KEGG   PATHWAY: bbub04728
Entry
bbub04728                   Pathway                                
Name
Dopaminergic synapse - Bubalus bubalis (water buffalo)
Description
Dopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning and memory, and endocrine regulation. Once released from presynaptic axonal terminals, DA interacts with at least five receptor subtypes in the central nervous system (CNS), which have been divided into two groups: the D1-like receptors (D1Rs), comprising D1 and D5 receptors, both positively coupled to adenylyl cyclase and cAMP production, and the D2-like receptors (D2Rs), comprising D2, D3, and D4 receptors, whose activation results in inhibition of adenylyl cyclase and suppression of cAMP production. In addition, D1Rs and D2Rs modulate intracellular Ca2+ levels and a number of Ca2+ -dependent intracellular signaling processes. Through diverse cAMP- and Ca2+-dependent and - independent mechanisms, DA influences neuronal activity, synaptic plasticity, and behavior. Presynaptically localized D2Rs regulate synthesis and release of DA as the main autoreceptor of the dopaminergic system.
Class
Organismal Systems; Nervous system
Pathway map
bbub04728  Dopaminergic synapse
bbub04728

Other DBs
GO: 0001963
Organism
Bubalus bubalis (water buffalo) [GN:bbub]
Gene
102395073  TH; tyrosine 3-monooxygenase [KO:K00501] [EC:1.14.16.2]
102405051  DDC; aromatic-L-amino-acid decarboxylase isoform X1 [KO:K01593] [EC:4.1.1.28 4.1.1.105]
102408717  SLC18A2; synaptic vesicular amine transporter isoform X1 [KO:K08155]
102409259  SLC18A1; chromaffin granule amine transporter [KO:K08155]
102399173  DRD1; D(1A) dopamine receptor [KO:K04144]
102404024  DRD5; D(1B) dopamine receptor [KO:K05840]
102391827  CALY; neuron-specific vesicular protein calcyon [KO:K15493]
102409250  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
102412320  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
102405830  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
102413748  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
102389945  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
102412452  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X8 [KO:K04958]
102401062  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X2 [KO:K04959]
102409793  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
102391725  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
102403292  calmodulin-1-like [KO:K02183]
102416387  calmodulin [KO:K02183]
102405655  calmodulin [KO:K02183]
102393421  calmodulin-1-like [KO:K02183]
102408582  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
123466194  calmodulin-1-like [KO:K02183]
102396094  CALM1; calmodulin-1 isoform X2 [KO:K02183]
102406525  CALM3; calmodulin-3 [KO:K02183]
102410813  CALM2; calmodulin-2 [KO:K02183]
102396037  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
102397549  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
102389415  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X19 [KO:K04515] [EC:2.7.11.17]
102416446  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X7 [KO:K04515] [EC:2.7.11.17]
102400064  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102415631  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102414534  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X7 [KO:K04348] [EC:3.1.3.16]
102415611  PRKCA; protein kinase C alpha type isoform X4 [KO:K02677] [EC:2.7.11.13]
102407189  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
102397646  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102393791  FOS; proto-oncogene C-Fos [KO:K04379]
102408597  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
112577614  neuroendocrine secretory protein 55 [KO:K04632]
102394701  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
102405387  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
102392366  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
102413383  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X4 [KO:K04345] [EC:2.7.11.11]
102401906  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102410577  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
102393344  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
112580290  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
102406078  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
102395032  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
102400784  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
102416630  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
102398301  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2 [KO:K09048]
102400864  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X4 [KO:K09047]
102392963  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X3 [KO:K09049]
102409665  MAPK12; mitogen-activated protein kinase 12 isoform X3 [KO:K04441] [EC:2.7.11.24]
102397149  MAPK14; mitogen-activated protein kinase 14 isoform X4 [KO:K04441] [EC:2.7.11.24]
102397694  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
102393434  MAPK8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
102396572  MAPK10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
102403452  MAPK9; mitogen-activated protein kinase 9 isoform X5 [KO:K04440] [EC:2.7.11.24]
102396013  PPP1R1B; protein phosphatase 1 regulatory subunit 1B isoform X2 [KO:K15494]
102393123  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
102395266  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
102396799  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
102394594  SCN1A; sodium channel protein type 1 subunit alpha isoform X1 [KO:K04833]
