KEGG   PATHWAY: hcq04625
Entry
hcq04625                    Pathway                                
Name
C-type lectin receptor signaling pathway - Hippocampus comes (tiger tail seahorse)
Description
C-type lectin receptors (CLRs) are a large superfamily of proteins characterized by the presence of one or more C-type lectin-like domains (CTLDs). CLRs function as pattern-recognition receptors (PRRs) for pathogen-derived ligands in dendric cells, macrophages, neutrophils, etc., such as Dectin-1 and Dectin-2 for recognition of fungi-derived B-glucan and high mannose-type carbohydrates. Upon ligand binding, CLRs stimulate intracellular signaling cascades that induce the production of inflammatory cytokines and chemokines, consequently triggering innate and adaptive immunity to pathogens.
Class
Organismal Systems; Immune system
Pathway map
hcq04625  C-type lectin receptor signaling pathway
hcq04625

Organism
Hippocampus comes (tiger tail seahorse) [GN:hcq]
Gene
109514406  lymphocyte-specific protein 1-like isoform X1 [KO:K14957]
109530360  hras; GTPase HRas [KO:K02833]
109530437  kras; GTPase KRas isoform X1 [KO:K07827]
109527013  GTPase HRas-like [KO:K07827]
109523396  mras; ras-related protein M-Ras [KO:K07831]
109525889  rras2; ras-related protein R-Ras2 [KO:K07830]
109524764  ras-related protein R-Ras-like [KO:K07830]
109507267  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109508419  transcription factor p65-like isoform X1 [KO:K04735]
109526416  relb; transcription factor RelB isoform X1 [KO:K09253]
109518416  interleukin-12 subunit alpha-like [KO:K05406]
109527235  interleukin-12 subunit beta-like [KO:K05425]
109524222  il12b; interleukin-12 subunit beta [KO:K05425]
109513432  interleukin-1 beta-like [KO:K04519]
109530546  syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
109511800  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
109507188  ptpn11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
109519328  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 14-like [KO:K04466] [EC:2.7.11.25]
109518541  mitogen-activated protein kinase kinase kinase 14-like [KO:K04466] [EC:2.7.11.25]
109516272  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
109518553  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
109510063  nfkb2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
109513068  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
109521562  itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
109522343  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
109530334  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
109526465  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
109519524  calmodulin [KO:K02183]
109509015  calmodulin-like [KO:K02183]
109525714  calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
109523201  calmodulin [KO:K02183]
109526386  calm3; calmodulin [KO:K02183]
109508156  calmodulin [KO:K02183]
109517961  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
109524286  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
109511881  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109525023  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
109517535  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like [KO:K04348] [EC:3.1.3.16]
109526689  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
109518367  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
109529694  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
109513634  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
109507442  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
109528640  nuclear factor of activated T-cells, cytoplasmic 3-like isoform X1 [KO:K17333]
109524107  nuclear factor of activated T-cells, cytoplasmic 4-like isoform X1 [KO:K17334]
109522542  il10; interleukin-10 [KO:K05443]
109510060  E3 SUMO-protein ligase EGR2-like [KO:K12496]
109529317  egr2; E3 SUMO-protein ligase EGR2 [KO:K12496]
109525261  egr3; early growth response protein 3 [KO:K12497]
109519080  ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
109522455  protein kinase C delta type-like isoform X1 [KO:K06068] [EC:2.7.11.13]
109514865  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
109526913  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109512265  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
109518426  caspase-1-A-like [KO:K01370] [EC:3.4.22.36]
109518427  caspase-1-A-like [KO:K01370] [EC:3.4.22.36]
109524079  bcl10; B-cell lymphoma/leukemia 10 [KO:K07368]
109532397  mucosa-associated lymphoid tissue lymphoma translocation protein 1-like [KO:K07369] [EC:3.4.22.-]
109531236  mucosa-associated lymphoid tissue lymphoma translocation protein 1-like isoform X1 [KO:K07369] [EC:3.4.22.-]
109520533  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
109528595  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
109525796  inhibitor of nuclear factor kappa-B kinase subunit beta-like [KO:K07209] [EC:2.7.11.10]
109519522  NF-kappa-B inhibitor alpha-like [KO:K04734]
109509783  NF-kappa-B inhibitor alpha-like [KO:K04734]
109508122  NF-kappa-B inhibitor alpha-like [KO:K04734]
