KEGG   PATHWAY: caua04912
Entry
caua04912                   Pathway                                
Name
GnRH signaling pathway - Carassius auratus (goldfish)
Description
Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its signal to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kinase C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasionally observed in a cell-specific fashion. Signaling downstream of protein kinase C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kinases (MAPKs), including extracellular-signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes.
Class
Organismal Systems; Endocrine system
Pathway map
caua04912  GnRH signaling pathway
caua04912

Organism
Carassius auratus (goldfish) [GN:caua]
Gene
113094585  progonadoliberin-3 [KO:K05252]
113063732  progonadoliberin IIB [KO:K05252]
113038772  progonadoliberin IIA [KO:K05252]
113117896  progonadoliberin-3 [KO:K05252]
113091658  putative gonadotropin-releasing hormone II receptor [KO:K04280]
113106305  putative gonadotropin-releasing hormone II receptor [KO:K04280]
113119351  gonadotropin-releasing hormone II receptor-like [KO:K04280]
113061616  putative gonadotropin-releasing hormone II receptor [KO:K04280]
113062069  gonadotropin-releasing hormone II receptor-like [KO:K04280]
113059424  gonadotropin-releasing hormone II receptor-like [KO:K04280]
113050265  guanine nucleotide-binding protein G(s) subunit alpha-like isoform X1 [KO:K04632]
113105096  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
113121087  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
113063272  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
113039324  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
113046191  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
113119536  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
113116166  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
113090787  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
113120648  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
113097331  adenylate cyclase type 3-like isoform X1 [KO:K08043] [EC:4.6.1.1]
113116527  adenylate cyclase type 3-like isoform X1 [KO:K08043] [EC:4.6.1.1]
113059808  adenylate cyclase type 3-like isoform X1 [KO:K08043] [EC:4.6.1.1]
113105408  adenylate cyclase type 2-like [KO:K08044] [EC:4.6.1.1]
113096274  adenylate cyclase type 4-like [KO:K08044] [EC:4.6.1.1]
113108405  adenylate cyclase type 5-like isoform X1 [KO:K08045] [EC:4.6.1.1]
113069207  adenylate cyclase type 5-like isoform X1 [KO:K08045] [EC:4.6.1.1]
113053059  adenylate cyclase type 5-like isoform X1 [KO:K08045] [EC:4.6.1.1]
113041064  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
113093005  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
113070523  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
113065498  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
113051418  adenylate cyclase type 2-like isoform X1 [KO:K08047] [EC:4.6.1.1]
113106060  adenylate cyclase type 2-like isoform X1 [KO:K08047] [EC:4.6.1.1]
113060337  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
113092585  adenylate cyclase type 8-like isoform X1 [KO:K08048] [EC:4.6.1.1]
113120779  adenylate cyclase type 8-like isoform X1 [KO:K08048] [EC:4.6.1.1]
113120872  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
113045049  adenylate cyclase type 8-like isoform X1 [KO:K08048] [EC:4.6.1.1]
113067623  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
113051739  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
113065061  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
113039957  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
113053706  cAMP-dependent protein kinase catalytic subunit alpha-like isoform X1 [KO:K04345] [EC:2.7.11.11]
113054947  prkacb; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
113067676  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
113069366  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
113097097  cAMP-dependent protein kinase catalytic subunit alpha-like isoform X1 [KO:K04345] [EC:2.7.11.11]
113051365  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
113046138  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
113039766  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
113095179  atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
113044626  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
113046737  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
113089994  cyclic AMP-dependent transcription factor ATF-4-like isoform X1 [KO:K04374]
113064999  guanine nucleotide-binding protein G(q) subunit alpha-like isoform X1 [KO:K04634]
113049838  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
113083927  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
113112706  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04635]
113113987  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04635]
113079298  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04635]
113082387  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04635]
113040036  guanine nucleotide-binding protein subunit alpha-11-like isoform X1 [KO:K04635]
113106612  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
113094095  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
113068500  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
113068501  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
113068549  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
113068550  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
113079052  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like [KO:K05858] [EC:3.1.4.11]
113083303  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like [KO:K05858] [EC:3.1.4.11]
113087941  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
