Entry
Name
Circadian entrainment - Cercocebus atys (sooty mangabey)
Description
Circadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhythms are synchronized to environmental cues. In mammals, a master clock is located in the suprachiasmatic nuclei (SCN) of the hypothalamus and may synchronize circadian oscillators in peripheral tissues. Light signal is the dominant synchronizer for master SCN clock. Downstream from the retina, glutamate and PACAP are released and trigger the activation of signal transduction cascades, including CamKII and nNOS activity, cAMP- and cGMP-dependent protein kinases, and mitogen-activated protein kinase (MAPK). Of non-photic entrainment, important phase shifting capabilities have been found for melatonin, which inhibits light-induced phase shifts through inhibition of adenylate cyclase (AC). Multiple entrainment pathways converge into CREB regulation. In turn, phosphorylated CREB activates clock gene expression.
Class
Organismal Systems; Environmental adaptation
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Cercocebus atys (sooty mangabey) [GN:
caty ]
Gene
105580611 GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208 ]
105585127 GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210 ]
105577760 GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211 ]
105595236 GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212 ]
105600970 CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183 ]
105571464 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
105596908 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
105589879 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
105597344 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
105580103 CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
105585726 ITPR1; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958 ]
105593244 ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960 ]
105589225 carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein isoform X1 [KO:K16513 ]
105598195 RASD1; dexamethasone-induced Ras-related protein 1 isoform X1 [KO:K07843 ]
105594342 GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630 ]
105573715 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
105583233 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
105588486 GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534 ]
105594434 GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536 ]
105584442 GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537 ]
105583036 GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825 ]
105597720 GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538 ]
105601141 GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539 ]
105586615 GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826 ]
105577543 GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540 ]
105580742 GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
105592180 GNG11; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546 ]
105581531 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546 ]
105601524 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347 ]
105595886 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
105592179 GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548 ]
105579462 GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549 ]
105579425 CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854 ]
105574047 CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855 ]
105572851 CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856 ]
105583951 ADCYAP1; LOW QUALITY PROTEIN: pituitary adenylate cyclase-activating polypeptide [KO:K05262 ]
105596271 ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587 ]
105585319 guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632 ]
105582968 CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850 ]
105585586 CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851 ]
105584209 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
105577494 PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
105582089 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
105575989 KCNJ3; G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997 ]
105582639 KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999 ]
105575434 KCNJ6; G protein-activated inward rectifier potassium channel 2 isoform X1 [KO:K05000 ]
105589290 KCNJ9; G protein-activated inward rectifier potassium channel 3 isoform X1 [KO:K05002 ]
Compound
Reference
Authors
Brown TM, Piggins HD
Title
Electrophysiology of the suprachiasmatic circadian clock.
Journal
Reference
Authors
Dickson L, Finlayson K
Title
VPAC and PAC receptors: From ligands to function.
Journal
Reference
Authors
Golombek DA, Rosenstein RE
Title
Physiology of circadian entrainment.
Journal
Reference
Authors
Dubocovich ML, Markowska M
Title
Functional MT1 and MT2 melatonin receptors in mammals.
Journal
Reference
Authors
Dubocovich ML, Delagrange P, Krause DN, Sugden D, Cardinali DP, Olcese J
Title
International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors.
Journal
Reference
Authors
Hardeland R
Title
Melatonin: signaling mechanisms of a pleiotropic agent.
Journal
Reference
Authors
Golombek DA, Ferreyra GA, Agostino PV, Murad AD, Rubio MF, Pizzio GA, Katz ME, Marpegan L, Bekinschtein TA
Title
From light to genes: moving the hands of the circadian clock.
Journal
Reference
Authors
Mertens I, Husson SJ, Janssen T, Lindemans M, Schoofs L
Title
PACAP and PDF signaling in the regulation of mammalian and insect circadian rhythms.
Journal
Reference
Authors
Kim DY, Choi HJ, Kim JS, Kim YS, Jeong DU, Shin HC, Kim MJ, Han HC, Hong SK, Kim YI
Title
Voltage-gated calcium channels play crucial roles in the glutamate-induced phase shifts of the rat suprachiasmatic circadian clock.
Journal
Reference
Authors
Agostino PV, Ferreyra GA, Murad AD, Watanabe Y, Golombek DA
Title
Diurnal, circadian and photic regulation of calcium/calmodulin-dependent kinase II and neuronal nitric oxide synthase in the hamster suprachiasmatic nuclei.
Journal
Reference
Authors
Ferreyra GA, Golombek DA
Title
Rhythmicity of the cGMP-related signal transduction pathway in the mammalian circadian system.
Journal
Reference
Authors
Butcher GQ, Lee B, Cheng HY, Obrietan K
Title
Light stimulates MSK1 activation in the suprachiasmatic nucleus via a PACAP-ERK/MAP kinase-dependent mechanism.
Journal
Reference
Authors
Hamada T, Niki T, Ziging P, Sugiyama T, Watanabe S, Mikoshiba K, Ishida N
Title
Differential expression patterns of inositol trisphosphate receptor types 1 and 3 in the rat suprachiasmatic nucleus.
Journal
Reference
Authors
Diaz-Munoz M, Dent MA, Granados-Fuentes D, Hall AC, Hernandez-Cruz A, Harrington ME, Aguilar-Roblero R
Title
Circadian modulation of the ryanodine receptor type 2 in the SCN of rodents.
Journal
Reference
Authors
Fang M, Jaffrey SR, Sawa A, Ye K, Luo X, Snyder SH
Title
Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON.
Journal
Reference
Authors
Takahashi H, Umeda N, Tsutsumi Y, Fukumura R, Ohkaze H, Sujino M, van der Horst G, Yasui A, Inouye ST, Fujimori A, Ohhata T, Araki R, Abe M
Title
Mouse dexamethasone-induced RAS protein 1 gene is expressed in a circadian rhythmic manner in the suprachiasmatic nucleus.
Journal
Reference
Authors
Cheng HY, Dziema H, Papp J, Mathur DP, Koletar M, Ralph MR, Penninger JM, Obrietan K
Title
The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock.
Journal
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