KEGG   PATHWAY: esp04910
Entry
esp04910                    Pathway                                
Name
Insulin signaling pathway - Etheostoma spectabile (orangethroat darter)
Description
Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR.
Other signal transduction proteins interact with IRS including GRB2. GRB2 is part of the cascade including SOS, RAS, RAF and MEK that leads to activation of mitogen-activated protein kinase (MAPK) and mitogenic responses in the form of gene transcription. SHC is another substrate of INSR. When tyrosine phosphorylated, SHC associates with GRB2 and can thus activate the RAS/MAPK pathway independently of IRS-1.
Class
Organismal Systems; Endocrine system
Pathway map
esp04910  Insulin signaling pathway
esp04910

Organism
Etheostoma spectabile (orangethroat darter) [GN:esp]
Gene
116696869  ins; insulin [KO:K04526]
116698703  LOW QUALITY PROTEIN: insulin receptor-like [KO:K04527] [EC:2.7.10.1]
116695992  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
116686365  insulin receptor substrate 1-B-like [KO:K16172]
116700901  insulin receptor substrate 1-B-like [KO:K16172]
116673813  insulin receptor substrate 2-like isoform X1 [KO:K07187]
116697727  irs2; insulin receptor substrate 2 [KO:K07187]
116669528  LOW QUALITY PROTEIN: insulin receptor substrate 2-B-like [KO:K07187]
116698567  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
116699207  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
116695430  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
116696146  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
116689915  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
116704085  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116675754  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
116678381  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
116699195  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
116692529  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116695417  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
116671370  pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
116673342  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116705099  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116670120  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116673142  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
116698290  gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
116703737  glycogen [starch] synthase, muscle-like [KO:K00693] [EC:2.4.1.11]
116672887  gys2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
116679804  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
116706431  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
116707200  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
116669662  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
116686659  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
116671320  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
116702550  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
116689305  serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
116705007  ppp1r3c; protein phosphatase 1 regulatory subunit 3C [KO:K07189]
116691860  protein phosphatase 1 regulatory subunit 3D-like [KO:K07189]
116683752  LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 3B-like [KO:K07189]
116692523  uncharacterized protein LOC116692523 isoform X1 [KO:K07189]
116687353  protein phosphatase 1 regulatory subunit 3D-like [KO:K07189]
116687705  protein phosphatase 1 regulatory subunit 3E-like [KO:K07189]
116689774  protein phosphatase 1 regulatory subunit 3C-like [KO:K07189]
116672876  uncharacterized protein LOC116672876 [KO:K07189]
116670983  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
116670988  phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
116692177  phkb; LOW QUALITY PROTEIN: phosphorylase b kinase regulatory subunit beta [KO:K07190]
116669491  phka1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
116687412  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
116705744  calm2; calmodulin-2 [KO:K02183]
116678688  calm3; calmodulin-3 [KO:K02183]
116706189  calm1; calmodulin-1 [KO:K02183]
116670661  calmodulin-1 [KO:K02183]
116687887  calml6; calmodulin-like protein 6 isoform X1 [KO:K02183]
116688267  calml4; calmodulin-like protein 4 [KO:K02183]
116707425  pygm; glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
116669709  pygl; glycogen phosphorylase, liver form [KO:K00688] [EC:2.4.1.1]
116700659  glycogen phosphorylase, muscle form-like [KO:K00688] [EC:2.4.1.1]
116693654  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
116698669  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116695686  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116703683  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
116692571  cAMP-dependent protein kinase type II-alpha regulatory subunit-like [KO:K04739]
116687570  slc25a20; mitochondrial carnitine/acylcarnitine carrier protein [KO:K04739]
116694663  cAMP-dependent protein kinase type II-beta regulatory subunit-like [KO:K04739]
116671487  prkar1a; cAMP-dependent protein kinase type I-alpha regulatory subunit [KO:K04739]
116702880  prkar1b; cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1 [KO:K04739]
116691214  lipe; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
116701791  hormone-sensitive lipase-like [KO:K07188] [EC:3.1.1.79]
116693186  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
116698707  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
116686371  slc2a4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
116691262  flotillin-1-like [KO:K07192]
116685746  flotillin-2 [KO:K07192]
116700524  flotillin-2a isoform X1 [KO:K07192]
116702169  flotillin-1 [KO:K07192]
116677519  sh2b2; SH2B adapter protein 2 [KO:K07193]
116683564  sorbin and SH3 domain-containing protein 1-like isoform X1 [KO:K06086]
116700199  E3 ubiquitin-protein ligase CBL-like isoform X1 [KO:K04707] [EC:2.3.2.27]
116687126  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
116700422  cblb; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
116674771  crk; adapter molecule crk [KO:K04438]
116700737  adapter molecule crk-like [KO:K04438]
116703898  crkl; crk-like protein [KO:K04438]
