KEGG   PATHWAY: csab04728
Entry
csab04728                   Pathway                                
Name
Dopaminergic synapse - Chlorocebus sabaeus (green monkey)
Description
Dopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning and memory, and endocrine regulation. Once released from presynaptic axonal terminals, DA interacts with at least five receptor subtypes in the central nervous system (CNS), which have been divided into two groups: the D1-like receptors (D1Rs), comprising D1 and D5 receptors, both positively coupled to adenylyl cyclase and cAMP production, and the D2-like receptors (D2Rs), comprising D2, D3, and D4 receptors, whose activation results in inhibition of adenylyl cyclase and suppression of cAMP production. In addition, D1Rs and D2Rs modulate intracellular Ca2+ levels and a number of Ca2+ -dependent intracellular signaling processes. Through diverse cAMP- and Ca2+-dependent and - independent mechanisms, DA influences neuronal activity, synaptic plasticity, and behavior. Presynaptically localized D2Rs regulate synthesis and release of DA as the main autoreceptor of the dopaminergic system.
Class
Organismal Systems; Nervous system
Pathway map
csab04728  Dopaminergic synapse
csab04728

Other DBs
GO: 0001963
Organism
Chlorocebus sabaeus (green monkey) [GN:csab]
Gene
103238895  TH; tyrosine hydroxylase [KO:K00501] [EC:1.14.16.2]
103226076  DDC; dopa decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
103216582  SLC18A2; solute carrier family 18 member A2 [KO:K08155]
103215416  SLC18A1; solute carrier family 18 member A1 [KO:K08155]
103245015  DRD1; dopamine receptor D1 [KO:K04144]
103246373  DRD5; dopamine receptor D5 [KO:K05840]
103245966  CALY; calcyon neuron specific vesicular protein [KO:K15493]
103219624  GNAQ; G protein subunit alpha q [KO:K04634]
103233299  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
103246591  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
103246657  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
103245842  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
103227941  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103218776  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
103221654  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103245424  CALML4; calmodulin like 4 [KO:K02183]
103237820  CALML5; calmodulin like 5 [KO:K02183]
103237822  CALML3; calmodulin like 3 [KO:K02183]
103229541  CALM1; calmodulin 1 [KO:K02183]
103234915  CALM3; calmodulin 3 [KO:K02183]
103220326  CALM2; calmodulin 2 [KO:K02183]
103236144  CAMK2D; calcium/calmodulin dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
103215984  CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
103226136  CAMK2B; calcium/calmodulin dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
103244792  CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
103236040  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
103215997  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
103215459  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
103243171  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
103229829  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
103235232  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
103229352  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
103243509  GNAS; GNAS complex locus [KO:K04632]
103243499  neuroendocrine secretory protein 55 [KO:K04632]
103222785  GNAL; G protein subunit alpha L [KO:K04633]
103228169  ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
103219549  PRKACG; protein kinase cAMP-activated catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
103224540  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103234377  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
103217717  CREB1; cAMP responsive element binding protein 1 [KO:K05870]
103217363  ATF2; activating transcription factor 2 [KO:K04450]
103223345  ATF4; activating transcription factor 4 [KO:K04374]
103236571  CREB3L1; cAMP responsive element binding protein 3 like 1 [KO:K09048]
103223942  CREB3L4; cAMP responsive element binding protein 3 like 4 [KO:K09048]
103226974  CREB3L2; cAMP responsive element binding protein 3 like 2 [KO:K09048]
103233716  CREB3L3; cAMP responsive element binding protein 3 like 3 [KO:K09048]
103219209  CREB3; cAMP responsive element binding protein 3 [KO:K09048]
103226299  CREB5; cAMP responsive element binding protein 5 [KO:K09047]
103221718  ATF6B; activating transcription factor 6 beta [KO:K09049]
103221595  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103221596  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
103223551  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103223553  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103245120  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
103215844  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
103235918  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
103243539  PPP1R1B; protein phosphatase 1 regulatory inhibitor subunit 1B [KO:K15494]
103218909  PPP1CA; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
103220572  PPP1CB; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
