KEGG   PATHWAY: msam04150
Entry
msam04150                   Pathway                                
Name
mTOR signaling pathway - Micropterus salmoides (largemouth bass)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
msam04150  mTOR signaling pathway
msam04150

Organism
Micropterus salmoides (largemouth bass) [GN:msam]
Gene
119882013  [KO:K04365] [EC:2.7.11.1]
119882161  [KO:K20403]
119882281  cab39; calcium-binding protein 39 [KO:K08272]
119882305  [KO:K06519]
119882431  [KO:K02353]
119882554  rps6kb1b; LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
119882692  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119882888  lamtor1; ragulator complex protein LAMTOR1 [KO:K20397]
119882983  fzd9b; frizzled-9b [KO:K02842]
119883041  fzd4; frizzled-4 [KO:K02354]
119883088  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
119883488  [KO:K06519]
119883533  ulk2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
119883760  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
119884053  [KO:K00572]
119884419  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
119884830  [KO:K04373] [EC:2.7.11.1]
119885002  [KO:K01357]
119885528  eif4ba; eukaryotic translation initiation factor 4Ba isoform X1 [KO:K03258]
119885543  [KO:K04513]
119885616  [KO:K00182]
119885635  si:dkeyp-97e7.9; DEP domain-containing mTOR-interacting protein [KO:K20402]
119885905  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
119886229  [KO:K04513]
119886249  nprl2; GATOR complex protein NPRL2 [KO:K20405]
119886274  sec13; LOW QUALITY PROTEIN: protein SEC13 homolog [KO:K14004]
119886325  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119886334  rhebl1; ras homolog, mTORC1 binding like 1 [KO:K07208]
119886647  [KO:K07827]
119886660  wnt7aa; wingless-type MMTV integration site family, member 7Aa isoform X1 [KO:K00572]
119886843  wnt4; protein Wnt-4a [KO:K00408]
119886944  [KO:K15728] [EC:3.1.3.4]
119888264  eif4ea; eukaryotic translation initiation factor 4E-1A isoform X1 [KO:K03259]
119888396  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
119888465  cab39l1; calcium binding protein 39, like 1 [KO:K08272]
119888918  insb; preproinsulin b [KO:K04526]
119889086  [KO:K00714]
119889167  [KO:K00714]
119889216  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
119889848  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
119890047  wdr59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
119890344  lpin1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
119890736  [KO:K02329]
119890805  [KO:K04373] [EC:2.7.11.1]
119891129  [KO:K08267]
119891193  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
119891295  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119891368  clip1a; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
119891527  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
119891545  nprl3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
119891547  [KO:K02649]
119891899  [KO:K07205]
119891984  castor1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
119892018  ulk1a; serine/threonine-protein kinase ULK1a isoform X1 [KO:K21357] [EC:2.7.11.1]
119892046  wnt9b; protein Wnt-9b [KO:K01064]
119892134  fzd10; frizzled-10 [KO:K02842]
119892222  fzd2; frizzled-2 [KO:K02235]
119892836  [KO:K01558]
119893029  atp6v1e1a; V-type proton ATPase subunit E 1a [KO:K02150]
119893206  lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
119893343  kras; GTPase KRas [KO:K07827]
119893549  strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
119893575  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
119893612  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
119893922  slc7a5; large neutral amino acids transporter small subunit 1 [KO:K13780]
119893953  wnt2; protein Wnt-2 [KO:K00182]
119894016  akt1s1; uncharacterized protein akt1s1 [KO:K16184]
119894125  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
119894129  prr5l; proline-rich protein 5-like isoform X1 [KO:K20411]
119894390  wnt7bb; protein Wnt-7b isoform X1 [KO:K00572]
119894873  fnip1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
119894913  lrp6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
119894945  ins; insulin [KO:K04526]
119895081  [KO:K04456] [EC:2.7.11.1]
119895400  rps6kb1a; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
119895529  atp6v1f; V-type proton ATPase subunit F [KO:K02151]
119895531  lamtor4; ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
119895612  wnt11; protein Wnt-11 [KO:K01384]
119895691  rraga; ras-related GTP-binding protein A [KO:K16185]
119895749  [KO:K02145] [EC:7.1.2.2]
119895873  castor2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
119896161  si:ch211-284e13.4; insulin receptor substrate 1-B [KO:K16172]
119896812  [KO:K04456] [EC:2.7.11.1]
119897057  mios; GATOR complex protein MIOS [KO:K20407]
119897131  lamtor2; ragulator complex protein LAMTOR2 [KO:K20398]
119897144  [KO:K03156]
119897265  rragca; ras-related GTP binding Ca [KO:K16186]
119897426  wnt4b; wingless-type MMTV integration site family, member 4b [KO:K00408]
119897443  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
119897496  prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
119897510  flcn; folliculin isoform X1 [KO:K09594]
119897652  sgk2b; serine/threonine-protein kinase Sgk2b isoform X1 [KO:K13302] [EC:2.7.11.1]
119897843  deptor; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
119897904  grb10b; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
119898039  fzd6; LOW QUALITY PROTEIN: frizzled-6 [KO:K02376]
119898061  [KO:K02148]
119898094  seh1l; nucleoporin SEH1 [KO:K14299]
119898122  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119898129  fzd1; frizzled-1 [KO:K02432]
119898451  [KO:K16186]
119898769  [KO:K19662] [EC:2.7.11.13]
119898991  rps6; 40S ribosomal protein S6 [KO:K02991]
119899340  [KO:K02677] [EC:2.7.11.13]
119899493  tsc2; tuberin isoform X1 [KO:K07207]
119899739  rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
119899805  [KO:K04688] [EC:2.7.11.1]
119899870  [KO:K03099]
119900224  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