116704339  rapgef1; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 1 [KO:K06277]
116705740  rhoq; rho-related GTP-binding protein RhoQ [KO:K07194]
116707304  cdc42-interacting protein 4 homolog [KO:K07196]
116702631  trip10; cdc42-interacting protein 4 isoform X1 [KO:K07196]
116702501  srebf1; sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
116700226  acaca; acetyl-CoA carboxylase 1 isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
116689793  acacb; acetyl-CoA carboxylase 2 isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
116671500  fasn; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
116686620  hexokinase-2-like [KO:K00844] [EC:2.7.1.1]
116687381  hexokinase-1-like isoform X1 [KO:K00844] [EC:2.7.1.1]
116689576  hexokinase-2-like [KO:K00844] [EC:2.7.1.1]
116689629  gck; hexokinase-4 isoform X1 [KO:K12407] [EC:2.7.1.2]
116704511  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
116694938  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
116690406  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
116699515  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
116704102  prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
116674234  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
116698656  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
116688407  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
116689072  LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
116700615  forkhead box protein O1-A-like [KO:K07201]
116672344  forkhead box protein O1-A-like [KO:K07201]
116707049  ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
116670962  g6pc; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
116670963  glucose-6-phosphatase-like [KO:K01084] [EC:3.1.3.9]
116671222  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
116702594  glucose-6-phosphatase-like isoform X1 [KO:K01084] [EC:3.1.3.9]
116688866  fructose-1,6-bisphosphatase 1-like [KO:K03841] [EC:3.1.3.11]
116690027  fructose-1,6-bisphosphatase isozyme 2-like [KO:K03841] [EC:3.1.3.11]
116704229  fructose-1,6-bisphosphatase 1-like [KO:K03841] [EC:3.1.3.11]
116687862  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
116672175  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
116692591  mtor; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
116702523  rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
116673415  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
116700771  ribosomal protein S6 kinase beta-1-like isoform X1 [KO:K04688] [EC:2.7.11.1]
116694798  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
116699593  rps6; 40S ribosomal protein S6 [KO:K02991]
116689334  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
116703982  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
116704954  eukaryotic translation initiation factor 4E-like isoform X1 [KO:K03259]
116678383  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
116699097  eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
116669937  eukaryotic translation initiation factor 4E-like [KO:K03259]
116696530  eukaryotic translation initiation factor 4E-1A [KO:K03259]
116704302  hamartin-like isoform X1 [KO:K07206]
116689998  tsc1; LOW QUALITY PROTEIN: hamartin [KO:K07206]
116704311  tsc2; tuberin isoform X1 [KO:K07207]
116698897  rheb; GTP-binding protein Rheb [KO:K07208]
116688416  GTP-binding protein Rheb-like [KO:K07208]
116707131  bad; bcl2-associated agonist of cell death [KO:K02158]
116691703  shc1; LOW QUALITY PROTEIN: SHC-transforming protein 1 [KO:K06279]
116696202  LOW QUALITY PROTEIN: SHC-transforming protein 2-like [KO:K17447]
116704435  shc3; SHC-transforming protein 3 [KO:K17448]
116703619  shc4; SHC-transforming protein 4 isoform X1 [KO:K17449]
116702397  grb2; growth factor receptor-bound protein 2 [KO:K04364]
116678819  LOW QUALITY PROTEIN: son of sevenless homolog 1-like [KO:K03099]
116669702  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
116694245  hras; GTPase HRas [KO:K02833]
116694484  kras; GTPase KRas isoform X1 [KO:K07827]
116703772  GTPase HRas-like [KO:K07827]
116689928  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
116673193  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
116693071  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116694773  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116699426  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
116699428  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
116695172  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116690322  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116703753  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
116694968  mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
116695847  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
116679543  ETS domain-containing protein Elk-1-like [KO:K04375]
116705481  suppressor of cytokine signaling 1-like [KO:K04694]
116703073  socs1; suppressor of cytokine signaling 1 [KO:K04694]
116707461  suppressor of cytokine signaling 3-like [KO:K04696]
116671758  suppressor of cytokine signaling 3-like [KO:K04696]
116703276  suppressor of cytokine signaling 3-like [KO:K04696]
116693718  suppressor of cytokine signaling 4-like [KO:K04697]
116692074  LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 1-like [KO:K05696] [EC:3.1.3.48]
116699847  receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
116695494  ptprf; receptor-type tyrosine-protein phosphatase F [KO:K05695] [EC:3.1.3.48]
116697416  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
116705432  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
116671539  mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
116703876  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116688937  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
116697285  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B-like [KO:K15909] [EC:3.1.3.86]
116684057  inppl1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [KO:K15909] [EC:3.1.3.86]
116705180  inpp5a; inositol polyphosphate-5-phosphatase A isoform X1 [KO:K01106] [EC:3.1.3.56]
Compound
C00031  D-Glucose
C00369  Starch
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14635525
  Authors
Ogawa W, Kasuga M.
