KEGG   PATHWAY: one00600
Entry
one00600                    Pathway                                
Name
Sphingolipid metabolism - Oncorhynchus nerka (sockeye salmon)
Class
Metabolism; Lipid metabolism
Pathway map
one00600  Sphingolipid metabolism
one00600

Module
one_M00066  Lactosylceramide biosynthesis [PATH:one00600]
one_M00094  Ceramide biosynthesis [PATH:one00600]
one_M00099  Sphingosine biosynthesis [PATH:one00600]
one_M00100  Sphingosine degradation [PATH:one00600]
Other DBs
GO: 0006665
Organism
Oncorhynchus nerka (sockeye salmon) [GN:one]
Gene
115101098  [KO:K12373] [EC:3.2.1.52]
115101123  [KO:K12353] [EC:3.1.4.12]
115101265  [KO:K12382]
115101378  [KO:K12357] [EC:3.2.1.18]
115102006  [KO:K09905] [EC:2.4.1.274 2.4.1.-]
115102035  [KO:K23727]
115102676  [KO:K04715] [EC:2.7.1.138]
115102917  [KO:K01080] [EC:3.1.3.4]
115103805  [KO:K04718] [EC:2.7.1.91]
115104292  [KO:K04718] [EC:2.7.1.91]
115104354  [KO:K01080] [EC:3.1.3.4]
115104678  [KO:K04711] [EC:3.5.1.-]
115104732  [KO:K01019] [EC:2.8.2.11]
115105970  plpp1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
115106352  [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
115106863  [KO:K04715] [EC:2.7.1.138]
115107156  [KO:K22697] [EC:2.7.8.48 3.1.4.62]
115107386  [KO:K24621]
115107406  acer1; alkaline ceramidase 1 [KO:K01441] [EC:3.5.1.23]
115107859  [KO:K04716] [EC:3.1.3.-]
115107894  [KO:K00654] [EC:2.3.1.50]
115108216  cers1; ceramide synthase 1 isoform X1 [KO:K04710] [EC:2.3.1.299]
115108335  [KO:K01080] [EC:3.1.3.4]
115108597  [KO:K07553] [EC:2.4.1.274]
115108751  [KO:K23727]
115109189  [KO:K04710] [EC:2.3.1.299]
115109304  [KO:K12352] [EC:3.1.4.12]
115110614  [KO:K01019] [EC:2.8.2.11]
115110615  [KO:K01019] [EC:2.8.2.11]
115110645  [KO:K04718] [EC:2.7.1.91]
115110707  [KO:K12354] [EC:3.1.4.12]
115110985  [KO:K01019] [EC:2.8.2.11]
115111024  [KO:K12353] [EC:3.1.4.12]
115111642  [KO:K12382]
115111849  [KO:K01080] [EC:3.1.3.4]
115112957  [KO:K22697] [EC:2.7.8.48 3.1.4.62]
115113246  [KO:K04712] [EC:1.14.19.17 1.14.18.5]
115113388  [KO:K01634] [EC:4.1.2.27]
115113842  [KO:K12354] [EC:3.1.4.12]
115114235  [KO:K24621]
115114498  kdsr; 3-ketodihydrosphingosine reductase isoform X1 [KO:K04708] [EC:1.1.1.102]
115114605  [KO:K01080] [EC:3.1.3.4]
115115054  [KO:K12383]
115116417  [KO:K01080] [EC:3.1.3.4]
115117514  [KO:K12357] [EC:3.2.1.18]
115117575  [KO:K04718] [EC:2.7.1.91]
115117695  [KO:K12354] [EC:3.1.4.12]
115117835  sptlc1; serine palmitoyltransferase 1 [KO:K00654] [EC:2.3.1.50]
115120290  [KO:K01080] [EC:3.1.3.4]
115120426  [KO:K12373] [EC:3.2.1.52]
115120930  [KO:K00720] [EC:2.4.1.80]
115121032  [KO:K01080] [EC:3.1.3.4]
115121086  [KO:K04718] [EC:2.7.1.91]
115122038  [KO:K12353] [EC:3.1.4.12]
115122789  gba; lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
115122869  [KO:K00654] [EC:2.3.1.50]
115123331  [KO:K12383]
115124173  [KO:K23727]
115124271  [KO:K12382]