109516575  nfkb1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
109528036  tumor necrosis factor-like [KO:K03156]
109521023  tumor necrosis factor-like [KO:K03156]
109513551  interleukin-6-like isoform X1 [KO:K05405]
109517785  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
109526648  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
109531841  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
109531842  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
109510475  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
109530381  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
109522222  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
109513124  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109523612  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
109512691  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
109518742  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
109521335  transcription factor AP-1-like [KO:K04448]
109532403  transcription factor AP-1-like [KO:K04448]
109511901  fcer1g; high affinity immunoglobulin epsilon receptor subunit gamma isoform X1 [KO:K07983]
109507723  C-type lectin domain family 4 member M-like isoform X1 [KO:K06563]
109513179  perlucin-like protein [KO:K06563]
109527499  CD209 antigen-like isoform X1 [KO:K06563]
109526407  arhgef12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
109511764  rho-related GTP-binding protein RhoA-B-like isoform X1 [KO:K04513]
109528419  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
109522387  rho-related GTP-binding protein RhoA-B [KO:K04513]
109531368  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
109510807  serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
109508957  ksr1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
109510784  kinase suppressor of Ras 1-like [KO:K14958]
109516852  plk3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
109513573  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
109507451  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
109522194  inhibitor of nuclear factor kappa-B kinase subunit epsilon-like isoform X1 [KO:K07211] [EC:2.7.11.10]
109517578  signal transducer and activator of transcription 1-like [KO:K11220]
109520194  stat1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
109518593  irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
109522346  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11221]
109522056  il17d; interleukin-17D [KO:K05492]
109516934  ubiquitin carboxyl-terminal hydrolase CYLD-like isoform X1 [KO:K08601] [EC:3.4.19.12]
109516522  ubiquitin carboxyl-terminal hydrolase CYLD-like isoform X1 [KO:K08601] [EC:3.4.19.12]
109521498  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
109513981  cyld; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
109531673  B-cell lymphoma 3 protein-like [KO:K09258]
109532275  C-C motif chemokine 17-like [KO:K21083]
109522522  MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
109526623  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109525170  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
109510845  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109513228  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
109520494  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109527142  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
109529152  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
109519133  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
109521214  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
109513456  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
109516036  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109510167  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109526229  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109532684  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
109528378  interferon regulatory factor 1-like [KO:K09444]
109515677  interferon regulatory factor 1-like isoform X1 [KO:K09444]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00159  D-Mannose
C00165  Diacylglycerol
C00584  Prostaglandin E2
C00965  1,3-beta-D-Glucan
C01019  L-Fucose
C01245  D-myo-Inositol 1,4,5-trisphosphate
C16844  Hydroxyl radical
C21790  Mycobacterial trehalose dimycolate
C21791  Rhodocytin
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:27291962
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
C-type lectin receptors in the control of T helper cell differentiation.
  Journal
Nat Rev Immunol 16:433-48 (2016)
DOI:10.1038/nri.2016.55
Reference
PMID:21350579
  Authors
Hajishengallis G, Lambris JD
  Title
Microbial manipulation of receptor crosstalk in innate immunity.
  Journal
Nat Rev Immunol 11:187-200 (2011)
DOI:10.1038/nri2918
Reference
PMID:28604735
  Authors
Iliev ID, Leonardi I
  Title
Fungal dysbiosis: immunity and interactions at mucosal barriers.
  Journal
Nat Rev Immunol 17:635-646 (2017)
DOI:10.1038/nri.2017.55
Reference
PMID:25002863
  Authors
Richardson MB, Williams SJ
  Title
MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns.
