Entry
Name
Cytokine-cytokine receptor interaction - Macaca mulatta (rhesus monkey)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
mcc04060 Cytokine-cytokine receptor interaction
Organism
Macaca mulatta (rhesus monkey) [GN:
mcc ]
Gene
100424175 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
100430035 TNFRSF10C; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 10C [KO:K22701 ]
100551506 TNFSF12; tumor necrosis factor ligand superfamily member 12 [KO:K05474 ]
100551507 TNFSF13; tumor necrosis factor ligand superfamily member 13 [KO:K05475 ]
106992315 TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375 ]
106995138 IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737 ]
114669829 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
574127 IL6ST; interleukin-6 receptor subunit beta precursor [KO:K05060 ]
574159 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
574199 IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063 ]
574200 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B isoform X1 [KO:K05150 ]
574222 CXCL1; growth-regulated alpha protein precursor [KO:K05505 ]
574224 CXCL13; C-X-C motif chemokine 13 precursor [KO:K10032 ]
574231 CCR7; C-C chemokine receptor type 7 precursor [KO:K04182 ]
574243 CXCL10; C-X-C motif chemokine 10 precursor [KO:K12671 ]
574300 IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068 ]
574304 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
574332 FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390 ]
574334 CXCL12; stromal cell-derived factor 1 precursor [KO:K10031 ]
574371 CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427 ]
574372 CXCL11; C-X-C motif chemokine 11 precursor [KO:K12672 ]
574387 IL1RAP; interleukin-1 receptor accessory protein precursor [KO:K04723 ]
641338 IL2RG; cytokine receptor common subunit gamma precursor [KO:K05070 ]
678654 TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
693569 OSMR; oncostatin-M-specific receptor subunit beta isoform X2 [KO:K05057 ]
693671 IL17RB; interleukin-17 receptor B isoform X1 [KO:K05165 ]
693917 TNFSF13B; tumor necrosis factor ligand superfamily member 13B isoform X2 [KO:K05476 ]
694139 LIFR; leukemia inhibitory factor receptor isoform X1 [KO:K05058 ]
694451 TNFSF10; tumor necrosis factor ligand superfamily member 10 precursor [KO:K04721 ]
694618 BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662 ]
694747 IL12B; interleukin-12 subunit beta precursor [KO:K05425 ]
694806 IL19; LOW QUALITY PROTEIN: interleukin-19 [KO:K05444 ]
695042 TNFRSF14; tumor necrosis factor receptor superfamily member 14 precursor [KO:K05152 ]
695059 EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X2 [KO:K05162 ]
696331 IL2RB; interleukin-2 receptor subunit beta precursor [KO:K05069 ]
697508 CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738 ]
698961 CSF3; granulocyte colony-stimulating factor [KO:K05423 ]
698972 IL17RE; interleukin-17 receptor E isoform X4 [KO:K05168 ]
699223 IL17RC; interleukin-17 receptor C isoform X1 [KO:K05166 ]
699559 TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154 ]
699604 IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130 ]
699674 TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142 ]
699726 IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131 ]
699869 IL7R; interleukin-7 receptor subunit alpha [KO:K05072 ]
699955 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
699970 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A isoform X2 [KO:K05149 ]
700201 IL11RA; interleukin-11 receptor subunit alpha isoform X3 [KO:K05056 ]
700579 IL37; LOW QUALITY PROTEIN: interleukin-37 [KO:K05485 ]
700588 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
700677 IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064 ]
700959 CNTFR; ciliary neurotrophic factor receptor subunit alpha precursor [KO:K05059 ]
701451 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
701658 IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
701792 CXCR5; C-X-C chemokine receptor type 5 isoform X1 [KO:K04190 ]
701850 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
702532 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
702944 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
703189 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
703239 TGFB3; transforming growth factor beta-3 precursor [KO:K13377 ]
703744 TNFRSF25; tumor necrosis factor receptor superfamily member 25 [KO:K05160 ]
703895 PF4V1; platelet factor 4 variant isoform X2 [KO:K05407 ]
704383 IL10RA; interleukin-10 receptor subunit alpha [KO:K05134 ]
704649 IL5RA; interleukin-5 receptor subunit alpha [KO:K05067 ]
704890 IL20RA; interleukin-20 receptor subunit alpha isoform X3 [KO:K05136 ]
705101 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
705268 IL36RN; interleukin-36 receptor antagonist protein [KO:K05483 ]
705404 IL4R; interleukin-4 receptor subunit alpha isoform X2 [KO:K05071 ]
706012 IL10RB; interleukin-10 receptor subunit beta isoform X2 [KO:K05135 ]
706255 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
707034 TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155 ]
707540 TGFB2; transforming growth factor beta-2 precursor [KO:K13376 ]
707749 CD40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160 ]
708281 TNFRSF9; tumor necrosis factor receptor superfamily member 9 precursor [KO:K05146 ]
708339 IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077 ]
709719 IL31RA; interleukin-31 receptor subunit alpha [KO:K22630 ]
710114 MSTN; growth/differentiation factor 8 precursor [KO:K05497 ]
710244 EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163 ]
710986 IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076 ]
711625 IFNLR1; interferon lambda receptor 1 isoform X1 [KO:K05140 ]
711638 IL1R2; interleukin-1 receptor type 2 precursor [KO:K04387 ]
711893 IL1RL1; interleukin-1 receptor-like 1 isoform X2 [KO:K05171 ]
712046 IL18RAP; interleukin-18 receptor accessory protein [KO:K05174 ]
712076 CXCL14; C-X-C motif chemokine 14 precursor [KO:K10033 ]
712212 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
712550 LTBR; tumor necrosis factor receptor superfamily member 3 precursor [KO:K03159 ]
712554 CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421 ]
712577 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
712627 IL23A; interleukin-23 subunit alpha precursor [KO:K05426 ]
712788 IL15RA; interleukin-15 receptor subunit alpha isoform 2 precursor [KO:K05074 ]
713485 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
713807 CD4; T-cell surface glycoprotein CD4 precursor [KO:K06454 ]
715454 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B precursor [KO:K05141 ]
715456 LIF; leukemia inhibitory factor isoform X1 [KO:K05419 ]
716650 TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722 ]
716690 IL6R; interleukin-6 receptor subunit alpha isoform X2 [KO:K05055 ]
716769 IL20RB; interleukin-20 receptor subunit beta [KO:K05137 ]
716826 TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722 ]
716901 TNFRSF10D; tumor necrosis factor receptor superfamily member 10D [KO:K22702 ]
717549 IL27RA; interleukin-27 receptor subunit alpha [KO:K19598 ]
717562 CSH2; chorionic somatomammotropin hormone 2 precursor [KO:K05438 ]
718135 CSH3; chorionic somatommamotropin hormone 3 precursor [KO:K05438 ]
718143 RELT; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156 ]
719264 IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X1 [KO:K05138 ]
720298 GDF1; embryonic growth/differentiation factor 1 [KO:K05495 ]
722033 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
722773 TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X2 [KO:K05145 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway