KEGG   PATHWAY: caty04010
Entry
caty04010                   Pathway                                
Name
MAPK signaling pathway - Cercocebus atys (sooty mangabey)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
caty04010  MAPK signaling pathway
caty04010

Other DBs
GO: 0000165
Organism
Cercocebus atys (sooty mangabey) [GN:caty]
Gene
105601562  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
105580650  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
105582968  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
105585586  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
105580474  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
105573107  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105579425  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
105574047  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
105572851  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
105575216  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
105583235  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
105573729  CACNA2D2; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
105585594  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
105582965  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
105579539  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
105583823  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
105580402  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
105575977  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
105599333  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
105575805  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
105586067  CACNG3; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
105599335  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
105599328  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
105595657  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
105595656  CACNG7; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
105595677  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
105593561  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105601580  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
105584148  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
105599331  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105586076  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105595654  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105571739  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
105601524  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
105595886  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
105571365  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105579229  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105597329  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105593014  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105576501  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
105571720  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
105599137  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
105574148  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
105577479  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
105578391  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
105594542  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
105597871  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
105589413  NF1; neurofibromin isoform X1 [KO:K08052]
105599108  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
105586356  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
105594391  RAP1A; ras-related protein Rap-1A [KO:K04353]
105600503  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
105571434  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
105576539  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
105576873  EREG; proepiregulin [KO:K09784]
105576872  AREG; amphiregulin [KO:K09782]
105599949  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
105595795  FGF2; fibroblast growth factor 2 [KO:K18497]
105577303  FGF3; fibroblast growth factor 3 [KO:K04358]
105577304  FGF4; fibroblast growth factor 4 [KO:K04358]
105601381  FGF20; fibroblast growth factor 20 [KO:K04358]
105579245  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105588213  FGF7; fibroblast growth factor 7 [KO:K04358]
105581649  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
105581863  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
105581939  FGF16; fibroblast growth factor 16 [KO:K04358]
105583515  FGF10; fibroblast growth factor 10 [KO:K04358]
105591678  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
105591918  FGF9; fibroblast growth factor 9 [KO:K04358]
105576825  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
105577305  FGF19; fibroblast growth factor 19 [KO:K22603]
105595256  FGF21; fibroblast growth factor 21 [KO:K22429]
105582993  FGF23; fibroblast growth factor 23 [KO:K22428]
105596338  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
105572781  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
105583006  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
105595271  NTF4; neurotrophin-4 [KO:K12457]
105577261  INS; insulin [KO:K04526]
105573305  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
105577264  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
105571784  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
105572960  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
105588762  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
105597890  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
105594352  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
105596830  KITLG; kit ligand [KO:K05461]
105595290  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
105591224  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
105577498  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
105590861  PGF; placenta growth factor isoform X1 [KO:K16859]
105597772  VEGFC; vascular endothelial growth factor C [KO:K05449]
105574688  FIGF; vascular endothelial growth factor D [KO:K05449]
105583213  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105584496  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
105594196  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
105582199  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
105593509  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
105593511  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
105593518  EFNA1; ephrin-A1 [KO:K05462]
105591709  EFNA2; ephrin-A2 [KO:K05462]
105576658  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
105583443  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
105591840  NRTN; neurturin [KO:K25414]
105594633  ARTN; artemin [KO:K25415]
105591856  PSPN; persephin [KO:K25416]
105588269  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105579553  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
105587314  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
105580144  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
105590801  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105577985  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
105585485  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105581716  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
105579459  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
105594539  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
105584243  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
105589163  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
105594004  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
105592013  PDGFRA; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105589876  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
105589873  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
105591986  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
105597061  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
105597064  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105590424  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
105591984  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
105598476  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
105591300  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
105599438  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
105571572  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
105577731  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105586728  SOS2; son of sevenless homolog 2 [KO:K03099]
105597205  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105577198  HRAS; GTPase HRas isoform X1 [KO:K02833]
105585038  KRAS; GTPase KRas isoform X1 [KO:K07827]
105596344  NRAS; GTPase NRas isoform X1 [KO:K07828]
105595298  RRAS; ras-related protein R-Ras [KO:K07829]
105595718  RRAS2; ras-related protein R-Ras2 [KO:K07830]
105586388  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
105590503  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
105589671  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105585803  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105601165  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105591800  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
105571358  LAMTOR3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
105598233  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105598850  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105594560  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
105591739  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
105593758  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
105594925  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
105574798  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
105575082  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
105572871  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105590499  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
105576435  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
105588384  MYC; myc proto-oncogene protein [KO:K04377]
105591452  SRF; serum response factor [KO:K04378]
105590868  FOS; proto-oncogene c-Fos [KO:K04379]
105585777  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
105589886  microtubule-associated protein tau-like [KO:K04380]
105594952  STMN1; stathmin isoform X1 [KO:K04381]
105579889  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
