KEGG ORTHOLOGY: K04969

ORTHOLOGY: K04969

Entry

K04969                      KO

Symbol

TRPC6

Name

transient receptor potential cation channel subfamily C member 6

Pathway

map04022

cGMP-PKG signaling pathway

map04360

Axon guidance

Disease

H00626

Focal segmental glomerulosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    K04969  TRPC6; transient receptor potential cation channel subfamily C member 6
09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    K04969  TRPC6; transient receptor potential cation channel subfamily C member 6
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04969  TRPC6; transient receptor potential cation channel subfamily C member 6
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Transient receptor potential channel (TRP)
   K04969  TRPC6; transient receptor potential cation channel subfamily C member 6

Other DBs

GO:

0015279

TC:

1.A.4.1.5

Genes

HSA:	7225(TRPC6)

PTR:	451503(TRPC6)

PPS:	100973373(TRPC6)

GGO:	101123927(TRPC6)

PON:	100455441(TRPC6)

PPYG:

129008522(TRPC6)

NLE:	100605906(TRPC6)

HMH:	116476851(TRPC6)

SSYN:

129479549(TRPC6)

MCC:	703611(TRPC6)

MCF:	102130248(TRPC6)

MTHB:

126936000

MNI:	105466503(TRPC6)

CSAB:

103248323(TRPC6)

CATY:

105591393(TRPC6)

PANU:

101023239(TRPC6)

TGE:	112607393(TRPC6)

MLEU:

105542726(TRPC6)

RRO:	104658787(TRPC6)

RBB:	108539706(TRPC6)

TFN:	117079924(TRPC6)

PTEH:

111540062(TRPC6)

CANG:

105500927(TRPC6)

CJC:	100395510(TRPC6)

SBQ:	101029846(TRPC6)

CIMI:

108316159(TRPC6)

ANAN:

105719044(TRPC6)

CSYR:

103273835(TRPC6)

MMUR:

105874578(TRPC6)

LCAT:

123641990(TRPC6)

PCOQ:

105822222(TRPC6)

OGA:	100946652(TRPC6)

MMU:	22068(Trpc6)

MCAL:

110301686(Trpc6)

MPAH:

110327426(Trpc6)

RNO:	89823(Trpc6)

MCOC:

116073047(Trpc6)

ANU:	117699749(Trpc6)

ASYL:

127689440(Trpc6)

MUN:	110540902(Trpc6)

CGE:	100757179(Trpc6)

MAUA:

101824973(Trpc6)

PROB:

127232829(Trpc6)

PLEU:

114707998(Trpc6)

MORG:

121451557(Trpc6)

MFOT:

126513704

AAMP:

119809721(Trpc6)

NGI:	103746485(Trpc6)

HGL:	101722559(Trpc6)

CPOC:

100135637(Trpc6)

CCAN:

109685024(Trpc6)

DORD:

105980650(Trpc6)

DSP:	122110242(Trpc6)

PLOP:

125349691(Trpc6)

NCAR:

124958780

MMMA:

107145719(Trpc6)

ITI:	101960109(Trpc6)

OCU:

100347206

OPI:	101524796(TRPC6)

TUP:	102495983(TRPC6)

GVR:	103605281(TRPC6)

CFA:	489435(TRPC6)

CLUD:

112671455(TRPC6)

VVP:	112925930(TRPC6)

VLG:	121499373(TRPC6)

NPO:	129496617(TRPC6)

AML:	100479387(TRPC6)

UMR:	103662550(TRPC6)

UAH:	113260153(TRPC6)

UAR:	123792490(TRPC6)

ELK:

111153888

LLV:

125079921

MPUF:

101673330(TRPC6)

MNP:	131998782(TRPC6)

MLK:	131834432(TRPC6)

NVS:	122913434(TRPC6)

ORO:	101381341(TRPC6)

EJU:	114211427(TRPC6)

ZCA:	113914443(TRPC6)

MLX:	118013137(TRPC6)

NSU:	110582062(TRPC6)

LWW:	102742756(TRPC6)

FCA:	101082685(TRPC6)

PYU:	121020808(TRPC6)

PCOO:

112865903(TRPC6)

PBG:	122482877(TRPC6)

PVIV:

125176888(TRPC6)

LRUF:

124504816

LGF:	123600574(TRPC6)

AJU:

106976483

PTG:	102952877(TRPC6)

PPAD:

109257529(TRPC6)

PUC:

125910903

PLEZ:

122199984(TRPC6)

HHV:	120219674(TRPC6)

BTA:	407151(TRPC6)

BOM:	102285734(TRPC6)