113117759  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
113055353  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
113094567  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
113050374  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
113110915  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
113061517  inositol 1,4,5-trisphosphate receptor type 2-like [KO:K04959]
113118284  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
113107211  inositol 1,4,5-trisphosphate receptor type 3-like isoform X1 [KO:K04960]
113069945  inositol 1,4,5-trisphosphate receptor type 3-like isoform X1 [KO:K04960]
113113030  calm2; calmodulin-2 [KO:K02183]
113078014  calmodulin [KO:K02183]
113043014  calmodulin-like protein 4 [KO:K02183]
113056129  calmodulin [KO:K02183]
113095065  calmodulin [KO:K02183]
113121099  calmodulin [KO:K02183]
113095975  calmodulin [KO:K02183]
113121164  calmodulin [KO:K02183]
113115290  calmodulin [KO:K02183]
113057229  calmodulin [KO:K02183]
113063032  calmodulin [KO:K02183]
113038517  calmodulin [KO:K02183]
113064143  calmodulin [KO:K02183]
113058580  calmodulin [KO:K02183]
113052481  calmodulin-like protein 4 [KO:K02183]
113117528  calmodulin [KO:K02183]
113111825  calmodulin [KO:K02183]
113106027  calmodulin-like protein 4 [KO:K02183]
113074893  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
113075261  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
113106329  calcium/calmodulin-dependent protein kinase type II delta 1 chain-like isoform X1 [KO:K04515] [EC:2.7.11.17]
113112733  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
113054639  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
113054696  calcium/calmodulin-dependent protein kinase type II subunit delta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
113048876  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
113048934  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
113056007  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
113068998  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
113044308  calcium/calmodulin-dependent protein kinase type II delta 2 chain-like isoform X1 [KO:K04515] [EC:2.7.11.17]
113051302  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
113057304  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
113098767  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
113063851  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
113110225  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
113110343  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
113038291  calcium/calmodulin-dependent protein kinase type II subunit alpha-like isoform X1 [KO:K04515] [EC:2.7.11.17]
113105940  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
113112165  calcium/calmodulin-dependent protein kinase type II subunit gamma-like [KO:K04515] [EC:2.7.11.17]
113049910  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
113097507  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
113047101  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
113053289  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
113047295  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
113093357  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
113079629  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
113044532  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
113070457  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
113044866  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
113055278  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
113094825  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
113050390  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
113110979  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
113048094  voltage-dependent L-type calcium channel subunit alpha-1C-like isoform X1 [KO:K04850]
113062313  voltage-dependent L-type calcium channel subunit alpha-1C-like isoform X1 [KO:K04850]
113055476  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
113107872  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
113110814  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
113076440  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
113079157  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
113070706  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
113087728  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853]
113107268  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
113093954  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
113107582  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1 [KO:K04857]
113040331  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
113053991  mitogen-activated protein kinase kinase kinase 1-like isoform X1 [KO:K04416] [EC:2.7.11.25]
113109546  mitogen-activated protein kinase kinase kinase 1-like isoform X1 [KO:K04416] [EC:2.7.11.25]
113092298  mitogen-activated protein kinase kinase kinase 2-like [KO:K04420] [EC:2.7.11.25]
113050870  mitogen-activated protein kinase kinase kinase 2-like [KO:K04420] [EC:2.7.11.25]
113066300  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
113099578  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
113046030  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
113047227  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
113047236  mitogen-activated protein kinase kinase kinase 3-like isoform X1 [KO:K04421] [EC:2.7.11.25]
113112502  mitogen-activated protein kinase kinase kinase 4-like isoform X1 [KO:K04428] [EC:2.7.11.25]
113056767  mitogen-activated protein kinase kinase kinase 4-like isoform X1 [KO:K04428] [EC:2.7.11.25]
113075496  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
113055995  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
