Entry Name Fc epsilon RI signaling pathway - Macaca mulatta (rhesus monkey)
Description Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map mcc04664 Fc epsilon RI signaling pathway
Other DBs Organism Macaca mulatta (rhesus monkey) [GN:
mcc ]
Gene 574371 CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427 ]
694685 VAV3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730 ]
696709 RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860 ]
697069 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116 ] [EC:3.1.4.11 ]
697830 MS4A2; high affinity immunoglobulin epsilon receptor subunit beta [KO:K08090 ]
698996 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
702041 GRB2; growth factor receptor-bound protein 2 [KO:K04364 ]
704656 LAT; linker for activation of T-cells family member 1 isoform X2 [KO:K07362 ]
707310 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
709959 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
710077 MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431 ] [EC:2.7.12.2 ]
710552 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
713170 ALOX5AP; arachidonate 5-lipoxygenase-activating protein [KO:K20735 ]
713227 VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730 ]
713777 SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099 ]
714173 PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859 ] [EC:3.1.4.11 ]
716098 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
717755 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
717832 INPP5D; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1 [KO:K03084 ] [EC:3.1.3.86 ]
718155 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430 ] [EC:2.7.12.2 ]
719305 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
719324 FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha [KO:K08089 ]
719367 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
720291 FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma precursor [KO:K07983 ]
721821 MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369 ] [EC:2.7.12.2 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Kawakami T, Galli SJ.
Title Regulation of mast-cell and basophil function and survival by IgE.
Journal Reference Authors Siraganian RP.
Title Mast cell signal transduction from the high-affinity IgE receptor.
Journal Reference Authors Janeway CA, Travers P, Walport M, Shlomchik MJ.
Title Immunobiology 6th edition
Journal Garland Science Publishing (2005)
Reference Authors Turner H, Kinet JP.
Title Signalling through the high-affinity IgE receptor Fc epsilonRI.
Journal Reference Authors Gilfillan AM, Tkaczyk C.
Title Integrated signalling pathways for mast-cell activation.
Journal Reference Authors Nadler MJ, Matthews SA, Turner H, Kinet JP.
Title Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function.
Journal Reference Authors Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang Y, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG.
Title Essential role for Gab2 in the allergic response.
Journal Reference Authors Nadler MJ, Kinet JP.
Title Uncovering new complexities in mast cell signaling.
Journal Related mcc04070 Phosphatidylinositol signaling system
KO pathway