BIU:	109569956(TRPC6)

BBUB:

102412671(TRPC6)

BBIS:

104994605(TRPC6)

CHX:	102177817(TRPC6)

OAS:	101121117(TRPC6)

BTAX:

128060428(TRPC6)

CSUM:

138092532(TRPC6)

ODA:	120876171(TRPC6)

CCAD:

122450041(TRPC6)

MREE:

136174183(TRPC6)

OVR:	110121590(TRPC6)

MBEZ:

129554256(TRPC6)

SSC:	100271728(TRPC6)

CFR:	102512774(TRPC6)

CBAI:

105083582(TRPC6)

CDK:	105087183(TRPC6)

VPC:	102531384(TRPC6)

BACU:

103005319(TRPC6)

BMUS:

118900136(TRPC6)

LVE:	103085471(TRPC6)

OOR:	101274391(TRPC6)

LALB:

132526253(TRPC6)

DLE:	111168367(TRPC6)

PCAD:

102976927(TRPC6)

PSIU:

116757835(TRPC6)

PPHC:

136126293(TRPC6)

NASI:

112409973(TRPC6)

ECB:	100061175(TRPC6)

EPZ:	103558241(TRPC6)

EAI:	106844984(TRPC6)

MYB:	102239842(TRPC6)

MYD:	102755044(TRPC6)

MMYO:

118664478(TRPC6)

MLF:	102423701(TRPC6)

MDT:	132240629(TRPC6)

MYUM:

139017460(TRPC6)

PKL:	118712865(TRPC6)

EFUS:

103292957(TRPC6)

MNA:	107532350(TRPC6)

DRO:	112317520(TRPC6)

SHON:

118975675(TRPC6)

AJM:	119058039(TRPC6)

PDIC:

114500762(TRPC6)

PHAS:

123805457(TRPC6)

MMF:	118627902(TRPC6)

PPAM:

129086037(TRPC6)

RFQ:	117029781(TRPC6)

PALE:

102883120(TRPC6)

PGIG:

120618091(TRPC6)

PVP:	105298272(TRPC6)

RAY:	107504646(TRPC6)

MJV:	108385701(TRPC6)

TOD:	119240414(TRPC6)

SARA:

101546960(TRPC6)

SFUM:

130024317(TRPC6)

SETR:

126016033(TRPC6)

LAV:	100658414(TRPC6)

TMU:

101344157

ETF:	101660573(TRPC6)

DNM:	101421897(TRPC6)

MDO:	100011660(TRPC6)

GAS:	123238980(TRPC6)

SHR:	100934690(TRPC6)

AFZ:

127554913

PCW:	110215009(TRPC6)

TVP:	118837982(TRPC6)

PBRV:

138154737(TRPC6)

OAA:	100079408(TRPC6)

TACU:

119941441(TRPC6)

GGA:	418989(TRPC6)

PCOC:

116244462(TRPC6)

MGP:	100545253(TRPC6)

CJO:	107308386(TRPC6)

TPAI:

128074799(TRPC6)

LMUT:

125688355(TRPC6)

NMEL:

110390063(TRPC6)

APLA:

101792490(TRPC6)

ACYG:

106034201(TRPC6)

CATA:

118245887(TRPC6)

AFUL:

116495494(TRPC6)

TGU:	100217642(TRPC6)

LSR:	110470013(TRPC6)

SCAN:

103827277(TRPC6)

PMOA:

120506759(TRPC6)

OTC:	121342558(TRPC6)

PRUF:

121364272(TRPC6)

ATRC:

139593353(TRPC6)

GFR:	102032318(TRPC6)

FAB:	101819991(TRPC6)

OMA:	130248453(TRPC6)

PHI:	102109392(TRPC6)

PMAJ:

107213387(TRPC6)

CCAE:

111924428(TRPC6)

CCW:	104690071(TRPC6)

CBRC:

103611337(TRPC6)

ACOE:

138110249(TRPC6)

ETL:	114065874(TRPC6)

ZAB:	102071456(TRPC6)

ZLE:	135450423(TRPC6)

ACHL:

103801942(TRPC6)

SVG:	106859387(TRPC6)

MMEA:

130576278(TRPC6)

HRT:	120748672(TRPC6)

SATI:

136357568(TRPC6)

CCIC:

134057487(TRPC6)

FPG:	101923731(TRPC6)

FCH:	102052129(TRPC6)

CCRI:

104157639(TRPC6)

NNT:	104409841(TRPC6)

SHAB:

115603644(TRPC6)

ACUN:

113485250(TRPC6)

TALA:

104366464(TRPC6)

ACHC:

115353557(TRPC6)

