KEGG   PATHWAY: mfot04810
Entry
mfot04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Microtus fortis (reed vole)
Class
Cellular Processes; Cell motility
Pathway map
mfot04810  Regulation of actin cytoskeleton
mfot04810

Other DBs
GO: 0030036
Organism
Microtus fortis (reed vole) [GN:mfot]
Gene
126515928  lysophosphatidic acid receptor 1 [KO:K04289]
126494363  lysophosphatidic acid receptor 2 [KO:K04291]
126492509  lysophosphatidic acid receptor 4 [KO:K04275]
126514917  lysophosphatidic acid receptor 5 isoform X1 [KO:K08390]
126505459  stromal cell-derived factor 1 isoform X1 [KO:K10031]
126505129  C-X-C chemokine receptor type 4 [KO:K04189]
126489747  prothrombin [KO:K01313] [EC:3.4.21.5]
126508543  proteinase-activated receptor 1 [KO:K03914]
126498130  insulin [KO:K04526]
126509286  LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
126513226  fibroblast growth factor 1 isoform X1 [KO:K18496]
126499184  fibroblast growth factor 2 [KO:K18497]
126498758  fibroblast growth factor 3 [KO:K04358]
126505447  fibroblast growth factor 8 isoform X1 [KO:K04358]
126506479  fibroblast growth factor 5 isoform X1 [KO:K04358]
126493460  fibroblast growth factor 16 [KO:K04358]
126507679  fibroblast growth factor 9 [KO:K04358]
126507935  fibroblast growth factor 10 [KO:K04358]
126488515  fibroblast growth factor 6 [KO:K04358]
126495432  fibroblast growth factor 7 [KO:K04358]
126489247  fibroblast growth factor 22 [KO:K04358]
126495878  fibroblast growth factor 4 [KO:K04358]
126498180  fibroblast growth factor 4 [KO:K04358]
126504839  fibroblast growth factor 20 [KO:K04358]
126498511  fibroblast growth factor 18 isoform X1 [KO:K04358]
126498894  fibroblast growth factor 19 [KO:K22603]
126488123  fibroblast growth factor 21 [KO:K22429]
126488494  fibroblast growth factor 23 [KO:K22428]
126514366  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
126515738  platelet-derived growth factor subunit B isoform X1 [KO:K17386]
126493287  platelet-derived growth factor D [KO:K05450]
126511557  platelet-derived growth factor C [KO:K05450]
126486513  insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
126500934  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
126504434  LOW QUALITY PROTEIN: fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
126515859  fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
126500888  fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
126502783  fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
126506425  platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
126511093  platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
126508782  fibronectin [KO:K05717]
126507956  integrin alpha-1 [KO:K06480]
126507958  integrin alpha-2 isoform X1 [KO:K06481]
126510551  integrin alpha-IIb [KO:K06476]
126510377  integrin alpha-3 isoform X1 [KO:K06482]
126487664  integrin alpha-4 [KO:K06483]
126491193  integrin alpha-5 [KO:K06484]
126489011  integrin alpha-6 isoform X1 [KO:K06485]
126492004  integrin alpha-7 isoform X1 [KO:K06583]
126506755  integrin alpha-8 isoform X1 [KO:K06584]
126501107  integrin alpha-9 [KO:K06585]
126490089  integrin alpha-10 [KO:K06586]
126507509  integrin alpha-11 [KO:K06587]
126487714  integrin alpha-V isoform X1 [KO:K06487]
126515909  integrin alpha-L [KO:K05718]
126515976  integrin alpha-M isoform X1 [KO:K06461]
126515949  integrin alpha-X-like isoform X1 [KO:K06462]
126514103  integrin alpha-E isoform X1 [KO:K06524]
126488541  integrin beta-1 [KO:K05719]
126513667  integrin beta-2-like protein [KO:K06464]
126502148  integrin beta-2 [KO:K06464]
126487550  integrin beta-3 isoform X1 [KO:K06493]
126500412  integrin beta-4 isoform X1 [KO:K06525]
126512191  integrin beta-5 isoform X1 [KO:K06588]
126489334  integrin beta-6 [KO:K06589]
126493610  integrin beta-7 isoform X1 [KO:K06590]
126487815  integrin beta-8 [KO:K06591]
126504268  T-kininogen 2-like isoform X1 [KO:K03898]
126504348  T-kininogen 2-like [KO:K03898]
126509114  B1 bradykinin receptor [KO:K03915]
126509113  B2 bradykinin receptor [KO:K03916]
126498481  muscarinic acetylcholine receptor M1 [KO:K04129]
126505258  muscarinic acetylcholine receptor M2 [KO:K04130]
126501568  muscarinic acetylcholine receptor M3 [KO:K04131]
126489785  muscarinic acetylcholine receptor M4 [KO:K04132]
126496811  muscarinic acetylcholine receptor M5 [KO:K04133]
126513419  complement C5 [KO:K03994]
126499661  complement component C6 [KO:K03995]
126499662  complement component C7 [KO:K03996]
126497906  complement component C8 alpha chain [KO:K03997]
126497932  complement component C8 beta chain isoform X1 [KO:K03998]
126509301  complement component C8 gamma chain [KO:K03999]
126499665  complement component C9 [KO:K04000]
