KEGG   PATHWAY: cvg04910
Entry
cvg04910                    Pathway                                
Name
Insulin signaling pathway - Cyprinodon variegatus (sheepshead minnow)
Description
Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR.
Other signal transduction proteins interact with IRS including GRB2. GRB2 is part of the cascade including SOS, RAS, RAF and MEK that leads to activation of mitogen-activated protein kinase (MAPK) and mitogenic responses in the form of gene transcription. SHC is another substrate of INSR. When tyrosine phosphorylated, SHC associates with GRB2 and can thus activate the RAS/MAPK pathway independently of IRS-1.
Class
Organismal Systems; Endocrine system
Pathway map
cvg04910  Insulin signaling pathway
cvg04910

Organism
Cyprinodon variegatus (sheepshead minnow) [GN:cvg]
Gene
107086316  insulin-like [KO:K04526]
107090300  ins; insulin [KO:K04526]
107094230  insr; insulin receptor [KO:K04527] [EC:2.7.10.1]
107100834  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
107087768  insulin receptor substrate 1-B-like isoform X1 [KO:K16172]
107091522  insulin receptor substrate 2-B-like [KO:K07187]
107086777  insulin receptor substrate 2-like [KO:K07187]
107096497  irs2; insulin receptor substrate 2 [KO:K07187]
107092854  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107097814  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
107083639  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
107088248  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
107095122  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
107099901  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
107099902  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
107086882  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
107102211  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
107096583  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107082599  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107082662  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
107089553  pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
107088634  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107094377  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107083482  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107099926  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107092050  gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
107095927  gys2; LOW QUALITY PROTEIN: glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
107095143  glycogen [starch] synthase, muscle-like [KO:K00693] [EC:2.4.1.11]
107093693  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
107082804  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
107096918  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
107094299  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
107096949  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
107082288  protein phosphatase 1 regulatory subunit 3C-like [KO:K07189]
107082882  ppp1r3c; protein phosphatase 1 regulatory subunit 3C [KO:K07189]
107086792  uncharacterized protein LOC107086792 isoform X1 [KO:K07189]
107086227  protein phosphatase 1 regulatory subunit 3C-B-like [KO:K07189]
107091054  protein phosphatase 1 regulatory subunit 3B-B-like [KO:K07189]
107082099  protein phosphatase 1 regulatory subunit 3D-like [KO:K07189]
107095317  uncharacterized protein LOC107095317 isoform X1 [KO:K07189]
107104094  protein phosphatase 1 regulatory subunit 3A-like [KO:K07189]
107102929  protein phosphatase 1 regulatory subunit 3D-like [KO:K07189]
107097080  ppp1r3b; protein phosphatase 1 regulatory subunit 3B isoform X1 [KO:K07189]
107084545  protein phosphatase 1 regulatory subunit 3E-like [KO:K07189]
107088313  phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
107089513  phosphorylase b kinase gamma catalytic chain, liver/testis isoform-like [KO:K00871] [EC:2.7.11.19]
107091521  phka1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
107102156  phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
107095486  calm1; calmodulin [KO:K02183]
107097487  calml4; calmodulin-like protein 4 [KO:K02183]
107084023  calmodulin-A isoform X1 [KO:K02183]
107094827  calmodulin [KO:K02183]
107094180  calmodulin [KO:K02183]
107089814  glycogen phosphorylase, muscle form-like [KO:K00688] [EC:2.4.1.1]
107102639  glycogen phosphorylase, muscle form-like [KO:K00688] [EC:2.4.1.1]
107086559  pygb; glycogen phosphorylase, brain form [KO:K00688] [EC:2.4.1.1]
