KEGG   PATHWAY: bbis00380
Entry
bbis00380                   Pathway                                
Name
Tryptophan metabolism - Bison bison bison (American bison)
Class
Metabolism; Amino acid metabolism
Pathway map
bbis00380  Tryptophan metabolism
bbis00380

Module
bbis_M00037  Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin [PATH:bbis00380]
bbis_M00038  Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate [PATH:bbis00380]
bbis_M00912  NAD biosynthesis, tryptophan => quinolinate => NAD [PATH:bbis00380]
Other DBs
GO: 0006568 0009851
Organism
Bison bison bison (American bison) [GN:bbis]
Gene
104997623  TDO2; tryptophan 2,3-dioxygenase [KO:K00453] [EC:1.13.11.11]
104993210  IDO1; indoleamine 2,3-dioxygenase 1 [KO:K00463] [EC:1.13.11.52]
104993211  IDO2; indoleamine 2,3-dioxygenase 2 isoform X1 [KO:K00463] [EC:1.13.11.52]
105000396  AFMID; kynurenine formamidase isoform X1 [KO:K01432] [EC:3.5.1.9]
104986247  KMO; kynurenine 3-monooxygenase [KO:K00486] [EC:1.14.13.9]
104998502  KYNU; kynureninase isoform X1 [KO:K01556] [EC:3.7.1.3]
104990305  HAAO; 3-hydroxyanthranilate 3,4-dioxygenase [KO:K00452] [EC:1.13.11.6]
104998476  ACMSD; 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase isoform X1 [KO:K03392] [EC:4.1.1.45]
104991682  ALDH8A1; aldehyde dehydrogenase family 8 member A1 isoform X1 [KO:K23234] [EC:1.2.1.32]
104998765  DHTKD1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial isoform X1 [KO:K15791] [EC:1.2.4.-]
105000066  DLST; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [KO:K00658] [EC:2.3.1.61]
104989711  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
104999844  GCDH; glutaryl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K00252] [EC:1.3.8.6]
104989051  HADHA; trifunctional enzyme subunit alpha, mitochondrial [KO:K07515] [EC:4.2.1.17 1.1.1.211]
104998607  EHHADH; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
105001339  ECHS1; enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
104994372  hydroxyacyl-coenzyme A dehydrogenase, mitochondrial-like isoform X1 [KO:K00022] [EC:1.1.1.35]
105002091  HADH; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
105005009  ACAT1; acetyl-CoA acetyltransferase, mitochondrial isoform X1 [KO:K00626] [EC:2.3.1.9]
104989285  ACAT2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
104988388  kynurenine--oxoglutarate transaminase 3-like [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
105000893  CCBL1; kynurenine--oxoglutarate transaminase 1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
105003300  CCBL2; kynurenine--oxoglutarate transaminase 3 isoform X1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
104997843  kynurenine/alpha-aminoadipate aminotransferase, mitochondrial-like [KO:K00825] [EC:2.6.1.7 2.6.1.39]
104997844  kynurenine/alpha-aminoadipate aminotransferase, mitochondrial [KO:K00825] [EC:2.6.1.7 2.6.1.39]
104981427  TPH1; tryptophan 5-hydroxylase 1 [KO:K00502] [EC:1.14.16.4]
104989308  TPH2; tryptophan 5-hydroxylase 2 [KO:K00502] [EC:1.14.16.4]
104981803  DDC; aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
104980043  ALDH2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
104993705  ALDH1B1; LOW QUALITY PROTEIN: aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
104990677  ALDH3A2; fatty aldehyde dehydrogenase isoform X1 [KO:K00128] [EC:1.2.1.3]
104993181  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
104997306  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
105003638  AOX1; aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
105003640  aldehyde oxidase 2 isoform X1 [KO:K00157] [EC:1.2.3.1]
105003643  aldehyde oxidase 4-like [KO:K00157] [EC:1.2.3.1]
104996841  ASMT; acetylserotonin O-methyltransferase [KO:K00543] [EC:2.1.1.4]
