KEGG   PATHWAY: mmu00280
Entry
mmu00280                    Pathway                                
Name
Valine, leucine and isoleucine degradation - Mus musculus (house mouse)
Class
Metabolism; Amino acid metabolism
Pathway map
mmu00280  Valine, leucine and isoleucine degradation
mmu00280

Module
mmu_M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:mmu00280]
mmu_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:mmu00280]
Other DBs
GO: 0006550 0006552 0006574
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
100328588  Il4i1b; interleukin 4 induced 1B [KO:K03334] [EC:1.4.3.2]
100470  Lao1; L-amino acid oxidase 1 [KO:K03334] [EC:1.4.3.2]
104776  Aldh6a1; aldehyde dehydrogenase family 6, subfamily A1 [KO:K00140] [EC:1.2.1.18 1.2.1.27]
110446  Acat1; acetyl-Coenzyme A acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]
110460  Acat2; acetyl-Coenzyme A acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
110695  Aldh7a1; aldehyde dehydrogenase family 7, member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
110821  Pcca; propionyl-Coenzyme A carboxylase, alpha polypeptide [KO:K01965] [EC:6.4.1.3]
11364  Acadm; acyl-Coenzyme A dehydrogenase, medium chain [KO:K00249] [EC:1.3.8.7]
113868  Acaa1a; acetyl-Coenzyme A acyltransferase 1A [KO:K07513] [EC:2.3.1.16]
11409  Acads; acyl-Coenzyme A dehydrogenase, short chain [KO:K00248] [EC:1.3.8.1]
11669  Aldh2; aldehyde dehydrogenase 2, mitochondrial [KO:K00128] [EC:1.2.1.3]
11671  Aldh3a2; aldehyde dehydrogenase family 3, subfamily A2 [KO:K00128] [EC:1.2.1.3]
11761  Aox1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
11992  Auh; AU RNA binding protein/enoyl-coenzyme A hydratase [KO:K05607] [EC:4.2.1.18]
12035  Bcat1; branched chain aminotransferase 1, cytosolic [KO:K00826] [EC:2.6.1.42]
12036  Bcat2; branched chain aminotransferase 2, mitochondrial [KO:K00826] [EC:2.6.1.42]
12039  Bckdha; branched chain ketoacid dehydrogenase E1, alpha polypeptide [KO:K00166] [EC:1.2.4.4]
12040  Bckdhb; branched chain ketoacid dehydrogenase E1, beta polypeptide [KO:K00167] [EC:1.2.4.4]
13171  Dbt; dihydrolipoamide branched chain transacylase E2 [KO:K09699] [EC:2.3.1.168]
13382  Dld; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
14204  Il4i1; interleukin 4 induced 1 [KO:K03334] [EC:1.4.3.2]
15107  Hadh; hydroxyacyl-Coenzyme A dehydrogenase [KO:K00022] [EC:1.1.1.35]
15108  Hsd17b10; hydroxysteroid (17-beta) dehydrogenase 10 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
15356  Hmgcl; 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [KO:K01640] [EC:4.1.3.4]
15360  Hmgcs2; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 [KO:K01641] [EC:2.3.3.10]
17850  Mmut; methylmalonyl-Coenzyme A mutase [KO:K01847] [EC:5.4.99.2]
208715  Hmgcs1; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 [KO:K01641] [EC:2.3.3.10]
208982  Hmgcll1; 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 [KO:K01640] [EC:4.1.3.4]
213043  Aox2; aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
224530  Acat3; acetyl-Coenzyme A acetyltransferase 3 [KO:K00626] [EC:2.3.1.9]
227095  Hibch; 3-hydroxyisobutyryl-Coenzyme A hydrolase [KO:K05605] [EC:3.1.2.4]
231086  Hadhb; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta [KO:K07509] [EC:2.3.1.16]
235674  Acaa1b; acetyl-Coenzyme A acyltransferase 1B [KO:K07513] [EC:2.3.1.16]
257633  Acsf3; acyl-CoA synthetase family member 3 [KO:K18660] [EC:6.2.1.76 6.2.1.-]
268782  Agxt2; alanine-glyoxylate aminotransferase 2 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
