KEGG   PATHWAY: mfot04010
Entry
mfot04010                   Pathway                                
Name
MAPK signaling pathway - Microtus fortis (reed vole)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
mfot04010  MAPK signaling pathway
mfot04010

Other DBs
GO: 0000165
Organism
Microtus fortis (reed vole) [GN:mfot]
Gene
126487773  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
126500249  voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
126505446  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
126511130  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
126497236  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
126512843  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
126510401  voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
126497157  voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
126515773  voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
126505025  voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
126500114  voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
126499863  voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
126511200  voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
126505517  voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
126510509  voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
126503206  voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
126493782  voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
126500247  voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
126515012  voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
126515791  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
126502377  voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
126515017  voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
126515011  voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
126493072  voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
126513437  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
126493059  voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
126493079  voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
126512376  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
126512697  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
126487741  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
126514970  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
126502354  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
126493096  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
126514346  guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
126493349  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
126491266  protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
126491367  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
126500819  calcineurin subunit B type 1 [KO:K06268]
126509907  calcineurin subunit B type 2 [KO:K06268]
126510654  ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
126508578  ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
126495464  RAS guanyl-releasing protein 1 [KO:K04350]
126498235  RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
126514223  ras guanyl-releasing protein 3 [KO:K12362]
126486727  RAS guanyl-releasing protein 4 [KO:K12363]
126511571  rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
126492432  neurofibromin isoform X1 [KO:K08052]
126487165  ras GTPase-activating protein 1 [KO:K04352]
126510661  ras GTPase-activating protein 2 [KO:K08053]
126495237  ras-related protein Rap-1A [KO:K04353]
126515662  ras-related protein Rap-1b [KO:K07836]
126509286  LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
126515578  protransforming growth factor alpha [KO:K08774]
126506595  proepiregulin [KO:K09784]
126506442  amphiregulin [KO:K09782]
126513226  fibroblast growth factor 1 isoform X1 [KO:K18496]
126499184  fibroblast growth factor 2 [KO:K18497]
126498758  fibroblast growth factor 3 [KO:K04358]
126505447  fibroblast growth factor 8 isoform X1 [KO:K04358]
126506479  fibroblast growth factor 5 isoform X1 [KO:K04358]
126493460  fibroblast growth factor 16 [KO:K04358]
126507679  fibroblast growth factor 9 [KO:K04358]
126507935  fibroblast growth factor 10 [KO:K04358]
126488515  fibroblast growth factor 6 [KO:K04358]
126495432  fibroblast growth factor 7 [KO:K04358]
126489247  fibroblast growth factor 22 [KO:K04358]
126495878  fibroblast growth factor 4 [KO:K04358]
126498180  fibroblast growth factor 4 [KO:K04358]
126504839  fibroblast growth factor 20 [KO:K04358]
126498511  fibroblast growth factor 18 isoform X1 [KO:K04358]
126498894  fibroblast growth factor 19 [KO:K22603]
126488123  fibroblast growth factor 21 [KO:K22429]
126488494  fibroblast growth factor 23 [KO:K22428]
126510837  beta-nerve growth factor [KO:K02582]
126490405  brain-derived neurotrophic factor [KO:K04355]
126514804  neurotrophin-3 [KO:K04356]
126488508  neurotrophin-3 isoform X1 [KO:K04356]
126488140  neurotrophin-4 [KO:K12457]
126498130  insulin [KO:K04526]
126503857  insulin-like growth factor I isoform X1 [KO:K05459]
126498128  insulin-like growth factor II isoform X1 [KO:K13769]
126514366  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
126515738  platelet-derived growth factor subunit B isoform X1 [KO:K17386]
126493287  platelet-derived growth factor D [KO:K05450]
126511557  platelet-derived growth factor C [KO:K05450]
126491876  macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
126497457  kit ligand isoform X1 [KO:K05461]
126488166  fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
126488914  vascular endothelial growth factor A isoform X1 [KO:K05448]
126498344  vascular endothelial growth factor B isoform X1 [KO:K16858]
126515159  placenta growth factor isoform X1 [KO:K16859]
126512703  vascular endothelial growth factor D isoform X1 [KO:K05449]
126504796  vascular endothelial growth factor C [KO:K05449]
126500116  hepatocyte growth factor isoform X1 [KO:K05460]
126514397  angiopoietin-1 isoform X1 [KO:K05465]
126498567  angiopoietin-2 [KO:K05466]
126507122  angiopoietin-4 [KO:K05467]
126486539  ephrin-A4 isoform X1 [KO:K05462]
126508304  ephrin-A5 isoform X1 [KO:K05462]
126489356  ephrin-A2 [KO:K05462]
126516149  ephrin-A1 isoform X1 [KO:K05462]
126499715  glial cell line-derived neurotrophic factor [KO:K05452]
126513287  neurturin-like [KO:K25414]
126490359  neurturin [KO:K25414]
126513148  artemin isoform X1 [KO:K25415]
126490372  persephin [KO:K25416]
126500934  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
126510532  receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
126492018  receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
126508767  LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
126504434  LOW QUALITY PROTEIN: fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
126515859  fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
126500888  fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
126502783  fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
126510451  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
126486514  high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
126502815  BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
126491593  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
126505922  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
126506425  platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
126511093  platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
126511027  macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
126506503  mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
126513533  receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
126513474  vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
126511400  vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
126506434  vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
126503908  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
126497972  angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
126508865  ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
126505488  proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
126500407  growth factor receptor-bound protein 2 [KO:K04364]
126514526  son of sevenless homolog 1 isoform X1 [KO:K03099]
126508440  son of sevenless homolog 2 isoform X1 [KO:K03099]
126498807  GTPase HRas [KO:K02833]
126515221  GTPase KRas isoform X1 [KO:K07827]
126510868  GTPase NRas [KO:K07828]
126488206  ras-related protein R-Ras isoform X1 [KO:K07829]
126502294  ras-related protein R-Ras2 isoform X1 [KO:K07830]
126499906  ras-related protein M-Ras isoform X1 [KO:K07831]
126496069  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
126505149  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
126505550  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
126507499  dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
126489299  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
126491279  ragulator complex protein LAMTOR3 [KO:K04370]
126489023  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
126515955  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
126515742  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
126489215  MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
126491736  ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
126508178  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
126515023  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
126497703  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
126515727  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
126486651  ETS domain-containing protein Elk-1 [KO:K04375]
126487478  ETS domain-containing protein Elk-1-like [KO:K04375]