105595443  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
105574211  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
105574213  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
105574214  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
105574265  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
105573465  TNF; tumor necrosis factor [KO:K03156]
105591122  IL1A; interleukin-1 alpha isoform X1 [KO:K04383]
105591123  IL1B; interleukin-1 beta [KO:K04519]
105598017  TGFB1; transforming growth factor beta-1 isoform X1 [KO:K13375]
105577004  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
105590879  TGFB3; transforming growth factor beta-3 [KO:K13377]
105583011  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105583647  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
105575191  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
105593039  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
105578253  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
105597557  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105587157  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
105599891  CD14; monocyte differentiation antigen CD14 [KO:K04391]
105584356  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105575821  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
105588572  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
105595026  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105571986  cell division control protein 42 homolog [KO:K04393]
105587262  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
105593734  LOW QUALITY PROTEIN: caspase-3-like [KO:K02187] [EC:3.4.22.56]
105597738  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105580591  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
105593386  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
105573904  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
105598716  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
105574390  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
105586809  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
105595891  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
105584287  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
105591754  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
105572923  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
105588814  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
105601489  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
105597211  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
105583649  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
105597167  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
105578700  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
105575136  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
105588450  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
105586525  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
105577476  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
105596958  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
105599635  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
105577434  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
105592087  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
105590736  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
105599537  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
105597970  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
105574867  mitogen-activated protein kinase kinase kinase MLK4 [KO:K17534] [EC:2.7.11.25]
105580265  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
105573954  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
105580169  mitogen-activated protein kinase kinase kinase MLT [KO:K04424] [EC:2.7.11.25]
105594905  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
105600400  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
105589048  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
105594238  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
105592749  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
105591548  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
105598928  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
105581389  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
105589128  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
105593750  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
105577799  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
105592787  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
105586861  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
105573702  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
105598710  FLNA; filamin-A isoform X1 [KO:K04437]
105598246  CRKL; crk-like protein [KO:K04438]
105584307  CRK; adapter molecule crk isoform X1 [KO:K04438]
105578731  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
105583572  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
105590417  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105591436  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105576775  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105592690  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
105592727  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105586882  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
105586884  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
105573171  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
105576691  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
105573733  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
105596570  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
105577485  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
105582133  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
105596502  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
105583982  NFATC3; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
105595973  JUN; transcription factor AP-1 [KO:K04448]
105577328  transcription factor jun-D [KO:K04449]
105601697  JUND; LOW QUALITY PROTEIN: transcription factor jun-D [KO:K04449]
105579833  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
105582225  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
105587252  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
105582838  MAX; protein max isoform X1 [KO:K04453]
105599094  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
105593379  HSPB1; heat shock protein beta-1 [KO:K04455]
105596769  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105597977  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105574942  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105586702  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
105581024  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
105598862  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
105575474  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
105581659  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
105577241  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105585143  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105577892  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105585544  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105579151  DUSP4; LOW QUALITY PROTEIN: dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105583720  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105596825  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
105598736  DUSP9; dual specificity protein phosphatase 9 isoform X1 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
105576981  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
105584840  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
105595180  PPP5C; serine/threonine-protein phosphatase 5 isoform X1 [KO:K04460] [EC:3.1.3.16]
105590580  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
105580058  heat shock cognate 71 kDa protein [KO:K03283]
105573430  heat shock 70 kDa protein 1 [KO:K03283]
105573431  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
105589238  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
105582685  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
105586041  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
105600975  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
105593716  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
105580323  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
105585587  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
105581830  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105595759  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105573773  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
105591505  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
105571369  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105581879  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
105577432  RELA; transcription factor p65 isoform X1 [KO:K04735]
105595132  RELB; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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PMID:12191611
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Pharmacol Ther 93:193-202 (2002)
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PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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Oncogene 22:5885-96 (2003)
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PMID:12676795
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Annu Rev Biochem 72:609-42 (2003)
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PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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PMID:14597384
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Gene 320:3-21 (2003)
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Cell 141:1117-34 (2010)
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Reference
PMID:22296764
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
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Biochim Biophys Acta 1843:2563-2582 (2014)
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Related
pathway
caty04070  Phosphatidylinositol signaling system
caty04110  Cell cycle
caty04115  p53 signaling pathway
caty04210  Apoptosis
caty04310  Wnt signaling pathway
caty04668  TNF signaling pathway
KO pathway
ko04010   
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