Entry
Name
Axon guidance - Camelus bactrianus (Bactrian camel)
Description
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class
Organismal Systems; Development and regeneration
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Camelus bactrianus (Bactrian camel) [GN:
cbai ]
Gene
105076495 LRRC4C; LOW QUALITY PROTEIN: leucine-rich repeat-containing protein 4C [KO:K07523 ]
105078942 PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859 ] [EC:3.1.4.11 ]
105066815 TRPC1; short transient receptor potential channel 1 isoform X1 [KO:K04964 ]
105067118 TRPC3; short transient receptor potential channel 3 isoform X1 [KO:K04966 ]
105066197 TRPC4; short transient receptor potential channel 4 isoform X1 [KO:K04967 ]
105075369 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105067906 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348 ] [EC:3.1.3.16 ]
105068979 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105074856 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333 ]
105068820 NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334 ]
105070875 CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
105075171 RGMA; LOW QUALITY PROTEIN: repulsive guidance molecule A [KO:K23096 ]
105079724 LRIG2; leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X1 [KO:K24609 ]
105074880 RASA1; LOW QUALITY PROTEIN: ras GTPase-activating protein 1 [KO:K04352 ]
105080234 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
105062385 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
105063651 GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630 ]
105075433 SRGAP2; SLIT-ROBO Rho GTPase-activating protein 2 isoform X1 [KO:K07526 ]
105081363 SRGAP1; LOW QUALITY PROTEIN: SLIT-ROBO Rho GTPase-activating protein 1 [KO:K07526 ]
105067425 SRGAP3; LOW QUALITY PROTEIN: SLIT-ROBO Rho GTPase-activating protein 3 [KO:K07526 ]
105074295 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
105063312 PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
105071167 PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
105066839 PIK3CB; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
105082679 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
105064416 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
105065663 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
105074832 PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093 ]
Compound
Reference
Authors
Guan KL, Rao Y.
Title
Signalling mechanisms mediating neuronal responses to guidance cues.
Journal
Reference
Authors
Govek EE, Newey SE, Van Aelst L.
Title
The role of the Rho GTPases in neuronal development.
Journal
Reference
Authors
Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
Title
Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
Journal
Reference
Authors
Negishi M, Oinuma I, Katoh H.
Title
Plexins: axon guidance and signal transduction.
Journal
Reference
Authors
Huot J.
Title
Ephrin signaling in axon guidance.
Journal
Reference
Authors
Patel BN, Van Vactor DL.
Title
Axon guidance: the cytoplasmic tail.
Journal
Reference
Authors
Yu TW, Bargmann CI.
Title
Dynamic regulation of axon guidance.
Journal
Reference
Authors
Dickson BJ.
Title
Molecular mechanisms of axon guidance.
Journal
Reference
Authors
Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
Title
The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
Journal
Reference
Authors
Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
Title
The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
Journal
Reference
Authors
Fujita Y, Yamashita T
Title
Axon growth inhibition by RhoA/ROCK in the central nervous system.
Journal
Reference
Authors
Yamashita T, Mueller BK, Hata K
Title
Neogenin and repulsive guidance molecule signaling in the central nervous system.
Journal
Reference
Authors
van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
Title
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
Journal
Related pathway
cbai04060 Cytokine-cytokine receptor interaction
KO pathway
LinkDB
All DBs