105000375  serotonin N-acetyltransferase [KO:K00669] [EC:2.3.1.87]
104990991  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
104991054  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
104999966  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
104980483  INMT; indolethylamine N-methyltransferase [KO:K00562] [EC:2.1.1.49 2.1.1.96]
105004981  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
104995675  IL4I1; L-amino-acid oxidase isoform X1 [KO:K03334] [EC:1.4.3.2]
105001109  AOC1; amiloride-sensitive amine oxidase [copper-containing] [KO:K11182] [EC:1.4.3.22]
104982462  CAT; catalase [KO:K03781] [EC:1.11.1.6]
Compound
C00024  Acetyl-CoA
C00078  L-Tryptophan
C00108  Anthranilate
C00322  2-Oxoadipate
C00328  L-Kynurenine
C00331  Indolepyruvate
C00332  Acetoacetyl-CoA
C00398  Tryptamine
C00463  Indole
C00527  Glutaryl-CoA
C00632  3-Hydroxyanthranilate
C00637  Indole-3-acetaldehyde
C00643  5-Hydroxy-L-tryptophan
C00780  Serotonin
C00877  Crotonoyl-CoA
C00954  Indole-3-acetate
C00955  Indole-3-ethanol
C00978  N-Acetylserotonin
C01111  7,8-Dihydroxykynurenate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01249  7,8-Dihydro-7,8-dihydroxykynurenate
C01252  4-(2-Aminophenyl)-2,4-dioxobutanoate
C01598  Melatonin
C01717  4-Hydroxy-2-quinolinecarboxylic acid
C01987  2-Aminophenol
C02161  2-Aminophenoxazin-3-one
C02172  N-Acetylisatin
C02220  2-Aminomuconate
C02298  N-Acetylindoxyl
C02470  Xanthurenic acid
C02693  (Indol-3-yl)acetamide
C02700  L-Formylkynurenine
C02775  2,3-Dihydroxyindole
C02937  Indole-3-acetaldehyde oxime
C02938  3-Indoleacetonitrile
C03227  3-Hydroxy-L-kynurenine
C03230  (Indol-3-yl)glycolaldehyde
C03453  gamma-Oxalocrotonate
C03574  2-Formylaminobenzaldehyde
C03722  Quinolinate
C03824  2-Aminomuconate semialdehyde
C04409  2-Amino-3-carboxymuconate semialdehyde
C05634  5-Hydroxyindoleacetaldehyde
C05635  5-Hydroxyindoleacetate
C05636  3-Hydroxykynurenamine
C05637  4,8-Dihydroxyquinoline
C05638  5-Hydroxykynurenamine
C05639  4,6-Dihydroxyquinoline
C05640  Cinnavalininate
C05641  5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate
C05642  Formyl-N-acetyl-5-methoxykynurenamine
C05643  6-Hydroxymelatonin
C05644  3-Methylindolepyruvate
C05645  4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
C05646  5-Hydroxyindolepyruvate
C05647  Formyl-5-hydroxykynurenamine
C05648  5-Hydroxy-N-formylkynurenine
C05651  5-Hydroxykynurenine
C05652  4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate
C05653  Formylanthranilate
C05654  5-(2'-Formylethyl)-4,6-dihydroxypicolinate
C05655  5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate
C05656  5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate
C05658  Indoxyl
C05659  5-Methoxytryptamine
C05660  5-Methoxyindoleacetate
C05663  6-Hydroxykynurenate
C05830  8-Methoxykynurenate
C05831  3-Methoxyanthranilate
C05832  5-Hydroxyindoleacetylglycine
C05834  3-Methyldioxyindole
C05835  2-Formaminobenzoylacetate
C05837  Glucobrassicin
C06212  N-Methylserotonin
C06213  N-Methyltryptamine
C08313  Skatole
C10164  Picolinic acid
C16516  Indolylmethylthiohydroximate
C16517  Indolylmethyl-desulfoglucosinolate
C16518  S-(Indolylmethylthiohydroximoyl)-L-cysteine
C17203  N-Hydroxyl-tryptamine
C22006  (R)-(Indol-3-yl)lactate
C22202  2-Oxoindole-3-acetate
Reference
PMID:15749753
  Authors
Woodward AW, Bartel B
  Title
Auxin: regulation, action, and interaction.
  Journal
Ann Bot 95:707-35 (2005)
DOI:10.1093/aob/mci083
Related
pathway
bbis00010  Glycolysis / Gluconeogenesis
bbis00400  Phenylalanine, tyrosine and tryptophan biosynthesis
bbis00760  Nicotinate and nicotinamide metabolism
KO pathway
ko00380   
LinkDB

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