KEGG   PATHWAY: mcc04151
Entry
mcc04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Macaca mulatta (rhesus monkey)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
mcc04151  PI3K-Akt signaling pathway
mcc04151

Other DBs
GO: 0043491
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100169972  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100424606  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100428484  ITGA10; integrin alpha-10 isoform X3 [KO:K06586]
100429807  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
100430603  LAMA5; laminin subunit alpha-5 [KO:K06240]
106992270  ITGA9; integrin alpha-9 [KO:K06585]
106992322  [KO:K05414]
106992736  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
106995138  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
106995851  IFNA6; interferon alpha-6 [KO:K05414]
106996003  [KO:K06856]
106999628  [KO:K06856]
114669732  [KO:K05438]
114669819  [KO:K05438]
114669841  PPP2R3B; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
114669851  [KO:K05092] [EC:2.7.10.1]
114669853  [KO:K11218] [EC:2.7.10.2]
114672663  [KO:K05414]
114672664  [KO:K05414]
114673168  [KO:K05438]
114673169  [KO:K05438]
114673968  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
114673987  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
114675718  [KO:K04737]
114675805  [KO:K06856]
114679736  [KO:K06856]
574133  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
574136  FGF2; fibroblast growth factor 2 [KO:K18497]
574159  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
574168  IL7; interleukin-7 precursor [KO:K05431]
574201  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
574209  VEGFA; vascular endothelial growth factor A isoform 1 precursor [KO:K05448]
574233  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
574254  KITLG; kit ligand isoform X1 [KO:K05461]
574276  THBS4; thrombospondin-4 [KO:K04659]
574281  IL4; interleukin-4 precursor [KO:K05430]
574290  TLR2; toll-like receptor 2 precursor [KO:K10159]
574300  IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068]
574304  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
574312  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
574315  ITGA5; integrin alpha-5 [KO:K06484]
574320  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
574345  FGF7; fibroblast growth factor 7 precursor [KO:K04358]
574360  TLR4; toll-like receptor 4 precursor [KO:K10160]
574362  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
613027  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
613031  TGFA; protransforming growth factor alpha isoform X2 [KO:K08774]
613269  FN1; fibronectin isoform X1 [KO:K05717]
641338  IL2RG; cytokine receptor common subunit gamma precursor [KO:K05070]
677689  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
692343  EPHA2; ephrin type-A receptor 2 precursor [KO:K05103] [EC:2.7.10.1]
693341  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
693357  [KO:K06238]
693359  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X7 [KO:K05629]
693505  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
693569  OSMR; oncostatin-M-specific receptor subunit beta isoform X2 [KO:K05057]
694090  ITGA11; integrin alpha-11 [KO:K06587]
694184  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
694248  COL9A2; collagen alpha-2(IX) chain isoform X2 [KO:K08131]
694544  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
694616  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
694626  MYC; myc proto-oncogene protein [KO:K04377]
694631  [KO:K05414]
694701  COL6A3; collagen alpha-3(VI) chain isoform X4 [KO:K06238]
694702  YWHAQ; 14-3-3 protein theta [KO:K16197]
694725  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
694965  TSC2; tuberin isoform X7 [KO:K07207]
695118  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
695215  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
695356  SGK2; serine/threonine-protein kinase Sgk2 isoform X3 [KO:K13303] [EC:2.7.11.1]
695441  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
695558  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
695650  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
695896  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
696207  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1 [KO:K01596] [EC:4.1.1.32]
696331  IL2RB; interleukin-2 receptor subunit beta precursor [KO:K05069]
696350  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
696372  RELN; reelin isoform X3 [KO:K06249] [EC:3.4.21.-]
696685  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
696759  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
696797  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X2 [KO:K04465]
696992  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
697002  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
697017  ANGPT1; angiopoietin-1 precursor [KO:K05465]
697082  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
697188  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
697336  NRTN; neurturin [KO:K25414]
697523  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X2 [KO:K06276] [EC:2.7.11.1]
697573  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
697643  ITGA6; integrin alpha-6 precursor [KO:K06485]
697718  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
697747  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
697986  GHR; growth hormone receptor precursor [KO:K05080]
698092  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X13 [KO:K05631]
698293  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
698444  IGF1; insulin-like growth factor I precursor [KO:K05459]
698494  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
