KEGG   PATHWAY: clv00230
Entry
clv00230                    Pathway                                
Name
Purine metabolism - Columba livia (rock pigeon)
Class
Metabolism; Nucleotide metabolism
Pathway map
clv00230  Purine metabolism
clv00230

Module
clv_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:clv00230]
clv_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:clv00230]
clv_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:clv00230]
clv_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:clv00230]
clv_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:clv00230]
clv_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:clv00230]
Other DBs
GO: 0006163 0042278
Organism
Columba livia (rock pigeon) [GN:clv]
Gene
102084140  NUDT9; ADP-ribose pyrophosphatase, mitochondrial [KO:K13988] [EC:3.6.1.13]
102096818  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
102084865  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
102098032  PGM1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
102098104  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
102090424  ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
102094075  LOW QUALITY PROTEIN: ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
102094405  PPAT; amidophosphoribosyltransferase isoform X1 [KO:K00764] [EC:2.4.2.14]
102088577  trifunctional purine biosynthetic protein adenosine-3-like isoform X1 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
102096509  GART; trifunctional purine biosynthetic protein adenosine-3 isoform X1 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
102094220  PAICS; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
102085431  uncharacterized protein LOC102085431 isoform X1 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
102094680  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
102094523  ATIC; LOW QUALITY PROTEIN: bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
102090841  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
102086436  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
102090381  cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
102087649  cytosolic 5'-nucleotidase 1B [KO:K01081] [EC:3.1.3.5]
102089317  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
102083969  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
102088365  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
102093549  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
102085091  PNP; purine nucleoside phosphorylase isoform X3 [KO:K03783] [EC:2.4.2.1]
102098949  LACC1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
102088328  hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
102095993  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
102098303  IMPDH2; LOW QUALITY PROTEIN: inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
102089990  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
102089814  nucleoside diphosphate kinase-like isoform X1 [KO:K00940] [EC:2.7.4.6]
102097779  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
102096005  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
102083428  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
106145761  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
102096691  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
102097064  adenylate kinase 9-like isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
102097422  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
102096210  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
102083509  ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
102083693  ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
102095399  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
102084729  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
102092438  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
102084705  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
102095170  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
102084263  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
102092037  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
102090406  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
102089192  GMPS; LOW QUALITY PROTEIN: GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
102084191  GMPR; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
102092167  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
102092316  GUK1; guanylate kinase [KO:K00942] [EC:2.7.4.8]
102092480  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
102089725  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
102098900  RRM2; LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
102092661  HDDC2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
102089555  DGUOK; deoxyguanosine kinase, mitochondrial [KO:K00904] [EC:2.7.1.113]
102092948  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
102091484  deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
102094692  PRUNE1; LOW QUALITY PROTEIN: exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
102094612  ADCY1; LOW QUALITY PROTEIN: adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
102097532  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
102092425  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
102085466  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
102092552  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
102090470  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
102086133  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
102095574  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
102090855  GUCY1A3; guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
102097143  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
102091873  GUCY1B3; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
102091284  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
102098904  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
102095707  LOW QUALITY PROTEIN: retinal guanylyl cyclase 1-like [KO:K12321] [EC:4.6.1.2]
102086091  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
102097001  LOW QUALITY PROTEIN: atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
102098846  NPR2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
102088233  atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
102086814  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X6 [KO:K13755] [EC:3.1.4.17]
102094883  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
102098603  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
102095986  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase [KO:K18283] [EC:3.1.4.17]
102086522  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
102098034  PDE3B; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
102090682  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X5 [KO:K13762] [EC:3.1.4.35]
102089467  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
102092176  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
102086877  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
102096756  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
102096582  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
102085261  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
102085640  PDE10A; LOW QUALITY PROTEIN: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
102083914  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
102098840  ADSSL1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
102091762  ADSS; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
102096385  AMPD2; AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
102083441  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
102085131  AMPD3; LOW QUALITY PROTEIN: AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
102086891  ADK; adenosine kinase [KO:K00856] [EC:2.7.1.20]
102096522  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
102094705  ADA2; adenosine deaminase CECR1 isoform X2 [KO:K19572] [EC:3.5.4.4]
102098125  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
102087854  AK1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
102087316  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
102089976  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
102087850  AK8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
102087041  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
102092799  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
102090510  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
102091586  ENTPD2; LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
102088824  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
102092189  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
102092374  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
102088899  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A [KO:K13293] [EC:3.1.4.53]
102097469  PDE4C; LOW QUALITY PROTEIN: cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
102083589  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
102096528  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
102093471  cAMP-specific 3',5'-cyclic phosphodiesterase 4D [KO:K13293] [EC:3.1.4.53]
102096010  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
102095903  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X2 [KO:K18436] [EC:3.1.4.53]
102096680  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
102083643  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
102093137  FHIT; bis(5'-adenosyl)-triphosphatase isoform X1 [KO:K01522] [EC:3.6.1.29]
102095285  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 isoform X1 [KO:K18424] [EC:3.6.1.29]
102093717  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
102083553  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
102096622  uricase [KO:K00365] [EC:1.7.3.3]
102087338  cadherin-1 [KO:K13484] [EC:3.5.2.17 4.1.1.97]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
clv00030  Pentose phosphate pathway
clv00220  Arginine biosynthesis
clv00250  Alanine, aspartate and glutamate metabolism
clv00260  Glycine, serine and threonine metabolism
clv00340  Histidine metabolism
clv00630  Glyoxylate and dicarboxylate metabolism
clv00730  Thiamine metabolism
clv00740  Riboflavin metabolism
clv00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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