113111626  dual specificity mitogen-activated protein kinase kinase 6-like isoform X1 [KO:K04433] [EC:2.7.12.2]
113111658  dual specificity mitogen-activated protein kinase kinase 6-like isoform X1 [KO:K04433] [EC:2.7.12.2]
113041113  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
113047963  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
113047964  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
113092486  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
113106988  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
113048526  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
113048528  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
113076476  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
113093289  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
113055097  mitogen-activated protein kinase 14B-like isoform X1 [KO:K04441] [EC:2.7.11.24]
113107629  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
113069393  mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
113058295  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
113064191  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
113100762  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
113074136  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
113118260  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
113056399  mitogen-activated protein kinase 7-like isoform X1 [KO:K04464] [EC:2.7.11.24]
113111996  mitogen-activated protein kinase 7-like [KO:K04464] [EC:2.7.11.24]
113094578  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
113062352  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113062962  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
113069794  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113115927  cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
113070145  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113070146  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113070147  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113070154  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113070174  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
113070191  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113070198  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
113070215  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113070798  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113045808  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
113117207  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
113086959  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113086991  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113087107  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113087123  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113087139  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
113087155  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113117853  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
113066158  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
113041873  phospholipase D1-like isoform X1 [KO:K01115] [EC:3.1.4.4]
113042490  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
113049103  phospholipase D1-like isoform X1 [KO:K01115] [EC:3.1.4.4]
113077441  phospholipase D2-like [KO:K01115] [EC:3.1.4.4]
113069723  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
113045923  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
113041276  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
113065632  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
113041157  cell division control protein 42 homolog isoform X1 [KO:K04393]
113055466  cell division control protein 42 homolog isoform X1 [KO:K04393]
113055513  cell division control protein 42 homolog isoform X1 [KO:K04393]
113116067  cell division control protein 42 homolog [KO:K04393]
113081684  cell division control protein 42 homolog [KO:K04393]
113099586  cell division control protein 42 homolog [KO:K04393]
113110861  cell division control protein 42 homolog isoform X1 [KO:K04393]
113055203  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
113067838  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
113101088  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
113112012  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
113079021  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
113098179  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
113064198  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
113112557  mitogen-activated protein kinase 8B isoform X1 [KO:K04440] [EC:2.7.11.24]
113056448  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
113056870  mitogen-activated protein kinase 8B isoform X1 [KO:K04440] [EC:2.7.11.24]
113064006  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
113038415  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
113038881  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
113064388  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
113112062  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
113121148  transcription factor AP-1-like [KO:K04448]
113063047  transcription factor AP-1-like [KO:K04448]
113069861  transcription factor AP-1-like [KO:K04448]
113070627  transcription factor AP-1-like [KO:K04448]
113057550  gonadotropin subunit beta-2 [KO:K08521]
113095973  glycoprotein hormones alpha chain 2 [KO:K08522]
113116998  cga; glycoprotein hormones alpha chain [KO:K08522]
113052489  gonadotropin subunit beta-1-like [KO:K05250]
113105977  gonadotropin subunit beta-1 [KO:K05250]
113091776  protein-tyrosine kinase 2-beta-like [KO:K05871] [EC:2.7.10.2]
113060836  protein-tyrosine kinase 2-beta-like isoform X1 [KO:K05871] [EC:2.7.10.2]
113121041  protein-tyrosine kinase 2-beta-like [KO:K05871] [EC:2.7.10.2]
113121042  protein-tyrosine kinase 2-beta-like [KO:K05871] [EC:2.7.10.2]