103239526  PPP1CC; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
103217230  SCN1A; sodium voltage-gated channel alpha subunit 1 [KO:K04833]
103218385  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
103227762  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
103234371  CACNA1A; calcium voltage-gated channel subunit alpha1 A [KO:K04344]
103239541  CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
103217112  KCNJ3; potassium voltage-gated channel subfamily J member 3 [KO:K04997]
103218752  KCNJ6; potassium voltage-gated channel subfamily J member 6 [KO:K05000]
103223740  KCNJ9; potassium voltage-gated channel subfamily J member 9 [KO:K05002]
103248811  KCNJ5; potassium voltage-gated channel subfamily J member 5 [KO:K04999]
103228289  DRD3; dopamine receptor D3 [KO:K04146]
103231255  DRD4; dopamine receptor D4 [KO:K04147]
103227664  GNAI2; G protein subunit alpha i2 [KO:K04630]
103224284  GNAI3; G protein subunit alpha i3 [KO:K04630]
103226652  GNAI1; G protein subunit alpha i1 [KO:K04630]
103233012  GNAO1; G protein subunit alpha o1 [KO:K04534]
103225777  GNB1; G protein subunit beta 1 [KO:K04536]
103246723  GNB2; G protein subunit beta 2 [KO:K04537]
103218476  GNB3; G protein subunit beta 3 [KO:K07825]
103221209  GNB4; G protein subunit beta 4 [KO:K04538]
103245611  GNB5; G protein subunit beta 5 [KO:K04539]
103228983  GNG2; G protein subunit gamma 2 [KO:K07826]
103233940  GNG3; G protein subunit gamma 3 [KO:K04540]
103236336  GNG5; G protein subunit gamma 5 [KO:K04542]
103233652  GNG7; G protein subunit gamma 7 [KO:K04543]
103234920  GNG8; G protein subunit gamma 8 [KO:K04544]
103219014  GNG10; G protein subunit gamma 10 [KO:K04545]
103226542  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
103224649  GNG12; G protein subunit gamma 12 [KO:K04347]
103243636  GNGT2; G protein subunit gamma transducin 2 [KO:K04549]
103248489  DRD2; dopamine receptor D2 [KO:K04145]
103248056  ARRB1; arrestin beta 1 [KO:K04439]
103242194  ARRB2; arrestin beta 2 [KO:K04439]
103244545  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
103215586  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
103235167  PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha [KO:K03456]
103248442  PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
103216725  PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta [KO:K04354]
103244749  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
103215510  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
103246406  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
103247478  PPP2R3B; protein phosphatase 2 regulatory subunit B''beta [KO:K11583]
103241631  PPP2R3A; protein phosphatase 2 regulatory subunit B''alpha [KO:K11583]
103228818  PPP2R3C; protein phosphatase 2 regulatory subunit B''gamma [KO:K11583]
103232471  PPP2R5B; protein phosphatase 2 regulatory subunit B'beta [KO:K11584]
103221482  PPP2R5D; protein phosphatase 2 regulatory subunit B'delta [KO:K11584]
103230127  PPP2R5A; protein phosphatase 2 regulatory subunit B'alpha [KO:K11584]
103229722  PPP2R5C; protein phosphatase 2 regulatory subunit B'gamma [KO:K11584]
103229152  PPP2R5E; protein phosphatase 2 regulatory subunit B'epsilon [KO:K11584]
103234702  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103230869  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103229784  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103234762  GSK3A; glycogen synthase kinase 3 alpha [KO:K08822] [EC:2.7.11.26]
103228213  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
103228072  GRIN2A; glutamate ionotropic receptor NMDA type subunit 2A [KO:K05209]
103218664  GRIN2B; glutamate ionotropic receptor NMDA type subunit 2B [KO:K05210]
103244826  GRIA1; glutamate ionotropic receptor AMPA type subunit 1 [KO:K05197]
103236440  GRIA2; glutamate ionotropic receptor AMPA type subunit 2 [KO:K05198]
103247371  GRIA3; glutamate ionotropic receptor AMPA type subunit 3 [KO:K05199]
103248371  GRIA4; glutamate ionotropic receptor AMPA type subunit 4 [KO:K05200]
103217064  KIF5C; kinesin family member 5C [KO:K10396]
103238089  KIF5B; kinesin family member 5B [KO:K10396]
103239501  KIF5A; kinesin family member 5A [KO:K10396]
103235664  CLOCK; clock circadian regulator [KO:K02223] [EC:2.3.1.48]
103239866  ARNTL; aryl hydrocarbon receptor nuclear translocator like [KO:K02296]
103214932  SLC6A3; solute carrier family 6 member 3 [KO:K05036]
103231841  MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
103231842  MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
103222988  COMT; catechol-O-methyltransferase [KO:K00545] [EC:2.1.1.6]
103247982  transmembrane O-methyltransferase [KO:K00545] [EC:2.1.1.6]
Compound
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00238  Potassium cation
C00355  3,4-Dihydroxy-L-phenylalanine
C00575  3',5'-Cyclic AMP
C01161  3,4-Dihydroxyphenylacetate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C03758  Dopamine
C05582  Homovanillate
C05587  3-Methoxytyramine
Reference
PMID:21303898
  Authors
Beaulieu JM, Gainetdinov RR
  Title
The physiology, signaling, and pharmacology of dopamine receptors.