698569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
698619  EGF; pro-epidermal growth factor isoform X2 [KO:K04357]
698830  HRAS; GTPase HRas [KO:K02833]
698840  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
698857  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
698888  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
698961  CSF3; granulocyte colony-stimulating factor [KO:K05423]
698996  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
699072  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
699163  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
699369  PRLR; prolactin receptor [KO:K05081]
699405  ITGB7; integrin beta-7 [KO:K06590]
699480  PSPN; persephin [KO:K25416]
699502  VEGFC; vascular endothelial growth factor C precursor [KO:K05449]
699520  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
699568  HSP90B1; endoplasmin precursor [KO:K09487]
699604  IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130]
699726  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
699869  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
700126  FGFR1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
700236  PDGFC; platelet-derived growth factor C [KO:K05450]
700281  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
700359  COL1A2; collagen alpha-2(I) chain precursor [KO:K06236]
700382  CCNE2; G1/S-specific cyclin-E2 isoform X2 [KO:K06626]
700454  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
700589  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
700591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
700606  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
700634  PTK2; focal adhesion kinase 1 isoform X8 [KO:K05725] [EC:2.7.10.2]
700688  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
700724  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
700731  FOXO3; forkhead box protein O3 [KO:K09408]
700885  GHV; growth hormone variant precursor [KO:K05438]
700962  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
701219  PGF; placenta growth factor isoform X2 [KO:K16859]
701237  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
701245  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
701313  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
701584  FGF10; fibroblast growth factor 10 precursor [KO:K04358]
701641  ARTN; artemin [KO:K25415]
701822  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
701835  IBSP; bone sialoprotein 2 [KO:K06253]
701847  FGF20; fibroblast growth factor 20 [KO:K04358]
702041  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
702072  FGF18; fibroblast growth factor 18 [KO:K04358]
702111  LAMB1; laminin subunit beta-1 isoform X2 [KO:K05636]
702225  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
702293  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
702396  AREG; amphiregulin [KO:K09782]
702502  EREG; proepiregulin [KO:K09784]
702532  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
702601  CHAD; chondroadherin [KO:K06248]
702720  TNC; tenascin isoform X1 [KO:K06252]
702727  FGF22; fibroblast growth factor 22 precursor [KO:K04358]
703004  MTCP1; protein p13 MTCP-1 [KO:K16837]
703173  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
703241  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
703336  [KO:K04542]
703399  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
703456  ITGA1; integrin alpha-1 [KO:K06480]
703466  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
703572  ITGA2; integrin alpha-2 precursor [KO:K06481]
703628  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
703700  [KO:K13304] [EC:2.7.11.1]
703707  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
703732  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
703770  ITGB4; integrin beta-4 isoform X4 [KO:K06525]
703814  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
703965  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
704010  [KO:K16197]
704102  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
704310  PDGFD; platelet-derived growth factor D isoform X2 [KO:K05450]
704351  EFNA5; ephrin-A5 precursor [KO:K05462]
704534  INS; insulin [KO:K04526]
704562  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
704683  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
704745  ITGA4; integrin alpha-4 [KO:K06483]
704851  COL2A1; collagen alpha-1(II) chain isoform X2 [KO:K19719]
704930  SPP1; osteopontin precursor [KO:K06250]
705017  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
705081  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
705121  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
705211  CD19; B-lymphocyte antigen CD19 isoform X3 [KO:K06465]
705404  IL4R; interleukin-4 receptor subunit alpha isoform X2 [KO:K05071]
705413  THBS1; thrombospondin-1 [KO:K16857]
705601  SOS2; son of sevenless homolog 2 [KO:K03099]
705612  FGF16; fibroblast growth factor 16 [KO:K04358]
705686  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
705819  IL6; interleukin-6 precursor [KO:K05405]
705882  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
705970  FGF1; fibroblast growth factor 1 [KO:K18496]
706009  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
706152  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
706345  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
706659  FGF17; fibroblast growth factor 17 precursor [KO:K04358]
706751  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
706946  IL3; interleukin-3 precursor [KO:K04736]
706988  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
707052  PRL; prolactin precursor [KO:K05439]
707170  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