HALD:

104324175

HLE:	104838459(TRPC6)

AGEN:

126048299

HHAR:

128153499(TRPC6)

GCL:

127015048

CSTI:

104562461

LDI:	104343078(TRPC6)

MNB:

103774479

DPUB:

104298363(TRPC6)

PPUS:

135189769(TRPC6)

AVIT:

104268254(TRPC6)

BRHI:

104487842(TRPC6)

EGZ:	104135783(TRPC6)

NNI:	104023127(TRPC6)

PCRI:

104032838(TRPC6)

PADL:

103926055(TRPC6)

AFOR:

103900621(TRPC6)

FGA:	104083414(TRPC6)

GSTE:

104264935(TRPC6)

CBOY:

140648745(TRPC6)

CLV:	102091070(TRPC6)

CNIC:

135987556(TRPC6)

MUI:	104543248(TRPC6)

PGUU:

104469334(TRPC6)

PLET:

104627745(TRPC6)

EHS:	104513616(TRPC6)

CMAC:

104473181

CUCA:

104055311(TRPC6)

TEO:	104370770(TRPC6)

BREG:

104635282

OHA:	104333026(TRPC6)

ACAR:

104527558(TRPC6)

CPEA:

104390266(TRPC6)

CVF:	104290319(TRPC6)

RTD:	128903880(TRPC6)

CRID:

134513342(TRPC6)

AAM:	106495527(TRPC6)

AROW:

112969939(TRPC6)

NPD:	112943718(TRPC6)

TGT:	104580722(TRPC6)

DNE:	112988549(TRPC6)

SCAM:

104143703(TRPC6)

ASN:

102369493

AMJ:	106737140(TRPC6)

CPOO:

109306742(TRPC6)

GGN:	109303135(TRPC6)

PSS:	102451460(TRPC6)

CMY:	102940225(TRPC6)

CCAY:

125633803(TRPC6)

DCC:	119844606(TRPC6)

CPIC:

101945471(TRPC6)

TST:	117871185(TRPC6)

CABI:

116822634

MRV:	120389420(TRPC6)

ACS:	100554810(trpc6)

ASAO:

132772207(TRPC6)

PVT:	110080248(TRPC6)

SUND:

121924717(TRPC6)

PBI:	103056319(TRPC6)

PMUR:

107293575(TRPC6)

CTIG:

120305931(TRPC6)

TSR:

106548408

PGUT:

117660739(TRPC6)

PCAE:

139317064(TRPC6)

APRI:

131199826(TRPC6)

PTEX:

113440503(TRPC6)

NSS:	113417296(TRPC6)

VKO:	123029499(TRPC6)

PMUA:

114595652(TRPC6)

PRAF:

128412578(TRPC6)

ZVI:	118084951(TRPC6)

HCG:	128352523(TRPC6)

GJA:

107125614

STOW:

125431266(TRPC6)

EMC:	129325953(TRPC6)

XLA:	108708737(trpc6.L) 108709028

XTR:	100493327(trpc6)

NPR:	108792715(TRPC6)

RTEM:

120929018(TRPC6)

ACAT:

141126970(TRPC6)

BBUF:

120996412(TRPC6)

BGAR:

122931936(TRPC6)

DTC:	141096385(TRPC6)

PWL:	138248641(TRPC6)

MUO:	115468485(TRPC6)

GSH:	117362992(TRPC6)

DRE:	102725535(trpc6b) 563989(trpc6a)

SRX:	107713306 107718961 107731462(trpc6)

SANH:

107681080(trpc6) 107691992 107703531

SGH:	107548129(trpc6) 107551642 107563508

CCAR:

109067630(trpc6a) 109109123(trpc6b)

CAUA:

113038610(trpc6) 113061698 113064288 113118749

CGIB:

127934468 127941857 127976924 127985786

PTET:

122326674(trpc6a) 122363158(trpc6b)

LROH:

127152788(trpc6a) 127180895(trpc6b)

GRF:	141292603(trpc6a) 141346185(trpc6b)

OMC:	131524271(trpc6b) 131529416(trpc6a)

PPRM:

120460042(trpc6b) 120494578(trpc6a)

RKG:	130073769(trpc6b) 130096503(trpc6a)

MAMB:

125253473(trpc6a) 125254163(trpc6b)

CIDE:

127500075 127503258

CERY:

137012832(trpc6a) 137022576(trpc6b)

MASI:

127416749 127428900 127431195 127455678

TROS:

130562730(trpc6b) 130570222(trpc6a)

TDW:	130408501(trpc6a) 130435504(trpc6b)

MANU:

129419390(trpc6b) 129423818(trpc6a)

PDAB:

135746391(trpc6b) 135776296(trpc6a)

IPU:	108264040(trpc6b) 108279060(trpc6a)

IFU:	128606968(trpc6b) 128622066(trpc6a)

PHYP:

113534583 113541495(trpc6)

SMEO:

124396036(trpc6b) 124397686(trpc6a)

TFD:	113634940(trpc6a) 113652679(trpc6b)

TVC:	132851689(trpc6b) 132859558(trpc6a)

CGAR:

128507231(trpc6a) 128527795(trpc6b)

NGRA:

132888262(trpc6b) 132895458(trpc6a)

TRN:	134322953(trpc6b) 134330168(trpc6a)

AMEX:

103025180(trpc6a) 103030189(trpc6b)

CMAO:

118817963(trpc6b) 118819912(trpc6a)

EEE:	113573977 113577460

CHAR:

105895379(trpc6a)

SPIL:

134079461(trpc6a)

TRU:	101067110 101068175

TFS:	130535090(trpc6b) 130537181(trpc6a)

TNG:	GSTEN00018975G001 GSTEN00035241G001

LCO:	104925978(trpc6) 104934506

NCC:	104962653 104964660

TBEN:

117468803(trpc6b) 117490450(trpc6a)

CGOB:

115017685(trpc6) 115018885

PGEO:

117457259(trpc6b) 117458764(trpc6a)

GACU:

117536182 117562026(trpc6b)

EMAC:

134872086(trpc6a) 134880855(trpc6b)

ELY:	117259875 117262737(trpc6a)

EFO:	125888736(trpc6b) 125898100(trpc6a)

PLEP:

121943479(trpc6b) 121953087(trpc6a)

SLUC:

116048417(trpc6b) 116064817(trpc6a)

ECRA:

117938446(trpc6b) 117955158(trpc6a)

ESP:	116682665(trpc6) 116700001

PFLV:

114552702 114566227

GAT:	120818552(trpc6b) 120822352(trpc6a)

PPUG:

119209162(trpc6b) 119215582(trpc6a)

AFB:	129089592(trpc6b) 129113087(trpc6a)

CLUM:

117741353(trpc6b) 117742635(trpc6a)

PSWI:

130209811(trpc6a) 130210265(trpc6b)

CANA:

137790363(trpc6b) 137802440(trpc6a)

CVE:	137875086(trpc6b) 137876360(trpc6a)

MSAM:

119882483(trpc6b) 119895197(trpc6a)

SCHU:

122878994(trpc6b) 122888658(trpc6a)

CUD:	121515893(trpc6b) 121519194(trpc6a)

SPUL:

138596787(trpc6a) 138596879(trpc6b)

LMIX:

132980750(trpc6b) 132987893(trpc6a)

ALAT:

119009479(trpc6b) 119031899(trpc6a)

ASTR:

137597096(trpc6b) 137606746(trpc6a)

MZE:	101482901 101486047

ONL:	100698870(trpc6) 100706122

OAU:	116313604(trpc6a) 116329244(trpc6b)

OLA:	101169223 101172353

OML:	112138659(trpc6a) 112149075(trpc6b)

CSAI:

133441960(trpc6b) 133459638(trpc6a)

XMA:	102232953 102237023

XCO:	114133615 114152827

XHE:	116708248 116728133

PRET:

103475033(trpc6) 103475477

PFOR:

103141029 103150361

PLAI:

106955046 106957724

PMEI:

106919006(trpc6) 106921272

GAF:	122833038(trpc6b) 122844409(trpc6a)

PPRL:

129359349(trpc6b) 129368822(trpc6a)

CVG:	107093470(trpc6) 107098507

CTUL:

119775857(trpc6a) 119782069(trpc6b)

GMU:	124876225(trpc6a)

NFU:	107380180(trpc6) 107386363

KMR:	108236037(trpc6b) 108236899(trpc6a)

ALIM:

106514081 106520599(trpc6)

NWH:	119411367(trpc6b) 119420744

AOCE:

111566218(trpc6a) 111575398(trpc6b)

EJA:	138196403(trpc6a) 138205313(trpc6b)

BFRE:

138631404(trpc6b) 138634694(trpc6a)

MCEP:

125013092(trpc6b) 125021458(trpc6a)

CSEM:

103377966 103395114

POV:	109628384 109630147(trpc6)

SSEN:

122760504 122762532 122773073(trpc6b)

SSOE:

131458430(trpc6a) 131463181(trpc6b)

HHIP:

117773360(trpc6b) 117774162(trpc6a)