126505010  ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
126503554  myc proto-oncogene protein [KO:K04377]
126488948  serum response factor isoform X1 [KO:K04378]
126515189  protein c-Fos [KO:K04379]
126487542  microtubule-associated protein tau isoform X1 [KO:K04380]
126509861  stathmin isoform X1 [KO:K04381]
126514185  cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
126494649  cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
126495156  cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
126495559  cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
126496837  cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
126496849  cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
126494877  tumor necrosis factor [KO:K03156]
126496717  interleukin-1 alpha isoform X1 [KO:K04383]
126496850  interleukin-1 beta [KO:K04519]
126494578  transforming growth factor beta-1 proprotein [KO:K13375]
126505361  transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
126507732  transforming growth factor beta-3 proprotein [KO:K13377]
126514827  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
126496981  interleukin-1 receptor type 1 [KO:K04386]
126512301  interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
126509812  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
126491130  TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
126511310  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
126511231  tumor necrosis factor receptor superfamily member 6 [KO:K04390]
126493390  monocyte differentiation antigen CD14 [KO:K04391]
126489822  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
126515814  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
126500329  ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
126508149  cell division control protein 42 homolog isoform X1 [KO:K04393]
126502907  tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
126495899  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
126504830  caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
126509272  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
126499615  death domain-associated protein 6 isoform X1 [KO:K02308]
126501081  myeloid differentiation primary response protein MyD88 [KO:K04729]
126496436  myeloid differentiation primary response protein MyD88-like [KO:K04729]
126490221  interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
126492812  interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
126504640  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
126493354  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
126489353  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
126503041  growth arrest and DNA damage-inducible protein GADD45 gamma isoform X1 [KO:K04402]
126515732  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
126513299  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
126490521  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
126514527  mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
126496902  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
126486624  mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
126508969  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
126512192  serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
126506982  serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
126513415  serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
126498234  mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
126507798  mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
126507983  mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
126498193  mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
126497096  mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
126514953  mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
126515181  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
126492541  mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
126504656  mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
126491182  mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
126504182  mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
126488175  mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
126508107  mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
126511959  mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
126503643  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
126497713  mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
126492295  serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
126515984  serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
126511642  serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
126513961  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
126491615  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
126514653  dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
126500469  dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
126489776  C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
126493129  C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
126498303  C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
126490219  filamin-A isoform X1 [KO:K04437]
126492419  adapter molecule crk isoform X1 [KO:K04438]
126488990  crk-like protein [KO:K04438]
126514030  beta-arrestin-2 isoform X1 [KO:K04439]
126508973  beta-arrestin-1 isoform X1 [KO:K04439]
126500615  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
126509741  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
126511413  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
126492719  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
126492755  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
126501977  mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
126502008  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
126511672  MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
126505043  MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
126499921  MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
126507210  ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
126498659  ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
126496720  M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
126515387  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
126502736  nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
126497948  transcription factor Jun [KO:K04448]
126491832  transcription factor JunD [KO:K04449]
126487367  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
126513928  cellular tumor antigen p53 isoform X1 [KO:K04451]
126514795  DNA damage-inducible transcript 3 protein [KO:K04452]
126508433  protein max isoform X1 [KO:K04453]
126507720  myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
126492740  heat shock protein beta-1 [KO:K04455]
126492538  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126502126  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
126509082  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126508368  protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
126497512  receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
126493734  tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
126505036  tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
126498056  dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
126498880  dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
126500001  dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
126489154  dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
126496637  dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
126504399  dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
126505375  dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
126497504  dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
126490273  dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
126502077  dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
126510137  dual specificity protein phosphatase 3 isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
126494781  serine/threonine-protein phosphatase 5 isoform X1 [KO:K04460] [EC:3.1.3.16]
126504002  protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
126494897  heat shock 70 kDa protein 1A [KO:K03283]
126494898  heat shock 70 kDa protein 1-like [KO:K03283]
126502327  heat shock cognate 71 kDa protein-like [KO:K03283]
126495372  heat shock 70 kDa protein 1A [KO:K03283]
126495373  heat shock 70 kDa protein 1A [KO:K03283]
126495911  heat shock cognate 71 kDa protein [KO:K03283]
126511180  LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
126499290  histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
126507420  dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
126514647  mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
126488791  nuclear receptor subfamily 4 group A member 1 [KO:K04465]
126510438  mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
126504083  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
126504411  inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
126490256  NF-kappa-B essential modulator isoform X1 [KO:K07210]
126492313  serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
126502367  nuclear factor NF-kappa-B p105 subunit [KO:K02580]
126505284  nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
126498562  transcription factor p65 isoform X1 [KO:K04735]
126490949  transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
mfot04070  Phosphatidylinositol signaling system
mfot04110  Cell cycle
mfot04115  p53 signaling pathway
mfot04210  Apoptosis
mfot04310  Wnt signaling pathway
mfot04668  TNF signaling pathway
KO pathway
ko04010   
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