126514346  guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
126514965  guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
126493349  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
126492160  FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
126502510  FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
126503359  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
126502806  breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
126492419  adapter molecule crk isoform X1 [KO:K04438]
126488990  crk-like protein [KO:K04438]
126498252  dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
126507045  proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
126514526  son of sevenless homolog 1 isoform X1 [KO:K03099]
126508440  son of sevenless homolog 2 isoform X1 [KO:K03099]
126498807  GTPase HRas [KO:K02833]
126515221  GTPase KRas isoform X1 [KO:K07827]
126510868  GTPase NRas [KO:K07828]
126488206  ras-related protein R-Ras isoform X1 [KO:K07829]
126502294  ras-related protein R-Ras2 isoform X1 [KO:K07830]
126499906  ras-related protein M-Ras isoform X1 [KO:K07831]
126512126  rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
126499173  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
126499912  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
126508229  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
126491758  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
126512534  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
126494148  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
126487921  guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
126509212  guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
126490381  proto-oncogene vav [KO:K05730]
126515247  rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
126496069  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
126505149  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
126505550  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
126514595  proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
126507499  dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
126489299  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
126489023  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
126515955  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
126492538  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126502126  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
126509082  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126491420  rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
126487351  rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
126493318  rho GTPase-activating protein 35 [KO:K05732]
126499773  transforming protein RhoA [KO:K04513]
126513781  transforming protein RhoA-like isoform X1 [KO:K04513]
126500660  transforming protein RhoA isoform X1 [KO:K04513]
126508779  transforming protein RhoA-like [KO:K04513]
126489822  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
126515814  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
126500329  ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
126508149  cell division control protein 42 homolog isoform X1 [KO:K04393]
126508969  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
126512192  serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
126491493  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
126486767  serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
126496845  serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
126496696  serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
126498352  rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
126492302  ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
126505647  rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
126501334  rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
126512146  myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
126507021  myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
126487709  myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
126501627  myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
126494310  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
126488330  serine/threonine-protein phosphatase PP1-alpha catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
126488640  serine/threonine-protein phosphatase PP1-alpha catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
126511688  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
126498518  serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
126497496  protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
126504961  protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
