 [KO:K20399 ]
719367 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
721605 LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068 ]
721821 MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369 ] [EC:2.7.12.2 ]
722033 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
722218 SLC3A2; 4F2 cell-surface antigen heavy chain isoform X1 [KO:K06519 ]
722264 NPRL3; GATOR complex protein NPRL3 isoform X1 [KO:K20406 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Kennedy BK, Lamming DW
Title The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
Journal Reference Authors Shimobayashi M, Hall MN
Title Making new contacts: the mTOR network in metabolism and signalling crosstalk.
Journal Reference Authors Huang K, Fingar DC
Title Growing knowledge of the mTOR signaling network.
Journal Reference Authors Bockaert J, Marin P
Title mTOR in Brain Physiology and Pathologies.
Journal Reference Authors Caron A, Richard D, Laplante M
Title The Roles of mTOR Complexes in Lipid Metabolism.
Journal Reference Authors Shimobayashi M, Hall MN
Title Multiple amino acid sensing inputs to mTORC1.
Journal Reference Authors Bar-Peled L, Sabatini DM
Title Regulation of mTORC1 by amino acids.
Journal Reference Authors Fingar DC
Title Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
Journal Reference Authors Cai H, Dong LQ, Liu F
Title Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
Journal Reference Authors Eyre TA, Collins GP, Goldstone AH, Cwynarski K
Title Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
Journal Reference Authors Jewell JL, Guan KL
Title Nutrient signaling to mTOR and cell growth.
Journal Reference Authors Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
Title mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
Journal Reference Authors Kim SG, Buel GR, Blenis J
Title Nutrient regulation of the mTOR complex 1 signaling pathway.
Journal Reference Authors Laplante M, Sabatini DM
Title mTOR signaling at a glance.
Journal Reference Authors Alessi DR, Sakamoto K, Bayascas JR
Title LKB1-dependent signaling pathways.
Journal Reference Authors Dan HC, Antonia RJ, Baldwin AS
Title PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
Journal Reference Authors Saxton RA, Sabatini DM
Title mTOR Signaling in Growth, Metabolism, and Disease.
Journal Related mcc04810 Regulation of actin cytoskeleton
KO pathway