268860  Abat; 4-aminobutyrate aminotransferase [KO:K13524] [EC:2.6.1.19 2.6.1.22]
353371  Oxct2b; 3-oxoacid CoA transferase 2B [KO:K01027] [EC:2.8.3.5]
52538  Acaa2; acetyl-CoA acyltransferase 2 [KO:K07508] [EC:2.3.1.16]
56357  Ivd; isovaleryl coenzyme A dehydrogenase [KO:K00253] [EC:1.3.8.4]
56752  Aldh9a1; aldehyde dehydrogenase 9, subfamily A1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
58875  Hibadh; 3-hydroxyisobutyrate dehydrogenase [KO:K00020] [EC:1.1.1.31]
64059  Oxct2a; 3-oxoacid CoA transferase 2A [KO:K01027] [EC:2.8.3.5]
66885  Acadsb; acyl-Coenzyme A dehydrogenase, short/branched chain [KO:K09478] [EC:1.3.8.5]
66904  Pccb; propionyl Coenzyme A carboxylase, beta polypeptide [KO:K01966] [EC:6.4.1.3 2.1.3.15]
66948  Acad8; acyl-Coenzyme A dehydrogenase family, member 8 [KO:K11538] [EC:1.3.99.-]
67041  Oxct1; 3-oxoacid CoA transferase 1 [KO:K01027] [EC:2.8.3.5]
71724  Aox3; aldehyde oxidase 3 [KO:K00157] [EC:1.2.3.1]
71872  Aox4; aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
72039  Mccc1; methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) [KO:K01968] [EC:6.4.1.4]
72535  Aldh1b1; aldehyde dehydrogenase 1 family, member B1 [KO:K00128] [EC:1.2.1.3]
73724  Mcee; methylmalonyl CoA epimerase [KO:K05606] [EC:5.1.99.1]
73988  4930438A08Rik; RIKEN cDNA 4930438A08 gene [KO:K03334] [EC:1.4.3.2]
74147  Ehhadh; enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
78038  Mccc2; methylcrotonoyl-Coenzyme A carboxylase 2 (beta) [KO:K01969] [EC:6.4.1.4]
78894  Aacs; acetoacetyl-CoA synthetase [KO:K01907] [EC:6.2.1.16]
93747  Echs1; enoyl Coenzyme A hydratase, short chain, 1, mitochondrial [KO:K07511] [EC:4.2.1.17]
97212  Hadha; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha [KO:K07515] [EC:4.2.1.17 1.1.1.211]
Compound
C00024  Acetyl-CoA
C00068  Thiamin diphosphate
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00164  Acetoacetate
C00183  L-Valine
C00233  4-Methyl-2-oxopentanoate
C00332  Acetoacetyl-CoA
C00349  2-Methyl-3-oxopropanoate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00407  L-Isoleucine
C00630  2-Methylpropanoyl-CoA
C00671  (S)-3-Methyl-2-oxopentanoic acid
C00683  (S)-Methylmalonyl-CoA
C01205  (R)-3-Amino-2-methylpropanoate
C01213  (R)-Methylmalonyl-CoA
C02170  Methylmalonate
C02939  3-Methylbutanoyl-CoA
C03069  3-Methylcrotonyl-CoA
C03231  3-Methylglutaconyl-CoA
C03284  L-3-Aminoisobutanoate
C03344  2-Methylacetoacetyl-CoA
C03345  2-Methylbut-2-enoyl-CoA
C03460  2-Methylprop-2-enoyl-CoA
C04405  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
C05996  Branched chain fatty acid
C05998  3-Hydroxyisovaleryl-CoA
C06000  (S)-3-Hydroxyisobutyryl-CoA
C06001  (S)-3-Hydroxyisobutyrate
C06002  (S)-Methylmalonate semialdehyde
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C15974  3-Methyl-1-hydroxybutyl-ThPP
C15975  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
C15976  2-Methyl-1-hydroxypropyl-ThPP
C15977  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
C15978  2-Methyl-1-hydroxybutyl-ThPP
C15979  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
C15980  (S)-2-Methylbutanoyl-CoA
C20827  3-Hydroxyisovalerate
Related
pathway
mmu00020  Citrate cycle (TCA cycle)
mmu00240  Pyrimidine metabolism
mmu00290  Valine, leucine and isoleucine biosynthesis
mmu00640  Propanoate metabolism
mmu00900  Terpenoid backbone biosynthesis
KO pathway
ko00280   

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