KEGG   PATHWAY: mcc05213
Entry
mcc05213                    Pathway                                
Name
Endometrial cancer - Macaca mulatta (rhesus monkey)
Description
Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification.
Class
Human Diseases; Cancer: specific types
Pathway map
mcc05213  Endometrial cancer
mcc05213

Disease
H00026  Endometrial cancer
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100424087  AXIN1; axin-1 isoform X1 [KO:K02157]
114672263  [KO:K10140]
114672301  [KO:K04375]
114675515  [KO:K14021]
574265  CTNNB1; catenin beta-1 [KO:K02105]
574320  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
574385  CTNNA1; catenin alpha-1 [KO:K05691]
613027  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
693443  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
693554  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
694544  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
694560  TCF7L1; transcription factor 7-like 1 isoform X2 [KO:K04490]
694626  MYC; myc proto-oncogene protein [KO:K04377]
694725  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
695776  LEF1; lymphoid enhancer-binding factor 1 isoform X3 [KO:K04492]
696040  CTNNA3; catenin alpha-3 [KO:K05691]
697523  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X2 [KO:K06276] [EC:2.7.11.1]
697573  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
697747  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
697835  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
698569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
698619  EGF; pro-epidermal growth factor isoform X2 [KO:K04357]
698782  MLH1; DNA mismatch repair protein Mlh1 isoform X1 [KO:K08734]
698830  HRAS; GTPase HRas [KO:K02833]
698996  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
700591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
700731  FOXO3; forkhead box protein O3 [KO:K09408]
701054  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
701759  TCF7L2; transcription factor 7-like 2 isoform X9 [KO:K04491]
702041  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
704387  CDH1; cadherin-1 [KO:K05689]
705121  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
705601  SOS2; son of sevenless homolog 2 [KO:K03099]
705713  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
706534  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
707169  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
707310  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
707345  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
707977  KRAS; GTPase KRas [KO:K07827]
708938  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
709089  NRAS; GTPase NRas [KO:K07828]
709944  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
709959  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
710234  TCF7; transcription factor 7 isoform X3 [KO:K02620]
710415  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
710552  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
711257  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
712135  CTNNA2; catenin alpha-2 [KO:K05691]
712610  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
713114  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
713777  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
713813  DDB2; DNA damage-binding protein 2 [KO:K10140]
714717  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
716098  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
716170  TP53; cellular tumor antigen p53 [KO:K04451]
717740  BAD; bcl2-associated agonist of cell death [KO:K02158]
718566  AXIN2; axin-2 isoform X1 [KO:K04385]
718948  BAX; apoptosis regulator BAX [KO:K02159]
719199  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
719367  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
721821  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15947972
  Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
  Title
Endometrial cancer.
  Journal
Cell Tissue Res 322:53-61 (2005)
DOI:10.1007/s00441-005-1109-5
Reference
PMID:14747944
  Authors
Lax SF.
  Title
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
  Journal
Virchows Arch 444:213-23 (2004)
DOI:10.1007/s00428-003-0947-3
Reference
PMID:16508724
  Authors
Shiozawa T, Konishi I.
  Title
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
  Journal
Int J Clin Oncol 11:13-21 (2006)
DOI:10.1007/s10147-005-0546-1
Reference
PMID:17028294
  Authors
Hecht JL, Mutter GL.
  Title
Molecular and pathologic aspects of endometrial carcinogenesis.
  Journal
J Clin Oncol 24:4783-91 (2006)
DOI:10.1200/JCO.2006.06.7173
Reference
PMID:11431710
  Authors
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
  Title
Molecular pathology of endometrial hyperplasia and carcinoma.
  Journal
Hum Pathol 32:569-77 (2001)
DOI:10.1053/hupa.2001.25929
Reference
PMID:15284264
  Authors
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
  Title
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
  Journal
J Clin Oncol 22:3126-32 (2004)
DOI:10.1200/JCO.2004.11.154
Reference
PMID:7585656
  Authors
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
  Title
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
  Journal
Cancer Res 55:5693-8 (1995)
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Related
pathway
mcc04010  MAPK signaling pathway
mcc04012  ErbB signaling pathway
mcc04060  Cytokine-cytokine receptor interaction
mcc04110  Cell cycle
mcc04115  p53 signaling pathway
mcc04151  PI3K-Akt signaling pathway
mcc04310  Wnt signaling pathway
mcc04520  Adherens junction
KO pathway
ko05213   

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