  Journal
Pharmacol Rev 63:182-217 (2011)
DOI:10.1124/pr.110.002642
Reference
PMID:15521361
  Authors
Neve KA, Seamans JK, Trantham-Davidson H
  Title
Dopamine receptor signaling.
  Journal
J Recept Signal Transduct Res 24:165-205 (2004)
DOI:10.1081/RRS-200029981
Reference
PMID:17408758
  Authors
Surmeier DJ, Ding J, Day M, Wang Z, Shen W
  Title
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons.
  Journal
Trends Neurosci 30:228-35 (2007)
DOI:10.1016/j.tins.2007.03.008
Reference
PMID:20224735
  Authors
Knab AM, Lightfoot JT
  Title
Does the difference between physically active and couch potato lie in the dopamine system?
  Journal
Int J Biol Sci 6:133-50 (2010)
DOI:10.7150/ijbs.6.133
Reference
PMID:10433257
  Authors
Greengard P, Allen PB, Nairn AC
  Title
Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade.
  Journal
Neuron 23:435-47 (1999)
DOI:10.1016/S0896-6273(00)80798-9
Reference
PMID:15590733
  Authors
Hu XT, Dong Y, Zhang XF, White FJ
  Title
Dopamine D2 receptor-activated Ca2+ signaling modulates voltage-sensitive sodium currents in rat nucleus accumbens neurons.
  Journal
J Neurophysiol 93:1406-17 (2005)
DOI:10.1152/jn.00771.2004
Reference
PMID:17349698
  Authors
Beaulieu JM, Gainetdinov RR, Caron MG
  Title
The Akt-GSK-3 signaling cascade in the actions of dopamine.
  Journal
Trends Pharmacol Sci 28:166-72 (2007)
DOI:10.1016/j.tips.2007.02.006
Reference
PMID:19138563
  Authors
De Mei C, Ramos M, Iitaka C, Borrelli E
  Title
Getting specialized: presynaptic and postsynaptic dopamine D2 receptors.
  Journal
Curr Opin Pharmacol 9:53-8 (2009)
DOI:10.1016/j.coph.2008.12.002
Reference
PMID:15381316
  Authors
Seamans JK, Yang CR
  Title
The principal features and mechanisms of dopamine modulation in the prefrontal cortex.
  Journal
Prog Neurobiol 74:1-58 (2004)
DOI:10.1016/j.pneurobio.2004.05.006
Reference
PMID:18353279
  Authors
Yao WD, Spealman RD, Zhang J
  Title
Dopaminergic signaling in dendritic spines.
  Journal
Biochem Pharmacol 75:2055-69 (2008)
DOI:10.1016/j.bcp.2008.01.018
Reference
PMID:20727368
  Authors
Li YC, Gao WJ
  Title
GSK-3beta activity and hyperdopamine-dependent behaviors.
  Journal
Neurosci Biobehav Rev 35:645-54 (2011)
DOI:10.1016/j.neubiorev.2010.08.001
Reference
PMID:15292232
  Authors
Tang TS, Bezprozvanny I
  Title
Dopamine receptor-mediated Ca(2+) signaling in striatal medium spiny neurons.
  Journal
J Biol Chem 279:42082-94 (2004)
DOI:10.1074/jbc.M407389200
Reference
PMID:12967774
  Authors
Bergson C, Levenson R, Goldman-Rakic PS, Lidow MS
  Title
Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling.
  Journal
Trends Pharmacol Sci 24:486-92 (2003)
DOI:10.1016/S0165-6147(03)00232-3
Reference
PMID:9457173
  Authors
Missale C, Nash SR, Robinson SW, Jaber M, Caron MG
  Title
Dopamine receptors: from structure to function.
  Journal
Physiol Rev 78:189-225 (1998)
DOI:10.1152/physrev.1998.78.1.189
Reference
PMID:19251795
  Authors
Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ
  Title
Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases?
  Journal
Eur Respir J 33:468-80 (2009)
DOI:10.1183/09031936.00056908
Related
pathway
csab00350  Tyrosine metabolism
csab04020  Calcium signaling pathway
csab04721  Synaptic vesicle cycle
csab04724  Glutamatergic synapse
csab05012  Parkinson disease
KO pathway
ko04728   
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