KEGG   PATHWAY: nle04150
Entry
nle04150                    Pathway                                
Name
mTOR signaling pathway - Nomascus leucogenys (northern white-cheeked gibbon)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
nle04150  mTOR signaling pathway
nle04150

Organism
Nomascus leucogenys (northern white-cheeked gibbon) [GN:nle]
Gene
100579446  RRAGB; ras-related GTP-binding protein B isoform X2 [KO:K16185]
100579506  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100579580  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
100580071  FZD2; frizzled-2 [KO:K02235]
100580823  [KO:K20396]
100580872  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100581072  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
100581139  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
100581346  EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X1 [KO:K03259]
100581626  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
100581749  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X4 [KO:K03158]
100582042  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
100582599  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100582848  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100583005  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
100583216  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
100583968  TNF; tumor necrosis factor [KO:K03156]
100584177  MIOS; GATOR complex protein MIOS isoform X1 [KO:K20407]
100584244  LPIN2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
100584384  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100584480  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100585595  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
100585864  SLC3A2; 4F2 cell-surface antigen heavy chain isoform X2 [KO:K06519]
100585975  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
100586052  WNT8A; protein Wnt-8a isoform X2 [KO:K00714]
100586194  SGK1; serine/threonine-protein kinase Sgk1 isoform X3 [KO:K13302] [EC:2.7.11.1]
100586389  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
100586655  SKP2; S-phase kinase-associated protein 2 isoform X2 [KO:K03875]
100586809  INS; insulin isoform X2 [KO:K04526]
100586976  LPIN1; phosphatidate phosphatase LPIN1 isoform X6 [KO:K15728] [EC:3.1.3.4]
100586986  CAB39; calcium-binding protein 39 [KO:K08272]
100587109  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100587112  TSC1; hamartin isoform X2 [KO:K07206]
100587148  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
100587259  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
100587307  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100587640  WNT10B; protein Wnt-10b [KO:K01357]
100587864  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100587992  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
100588081  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100588218  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100588224  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
100588298  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
100588311  FZD4; frizzled-4 [KO:K02354]
100588313  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
100588468  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100589091  FZD5; frizzled-5 [KO:K02375]
100589839  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
100589994  FZD3; frizzled-3 [KO:K02329]
100590165  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100590499  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
100590939  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100591065  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
100591113  WDR24; GATOR complex protein WDR24 isoform X1 [KO:K20408]
100591263  DEPDC5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
100591270  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100591651  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100591782  EIF4B; eukaryotic translation initiation factor 4B isoform X2 [KO:K03258]
100591827  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100592103  NRAS; GTPase NRas [KO:K07828]
100592171  RRAGD; ras-related GTP-binding protein D [KO:K16186]
100592235  SESN2; sestrin-2 isoform X1 [KO:K20394]
100592282  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
100592375  FZD9; frizzled-9 [KO:K02842]
100592578  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
100592812  LAMTOR1; ragulator complex protein LAMTOR1 isoform X1 [KO:K20397]
100593010  [KO:K06276] [EC:2.7.11.1]
100593186  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
100593280  FNIP2; folliculin-interacting protein 2 isoform X4 [KO:K20401]
100593288  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
100593410  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
100593463  CAB39L; calcium-binding protein 39-like isoform X1 [KO:K08272]
100593717  FZD8; frizzled-8 [KO:K02375]
100593773  KRAS; GTPase KRas isoform X1 [KO:K07827]
100593862  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
100593900  WNT7A; protein Wnt-7a [KO:K00572]
100593960  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
100593970  NPRL2; GATOR complex protein NPRL2 isoform X1 [KO:K20405]
100594291  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
100594380  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X2 [KO:K04373] [EC:2.7.11.1]
100594864  WNT11; protein Wnt-11 [KO:K01384]
100594976  STRADB; STE20-related kinase adapter protein beta [KO:K17532]
100594981  PRR5L; proline-rich protein 5-like [KO:K20411]
100595027  ATP6V1F; V-type proton ATPase subunit F isoform X1 [KO:K02151]
100595096  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
100595140  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
100595170  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
100595274  HRAS; GTPase HRas isoform X1 [KO:K02833]
100595306  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
100596071  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
100596197  TELO2; telomere length regulation protein TEL2 homolog [KO:K11137]
100596225  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100596415  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
100596686  WNT5B; protein Wnt-5b [KO:K00444]
100597388  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
100597533  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100597685  FZD7; frizzled-7 [KO:K02432]
100598015  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
100598314  FLCN; folliculin [KO:K09594]
100598486  RHEB; GTP-binding protein Rheb [KO:K07208]
100599227  PRR5; proline-rich protein 5 [KO:K20411]
100599301  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100599381  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100599409  GRB10; growth factor receptor-bound protein 10 isoform X2 [KO:K20064]
100600353  WNT2; protein Wnt-2 [KO:K00182]
100600495  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
100600574  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100600765  [KO:K02991]
100601105  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
100601179  NPRL3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
100601464  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100601574  RPS6; 40S ribosomal protein S6 [KO:K02991]
100601949  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
100602014  WNT5A; protein Wnt-5a [KO:K00444]
100602251  LAMTOR2; ragulator complex protein LAMTOR2 isoform X1 [KO:K20398]
100602326  RRAGC; ras-related GTP-binding protein C [KO:K16186]
100602458  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
100602473  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
100602760  WNT9B; protein Wnt-9b isoform X1 [KO:K01064]
100602961  SEC13; protein SEC13 homolog isoform X3 [KO:K14004]
100603238  WNT8B; protein Wnt-8b [KO:K00714]
100603499  WDR59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
100603705  FZD6; frizzled-6 [KO:K02376]
100603833  SEH1L; nucleoporin SEH1 isoform X2 [KO:K14299]
100604169  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X2 [KO:K23080]
100604331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100604353  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
100604902  [KO:K07207]
100604956  RRAGA; ras-related GTP-binding protein A [KO:K16185]
100605147  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100605208  ATP6V1G3; V-type proton ATPase subunit G 3 isoform X2 [KO:K02152]
100605265  RICTOR; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
100605294  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
100605346  FZD1; frizzled-1 [KO:K02432]
100605788  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100605899  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
100605911  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
100605966  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
100606014  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X2 [KO:K04373] [EC:2.7.11.1]
100606015  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
100606336  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
100606492  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
100606502  WNT9A; protein Wnt-9a [KO:K01064]
100606602  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
100606818  WNT6; protein Wnt-6 [KO:K00445]
100606846  WNT3A; protein Wnt-3a isoform X2 [KO:K00312]
100606885  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100607164  WNT10A; protein Wnt-10a [KO:K01357]
100607291  RHOA; transforming protein RhoA [KO:K04513]
100607588  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
100607602  SLC38A9; sodium-coupled neutral amino acid transporter 9 [KO:K14995]
100607762  FZD10; frizzled-10 [KO:K02842]
100607873  IRS1; insulin receptor substrate 1 [KO:K16172]
100607954  WNT2B; protein Wnt-2b isoform X2 [KO:K00182]
105740136  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
115830880  LAMTOR4; ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
115831277  [KO:K06276] [EC:2.7.11.1]
115831278  [KO:K07207]
115838242  [KO:K08269] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
nle00561  Glycerolipid metabolism
nle04010  MAPK signaling pathway
nle04140  Autophagy - animal
nle04151  PI3K-Akt signaling pathway
nle04152  AMPK signaling pathway
nle04810  Regulation of actin cytoskeleton
nle04910  Insulin signaling pathway
KO pathway
ko04150   

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