107097188  pygl; glycogen phosphorylase, liver form [KO:K00688] [EC:2.4.1.1]
107085578  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
107087201  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107094434  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
107090031  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107093417  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
107086013  prkar2b; cAMP-dependent protein kinase type II-beta regulatory subunit [KO:K04739]
107095222  prkar1b; cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1 [KO:K04739]
107098948  cAMP-dependent protein kinase type II-alpha regulatory subunit-like [KO:K04739]
107103105  prkar2a; cAMP-dependent protein kinase type II-alpha regulatory subunit [KO:K04739]
107101038  prkar1a; cAMP-dependent protein kinase type I-alpha regulatory subunit [KO:K04739]
107083574  lipe; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
107094452  prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
107094237  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
107087738  slc2a4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
107082208  flot1; flotillin-1 [KO:K07192]
107086736  flotillin-1 [KO:K07192]
107090345  flot2; flotillin-2 isoform X1 [KO:K07192]
107081929  sh2b2; SH2B adapter protein 2 [KO:K07193]
107088489  sorbin and SH3 domain-containing protein 1-like [KO:K06086]
107088320  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
107098202  E3 ubiquitin-protein ligase CBL-like [KO:K04707] [EC:2.3.2.27]
107090966  crkl; crk-like protein [KO:K04438]
107081852  adapter molecule crk-like [KO:K04438]
107094348  crk; adapter molecule crk [KO:K04438]
107104265  LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 1-like [KO:K06277]
107089763  rapgef1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
107096847  rhoq; rho-related GTP-binding protein RhoQ isoform X1 [KO:K07194]
107090249  exoc7; exocyst complex component 7 isoform X1 [KO:K07195]
107083093  cdc42-interacting protein 4 homolog isoform X1 [KO:K07196]
107101804  cdc42-interacting protein 4 homolog isoform X1 [KO:K07196]
107092842  srebf1; sterol regulatory element-binding protein 1 [KO:K07197]
107095795  acaca; acetyl-CoA carboxylase 1 isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
107100048  acetyl-CoA carboxylase-like isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
107087621  fasn; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
107094661  hexokinase-2-like isoform X1 [KO:K00844] [EC:2.7.1.1]
107098687  hexokinase-1 isoform X1 [KO:K00844] [EC:2.7.1.1]
107092161  hexokinase-1-like [KO:K00844] [EC:2.7.1.1]
107090296  glucokinase-like [KO:K00844] [EC:2.7.1.1]
107092140  putative hexokinase HKDC1 isoform X1 [KO:K00844] [EC:2.7.1.1]
107089653  gck; glucokinase [KO:K12407] [EC:2.7.1.2]
107096813  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
107094060  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
107091056  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
107097806  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
107092335  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
107082141  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
107101406  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
107093725  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
107083377  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
107100921  5'-AMP-activated protein kinase subunit gamma-2-like isoform X1 [KO:K07200]
107095350  forkhead box protein O1-A-like [KO:K07201]
107099244  forkhead box protein O1-A-like [KO:K07201]
107086393  ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha [KO:K07202]
107082019  g6pc2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
107092961  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
107093009  g6pc; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
107093022  glucose-6-phosphatase-like [KO:K01084] [EC:3.1.3.9]
107096505  fructose-1,6-bisphosphatase 1-like [KO:K03841] [EC:3.1.3.11]
107096511  fructose-1,6-bisphosphatase isozyme 2-like [KO:K03841] [EC:3.1.3.11]
107093359  fructose-1,6-bisphosphatase 1-like [KO:K03841] [EC:3.1.3.11]
107103895  phosphoenolpyruvate carboxykinase, cytosolic [GTP]-like [KO:K01596] [EC:4.1.1.32]
107086709  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
107085497  rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
107086988  rps6kb2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
