KEGG   PATHWAY: mcc04810
Entry
mcc04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Macaca mulatta (rhesus monkey)
Class
Cellular Processes; Cell motility
Pathway map
mcc04810  Regulation of actin cytoskeleton
mcc04810

Other DBs
GO: 0030036
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100424246  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
100424606  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100427850  ITGAX; integrin alpha-X isoform X1 [KO:K06462]
100428388  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
100428484  ITGA10; integrin alpha-10 isoform X3 [KO:K06586]
100429106  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
106992270  ITGA9; integrin alpha-9 [KO:K06585]
106996837  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X3 [KO:K05755]
106997584  MYL10; myosin regulatory light chain 10 isoform X3 [KO:K12756]
107000212  [KO:K05765]
114673968  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
114674157  PPP1R12C; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12C [KO:K17457]
574136  FGF2; fibroblast growth factor 2 [KO:K18497]
574195  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
574285  ACTB; actin, cytoplasmic 1 [KO:K05692]
574312  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
574315  ITGA5; integrin alpha-5 [KO:K06484]
574330  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
574334  CXCL12; stromal cell-derived factor 1 precursor [KO:K10031]
574345  FGF7; fibroblast growth factor 7 precursor [KO:K04358]
574362  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
613027  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
613269  FN1; fibronectin isoform X1 [KO:K05717]
693405  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
693443  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
693551  SCIN; adseverin [KO:K05768]
693554  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
693666  ACTN4; alpha-actinin-4 [KO:K05699]
693875  CFL2; cofilin-2 [KO:K05765]
693976  ARHGEF6; rho guanine nucleotide exchange factor 6 [KO:K05729]
694090  ITGA11; integrin alpha-11 [KO:K06587]
694223  C9; complement component C9 [KO:K04000]
694685  VAV3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
694725  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
694957  MYL12B; myosin regulatory light chain 12B [KO:K12757]
695017  MYH9; myosin-9 isoform X1 [KO:K10352]
695077  MYL12A; myosin, light chain 12A, regulatory, non-sarcomeric isoform X1 [KO:K12757]
695366  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
695449  FAM49B; protein FAM49B [KO:K27976]
695530  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X2 [KO:K13710]
695735  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
695896  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
695990  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
696266  C6; complement component C6 [KO:K03995]
696336  PXN; paxillin isoform X1 [KO:K05760]
696556  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
696584  CRKL; crk-like protein [KO:K04438]
696676  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
696709  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
696926  C7; complement component C7 isoform X2 [KO:K03996]
697002  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
697080  ACTR2; actin-related protein 2 [KO:K17260]
697643  ITGA6; integrin alpha-6 precursor [KO:K06485]
697747  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
697765  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
698223  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
698494  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
698538  [KO:K17457]
698569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
698585  PAK1; serine/threonine-protein kinase PAK 1 isoform X5 [KO:K04409] [EC:2.7.11.1]
698619  EGF; pro-epidermal growth factor isoform X2 [KO:K04357]
698830  HRAS; GTPase HRas [KO:K02833]
698888  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
698921  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
698947  FAM49A; protein FAM49A [KO:K27976]
698962  RGCC; regulator of cell cycle RGCC [KO:K26108]
698996  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
699042  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
699140  DIAPH2; protein diaphanous homolog 2 isoform X2 [KO:K05741]
699405  ITGB7; integrin beta-7 [KO:K06590]
699494  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
699700  RRAS2; ras-related protein R-Ras2 [KO:K07830]
699705  GSN; gelsolin isoform X1 [KO:K05768]
700126  FGFR1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
700236  PDGFC; platelet-derived growth factor C [KO:K05450]
700454  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
700467  C5; complement C5 isoform X1 [KO:K03994]
700536  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
700538  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
700559  ENAH; protein enabled homolog isoform X1 [KO:K05746]
700591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
700634  PTK2; focal adhesion kinase 1 isoform X8 [KO:K05725] [EC:2.7.10.2]
700788  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
700918  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
700962  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
701057  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
701134  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 isoform X1 [KO:K05720]
701185  CRK; adapter molecule crk isoform X1 [KO:K04438]
701584  FGF10; fibroblast growth factor 10 precursor [KO:K04358]
701589  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
701847  FGF20; fibroblast growth factor 20 [KO:K04358]
702072  FGF18; fibroblast growth factor 18 [KO:K04358]
702288  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
702727  FGF22; fibroblast growth factor 22 precursor [KO:K04358]
703173  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
703302  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
703422  ARHGEF4; rho guanine nucleotide exchange factor 4 [KO:K05769]
703456  ITGA1; integrin alpha-1 [KO:K06480]
703572  ITGA2; integrin alpha-2 precursor [KO:K06481]
703698  BDKRB2; B2 bradykinin receptor [KO:K03916]
703770  ITGB4; integrin beta-4 isoform X4 [KO:K06525]
703982  PFN3; profilin-3 [KO:K05759]
704310  PDGFD; platelet-derived growth factor D isoform X2 [KO:K05450]
704416  PFN4; profilin-4 [KO:K05759]
704534  INS; insulin [KO:K04526]
704716  EZR; ezrin isoform X1 [KO:K08007]
704745  ITGA4; integrin alpha-4 [KO:K06483]
704956  ABI2; abl interactor 2 isoform X7 [KO:K05751]
705601  SOS2; son of sevenless homolog 2 [KO:K03099]
705612  FGF16; fibroblast growth factor 16 [KO:K04358]
705671  [KO:K05692]
705775  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X6 [KO:K12329]
705782  NCKAP1L; nck-associated protein 1-like isoform X1 [KO:K05750]
705970  FGF1; fibroblast growth factor 1 [KO:K18496]
706217  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
706455  RHOA; transforming protein RhoA [KO:K04513]
706659  FGF17; fibroblast growth factor 17 precursor [KO:K04358]