707247  ITGB8; integrin beta-8 precursor [KO:K06591]
707279  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
707310  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
707370  F2R; proteinase-activated receptor 1 [KO:K03914]
707407  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
707455  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
707539  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
707575  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
707725  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
707756  ITGAV; integrin alpha-V precursor [KO:K06487]
707870  IRS1; insulin receptor substrate 1 [KO:K16172]
707892  LAMB2; laminin subunit beta-2 precursor [KO:K06243]
707977  KRAS; GTPase KRas [KO:K07827]
708017  IL2; interleukin-2 precursor [KO:K05429]
708165  THBS2; thrombospondin-2 [KO:K04659]
708193  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
708227  IGF1R; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:2.7.10.1]
708287  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
708316  HGF; hepatocyte growth factor isoform X3 [KO:K05460]
708431  HSP90AA1; heat shock protein 90kDa alpha (cytosolic), class A member 1 [KO:K04079]
708499  VTN; vitronectin [KO:K06251]
708583  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
708587  TNN; tenascin-N isoform X1 [KO:K06252]
708707  TNR; tenascin-R [KO:K06252]
708717  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
708918  FGF3; fibroblast growth factor 3 precursor [KO:K04358]
708938  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
709016  FGF4; fibroblast growth factor 4 [KO:K04358]
709062  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
709089  NRAS; GTPase NRas [KO:K07828]
709109  FGF19; fibroblast growth factor 19 [KO:K22603]
709208  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
709489  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
709493  COL6A2; collagen alpha-2(VI) chain isoform X2 [KO:K06238]
709511  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3 [KO:K04467] [EC:2.7.11.10]
709559  IFNA13; interferon alpha-1/13 precursor [KO:K05414]
709587  [KO:K11583]
709723  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
709755  IFNA8; interferon alpha-8 [KO:K05414]
709757  NTRK2; BDNF/NT-3 growth factors receptor precursor [KO:K04360] [EC:2.7.10.1]
709948  IFNA2; interferon alpha-2 precursor [KO:K05414]
709959  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
710000  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
710324  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
710326  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
710379  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
710387  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
710415  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
710487  [KO:K05414]
710528  [KO:K05414]
710548  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
710552  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
710568  [KO:K05414]
710643  FGF23; fibroblast growth factor 23 precursor [KO:K22428]
710654  IFNA10; interferon alpha-4 precursor [KO:K05414]
710739  FGF6; fibroblast growth factor 6 [KO:K04358]
710751  [KO:K05414]
710802  IGF2; insulin-like growth factor II isoform X2 [KO:K13769]
710828  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
710848  [KO:K05414]
711002  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
711023  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
711088  [KO:K05414]
711252  IFNA21; interferon alpha-21 [KO:K05414]
711335  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
711353  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
711374  [KO:K16197]
711407  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
711414  IFNB1; interferon beta precursor [KO:K05415]
711512  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
711681  NGF; beta-nerve growth factor [KO:K02582]
711796  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
711920  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
711979  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
712053  G6PC; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
712274  [KO:K02991]
712321  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
712444  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
712634  BRCA1; breast cancer type 1 susceptibility protein homolog [KO:K10605] [EC:2.3.2.27]
712654  VEGFD; vascular endothelial growth factor D [KO:K05449]
712829  FGFR3; fibroblast growth factor receptor 3 isoform X10 [KO:K05094] [EC:2.7.10.1]
712848  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
713035  BCL2L1; bcl-2-like protein 1 [KO:K04570]
713082  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
713114  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
713283  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
713391  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
713485  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
713487  EIF4E2; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
713777  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
713913  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
714231  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
714276  G6PC3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
714419  [KO:K06856]
714546  EPOR; erythropoietin receptor [KO:K05079]
714645  TSC1; hamartin isoform X1 [KO:K07206]
714717  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
714780  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
714809  COL9A1; collagen alpha-1(IX) chain isoform X4 [KO:K08131]
714922  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