107096319  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
107087452  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
107097681  rps6; 40S ribosomal protein S6 [KO:K02991]
107090959  eukaryotic translation initiation factor 4E-binding protein 1-like isoform X1 [KO:K07205]
107103682  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
107095806  eukaryotic translation initiation factor 4E-1A isoform X1 [KO:K03259]
107100654  eukaryotic translation initiation factor 4E-like [KO:K03259]
107085786  eukaryotic translation initiation factor 4E-1A-like isoform X1 [KO:K03259]
107092329  eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
107102465  hamartin-like [KO:K07206]
107097901  hamartin-like isoform X1 [KO:K07206]
107098599  tsc2; tuberin isoform X1 [KO:K07207]
107082144  rhebl1; GTPase RhebL1 [KO:K07208]
107089433  rheb; GTP-binding protein Rheb [KO:K07208]
107084153  bad; bcl2-associated agonist of cell death [KO:K02158]
107088415  shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
107085719  shc2; SHC-transforming protein 2 [KO:K17447]
107085834  shc3; SHC-transforming protein 3 [KO:K17448]
107085339  shc4; SHC-transforming protein 4 isoform X1 [KO:K17449]
107093104  grb2; growth factor receptor-bound protein 2 [KO:K04364]
107082681  son of sevenless homolog 1-like [KO:K03099]
107097178  sos2; son of sevenless homolog 2 [KO:K03099]
107085426  hras; GTPase HRas isoform X1 [KO:K02833]
107104069  kras; GTPase KRas isoform X1 [KO:K07827]
107095138  GTPase HRas-like [KO:K07827]
107104990  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
107098826  braf; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
107088168  raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
107102008  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107089725  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
107101186  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107095925  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107097727  mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
107081993  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
107097013  ETS domain-containing protein Elk-3-like [KO:K04375]
107093520  suppressor of cytokine signaling 1-like [KO:K04694]
107086411  suppressor of cytokine signaling 1-like [KO:K04694]
107104809  suppressor of cytokine signaling 1-like [KO:K04694]
107100762  socs2; suppressor of cytokine signaling 2 [KO:K04695]
107083123  suppressor of cytokine signaling 3-like [KO:K04696]
107089248  socs3; suppressor of cytokine signaling 3 [KO:K04696]
107083884  socs4; suppressor of cytokine signaling 4 [KO:K04697]
107090730  tyrosine-protein phosphatase non-receptor type 1-like [KO:K05696] [EC:3.1.3.48]
107085934  receptor-type tyrosine-protein phosphatase F-like isoform X1 [KO:K05695] [EC:3.1.3.48]
107098440  receptor-type tyrosine-protein phosphatase F-like [KO:K05695] [EC:3.1.3.48]
107085828  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107101533  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107102050  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
107086602  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107089660  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
107102648  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B-like [KO:K15909] [EC:3.1.3.86]
107091942  inppl1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [KO:K15909] [EC:3.1.3.86]
107093121  inpp5a; type I inositol 1,4,5-trisphosphate 5-phosphatase [KO:K01106] [EC:3.1.3.56]
107082317  type I inositol 1,4,5-trisphosphate 5-phosphatase-like [KO:K01106] [EC:3.1.3.56]
Compound
C00031  D-Glucose
C00369  Starch
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14635525
  Authors
Ogawa W, Kasuga M.
  Title
[Mechanism of insulin action and diabetes mellitus]
  Journal
Seikagaku 75:1332-44 (2003)
Reference
PMID:11282018
  Authors
Bevan P.
  Title
Insulin signalling.
  Journal
J Cell Sci 114:1429-30 (2001)
Reference
PMID:12867054
  Authors
Kanzaki M, Pessin JE.
  Title
Insulin signaling: GLUT4 vesicles exit via the exocyst.
  Journal
Curr Biol 13:R574-6 (2003)
DOI:10.1016/S0960-9822(03)00478-0
Reference
PMID:10196204
  Authors
Moodie SA, Alleman-Sposeto J, Gustafson TA.
  Title
Identification of the APS protein as a novel insulin receptor substrate.
  Journal
J Biol Chem 274:11186-93 (1999)
DOI:10.1074/jbc.274.16.11186
Reference
PMID:15733744
  Authors
Gual P, Le Marchand-Brustel Y, Tanti JF.
  Title
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.