102407190  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X9 [KO:K04850]
102405249  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
102404131  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X4 [KO:K04344]
102395660  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
102410731  KCNJ3; G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997]
102400825  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
102402372  KCNJ9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
102392060  KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
102413222  DRD3; D(3) dopamine receptor [KO:K04146]
102413668  GNAI2; guanine nucleotide-binding protein G(I) subunit alpha-2 [KO:K04630]
102401306  GNAI1; guanine nucleotide-binding protein G(I) subunit alpha-1 [KO:K04630]
102409247  GNAI3; guanine nucleotide-binding protein G(I) subunit alpha-3 [KO:K04630]
102394976  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X2 [KO:K04534]
102406849  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
102399170  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
102414827  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
102399967  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
102400794  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
102412203  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2 [KO:K07826]
102393962  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
102405602  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X2 [KO:K04541]
102411670  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102402000  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
102406523  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
102410454  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
102403796  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
102401812  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
102402691  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1 [KO:K04347]
102396193  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
102408374  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X1 [KO:K04547]
102402143  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
102409522  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
102395376  DRD2; D(2) dopamine receptor [KO:K04145]
102398812  ARRB2; beta-arrestin-2 isoform X3 [KO:K04439]
102408724  ARRB1; beta-arrestin-1 isoform X4 [KO:K04439]
102398465  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
102407460  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
102396397  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
102409320  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2 [KO:K03456]
102412869  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
102412546  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
102392164  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
102393986  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X6 [KO:K04354]
102400472  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354]
102390645  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354]
102399525  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
102399159  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
102414603  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
102398540  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X2 [KO:K11584]
102406434  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
102412395  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
102411610  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X22 [KO:K11584]
102414330  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
102397969  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102398761  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102391021  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
102398502  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
102401080  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
102409649  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
102412577  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
102406405  GRIA1; glutamate receptor 1 isoform X3 [KO:K05197]
102391738  GRIA2; glutamate receptor 2 isoform X4 [KO:K05198]
102399596  GRIA3; glutamate receptor 3 isoform X2 [KO:K05199]
102409370  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
102391540  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
102414769  KIF5C; kinesin heavy chain [KO:K10396]
102411476  KIF5B; kinesin-1 heavy chain isoform X3 [KO:K10396]
102414002  CLOCK; circadian locomoter output cycles protein kaput isoform X1 [KO:K02223] [EC:2.3.1.48]
102400190  ARNTL; aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X1 [KO:K02296]
102401631  SLC6A3; LOW QUALITY PROTEIN: sodium-dependent dopamine transporter [KO:K05036]
102404714  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
102405347  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
102392023  TOMT; transmembrane O-methyltransferase isoform X1 [KO:K00545] [EC:2.1.1.6]
Compound
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00238  Potassium cation
C00355  3,4-Dihydroxy-L-phenylalanine
C00575  3',5'-Cyclic AMP
C01161  3,4-Dihydroxyphenylacetate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C03758  Dopamine
C05582  Homovanillate
C05587  3-Methoxytyramine
Reference
PMID:21303898
  Authors
Beaulieu JM, Gainetdinov RR
  Title
The physiology, signaling, and pharmacology of dopamine receptors.
  Journal
Pharmacol Rev 63:182-217 (2011)
DOI:10.1124/pr.110.002642
Reference
PMID:15521361
  Authors
Neve KA, Seamans JK, Trantham-Davidson H
  Title
Dopamine receptor signaling.
