KEGG   PATHWAY: ecb03013
Entry
ecb03013                    Pathway                                
Name
Nucleocytoplasmic transport - Equus caballus (horse)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
ecb03013  Nucleocytoplasmic transport
ecb03013

Other DBs
GO: 0050658
Organism
Equus caballus (horse) [GN:ecb]
Gene
100063811  AAAS; aladin isoform X1 [KO:K14320]
100053709  NUPL2; nucleoporin-like protein 2 [KO:K14321]
100066964  GLE1; nucleoporin GLE1 [KO:K18723]
100054938  ATP-dependent RNA helicase DDX19B isoform X2 [KO:K18655] [EC:5.6.2.7]
100068576  ATP-dependent RNA helicase DDX19A isoform X1 [KO:K18655] [EC:5.6.2.7]
100050441  RAE1; mRNA export factor [KO:K14298]
100052986  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X2 [KO:K14297]
100069634  NUP214; LOW QUALITY PROTEIN: nuclear pore complex protein Nup214 [KO:K14317]
111767496  nuclear pore complex protein Nup214-like isoform X1 [KO:K14317]
100061117  NUP88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
100060826  E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
100628308  RANGAP1; ran GTPase-activating protein 1 [KO:K14319]
100065385  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
100049890  small ubiquitin-related modifier 2 [KO:K12160]
100067107  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
100630015  SUMO3; small ubiquitin-related modifier 3 isoform X1 [KO:K12160]
100630536  SUMO2; small ubiquitin-related modifier 2 isoform X1 [KO:K12160]
100058528  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
100052049  NUP85; nuclear pore complex protein Nup85 isoform X2 [KO:K14304]
100057913  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
100059287  NUP107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
100065427  NUP133; nuclear pore complex protein Nup133 isoform X1 [KO:K14300]
100630847  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
100064615  NUP43; nucleoporin Nup43 [KO:K14305]
100053164  NUP37; nucleoporin Nup37 [KO:K14302]
100054592  AHCTF1; protein ELYS isoform X1 [KO:K25129]
100056315  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
100060548  NUP62CL; nucleoporin-62 C-terminal-like protein isoform X1 [KO:K14306]
100059114  NUP58; nucleoporin p58/p45 isoform X1 [KO:K14307]
100051138  NUP54; nucleoporin p54 isoform X2 [KO:K14308]
100064995  NUP205; nuclear pore complex protein Nup205 isoform X1 [KO:K14310]
100070114  NUP188; nucleoporin NUP188 homolog isoform X1 [KO:K14311]
100053405  NUP155; nuclear pore complex protein Nup155 [KO:K14312]
100051892  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
100054143  NUP35; nucleoporin NUP53 [KO:K14313]
100050513  NDC1; nucleoporin NDC1 isoform X1 [KO:K14315]
100055192  NUP210; nuclear pore membrane glycoprotein 210 isoform X1 [KO:K14314]
100056659  NUP210L; nuclear pore membrane glycoprotein 210-like isoform X6 [KO:K14314]
100064071  POM121L2; POM121-like protein 2 [KO:K14316]
100061320  POM121C; nuclear envelope pore membrane protein POM 121C isoform X1 [KO:K14316]
111774246  nuclear envelope pore membrane protein POM 121C-like [KO:K14316]
100054802  TMEM33; transmembrane protein 33 [KO:K20724]
100049850  TPR; nucleoprotein TPR isoform X1 [KO:K09291]
100051494  NUP50; nuclear pore complex protein Nup50 [KO:K14295]
100066078  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
100059276  SENP2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
100070623  KPNA1; importin subunit alpha-5 [KO:K23940]
100053778  KPNA2; importin subunit alpha-1 [KO:K15043]
100146627  KPNA7; importin subunit alpha-8 [KO:K15043]
100052650  KPNA4; importin subunit alpha-3 [KO:K23583]
100055705  KPNA3; importin subunit alpha-4 isoform X1 [KO:K23583]
100067045  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
