KEGG   PATHWAY: ifu04150
Entry
ifu04150                    Pathway                                
Name
mTOR signaling pathway - Ictalurus furcatus (blue catfish)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
ifu04150  mTOR signaling pathway
ifu04150

Organism
Ictalurus furcatus (blue catfish) [GN:ifu]
Gene
128611778  slc7a5; large neutral amino acids transporter small subunit 1 [KO:K13780]
128622637  slc3a2b; solute carrier family 3 member 2b [KO:K06519]
128610087  4F2 cell-surface antigen heavy chain [KO:K06519]
128620403  slc38a9; sodium-coupled neutral amino acid transporter 9 [KO:K14995]
128599802  atp6v1ab; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
128612427  atp6v1ba; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
128620597  V-type proton ATPase subunit B, brain isoform [KO:K02147]
128620599  V-type proton ATPase subunit B, brain isoform [KO:K02147]
128613155  atp6v1c2; V-type proton ATPase subunit C 1-B [KO:K02148]
128615512  atp6v1c1b; V-type proton ATPase subunit C 1-B isoform X1 [KO:K02148]
128599658  atp6v1c1a; V-type proton ATPase subunit C 1-A [KO:K02148]
128600951  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
128623392  atp6v1e1b; V-type proton ATPase subunit E 1 [KO:K02150]
128611696  atp6v1e1a; V-type proton ATPase subunit E 1a [KO:K02150]
128623688  atp6v1f; V-type proton ATPase subunit F [KO:K02151]
128603533  atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
128609599  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
128621671  lamtor1; ragulator complex protein LAMTOR1 [KO:K20397]
128599940  lamtor2; ragulator complex protein LAMTOR2 [KO:K20398]
128605465  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
128623615  lamtor4; ragulator complex protein LAMTOR4 [KO:K20399]
128607903  lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
128608603  flcn; folliculin [KO:K09594]
128622297  fnip1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
128604090  fnip2; folliculin-interacting protein 2 isoform X1 [KO:K20401]
128611060  rraga; ras-related GTP-binding protein A [KO:K16185]
128618524  rragcb; ras-related GTP binding Cb [KO:K16186]
128612693  rragca; ras-related GTP binding Ca [KO:K16186]
128612857  rragd; ras-related GTP-binding protein D [KO:K16186]
128600631  sesn2; sestrin-2 [KO:K20394]
128599024  castor1; cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080]
128603496  castor2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
128599710  mios; GATOR complex protein MIOS [KO:K20407]
128600728  seh1l; nucleoporin SEH1 [KO:K14299]
128605227  wdr24; GATOR complex protein WDR24 isoform X1 [KO:K20408]
128606435  wdr59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
128625182  sec13; protein SEC13 homolog [KO:K14004]
128620087  depdc5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
128615119  nprl2; GATOR complex protein NPRL2 [KO:K20405]
128600356  nprl3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
128622770  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
128623918  rnf152; E3 ubiquitin-protein ligase rnf152 [KO:K15705] [EC:2.3.2.27]
128616363  rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
128603782  akt1s1; uncharacterized protein akt1s1 isoform X1 [KO:K16184]
128607588  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
128608801  deptor; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
128616741  mlst8; target of rapamycin complex subunit lst8 [KO:K08266]
128605344  telo2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
128619710  tti1; TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
128619963  clip1b; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
128625636  clip1a; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
128615352  grb10a; growth factor receptor-bound protein 10a isoform X1 [KO:K20064]
128605385  grb10b; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
128612637  lpin1a; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
128619175  lpin1b; phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
128614656  zgc:123305 [KO:K15728] [EC:3.1.3.4]
128609594  lpin2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
128607389  ulk1a; serine/threonine-protein kinase ULK1a isoform X1 [KO:K21357] [EC:2.7.11.1]
128622170  ulk1b; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
128621163  ulk2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
128622585  eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
128619856  eif4e2rs1; eukaryotic translation initiation factor 4E family member 2 related sequence 1 [KO:K03259]
128605472  eif4eb; eukaryotic translation initiation factor 4eb isoform X1 [KO:K03259]
128603799  eif4e1b; eukaryotic translation initiation factor 4E-1B isoform X1 [KO:K03259]
128623832  eif4e2; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
128604393  ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
128621550  rps6kb1b; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
128619242  eif4ba; eukaryotic translation initiation factor 4Ba isoform X1 [KO:K03258]
128614778  eif4bb; eukaryotic translation initiation factor 4Bb [KO:K03258]
128604445  rps6; 40S ribosomal protein S6 [KO:K02991]
128602826  strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
128615005  stradb; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
128624436  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
128611370  cab39l1; calcium binding protein 39, like 1 [KO:K08272]
128601951  cab39l; calcium-binding protein 39-like [KO:K08272]
128603610  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
128601100  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
128622311  tsc1b; TSC complex subunit 1b [KO:K07206]
128625591  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
128601858  tsc2; tuberin isoform X1 [KO:K07207]
128620792  tbc1d7; TBC1 domain family member 7 [KO:K20396]
128613943  rheb; GTP-binding protein Rheb [KO:K07208]
128614912  rhebl1; ras homolog, mTORC1 binding like 1 [KO:K07208]
128605019  DNA damage-inducible transcript 4 protein-like [KO:K08270]
128616621  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
128619702  wnt1; protein Wnt-1 [KO:K03209]
128606728  wnt2; protein Wnt-2 [KO:K00182]
128608003  wnt2bb; wingless-type MMTV integration site family, member 2Bb [KO:K00182]
128614512  wnt2ba; wingless-type MMTV integration site family, member 2Ba [KO:K00182]
128610584  wnt3a; protein Wnt-3a [KO:K00312]
128616654  wnt3; proto-oncogene Wnt-3 [KO:K00312]
128617689  wnt4b; wingless-type MMTV integration site family, member 4b [KO:K00408]