  Title
[Mechanism of insulin action and diabetes mellitus]
  Journal
Seikagaku 75:1332-44 (2003)
Reference
PMID:11282018
  Authors
Bevan P.
  Title
Insulin signalling.
  Journal
J Cell Sci 114:1429-30 (2001)
Reference
PMID:12867054
  Authors
Kanzaki M, Pessin JE.
  Title
Insulin signaling: GLUT4 vesicles exit via the exocyst.
  Journal
Curr Biol 13:R574-6 (2003)
DOI:10.1016/S0960-9822(03)00478-0
Reference
PMID:10196204
  Authors
Moodie SA, Alleman-Sposeto J, Gustafson TA.
  Title
Identification of the APS protein as a novel insulin receptor substrate.
  Journal
J Biol Chem 274:11186-93 (1999)
DOI:10.1074/jbc.274.16.11186
Reference
PMID:15733744
  Authors
Gual P, Le Marchand-Brustel Y, Tanti JF.
  Title
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.
  Journal
Biochimie 87:99-109 (2005)
DOI:10.1016/j.biochi.2004.10.019
Reference
PMID:9748166
  Authors
Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ.
  Title
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
  Journal
Science 281:2042-5 (1998)
DOI:10.1126/science.281.5385.2042
Reference
PMID:11742412
  Authors
Saltiel AR, Kahn CR.
  Title
Insulin signalling and the regulation of glucose and lipid metabolism.
  Journal
Nature 414:799-806 (2001)
DOI:10.1038/414799a
Reference
PMID:15624019
  Authors
Inoki K, Corradetti MN, Guan KL.
  Title
Dysregulation of the TSC-mTOR pathway in human disease.
  Journal
Nat Genet 37:19-24 (2005)
DOI:10.1038/ng1494
Reference
PMID:16288289
  Authors
Ruggero D, Sonenberg N.
  Title
The Akt of translational control.
  Journal
Oncogene 24:7426-34 (2005)
DOI:10.1038/sj.onc.1209098
Reference
PMID:10567225
  Authors
Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR.
  Title
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.
  Journal
Biochem J 344 Pt 2:427-31 (1999)
DOI:10.1042/bj3440427
Reference
PMID:9445476
  Authors
Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G.
  Title
Phosphorylation and activation of p70s6k by PDK1.
  Journal
Science 279:707-10 (1998)
DOI:10.1126/science.279.5351.707
Reference
PMID:9609110
  Authors
Ogawa W, Matozaki T, Kasuga M.
  Title
Role of binding proteins to IRS-1 in insulin signalling.
  Journal
Mol Cell Biochem 182:13-22 (1998)
Reference
PMID:9609111
  Authors
Ceresa BP, Pessin JE.
  Title
Insulin regulation of the Ras activation/inactivation cycle.
  Journal
Mol Cell Biochem 182:23-9 (1998)
Reference
PMID:15229476
  Authors
Pollak MN, Schernhammer ES, Hankinson SE.
  Title
Insulin-like growth factors and neoplasia.
  Journal
Nat Rev Cancer 4:505-18 (2004)
DOI:10.1038/nrc1387
Reference
PMID:9346240
  Authors
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME.
  Title
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
  Journal
Cell 91:231-41 (1997)
DOI:10.1016/S0092-8674(00)80405-5
Reference
PMID:17344645
  Authors
Ferre P, Foufelle F
  Title
SREBP-1c transcription factor and lipid homeostasis: clinical perspective.
  Journal
Horm Res 68:72-82 (2007)
DOI:10.1159/000100426
Reference
PMID:18291668
  Authors
Raghow R, Yellaturu C, Deng X, Park EA, Elam MB
  Title
SREBPs: the crossroads of physiological and pathological lipid homeostasis.
  Journal
Trends Endocrinol Metab 19:65-73 (2008)
DOI:10.1016/j.tem.2007.10.009
Reference
PMID:11343120
  Authors
Clement S, Krause U, Desmedt F, Tanti JF, Behrends J, Pesesse X, Sasaki T, Penninger J, Doherty M, Malaisse W, Dumont JE, Le Marchand-Brustel Y, Erneux C, Hue L, Schurmans S
  Title
The lipid phosphatase SHIP2 controls insulin sensitivity.
  Journal
Nature 409:92-7 (2001)
DOI:10.1038/35051094
Reference
PMID:12791379
  Authors
Backers K, Blero D, Paternotte N, Zhang J, Erneux C
  Title
The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases.
  Journal
Adv Enzyme Regul 43:15-28 (2003)
DOI:10.1016/S0065-2571(02)00043-2
Related
pathway
esp00010  Glycolysis / Gluconeogenesis
esp00061  Fatty acid biosynthesis
esp00500  Starch and sucrose metabolism
esp04010  MAPK signaling pathway
esp04070  Phosphatidylinositol signaling system
esp04210  Apoptosis
KO pathway
ko04910   
LinkDB

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