KEGG   PATHWAY: achc00230
Entry
achc00230                   Pathway                                
Name
Purine metabolism - Aquila chrysaetos chrysaetos (golden eagle)
Class
Metabolism; Nucleotide metabolism
Pathway map
achc00230  Purine metabolism
achc00230

Module
achc_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:achc00230]
achc_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:achc00230]
achc_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:achc00230]
achc_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:achc00230]
achc_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:achc00230]
achc_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:achc00230]
Other DBs
GO: 0006163 0042278
Organism
Aquila chrysaetos chrysaetos (golden eagle) [GN:achc]
Gene
115338566  ADP-ribose pyrophosphatase, mitochondrial-like isoform X1 [KO:K13988] [EC:3.6.1.13]
115346457  NUDT9; ADP-ribose pyrophosphatase, mitochondrial [KO:K13988] [EC:3.6.1.13]
115342335  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
115342293  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
115349391  PGM1; LOW QUALITY PROTEIN: phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
115344520  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
115333530  PRPS1; ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
115334564  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
115348443  PPAT; amidophosphoribosyltransferase isoform X1 [KO:K00764] [EC:2.4.2.14]
115343826  trifunctional purine biosynthetic protein adenosine-3-like [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
115343827  trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
115348362  trihelix transcription factor GT-2 isoform X2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
121232396  multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
115352490  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
115342834  ATIC; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
115345371  APRT; adenine phosphoribosyltransferase isoform X2 [KO:K00759] [EC:2.4.2.7]
115335942  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
115349851  cytosolic purine 5'-nucleotidase-like isoform X1 [KO:K01081] [EC:3.1.3.5]
115351084  cytosolic 5'-nucleotidase 1B-like [KO:K01081] [EC:3.1.3.5]
115351504  NT5C1A; cytosolic 5'-nucleotidase 1A isoform X2 [KO:K01081] [EC:3.1.3.5]
115351637  cytosolic 5'-nucleotidase 1A-like isoform X1 [KO:K01081] [EC:3.1.3.5]
115341008  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
115347924  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
115353468  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
115346418  purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
115350753  LACC1; purine nucleoside phosphorylase LACC1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
115333639  HPRT1; hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
115346134  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
115353695  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
115343618  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
115341320  nucleoside diphosphate kinase-like isoform X1 [KO:K00940] [EC:2.7.4.6]
115341321  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
115341543  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
115335732  nucleoside diphosphate kinase, mitochondrial isoform X2 [KO:K00940] [EC:2.7.4.6]
115335733  NME3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
115338651  adenylate kinase 9-like isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
115339765  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
115348075  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X5 [KO:K01510] [EC:3.6.1.5]
115335102  ectonucleoside triphosphate diphosphohydrolase 8-like isoform X2 [KO:K01510] [EC:3.6.1.5]
115335138  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
115335274  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X2 [KO:K01510] [EC:3.6.1.5]
115341001  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
115350137  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
115350434  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
115352770  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
115338235  U8 snoRNA-decapping enzyme-like [KO:K16855] [EC:3.6.1.62 3.6.1.64]
115349073  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
115350051  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
115336634  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
115347085  GMPS; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
115353137  GMPR; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
115336659  GDA; guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
115339759  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
115353382  RRM1; ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
115351299  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
115340426  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
115351085  HDDC2; 5'-deoxynucleotidase HDDC2 [KO:K07023] [EC:3.1.3.89]
115350440  DGUOK; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
115346113  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
115334442  deoxycytidine kinase 2 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
115342065  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
115345552  PRUNE1; exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
115352949  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
115353041  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
115351414  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
115342497  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
115351035  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
115345521  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
115340454  ADCY8; LOW QUALITY PROTEIN: adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
115336030  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
115353333  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
115342635  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
115347488  guanylate cyclase soluble subunit beta-2-like isoform X1 [KO:K12319] [EC:4.6.1.2]
115342603  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
115336322  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
115353538  GUCY2F; retinal guanylyl cyclase 2 isoform X1 [KO:K12322] [EC:4.6.1.2]
115345295  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
115336875  atrial natriuretic peptide receptor 2-like [KO:K12324] [EC:4.6.1.2]
115351306  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
115338822  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
115342735  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
115353483  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X2 [KO:K18283] [EC:3.1.4.17]
115352728  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
115351550  PDE3B; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
115346008  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
115337141  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
115348487  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1 [KO:K13757] [EC:3.1.4.35]
115346725  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
115341553  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
115336302  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
115343809  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
115344509  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
115342912  PDE11A; LOW QUALITY PROTEIN: dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
115350165  ADSS2; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
115335351  ADSS1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
115351526  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
115335444  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
115335490  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
115348371  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
115339763  ADA; adenosine deaminase isoform X1 [KO:K01488] [EC:3.5.4.4]
115352319  ADA2; adenosine deaminase 2 isoform X1 [KO:K19572] [EC:3.5.4.4]
115351513  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
115334783  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
115335403  AK8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
115348821  AK7; adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
115348876  AK5; LOW QUALITY PROTEIN: adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
115349350  AK4; adenylate kinase 4, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
115336720  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
115336624  AK3; LOW QUALITY PROTEIN: GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
115335417  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 isoform X1 [KO:K01509] [EC:3.6.1.-]
115350515  NTPCR; cancer-related nucleoside-triphosphatase isoform X1 [KO:K06928] [EC:3.6.1.15]
115344745  ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
115344872  venom phosphodiesterase 1 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
115349573  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X3 [KO:K13293] [EC:3.1.4.53]
115336762  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
115338390  LOW QUALITY PROTEIN: cAMP-specific 3',5'-cyclic phosphodiesterase 4A [KO:K13293] [EC:3.1.4.53]
121232871  cAMP-specific 3',5'-cyclic phosphodiesterase 4D-like isoform X1 [KO:K13293] [EC:3.1.4.53]
115348903  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
115344688  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
115340247  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
115336517  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
115341120  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
115353658  FHIT; bis(5'-adenosyl)-triphosphatase isoform X1 [KO:K01522] [EC:3.6.1.29]
115351223  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 isoform X1 [KO:K18424] [EC:3.6.1.29]
115340631  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
115348119  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
115349367  uricase-like [KO:K00365] [EC:1.7.3.3]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
achc00030  Pentose phosphate pathway
achc00220  Arginine biosynthesis
achc00250  Alanine, aspartate and glutamate metabolism
achc00260  Glycine, serine and threonine metabolism
achc00340  Histidine metabolism
achc00630  Glyoxylate and dicarboxylate metabolism
achc00730  Thiamine metabolism
achc00740  Riboflavin metabolism
achc00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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