HSP:	118105865(trpc6b) 118122175(trpc6a)

PPLT:

128440071(trpc6b) 128456722(trpc6a)

SMAU:

118299876(trpc6b) 118301145(trpc6a)

LCF:	108876169(trpc6b) 108893714(trpc6a)

SDU:	111233640(trpc6) 111234535

SLAL:

111654061 111666228

XGL:	120791792(trpc6b) 120802265(trpc6a)

HCQ:	109509759 109526194

SSCV:

125971895(trpc6b) 125982290(trpc6a)

SBIA:

133492182(trpc6a) 133504421(trpc6b)

PEE:	133405110(trpc6b) 133415980(trpc6a)

PTAO:

133467403 133482522(trpc6b)

BPEC:

110158353 110163758

ENY:	140360771(trpc6a) 140366879

MALB:

109959210 109968474

BSPL:

114868312(trpc6b) 114869501(trpc6a)

SJO:	128359858(trpc6b) 128370984(trpc6a)

SSCO:

133981006(trpc6b) 133994422(trpc6a)

GMH:	115546535 115560825

SASA:

106581586

STRU:

115155041 115163862(trpc6)

OTW:	112236610(trpc6b) 112237126

OMY:	110507252(trpc6b) 110533246(trpc6a)

OGO:	123990980 123993883(trpc6b)

ONE:	115116006 115128094

OKI:	109873346 109883923

OKE:	118379925 118380829(trpc6b)

OMM:

135553495

OCLA:

139385804 139385805 139417898

SALP:

112070165 112073897

SNH:	120018910(trpc6b) 120056726

CCLU:

121559375 121566965(trpc6b)

ELS:	105006665 106024038

OEP:	134028807(trpc6b) 134039341(trpc6a)

SFM:

108924678

PKI:	111837964(trpc6)

AANG:

118209580 118235588(trpc6a)

AROT:

135236574(trpc6b) 135258487(trpc7b) 135263751(trpc6a)

CCOG:

133108612 133133293(trpc6a)

LOC:	102693540(trpc6)

ARUT:

117405188 117972628

PSEX:

120523242(trpc6a)

LCM:

CMK:

RTP:

CPLA:

HOC:

LERI:

HAKA:

BFO:

BBEL:

SPU:	580692 584724

LPIC:

129259661 129263430 129267320

AJJ:	139963801 139984213

ARUN:

117300964 117301858 117303380 117303603

AAMU:

139948290 139950127 139953317

AFIL:

140162956

PFLL:

139115635 139115842 139126072 139129601 139129622 139133153 139133573 139134684 139140282 139149103 139149104 139149108 139149109 139149111

CGIG:

LBD:

AROA:

AGRG:

AGB:

PPYR:

AGS:

RMD:

ACOO:

DVT:	126897942 126899483

IEL:

TCF:

LPOL:

PVUL:

PCAN:

112556131 112558840 112559820 112559821

LSAX:

138952831 138965664 138965681 138971986 138978888

BGT:	106053674 106062840 106066048

GAE:	121378604 121388093 121390271

HRF:	124110756 124138946 124138947 124139082

HRJ:	124262554 124271384 124272048 124290248

HASI:

137258337 137258338 137258440 137261657 137268320 137283606

HCRA:

139447768 139454169 139469619 139477682

CRG:	105320869 105327021 117682600

CANU:

128161805 128189802 128190596

CVN:	111107230 111110362 111127290 111136627

OED:	125650209 125683255 130051451

PMAX:

117314627 117337596

AIRR:

138315549 138315789

MMER:

123548405 123564762

RPHI:

132740347 132743270 132747832

DPOL:

127846244

MAEA:

128223091 128242890 128242915

OBI:

106878508

OSN:	115213014 115215437 115220538

LJP:	135465740 135467264 135472939 135475597 135475625 135479479 135479687

LAK:	106151511 106154271 106154886 106154900 106179893

LLON:

135486275 135494094 135497360

EPA:

110244770

ATEN:

116300554

MCAZ:

138029384 138029404 138029440

MFOO:

137984999 137993662

PDAM:

113672142

» show all

Reference

PMID:15924139

Authors

Reiser J, Polu KR, Moller CC, Kenlan P, Altintas MM, Wei C, Faul C, Herbert S, Villegas I, Avila-Casado C, McGee M, Sugimoto H, Brown D, Kalluri R, Mundel P, Smith PL, Clapham DE, Pollak MR

Title

TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function.

Journal

Nat Genet 37:739-44 (2005)
DOI:10.1038/ng1592

Sequence

[hsa:7225]

LinkDB

DBGET integrated database retrieval system