Entry Name Mitophagy - animal - Ictalurus furcatus (blue catfish)
Description Mitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process called reactive oxidative species (ROS) lead to mitochondrial dysfunction. If the damage is too excessive to be repaired, such mitochondria are selectively recognized and targeted for degradation by a specific mode of autophagy, termed mitophagy. The loss of the mitochondrial membrane potential can induce mitophagy, involving the kinase PINK1 and the E3 ligase Parkin. PINK1 serves as the sensor for the mitochondrial depolarization and recruits Parkin, followed by ubiquitin-dependent recruitment of mitophagy receptors. There are also several PINK1/Parkin-independent mitophagy pathways, in which a group of LIR-containing receptors are required in response to different stimuli. Mitophagy contributes to the maintenance of a healthy mitochondrial network and the prevention of programmed cell death.
Class Cellular Processes; Transport and catabolismBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Ictalurus furcatus (blue catfish) [GN:
ifu ]
Gene 128617889 ambra1b; activating molecule in BECN1-regulated autophagy protein 1B [KO:K17985 ]
128600638 tomm7; mitochondrial import receptor subunit TOM7 homolog [KO:K17771 ]
128606052 tomm40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518 ]
128616168 tomm40l; mitochondrial import receptor subunit TOM40B [KO:K11518 ]
128603185 si:dkey-71l1.1; mitochondrial import receptor subunit TOM40 homolog [KO:K11518 ]
128614207 tomm20b; mitochondrial import receptor subunit TOM20 homolog B [KO:K17770 ]
128615992 rhot1b; mitochondrial Rho GTPase 1b isoform X1 [KO:K07870 ] [EC:3.6.5.-]
128600324 rhot1a; mitochondrial Rho GTPase 1-A isoform X1 [KO:K07870 ] [EC:3.6.5.-]
128609262 tax1bp1b; tax1-binding protein 1 homolog B isoform X1 [KO:K21347 ]
128600419 tax1bp1a; tax1-binding protein 1 homolog A isoform X1 [KO:K21347 ]
128617556 calcoco2; calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348 ]
128611114 gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341 ]
128608162 zgc:92606; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341 ]
128611117 map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435 ]
128611519 map1lc3cl; uncharacterized protein map1lc3cl isoform X1 [KO:K10435 ]
128614220 map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435 ]
128624808 map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435 ]
128616708 bnip3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464 ]
128620116 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15465 ]
128611603 samm50; sorting and assembly machinery component 50 homolog A [KO:K07277 ]
128623649 samm50l; sorting and assembly machinery component 50 homolog B [KO:K07277 ]
128600950 eif2s1b; eukaryotic translation initiation factor 2 subunit 1b [KO:K03237 ]
128616133 atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374 ]
128603833 june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448 ]
128620960 hif1al; hypoxia inducible factor 1 subunit alpha, like [KO:K08268 ]
128618960 microphthalmia-associated transcription factor-like isoform X1 [KO:K09455 ]
128615021 mitfa; melanocyte inducing transcription factor a isoform X1 [KO:K09455 ]
128624164 rabgef1l; RAB guanine nucleotide exchange factor (GEF) 1, like [KO:K20131 ]
Compound Reference Authors Pickrell AM, Youle RJ
Title The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
Journal Reference Authors Durcan TM, Fon EA
Title The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications.
Journal Reference Authors Shirihai OS, Song M, Dorn GW 2nd
Title How mitochondrial dynamism orchestrates mitophagy.
Journal Reference Authors Hamacher-Brady A, Brady NR
Title Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy.
Journal Reference Authors Yamano K, Matsuda N, Tanaka K
Title The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation.
Journal Reference Authors Yamaguchi O, Murakawa T, Nishida K, Otsu K
Title Receptor-mediated mitophagy.
Journal Reference Authors Roberts RF, Tang MY, Fon EA, Durcan TM
Title Defending the mitochondria: The pathways of mitophagy and mitochondrial-derived vesicles.
Journal Reference Authors Arena G, Valente EM
Title PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease.
Journal Related KO pathway LinkDB All DBs