115125281  [KO:K00720] [EC:2.4.1.80]
115125322  [KO:K24622]
115125335  [KO:K01080] [EC:3.1.3.4]
115125518  smpd1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
115125666  [KO:K00725] [EC:2.4.1.92]
115126316  [KO:K12382]
115126800  [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
115127098  [KO:K01080] [EC:3.1.3.4]
115127374  [KO:K12382]
115127551  [KO:K12352] [EC:3.1.4.12]
115127782  [KO:K01080] [EC:3.1.3.4]
115128218  [KO:K24621]
115128279  [KO:K01186] [EC:3.2.1.18]
115129802  [KO:K01080] [EC:3.1.3.4]
115130087  [KO:K12373] [EC:3.2.1.52]
115130869  gla; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
115131731  [KO:K01186] [EC:3.2.1.18]
115131766  [KO:K24621]
115131870  cers5; ceramide synthase 5 [KO:K23727]
115132514  [KO:K04715] [EC:2.7.1.138]
115133558  [KO:K01441] [EC:3.5.1.23]
115134184  arsa; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
115134367  [KO:K12352] [EC:3.1.4.12]
115134476  [KO:K04715] [EC:2.7.1.138]
115135102  [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
115135148  [KO:K04712] [EC:1.14.19.17 1.14.18.5]
115135306  [KO:K01634] [EC:4.1.2.27]
115135581  [KO:K12357] [EC:3.2.1.18]
115135796  smpd2; sphingomyelin phosphodiesterase 2 [KO:K12351] [EC:3.1.4.12]
115135875  [KO:K04711] [EC:3.5.1.-]
115136129  [KO:K04712] [EC:1.14.19.17 1.14.18.5]
115137213  [KO:K01441] [EC:3.5.1.23]
115137314  glb1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
115137319  [KO:K12348] [EC:3.5.1.23]
115137960  gba2; non-lysosomal glucosylceramidase [KO:K17108] [EC:3.2.1.45]
115139823  [KO:K00725] [EC:2.4.1.92]
115140300  [KO:K01080] [EC:3.1.3.4]
115140542  [KO:K01019] [EC:2.8.2.11]
115141962  sgpp2; sphingosine-1-phosphate phosphatase 2 [KO:K04717] [EC:3.1.3.-]
115142593  [KO:K04718] [EC:2.7.1.91]
115143172  [KO:K00725] [EC:2.4.1.92]
115144056  [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
115144057  asah2; neutral ceramidase [KO:K12349] [EC:3.5.1.23]
115144462  [KO:K22697] [EC:2.7.8.48 3.1.4.62]
115144772  [KO:K04715] [EC:2.7.1.138]
115145403  [KO:K07553] [EC:2.4.1.274]
115145419  cers6; ceramide synthase 6 [KO:K23727]
115145460  [KO:K01080] [EC:3.1.3.4]
115145863  [KO:K12348] [EC:3.5.1.23]
115145879  sptlc2; serine palmitoyltransferase 2 isoform X1 [KO:K00654] [EC:2.3.1.50]
115145972  [KO:K01202] [EC:3.2.1.46]
115146155  sgpp1; sphingosine-1-phosphate phosphatase 1 [KO:K04716] [EC:3.1.3.-]
115146459  degs2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
115146705  [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
C23072  Oxidized ceramide
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
one00260  Glycine, serine and threonine metabolism
one00601  Glycosphingolipid biosynthesis - lacto and neolacto series
one00603  Glycosphingolipid biosynthesis - globo and isoglobo series
one00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   

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