KEGG PATHWAY: mfot04662

KEGG

PATHWAY: mfot04662

Entry

mfot04662                   Pathway

Name

B cell receptor signaling pathway - Alexandromys fortis (reed vole)

Description

B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.

Class

Organismal Systems; Immune system

Pathway map

B cell receptor signaling pathway

Other DBs

GO:

Organism

Alexandromys fortis (reed vole) [GN:mfot]

Gene

[KO:K15909] [EC:3.1.3.86]

[KO:K04371] [EC:2.7.11.24]

[KO:K03084] [EC:3.1.3.86]

[KO:K04369] [EC:2.7.12.2]

[KO:K04348] [EC:3.1.3.16]

[KO:K04348] [EC:3.1.3.16]

[KO:K04456] [EC:2.7.11.1]

[KO:K07370] [EC:2.7.10.2]

[KO:K00922] [EC:2.7.1.153]

[KO:K00922] [EC:2.7.1.153]

[KO:K04456] [EC:2.7.11.1]

[KO:K19662] [EC:2.7.11.13]

[KO:K05855] [EC:2.7.10.2]

[KO:K05859] [EC:3.1.4.11]

[KO:K04467] [EC:2.7.11.10]

[KO:K07209] [EC:2.7.11.10]

[KO:K04366] [EC:2.7.11.1]

[KO:K03083] [EC:2.7.11.26]

[KO:K04368] [EC:2.7.12.2]

[KO:K08890] [EC:2.7.10.2]

[KO:K00922] [EC:2.7.1.153]

[KO:K04456] [EC:2.7.11.1]

[KO:K07369] [EC:3.4.22.-]

[KO:K05697] [EC:3.1.3.48]

[KO:K05854] [EC:2.7.10.2]

[KO:K04371] [EC:2.7.11.24]

Compound

Calcium cation

Diacylglycerol

D-myo-Inositol 1,4,5-trisphosphate

Phosphatidylinositol-3,4,5-trisphosphate

Reference

Authors

Niiro H, Clark EA.

Title

Regulation of B-cell fate by antigen-receptor signals.

Journal

Nat Rev Immunol 2:945-56 (2002)
DOI:10.1038/nri955

Reference

Authors

Kurosaki T.

Title

Genetic analysis of B cell antigen receptor signaling.

Journal

Annu Rev Immunol 17:555-92 (1999)
DOI:10.1146/annurev.immunol.17.1.555

Reference

Authors

Nitschke L.

Title

The role of CD22 and other inhibitory co-receptors in B-cell activation.

Journal

Curr Opin Immunol 17:290-7 (2005)
DOI:10.1016/j.coi.2005.03.005

Reference

Authors

Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.

Title

Complement: central to innate immunity and bridging to adaptive responses.

Journal

Immunol Lett 97:171-9 (2005)
DOI:10.1016/j.imlet.2004.11.010

Reference

Authors

Kurosaki T.

Title

Regulation of B-cell signal transduction by adaptor proteins.

Journal

Nat Rev Immunol 2:354-63 (2002)
DOI:10.1038/nri801

Reference

Authors

Nitschke L, Tsubata T.

Title

Molecular interactions regulate BCR signal inhibition by CD22 and CD72.

Journal

Trends Immunol 25:543-50 (2004)
DOI:10.1016/j.it.2004.08.002

Reference

Authors

Jumaa H, Hendriks RW, Reth M.

Title

B cell signaling and tumorigenesis.

Journal

Annu Rev Immunol 23:415-45 (2005)
DOI:10.1146/annurev.immunol.23.021704.115606

Reference

Authors

Rickert RC.

Title

Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.

Journal

Curr Opin Immunol 17:237-43 (2005)
DOI:10.1016/j.coi.2005.03.001

Reference

Authors

Zouali M, Sarmay G

Title

B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.

Journal

Arthritis Rheum 50:2730-41 (2004)
DOI:10.1002/art.20487

Reference

Authors

Chiles TC.

Title

Regulation and function of cyclin D2 in B lymphocyte subsets.

Journal

J Immunol 173:2901-7 (2004)
DOI:10.4049/jimmunol.173.5.2901

Reference

Authors

Allam A, Marshall AJ

Title

Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.

Journal

Immunol Lett 97:7-17 (2005)
DOI:10.1016/j.imlet.2004.09.019

Reference

Authors

Gold MR

Title

To make antibodies or not: signaling by the B-cell antigen receptor.

Journal

Trends Pharmacol Sci 23:316-24 (2002)
DOI:10.1016/S0165-6147(02)02045-X

Reference

Authors

Fu C, Turck CW, Kurosaki T, Chan AC

Title

BLNK: a central linker protein in B cell activation.

Journal

Immunity 9:93-103 (1998)
DOI:10.1016/S1074-7613(00)80591-9

Reference

Authors

Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T

Title

BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.

Journal

Immunity 13:817-27 (2000)
DOI:10.1016/S1074-7613(00)00079-0

Reference

Authors

Shinohara H, Maeda S, Watarai H, Kurosaki T

Title

IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.

Journal

J Exp Med 204:3285-93 (2007)
DOI:10.1084/jem.20070379

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