113097198  protein-tyrosine kinase 2-beta-like [KO:K05871] [EC:2.7.10.2]
113117730  protein-tyrosine kinase 2-beta-like [KO:K05871] [EC:2.7.10.2]
113051472  72 kDa type IV collagenase-like [KO:K01398] [EC:3.4.24.24]
113106043  72 kDa type IV collagenase-like [KO:K01398] [EC:3.4.24.24]
113119884  matrix metalloproteinase-14-like [KO:K07763] [EC:3.4.24.80]
113044985  matrix metalloproteinase-14-like [KO:K07763] [EC:3.4.24.80]
113052124  matrix metalloproteinase-14-like [KO:K07763] [EC:3.4.24.80]
113052125  matrix metalloproteinase-14-like [KO:K07763] [EC:3.4.24.80]
113105708  matrix metalloproteinase-14-like [KO:K07763] [EC:3.4.24.80]
113076889  proheparin-binding EGF-like growth factor [KO:K08523]
113113723  proheparin-binding EGF-like growth factor [KO:K08523]
113057675  proheparin-binding EGF-like growth factor [KO:K08523]
113038470  proheparin-binding EGF-like growth factor [KO:K08523]
113064063  proheparin-binding EGF-like growth factor [KO:K08523]
113092711  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
113042612  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
113114389  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
113045981  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
113047808  growth factor receptor-bound protein 2-like [KO:K04364]
113050680  growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
113097902  growth factor receptor-bound protein 2-like isoform X1 [KO:K04364]
113046804  growth factor receptor-bound protein 2-like [KO:K04364]
113112475  son of sevenless homolog 2-like [KO:K03099]
113056783  sos2; son of sevenless homolog 2 [KO:K03099]
113110612  son of sevenless homolog 1-like [KO:K03099]
113110616  son of sevenless homolog 1-like [KO:K03099]
113106249  GTPase HRas [KO:K02833]
113067303  GTPase HRas-like [KO:K02833]
113043599  GTPase HRas-like [KO:K02833]
113051345  GTPase HRas-like [KO:K02833]
113067076  ras-like protein isoform X1 [KO:K07827]
113043474  GTPase HRas-like [KO:K07827]
113043560  GTPase KRas [KO:K07827]
113046915  GTPase HRas-like [KO:K07827]
113106980  GTPase NRas-like [KO:K07828]
113071752  GTPase NRas [KO:K07828]
113083541  GTPase NRas-like [KO:K07828]
113054940  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
113068641  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
113061451  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
113118360  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
113045154  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
113045216  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
113064928  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
113039644  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
113047409  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
113068089  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
113072016  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
113046952  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
113107010  ETS domain-containing protein Elk-1-like [KO:K04375]
113074153  ETS domain-containing protein Elk-1-like [KO:K04375]
113041340  early growth response protein 1-B-like [KO:K09203]
113113598  early growth response protein 1 [KO:K09203]
113069578  early growth response protein 1-like [KO:K09203]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00416  Phosphatidate
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:15350605
  Authors
Ruf F, Sealfon SC.
  Title
Genomics view of gonadotrope signaling circuits.
  Journal
Trends Endocrinol Metab 15:331-8 (2004)
DOI:10.1016/j.tem.2004.07.008
Reference
PMID:15613448
  Authors
Harrison GS, Wierman ME, Nett TM, Glode LM.
  Title
Gonadotropin-releasing hormone and its receptor in normal and malignant cells.
  Journal
Endocr Relat Cancer 11:725-48 (2004)
DOI:10.1677/erc.1.00777
Reference
PMID:15982836
  Authors
Pawson AJ, McNeilly AS.
  Title
The pituitary effects of GnRH.
  Journal
Anim Reprod Sci 88:75-94 (2005)
DOI:10.1016/j.anireprosci.2005.05.010
Reference
  Authors
DeGroot LJ, Jameson JL (ed).
  Title
Endocrinology (Fifth edition)
  Journal
Elsevier Saunders (2006)
Reference
PMID:10707049
  Authors
Naor Z, Benard O, Seger R.
  Title
Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor.
  Journal
Trends Endocrinol Metab 11:91-9 (2000)
DOI:10.1016/S1043-2760(99)00232-5
Reference
PMID:14596811
  Authors
Ruf F, Fink MY, Sealfon SC.
  Title
Structure of the GnRH receptor-stimulated signaling network: insights from genomics.
  Journal
Front Neuroendocrinol 24:181-99 (2003)
DOI:10.1016/S0091-3022(03)00027-X
Reference
PMID:12943720
  Authors
Farshori PQ, Shah BH, Arora KK, Martinez-Fuentes A, Catt KJ.
  Title
Activation and nuclear translocation of PKCdelta, Pyk2 and ERK1/2 by gonadotropin releasing hormone in HEK293 cells.
  Journal
J Steroid Biochem Mol Biol 85:337-47 (2003)
DOI:10.1016/S0960-0760(03)00226-7
Reference
PMID:15080147
  Authors
Shah BH, Catt KJ.
  Title
Matrix metalloproteinases in reproductive endocrinology.
  Journal
Trends Endocrinol Metab 15:47-9 (2004)
DOI:10.1016/j.tem.2004.01.004
Reference
PMID:12963732
  Authors
Roelle S, Grosse R, Aigner A, Krell HW, Czubayko F, Gudermann T.
  Title
Matrix metalloproteinases 2 and 9 mediate epidermal growth factor receptor transactivation by gonadotropin-releasing hormone.
  Journal
J Biol Chem 278:47307-18 (2003)
DOI:10.1074/jbc.M304377200
Reference
PMID:18708085
  Authors
Naor Z
  Title
Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor.
  Journal
Front Neuroendocrinol 30:10-29 (2009)
DOI:10.1016/j.yfrne.2008.07.001
Related
pathway
caua04010  MAPK signaling pathway
caua04020  Calcium signaling pathway
caua04060  Cytokine-cytokine receptor interaction
caua04080  Neuroactive ligand-receptor interaction
KO pathway
ko04912   
LinkDB

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