100070377  KPNA6; importin subunit alpha-7 isoform X2 [KO:K15042]
100069121  KPNB1; importin subunit beta-1 [KO:K14293]
100073294  TNPO1; transportin-1 isoform X1 [KO:K18752]
100063482  TNPO2; transportin-2 isoform X1 [KO:K18727]
100071795  TNPO3; transportin-3 isoform X1 [KO:K15436]
100051517  IPO4; importin-4 isoform X4 [KO:K20221]
100060424  IPO5; importin-5 isoform X1 [KO:K20222]
100055677  IPO7; importin-7 [KO:K20223]
100064845  IPO8; importin-8 isoform X1 [KO:K18755]
100063664  IPO9; importin-9 [KO:K20224]
100050828  IPO11; importin-11 isoform X1 [KO:K25201]
100066178  IPO13; importin-13 [KO:K25202]
100051100  SNUPN; snurportin-1 [KO:K13151]
100051994  XPO1; exportin-1 isoform X1 [KO:K14290]
100056886  CSE1L; exportin-2 [KO:K18423]
100051579  XPOT; exportin-T isoform X1 [KO:K14288]
100054789  XPO4; exportin-4 isoform X2 [KO:K25203]
100067497  XPO5; exportin-5 isoform X1 [KO:K14289]
100064463  XPO6; exportin-6 isoform X1 [KO:K25204]
100056362  XPO7; exportin-7 isoform X3 [KO:K18460]
100070317  RANBP17; ran-binding protein 17 isoform X1 [KO:K24115]
100062767  RAN; GTP-binding nuclear protein Ran [KO:K07936]
100060464  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
100009682  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
100073058  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
100064523  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
100060150  NCBP2; nuclear cap-binding protein subunit 2 isoform X2 [KO:K12883]
100062312  NMD3; 60S ribosomal export protein NMD3 isoform X1 [KO:K07562]
100034052  RBM8A; RNA-binding protein 8A [KO:K12876]
100060994  MAGOH; protein mago nashi homolog [KO:K12877]
100065075  protein mago nashi homolog 2 isoform X1 [KO:K12877]
100063178  protein mago nashi homolog 2 isoform X1 [KO:K12877]
100067814  CASC3; protein CASC3 [KO:K14323]
100056586  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
100055865  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X4 [KO:K12875]
100050218  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
100065738  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
100060952  PNN; pinin [KO:K13114]
106782613  ALYREF; THO complex subunit 4 [KO:K12881]
100071059  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
100069342  UPF2; regulator of nonsense transcripts 2 isoform X2 [KO:K14327]
100058559  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
100069294  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
100049009  NXF1; nuclear RNA export factor 1 isoform 2 [KO:K14284]
100060240  nuclear RNA export factor 3 [KO:K14284]
100060140  nuclear RNA export factor 3 isoform X2 [KO:K14284]
100060201  nuclear RNA export factor 2 [KO:K14284]
100060857  LOW QUALITY PROTEIN: nuclear RNA export factor 2 [KO:K14284]
100067224  nuclear RNA export factor 3-like [KO:K14284]
111771475  nuclear RNA export factor 3-like [KO:K14284]
100059798  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
102149448  NXT1; NTF2-related export protein 1 [KO:K14285]
100146384  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
100071467  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
100059063  PYM1; partner of Y14 and mago isoform X1 [KO:K14294]
100051155  THOC1; THO complex subunit 1 isoform X1 [KO:K12878]
100055091  THOC2; THO complex subunit 2 isoform X6 [KO:K12879]
100059017  THOC5; THO complex subunit 5 homolog isoform X2 [KO:K13174]
100068915  THOC6; THO complex subunit 6 homolog isoform X2 [KO:K13175]
100056004  THOC7; THO complex subunit 7 homolog [KO:K13176]
100068979  THOC3; THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
ecb03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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