  Journal
J Recept Signal Transduct Res 24:165-205 (2004)
DOI:10.1081/RRS-200029981
Reference
PMID:17408758
  Authors
Surmeier DJ, Ding J, Day M, Wang Z, Shen W
  Title
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons.
  Journal
Trends Neurosci 30:228-35 (2007)
DOI:10.1016/j.tins.2007.03.008
Reference
PMID:20224735
  Authors
Knab AM, Lightfoot JT
  Title
Does the difference between physically active and couch potato lie in the dopamine system?
  Journal
Int J Biol Sci 6:133-50 (2010)
DOI:10.7150/ijbs.6.133
Reference
PMID:10433257
  Authors
Greengard P, Allen PB, Nairn AC
  Title
Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade.
  Journal
Neuron 23:435-47 (1999)
DOI:10.1016/S0896-6273(00)80798-9
Reference
PMID:15590733
  Authors
Hu XT, Dong Y, Zhang XF, White FJ
  Title
Dopamine D2 receptor-activated Ca2+ signaling modulates voltage-sensitive sodium currents in rat nucleus accumbens neurons.
  Journal
J Neurophysiol 93:1406-17 (2005)
DOI:10.1152/jn.00771.2004
Reference
PMID:17349698
  Authors
Beaulieu JM, Gainetdinov RR, Caron MG
  Title
The Akt-GSK-3 signaling cascade in the actions of dopamine.
  Journal
Trends Pharmacol Sci 28:166-72 (2007)
DOI:10.1016/j.tips.2007.02.006
Reference
PMID:19138563
  Authors
De Mei C, Ramos M, Iitaka C, Borrelli E
  Title
Getting specialized: presynaptic and postsynaptic dopamine D2 receptors.
  Journal
Curr Opin Pharmacol 9:53-8 (2009)
DOI:10.1016/j.coph.2008.12.002
Reference
PMID:15381316
  Authors
Seamans JK, Yang CR
  Title
The principal features and mechanisms of dopamine modulation in the prefrontal cortex.
  Journal
Prog Neurobiol 74:1-58 (2004)
DOI:10.1016/j.pneurobio.2004.05.006
Reference
PMID:18353279
  Authors
Yao WD, Spealman RD, Zhang J
  Title
Dopaminergic signaling in dendritic spines.
  Journal
Biochem Pharmacol 75:2055-69 (2008)
DOI:10.1016/j.bcp.2008.01.018
Reference
PMID:20727368
  Authors
Li YC, Gao WJ
  Title
GSK-3beta activity and hyperdopamine-dependent behaviors.
  Journal
Neurosci Biobehav Rev 35:645-54 (2011)
DOI:10.1016/j.neubiorev.2010.08.001
Reference
PMID:15292232
  Authors
Tang TS, Bezprozvanny I
  Title
Dopamine receptor-mediated Ca(2+) signaling in striatal medium spiny neurons.
  Journal
J Biol Chem 279:42082-94 (2004)
DOI:10.1074/jbc.M407389200
Reference
PMID:12967774
  Authors
Bergson C, Levenson R, Goldman-Rakic PS, Lidow MS
  Title
Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling.
  Journal
Trends Pharmacol Sci 24:486-92 (2003)
DOI:10.1016/S0165-6147(03)00232-3
Reference
PMID:9457173
  Authors
Missale C, Nash SR, Robinson SW, Jaber M, Caron MG
  Title
Dopamine receptors: from structure to function.
  Journal
Physiol Rev 78:189-225 (1998)
DOI:10.1152/physrev.1998.78.1.189
Reference
PMID:19251795
  Authors
Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ
  Title
Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases?
  Journal
Eur Respir J 33:468-80 (2009)
DOI:10.1183/09031936.00056908
Related
pathway
bbub00350  Tyrosine metabolism
bbub04020  Calcium signaling pathway
bbub04721  Synaptic vesicle cycle
bbub04724  Glutamatergic synapse
bbub05012  Parkinson disease
KO pathway
ko04728   
LinkDB

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