126493652  protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
126511699  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
126500801  myosin regulatory light chain 2, atrial isoform [KO:K12754]
126507081  myosin regulatory light polypeptide 9 [KO:K12755]
126491927  myosin regulatory light chain 10 [KO:K12756]
126507643  myosin regulatory light chain 12B-like [KO:K12757]
126516047  myosin regulatory light chain 12B isoform X1 [KO:K12757]
126515894  myosin regulatory light chain 11 [KO:K12758]
126513884  myosin-10 [KO:K10352]
126488090  myosin-14 isoform X1 [KO:K10352]
126515704  myosin-9 [KO:K10352]
126490706  myosin-11 [KO:K10352]
126491939  protein diaphanous homolog 1 [KO:K05740]
126491290  protein diaphanous homolog 2 isoform X1 [KO:K05741]
126506383  sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
126489290  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
126489992  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
126511428  phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
126507854  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
126514731  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
126510360  phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
126508803  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
126516009  LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
126500782  LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
126511989  protein diaphanous homolog 3 [KO:K05745]
126500331  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
126502055  protein enabled homolog [KO:K05746]
126503931  actin nucleation-promoting factor WASL [KO:K23612]
126506654  actin-binding protein WASF2 [KO:K05748]
126499462  cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
126500487  LOW QUALITY PROTEIN: cytoplasmic FMR1-interacting protein 1 [KO:K05749]
126487055  nck-associated protein 1 [KO:K05750]
126491210  nck-associated protein 1-like isoform X1 [KO:K05750]
126508816  abl interactor 2 isoform X1 [KO:K05751]
126505483  protein BRICK1 [KO:K05752]
126487635  actin-binding protein WASF1 isoform X1 [KO:K05753]
126495976  actin-related protein 2-like [KO:K17260]
126513210  actin-related protein 3 [KO:K18584]
126489447  actin-related protein 3B isoform X1 [KO:K18584]
126496113  actin-related protein 2/3 complex subunit 1B-like [KO:K05757]
126489818  actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757]
126489828  actin-related protein 2/3 complex subunit 1A [KO:K05757]
126503629  actin-related protein 2/3 complex subunit 1B-like [KO:K05757]
126492927  actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
126507986  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
126511635  actin-related protein 2/3 complex subunit 3 [KO:K05756]
126505461  actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
126488562  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
126490149  actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
126497376  actin-related protein 2/3 complex subunit 5 [KO:K05754]
126505916  LOW QUALITY PROTEIN: actin-like [KO:K05692]
126500538  actin, cytoplasmic 2 [KO:K05692]
126514350  actin, cytoplasmic 1 [KO:K05692]
126493121  profilin-2-like [KO:K05759]
126514075  profilin-1 [KO:K05759]
126487474  profilin-2 isoform X1 [KO:K05759]
126502887  profilin-3 [KO:K05759]
126490718  profilin-4 [KO:K05759]
126511626  paxillin isoform X1 [KO:K05760]
126497617  ezrin [KO:K08007]
126510020  radixin isoform X1 [KO:K05762]
126490830  moesin [KO:K05763]
126512679  thymosin beta-4 [KO:K05764]
126498868  cofilin-1 [KO:K05765]
126499601  cofilin-2 [KO:K05765]
126491380  cofilin-1-like [KO:K05765]
126492321  protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
126487987  protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
126498510  protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
126491405  vinculin isoform X1 [KO:K05700]
126508656  ras GTPase-activating-like protein IQGAP1 [KO:K16848]
126508536  ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
126516098  ras GTPase-activating-like protein IQGAP3 [KO:K05767]
126511533  scinderin [KO:K05768]
126491231  gelsolin isoform X1 [KO:K05768]
126486623  alpha-actinin-4 isoform X1 [KO:K05699]
126511478  alpha-actinin-1 isoform X1 [KO:K05699]
126489265  adenomatous polyposis coli protein 2 [KO:K02085]
126497105  adenomatous polyposis coli protein isoform X1 [KO:K02085]
126507619  spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
126496931  LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 4 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
mfot04010  MAPK signaling pathway
mfot04510  Focal adhesion
mfot04520  Adherens junction
KO pathway
ko04810   
LinkDB

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