119900270  tbc1d7; TBC1 domain family member 7 [KO:K20396]
119900335  [KO:K00922] [EC:2.7.1.153]
119900503  [KO:K02649]
119900689  [KO:K04527] [EC:2.7.10.1]
119900881  map2k2a; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
119901030  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
119901707  [KO:K02375]
119901826  rheb; GTP-binding protein Rheb [KO:K07208]
119901850  stradb; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
119901871  insra; insulin receptor a isoform X1 [KO:K04527] [EC:2.7.10.1]
119901909  lpin2; LOW QUALITY PROTEIN: phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
119901915  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
119901980  wnt9a; LOW QUALITY PROTEIN: protein Wnt-9a [KO:K01064]
119901989  wnt3a; protein Wnt-3a [KO:K00312]
119902209  [KO:K02353]
119902234  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
119902325  [KO:K00922] [EC:2.7.1.153]
119902368  [KO:K02649]
119902602  depdc5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
119902876  eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
119902904  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
119902918  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
119903335  [KO:K01558]
119903884  wnt6b; protein Wnt-6 [KO:K00445]
119904205  wnt10a; protein Wnt-10a [KO:K01357]
119904210  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
119904407  fzd5; frizzled-5 [KO:K02375]
119904785  [KO:K02432]
119904907  [KO:K02432]
119904984  [KO:K04513]
119905231  dvl1a; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
119905315  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
119905430  [KO:K04513]
119905583  lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
119905617  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
119905729  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
119905919  [KO:K07203] [EC:2.7.11.1]
119905945  tti1; TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
119905971  [KO:K05459]
119906073  wnt5a; protein Wnt-5a [KO:K00444]
119906119  [KO:K13780]
119906144  [KO:K00182]
119906204  wnt10b; protein Wnt-10b isoform X1 [KO:K01357]
119906206  wnt1; protein Wnt-1 [KO:K03209]
119906237  [KO:K00572]
119906688  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
119906746  fzd8a; frizzled-8a [KO:K02375]
119906981  [KO:K20064]
119907433  atp6v1c1b; V-type proton ATPase subunit C 1-B [KO:K02148]
119907846  [KO:K16186]
119908117  sesn2; sestrin-2 isoform X1 [KO:K20394]
119908795  sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
119908976  [KO:K15728] [EC:3.1.3.4]
119909193  fzd3a; frizzled-3a [KO:K02329]
119909532  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
119909745  si:ch211-195b13.1; STKc_SGK domain-containing protein isoform X1 [KO:K13302] [EC:2.7.11.1]
119909777  [KO:K06519]
119909849  atp6v1c2; V-type proton ATPase subunit C 1-B [KO:K02148]
119909978  atp6v1ab; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
119910200  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
119910225  sos2; son of sevenless homolog 2 [KO:K03099]
119910514  [KO:K04373] [EC:2.7.11.1]
119910551  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119910559  rragd; ras-related GTP-binding protein D [KO:K16186]
119910882  eif4eb; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4eb [KO:K03259]
119911264  [KO:K15728] [EC:3.1.3.4]
119911745  si:ch73-335l21.1; insulin receptor substrate 1-B [KO:K16172]
119912192  slc3a2a; solute carrier family 3 member 2a isoform X1 [KO:K06519]
119912367  dvl2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
119912374  eif4e2rs1; eukaryotic translation initiation factor 4E family member 2 related sequence 1 [KO:K03259]
119912407  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119912850  [KO:K15705] [EC:2.3.2.27]
119913991  atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
119914041  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119914082  atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
119914190  slc38a9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
119914204  tsc1b; TSC complex subunit 1b [KO:K07206]
119914257  mapkap1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
119914326  clip1b; LOW QUALITY PROTEIN: CAP-Gly domain-containing linker protein 1 [KO:K10421]
119914369  ulk1b; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
119914397  skp2; S-phase kinase-associated protein 2 [KO:K03875]
119914607  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
119914828  [KO:K07205]
119915279  prr5a; proline-rich protein 5a [KO:K20411]
119915330  [KO:K08272]
119915458  [KO:K04467] [EC:2.7.11.10]
119915538  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
119915629  mlst8; target of rapamycin complex subunit lst8 [KO:K08266]
119915705  [KO:K08272]
119915826  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
119916169  telo2; telomere length regulation protein TEL2 homolog [KO:K11137]
119916342  wdr24; GATOR complex protein WDR24 [KO:K20408]
119916605  wnt3; proto-oncogene Wnt-3 [KO:K00312]
119916780  [KO:K15705] [EC:2.3.2.27]
119916859  [KO:K02147]
119916983  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119917048  wnt8b; protein Wnt-8b [KO:K00714]
119917190  ptena; phosphatase and tensin homolog A [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
119917364  [KO:K04467] [EC:2.7.11.10]
119917366  eif4e1c; eukaryotic translation initiation factor 4E family member 1c isoform X1 [KO:K03259]
119917907  igf1; insulin-like growth factor I [KO:K05459]
119917912  wnt7ba; protein Wnt-7b isoform X1 [KO:K00572]
119917946  [KO:K20411]
119917992  braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
119918308  wnt5b; protein Wnt-5b isoform X1 [KO:K00444]
119918378  atp6v1e1b; V-type proton ATPase subunit E 1 [KO:K02150]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
msam00561  Glycerolipid metabolism
msam04010  MAPK signaling pathway
msam04140  Autophagy - animal
msam04810  Regulation of actin cytoskeleton
msam04910  Insulin signaling pathway
KO pathway
ko04150   

DBGET integrated database retrieval system