706720  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
707169  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
707170  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
707247  ITGB8; integrin beta-8 precursor [KO:K06591]
707279  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
707293  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
707310  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
707329  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
707345  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
707361  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
707370  F2R; proteinase-activated receptor 1 [KO:K03914]
707466  KNG1; kininogen-1 [KO:K03898]
707637  CDC42; cell division control protein 42 homolog [KO:K04393]
707725  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
707756  ITGAV; integrin alpha-V precursor [KO:K06487]
707809  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
707977  KRAS; GTPase KRas [KO:K07827]
708444  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
708901  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
708918  FGF3; fibroblast growth factor 3 precursor [KO:K04358]
708938  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
709016  FGF4; fibroblast growth factor 4 [KO:K04358]
709018  RDX; radixin isoform X2 [KO:K05762]
709089  NRAS; GTPase NRas [KO:K07828]
709109  FGF19; fibroblast growth factor 19 [KO:K22603]
709199  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
709208  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
709283  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
709784  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
709836  ACTR3; actin-related protein 3 [KO:K18584]
709935  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
709959  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
710007  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
710115  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X4 [KO:K00921] [EC:2.7.1.150]
710314  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
710415  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
710552  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
710577  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
710643  FGF23; fibroblast growth factor 23 precursor [KO:K22428]
710724  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
710739  FGF6; fibroblast growth factor 6 [KO:K04358]
710753  PFN1; profilin-1 [KO:K05759]
710959  TMSB4X; thymosin beta-4 [KO:K05764]
711124  NCKAP1; nck-associated protein 1 [KO:K05750]
711353  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
711712  MSN; moesin [KO:K05763]
711778  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
711898  SSH2; protein phosphatase Slingshot homolog 2 isoform X3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
711937  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
711945  ITGAL; integrin alpha-L isoform X2 [KO:K05718]
711994  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
712026  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
712096  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X2 [KO:K07532]
712251  BDKRB1; B1 bradykinin receptor [KO:K03915]
712699  SSH3; protein phosphatase Slingshot homolog 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
712729  F2; prothrombin precursor [KO:K01313] [EC:3.4.21.5]
712829  FGFR3; fibroblast growth factor receptor 3 isoform X10 [KO:K05094] [EC:2.7.10.1]
712830  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
713227  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
713283  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
713460  PFN2; profilin-2 isoform X1 [KO:K05759]
713687  ACTG1; actin, cytoplasmic 2 [KO:K05692]
713777  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
713882  MYH11; myosin-11 isoform X1 [KO:K10352]
713965  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
714717  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
714780  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
714832  ITGAM; integrin alpha-M isoform X3 [KO:K06461]
714896  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
714931  ITGAD; integrin alpha-D isoform X5 [KO:K06594]
714955  ITGA2B; integrin alpha-IIb isoform X2 [KO:K06476]
714984  CYFIP2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
715120  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
715422  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
715710  ITGB5; integrin beta-5 precursor [KO:K06588]
715899  BRK1; protein BRICK1 [KO:K05752]
715949  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
715965  ACTR3B; actin-related protein 3B [KO:K18584]
716082  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
716098  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
716114  C8A; complement component C8 alpha chain [KO:K03997]
716132  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
716155  C8B; complement component C8 beta chain isoform X1 [KO:K03998]
716352  MRAS; ras-related protein M-Ras [KO:K07831]
716614  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
716936  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
716944  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
717379  ITGB3; integrin beta-3 [KO:K06493]
717755  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
718144  GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639]
718288  FGF21; fibroblast growth factor 21 [KO:K22429]
718635  ARPC1A; actin-related protein 2/3 complex subunit 1A isoform X2 [KO:K05757]
718668  ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757]
718670  INSRR; insulin receptor-related protein isoform X1 [KO:K05086] [EC:2.7.10.1]
718939  RRAS; ras-related protein R-Ras [KO:K07829]
719305  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
719367  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
719458  PAK5; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
719560  MYH14; myosin-14 isoform X1 [KO:K10352]
719575  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
719579  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
719844  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
720079  SLC9A1; sodium/hydrogen exchanger 1 isoform X3 [KO:K05742]
721324  FGF9; fibroblast growth factor 9 [KO:K04358]
721468  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
721483  ITGAE; integrin alpha-E [KO:K06524]
721647  C8G; complement component C8 gamma chain [KO:K03999]
721735  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
721744  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
721821  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
721882  CFL1; cofilin-1 [KO:K05765]
721921  VCL; vinculin isoform X1 [KO:K05700]
721979  MYH10; myosin-10 isoform X4 [KO:K10352]
722198  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X2 [KO:K12330]
722394  FGF8; fibroblast growth factor 8 [KO:K04358]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
mcc04010  MAPK signaling pathway
mcc04510  Focal adhesion
mcc04520  Adherens junction
KO pathway
ko04810   

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