PATHWAY: ccar04145 Help
Entry
Name
Phagosome - Cyprinus carpio (common carp)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Cyprinus carpio (common carp) [GN:
ccar ]
Gene
109059998 H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751 ]
109060009 H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751 ]
109062092 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
109074733 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751 ]
109049157 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
109056657 H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751 ]
109085839 patr class I histocompatibility antigen, A-5 alpha chain-like [KO:K06751 ]
109059573 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751 ]
109091263 LOW QUALITY PROTEIN: major histocompatibility complex class I-related gene protein-like [KO:K06751 ]
109062694 class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like [KO:K06751 ]
109111459 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751 ]
109052650 H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
109053239 LOW QUALITY PROTEIN: H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
109053241 H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752 ]
109053242 rano class II histocompatibility antigen, A beta chain-like [KO:K06752 ]
109052679 H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
109053193 H-2 class II histocompatibility antigen, A-U alpha chain-like isoform X1 [KO:K06752 ]
109112544 HLA class II histocompatibility antigen, DP alpha 1 chain-like isoform X1 [KO:K06752 ]
109109117 H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
109109118 H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752 ]
109056324 H-2 class II histocompatibility antigen, E-D alpha chain-like [KO:K06752 ]
109051706 H-2 class II histocompatibility antigen, A-U alpha chain-like isoform X1 [KO:K06752 ]
109051707 H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
109068517 HLA class II histocompatibility antigen, DO alpha chain-like [KO:K06752 ]
109112903 HLA class II histocompatibility antigen, DO alpha chain-like [KO:K06752 ]
109060117 H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
109060118 H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
109094894 H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
109084771 H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
109084772 HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752 ]
109095323 rano class II histocompatibility antigen, A beta chain-like isoform X1 [KO:K06752 ]
109095325 H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
109107207 rano class II histocompatibility antigen, A beta chain-like [KO:K06752 ]
109061736 H-2 class II histocompatibility antigen, I-E beta chain-like [KO:K06752 ]
109061739 RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752 ]
109082076 H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
109101049 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
109102785 RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752 ]
109078172 hepatocyte growth factor-regulated tyrosine kinase substrate-like [KO:K12182 ]
109081789 LOW QUALITY PROTEIN: hepatocyte growth factor-regulated tyrosine kinase substrate-like [KO:K12182 ]
109071070 LOW QUALITY PROTEIN: V-type proton ATPase subunit B, brain isoform-like [KO:K02147 ]
109058748 LOW QUALITY PROTEIN: V-type proton ATPase subunit C 1-A-like [KO:K02148 ]
109053873 LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a-like [KO:K02154 ]
109063712 LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a-like [KO:K02154 ]
109059433 V-type proton ATPase 16 kDa proteolipid subunit-like isoform X1 [KO:K02155 ]
109062620 LOW QUALITY PROTEIN: cytoplasmic dynein 1 intermediate chain 1-like [KO:K10415 ]
109061597 cytoplasmic dynein 1 intermediate chain 1-like isoform X1 [KO:K10415 ]
109092169 cytoplasmic dynein 1 intermediate chain 2-like isoform X1 [KO:K10415 ]
109111811 LOW QUALITY PROTEIN: cytoplasmic dynein 1 light intermediate chain 1-like [KO:K10416 ]
109076693 cytoplasmic dynein 1 light intermediate chain 2-like isoform X1 [KO:K10416 ]
109046826 cytoplasmic dynein 1 light intermediate chain 1-like isoform X1 [KO:K10416 ]
109093271 cytoplasmic dynein 1 light intermediate chain 2-like isoform X1 [KO:K10416 ]
109106208 cytoplasmic dynein 1 light intermediate chain 2-like isoform X1 [KO:K10416 ]
109087165 lysosome-associated membrane glycoprotein 1-like isoform X1 [KO:K06528 ]
109091081 sec61a1; protein transport protein Sec61 subunit alpha [KO:K10956 ]
109105977 protein transport protein Sec61 subunit beta-like isoform X1 [KO:K09481 ]
109113600 LOW QUALITY PROTEIN: protein transport protein Sec61 subunit gamma-like [KO:K07342 ]
109113072 high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498 ]
109090404 LOW QUALITY PROTEIN: scavenger receptor class B member 1-like [KO:K13885 ]
109053980 ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392 ]
Compound
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
Authors
Stuart LM, Ezekowitz RA
Title
Phagocytosis: elegant complexity.
Journal
Reference
Authors
Tjelle TE, Lovdal T, Berg T
Title
Phagosome dynamics and function.
Journal
Reference
Authors
Dupuy AG, Caron E
Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
Journal
Reference
Authors
Brumell JH, Grinstein S
Title
Salmonella redirects phagosomal maturation.
Journal
Reference
Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
Journal
Reference
Authors
Luzio JP, Pryor PR, Bright NA
Title
Lysosomes: fusion and function.
Journal
Reference
Authors
Sumimoto H
Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
Journal
Related pathway
ccar04620 Toll-like receptor signaling pathway
KO pathway
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