  Journal
Biochimie 87:99-109 (2005)
DOI:10.1016/j.biochi.2004.10.019
Reference
PMID:9748166
  Authors
Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ.
  Title
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
  Journal
Science 281:2042-5 (1998)
DOI:10.1126/science.281.5385.2042
Reference
PMID:11742412
  Authors
Saltiel AR, Kahn CR.
  Title
Insulin signalling and the regulation of glucose and lipid metabolism.
  Journal
Nature 414:799-806 (2001)
DOI:10.1038/414799a
Reference
PMID:15624019
  Authors
Inoki K, Corradetti MN, Guan KL.
  Title
Dysregulation of the TSC-mTOR pathway in human disease.
  Journal
Nat Genet 37:19-24 (2005)
DOI:10.1038/ng1494
Reference
PMID:16288289
  Authors
Ruggero D, Sonenberg N.
  Title
The Akt of translational control.
  Journal
Oncogene 24:7426-34 (2005)
DOI:10.1038/sj.onc.1209098
Reference
PMID:10567225
  Authors
Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR.
  Title
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.
  Journal
Biochem J 344 Pt 2:427-31 (1999)
DOI:10.1042/bj3440427
Reference
PMID:9445476
  Authors
Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G.
  Title
Phosphorylation and activation of p70s6k by PDK1.
  Journal
Science 279:707-10 (1998)
DOI:10.1126/science.279.5351.707
Reference
PMID:9609110
  Authors
Ogawa W, Matozaki T, Kasuga M.
  Title
Role of binding proteins to IRS-1 in insulin signalling.
  Journal
Mol Cell Biochem 182:13-22 (1998)
Reference
PMID:9609111
  Authors
Ceresa BP, Pessin JE.
  Title
Insulin regulation of the Ras activation/inactivation cycle.
  Journal
Mol Cell Biochem 182:23-9 (1998)
Reference
PMID:15229476
  Authors
Pollak MN, Schernhammer ES, Hankinson SE.
  Title
Insulin-like growth factors and neoplasia.
  Journal
Nat Rev Cancer 4:505-18 (2004)
DOI:10.1038/nrc1387
Reference
PMID:9346240
  Authors
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME.
  Title
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
  Journal
Cell 91:231-41 (1997)
DOI:10.1016/S0092-8674(00)80405-5
Reference
PMID:17344645
  Authors
Ferre P, Foufelle F
  Title
SREBP-1c transcription factor and lipid homeostasis: clinical perspective.
  Journal
Horm Res 68:72-82 (2007)
DOI:10.1159/000100426
Reference
PMID:18291668
  Authors
Raghow R, Yellaturu C, Deng X, Park EA, Elam MB
  Title
SREBPs: the crossroads of physiological and pathological lipid homeostasis.
  Journal
Trends Endocrinol Metab 19:65-73 (2008)
DOI:10.1016/j.tem.2007.10.009
Reference
PMID:11343120
  Authors
Clement S, Krause U, Desmedt F, Tanti JF, Behrends J, Pesesse X, Sasaki T, Penninger J, Doherty M, Malaisse W, Dumont JE, Le Marchand-Brustel Y, Erneux C, Hue L, Schurmans S
  Title
The lipid phosphatase SHIP2 controls insulin sensitivity.
  Journal
Nature 409:92-7 (2001)
DOI:10.1038/35051094
Reference
PMID:12791379
  Authors
Backers K, Blero D, Paternotte N, Zhang J, Erneux C
  Title
The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases.
  Journal
Adv Enzyme Regul 43:15-28 (2003)
DOI:10.1016/S0065-2571(02)00043-2
Related
pathway
cvg00010  Glycolysis / Gluconeogenesis
cvg00061  Fatty acid biosynthesis
cvg00500  Starch and sucrose metabolism
cvg04010  MAPK signaling pathway
cvg04070  Phosphatidylinositol signaling system
cvg04210  Apoptosis
KO pathway
ko04910   
LinkDB

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