128625114  wnt4; protein Wnt-4a [KO:K00408]
128607658  wnt5a; protein Wnt-5a [KO:K00444]
128623665  wnt5b; protein Wnt-5b [KO:K00444]
128608433  wnt6b; protein Wnt-6 isoform X1 [KO:K00445]
128616173  wnt6a; protein Wnt-6 [KO:K00445]
128618153  wnt7bb; protein Wnt-7b isoform X1 [KO:K00572]
128623325  wnt7ba; protein Wnt-7b [KO:K00572]
128619718  protein Wnt-7a [KO:K00572]
128625194  wnt7aa; wingless-type MMTV integration site family, member 7Aa [KO:K00572]
128611154  protein Wnt-8a-like isoform X1 [KO:K00714]
128611157  protein Wnt-8-like isoform X1 [KO:K00714]
128605660  wnt8b; protein Wnt-8b [KO:K00714]
128610585  wnt9a; protein Wnt-9a [KO:K01064]
128602544  wnt9b; protein Wnt-9b [KO:K01064]
128608432  wnt10a; protein Wnt-10a isoform X1 [KO:K01357]
128619701  wnt10b; protein Wnt-10b [KO:K01357]
128620594  wnt11; protein Wnt-11 isoform X1 [KO:K01384]
128623077  wnt16; protein Wnt-16 [KO:K01558]
128608964  fzd7a; frizzled-7a [KO:K02432]
128616100  fzd7b; frizzled-7b [KO:K02432]
128602981  fzd2; frizzled-2 [KO:K02235]
128613224  fzd3b; frizzled-3b isoform X1 [KO:K02329]
128600881  fzd3a; frizzled-3a [KO:K02329]
128621631  fzd4; frizzled-4 [KO:K02354]
128614780  fzd8a; frizzled-8a [KO:K02375]
128608724  fzd5; frizzled-5 [KO:K02375]
128599675  fzd6; frizzled-6 isoform X1 [KO:K02376]
128603620  fzd9a; frizzled-9 [KO:K02842]
128607363  fzd10; frizzled-10 [KO:K02842]
128606966  fzd9b; frizzled-9b [KO:K02842]
128623538  lrp6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
128606525  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
128619797  dvl1a; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
128609787  dvl3a; segment polarity protein dishevelled homolog DVL-3a [KO:K02353]
128610166  dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
128608684  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
128601885  gsk3bb; glycogen synthase kinase 3 beta, genome duplicate b [KO:K03083] [EC:2.7.11.26]
128615339  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
128610592  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
128607709  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
128603617  insulin-like [KO:K04526]
128617816  insulin [KO:K04526]
128603190  insulin-like [KO:K04526]
128623736  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
128613547  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
128609860  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
128606740  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
128613996  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
128616031  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
128599154  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
128614273  sos1; son of sevenless homolog 1 [KO:K03099]
128618140  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
128602959  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
128618149  kras; GTPase KRas isoform X1 [KO:K07827]
128601824  zgc:55558; GTPase KRas [KO:K07827]
128608137  nras; GTPase NRas [KO:K07828]
128623239  braf; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
128619536  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
128624988  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
128606701  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
128613746  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
128624239  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
128602235  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
128625408  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
128611054  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
128612490  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
128605255  rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
128599374  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
128621416  irs1; insulin receptor substrate 1-B [KO:K16172]
128614576  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
128603480  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
128613582  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
128619025  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
128619253  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
128623950  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
128612336  ptena; phosphatase and tensin homolog A [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
128616526  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
128604408  pdpk1b; 3-phosphoinositide dependent protein kinase 1b isoform X1 [KO:K06276] [EC:2.7.11.1]
128600260  pdpk1a; 3-phosphoinositide-dependent protein kinase 1a [KO:K06276] [EC:2.7.11.1]
128613234  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128606850  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
128605437  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128601820  akt3b; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
128605794  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
128603353  mapkap1; target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
128622007  rictorb; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
128611556  prr5a; proline-rich protein 5a [KO:K20411]
128618584  prr5l; proline-rich protein 5-like isoform X1 [KO:K20411]
128623230  proline-rich protein 5 isoform X1 [KO:K20411]
128602961  proline-rich protein 5-like isoform X1 [KO:K20411]
128619107  rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513]
128608000  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
128608047  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
128614524  rhoca; ras homolog family member Ca [KO:K04513]
128608335  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
128624840  transforming protein RhoA-like [KO:K04513]
128615331  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
128625389  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
128622033  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
128601966  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
128608413  prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
128619921  sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
128615815  si:ch211-195b13.1; STKc_SGK domain-containing protein [KO:K13302] [EC:2.7.11.1]
128599976  sgk2b; serine/threonine-protein kinase Sgk2b [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
ifu00561  Glycerolipid metabolism
ifu04010  MAPK signaling pathway
ifu04140  Autophagy - animal
ifu04810  Regulation of actin cytoskeleton
ifu04910  Insulin signaling pathway
KO pathway
ko04150   
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