KEGG   PATHWAY: dne00230
Entry
dne00230                    Pathway                                
Name
Purine metabolism - Dromaius novaehollandiae (emu)
Class
Metabolism; Nucleotide metabolism
Pathway map
dne00230  Purine metabolism
dne00230

Module
dne_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:dne00230]
dne_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:dne00230]
dne_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:dne00230]
dne_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:dne00230]
dne_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:dne00230]
dne_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:dne00230]
Other DBs
GO: 0006163 0042278
Organism
Dromaius novaehollandiae (emu) [GN:dne]
Gene
112984725  NUDT9; ADP-ribose pyrophosphatase, mitochondrial [KO:K13988] [EC:3.6.1.13]
112995542  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
112994759  NUDT5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
112990100  PGM1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
112979498  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
112993539  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
112989673  ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
112979522  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
112988207  trifunctional purine biosynthetic protein adenosine-3-like isoform X1 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
112988210  trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
112979521  multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
112984122  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
112995670  ATIC; bifunctional purine biosynthesis protein PURH isoform X1 [KO:K00602] [EC:2.1.2.3 3.5.4.10]
112989071  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
112981998  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
112982474  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
112989285  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
112985063  LOW QUALITY PROTEIN: cytosolic 5'-nucleotidase 1B-like [KO:K01081] [EC:3.1.3.5]
112978975  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
112980440  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
112995864  NT5E; 5'-nucleotidase isoform X1 [KO:K19970] [EC:3.1.3.5]
112987456  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
112988187  LACC1; laccase domain-containing protein 1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
112987667  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
112989710  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
112984685  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
112981092  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
112982618  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
112982619  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
112989982  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
112990558  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
112986900  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
112995138  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
112982424  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
112989792  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
112986757  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
112986795  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
112986796  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
112991620  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
112996732  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
112995428  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
112985530  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
112997346  ITPA; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
112980054  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112987800  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
112981318  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
112991043  GMPR; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
112981857  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
112980943  GUK1; guanylate kinase [KO:K00942] [EC:2.7.4.8]
112993727  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
112981527  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
112994955  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
112986014  HDDC2; HD domain-containing protein 2 isoform X1 [KO:K07023] [EC:3.1.3.89]
112996195  DGUOK; deoxyguanosine kinase, mitochondrial [KO:K00904] [EC:2.7.1.113]
112985133  DCK; deoxycytidine kinase isoform X1 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
112996956  deoxycytidine kinase-like [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
112990051  PRUNE1; exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
112997517  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
112982724  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
112984267  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
112994245  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
112984414  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
112991309  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
112986919  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
112995311  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X1 [KO:K12318] [EC:4.6.1.2]
112983213  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
112995298  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
112988883  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
112984535  GUCY2C; heat-stable enterotoxin receptor isoform X1 [KO:K12320] [EC:4.6.1.2]
112995512  retinal guanylyl cyclase 1-like [KO:K12321] [EC:4.6.1.2]
112981927  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
112993621  NPR2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
112993378  LOW QUALITY PROTEIN: atrial natriuretic peptide receptor 1-like [KO:K12324] [EC:4.6.1.2]
112989230  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
112983562  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
112991004  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
112978911  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
112985679  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
112980898  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
112982326  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
112979711  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
112993697  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
112990611  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
112993425  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
112981978  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
112988973  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
112978776  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
112994877  adenylosuccinate synthetase isozyme 2-like [KO:K01939] [EC:6.3.4.4]
112990645  ADSSL1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
112984619  ADSS; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
112985711  AMPD3; AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
112985880  AMPD2; AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
112993315  ADK; adenosine kinase [KO:K00856] [EC:2.7.1.20]
112979089  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
112993408  ADA2; adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
112981247  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
112987686  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
112982133  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
112984162  AK8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
112991329  AK1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
112991479  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
112988723  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
112981661  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
112986780  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
112993546  NTPCR; cancer-related nucleoside-triphosphatase isoform X1 [KO:K06928] [EC:3.6.1.15]
112995370  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
112996165  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
112995758  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
112991474  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
112986556  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
112995514  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
112990128  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
112996007  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
112987044  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
112984677  FHIT; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
112979533  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 isoform X1 [KO:K18424] [EC:3.6.1.29]
112987878  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
112981608  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
112993126  uricase-like [KO:K00365] [EC:1.7.3.3]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
dne00030  Pentose phosphate pathway
dne00220  Arginine biosynthesis
dne00250  Alanine, aspartate and glutamate metabolism
dne00260  Glycine, serine and threonine metabolism
dne00340  Histidine metabolism
dne00630  Glyoxylate and dicarboxylate metabolism
dne00730  Thiamine metabolism
dne00740  Riboflavin metabolism
dne00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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