  Journal
Front Immunol 5:288 (2014)
DOI:10.3389/fimmu.2014.00288
Reference
PMID:21924922
  Authors
Vautier S, MacCallum DM, Brown GD
  Title
C-type lectin receptors and cytokines in fungal immunity.
  Journal
Cytokine 58:89-99 (2012)
DOI:10.1016/j.cyto.2011.08.031
Reference
PMID:22170181
  Authors
Gauglitz GG, Callenberg H, Weindl G, Korting HC
  Title
Host defence against Candida albicans and the role of pattern-recognition receptors.
  Journal
Acta Derm Venereol 92:291-8 (2012)
DOI:10.2340/00015555-1250
Reference
PMID:22973279
  Authors
Cunha C, Carvalho A, Esposito A, Bistoni F, Romani L
  Title
DAMP signaling in fungal infections and diseases.
  Journal
Front Immunol 3:286 (2012)
DOI:10.3389/fimmu.2012.00286
Reference
PMID:29449845
  Authors
Tang J, Lin G, Langdon WY, Tao L, Zhang J
  Title
Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity.
  Journal
Front Immunol 9:123 (2018)
DOI:10.3389/fimmu.2018.00123
Reference
PMID:27999992
  Authors
Mayer S, Raulf MK, Lepenies B
  Title
C-type lectins: their network and roles in pathogen recognition and immunity.
  Journal
Histochem Cell Biol 147:223-237 (2017)
DOI:10.1007/s00418-016-1523-7
Reference
PMID:23570314
  Authors
Plato A, Willment JA, Brown GD
  Title
C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways.
  Journal
Int Rev Immunol 32:134-56 (2013)
DOI:10.3109/08830185.2013.777065
Reference
PMID:22344277
  Authors
Dupaul-Chicoine J, Saleh M
  Title
A new path to IL-1beta production controlled by caspase-8.
  Journal
Nat Immunol 13:211-2 (2012)
DOI:10.1038/ni.2241
Reference
PMID:24009832
  Authors
Batbayar S, Lee DH, Kim HW
  Title
Immunomodulation of Fungal beta-Glucan in Host Defense Signaling by Dectin-1.
  Journal
Biomol Ther (Seoul) 20:433-45 (2012)
DOI:10.4062/biomolther.2012.20.5.433
Reference
PMID:28606994
  Authors
Bendickova K, Tidu F, Fric J
  Title
Calcineurin-NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy.
  Journal
EMBO Mol Med 9:990-999 (2017)
DOI:10.15252/emmm.201707698
Reference
PMID:18998127
  Authors
den Dunnen J, Gringhuis SI, Geijtenbeek TB
  Title
Innate signaling by the C-type lectin DC-SIGN dictates immune responses.
  Journal
Cancer Immunol Immunother 58:1149-57 (2009)
DOI:10.1007/s00262-008-0615-1
Reference
PMID:28640912
  Authors
Marakalala MJ, Ndlovu H
  Title
Signaling C-type lectin receptors in antimycobacterial immunity.
  Journal
PLoS Pathog 13:e1006333 (2017)
DOI:10.1371/journal.ppat.1006333
Reference
PMID:24867235
  Authors
Gringhuis SI, Kaptein TM, Wevers BA, Mesman AW, Geijtenbeek TB
  Title
Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKepsilon- and CYLD-dependent Bcl3 activation.
  Journal
Nat Commun 5:3898 (2014)
DOI:10.1038/ncomms4898
Reference
PMID:19521399
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
Signalling through C-type lectin receptors: shaping immune responses.
  Journal
Nat Rev Immunol 9:465-79 (2009)
DOI:10.1038/nri2569
Reference
PMID:19122653
  Authors
Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB
  Title
Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.
  Journal
Nat Immunol 10:203-13 (2009)
DOI:10.1038/ni.1692
KO pathway
ko04625   
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