714955  ITGA2B; integrin alpha-IIb isoform X2 [KO:K06476]
714981  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
715212  LAMC2; laminin subunit gamma-2 [KO:K06246]
715213  ANGPT4; angiopoietin-4 [KO:K05467]
715265  LAMC1; laminin subunit gamma-1 [KO:K05635]
715307  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
715378  RHEB; GTP-binding protein Rheb [KO:K07208]
715390  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
715394  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
715517  YWHAG; 14-3-3 protein gamma [KO:K16198]
715650  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
715710  ITGB5; integrin beta-5 precursor [KO:K06588]
715908  CRTC2; CREB-regulated transcription coactivator 2 [KO:K16333]
715919  RELA; transcription factor p65 isoform X1 [KO:K04735]
715949  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
715951  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
716098  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
716170  TP53; cellular tumor antigen p53 [KO:K04451]
716313  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
716412  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
716690  IL6R; interleukin-6 receptor subunit alpha isoform X2 [KO:K05055]
716811  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
716998  TNXB; tenascin-X isoform X7 [KO:K06252]
717016  YWHAH; 14-3-3 protein eta [KO:K16198]
717050  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
717078  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
717315  EFNA4; ephrin-A4 isoform X2 [KO:K05462]
717319  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
717373  EFNA3; ephrin-A3 precursor [KO:K05462]
717379  ITGB3; integrin beta-3 [KO:K06493]
717399  EFNA1; ephrin-A1 [KO:K05462]
717562  CSH2; chorionic somatomammotropin hormone 2 precursor [KO:K05438]
717572  THBS3; thrombospondin-3 precursor [KO:K04659]
717703  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
717740  BAD; bcl2-associated agonist of cell death [KO:K02158]
717755  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
717788  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
717994  OSM; oncostatin-M precursor [KO:K05418]
718116  CSH4; somatotropin precursor [KO:K05438]
718135  CSH3; chorionic somatommamotropin hormone 3 precursor [KO:K05438]
718156  GH1; somatotropin precursor [KO:K05438]
718223  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
718284  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
718288  FGF21; fibroblast growth factor 21 [KO:K22429]
718412  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
718474  [KO:K05438]
718534  NTF4; neurotrophin-4 precursor [KO:K12457]
718834  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
718894  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X9 [KO:K11584]
719199  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
719239  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X2 [KO:K05454]
719248  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
719294  EPO; erythropoietin precursor [KO:K05437]
719319  COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
719331  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
719367  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
719670  NTRK1; high affinity nerve growth factor receptor isoform X3 [KO:K03176] [EC:2.7.10.1]
719844  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
719929  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
719943  COL9A3; collagen alpha-3(IX) chain isoform X2 [KO:K08131]
720040  JAK3; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
720156  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
720286  COMP; cartilage oligomeric matrix protein [KO:K04659]
720452  [KO:K06856]
720904  [KO:K06856]
720935  [KO:K06856]
720945  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
720985  [KO:K06856]
721002  [KO:K06856]
721083  [KO:K06856]
721231  EFNA2; ephrin-A2 [KO:K05462]
721324  FGF9; fibroblast growth factor 9 [KO:K04358]
721712  FLT3; LOW QUALITY PROTEIN: receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
721731  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X2 [KO:K04688] [EC:2.7.11.1]
721821  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
721825  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
721855  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
721988  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
722019  VWF; von Willebrand factor precursor [KO:K03900]
722023  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
722026  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
722027  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
722068  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
722115  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
722278  [KO:K06856]
722394  FGF8; fibroblast growth factor 8 [KO:K04358]
722398  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
722430  LAMC3; laminin subunit gamma-3 [KO:K06247]
722472  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
735307  [KO:K05438]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
mcc00010  Glycolysis / Gluconeogenesis
mcc04010  MAPK signaling pathway
mcc04012  ErbB signaling pathway
mcc04062  Chemokine signaling pathway
mcc04064  NF-kappa B signaling pathway
mcc04068  FoxO signaling pathway
mcc04110  Cell cycle
mcc04115  p53 signaling pathway
mcc04150  mTOR signaling pathway
mcc04210  Apoptosis
mcc04370  VEGF signaling pathway
mcc04510  Focal adhesion
mcc04620  Toll-like receptor signaling pathway
mcc04630  JAK-STAT signaling pathway
mcc04662  B cell receptor signaling pathway
mcc04910  Insulin signaling pathway
KO pathway
ko04151   

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