Entry
Name
Amoebiasis
Description
Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response.
Class
Human Diseases; Infectious disease: parasitic
BRITE hierarchy
Pathway map
Ortholog table
Disease
Orthology
K04386 interleukin 1 receptor type I
K04387 interleukin 1 receptor type II
K02580 nuclear factor NF-kappa-B p105 subunit
K04735 transcription factor p65
K04455 heat shock protein beta-1
K13970 galactose-inhibitable lectin heavy subunit
K13971 galactose-inhibitable lectin light subunit
K13972 galactose-inhibitable lectin intermediate subunit
K13973 pore-forming peptide ameobapore
K06856 immunoglobulin heavy chain
K04634 guanine nucleotide-binding protein G(q) subunit alpha
K04635 guanine nucleotide-binding protein subunit alpha-11
K04636 guanine nucleotide-binding protein subunit alpha-14
K04637 guanine nucleotide-binding protein subunit alpha-15
K13974 calcium-binding protein
K04632 guanine nucleotide-binding protein G(s) subunit alpha
K04633 guanine nucleotide-binding protein G(olf) subunit alpha
K13975 phagosome-associated TMK96
K07887 Ras-related protein Rab-5A
K07888 Ras-related protein Rab-5B
K07889 Ras-related protein Rab-5C
K07897 Ras-related protein Rab-7A
K07898 Ras-related protein Rab-7B
K04391 monocyte differentiation antigen CD14
K05505 C-X-C motif chemokine 1/2/3
K05427 granulocyte-macrophage colony-stimulating factor
K03156 tumor necrosis factor superfamily, member 2
K06448 T-cell surface glycoprotein CD1
K19720 collagen type III alpha
K13977 LIM domain-containing protein
K02649 phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153 ]
K13375 transforming growth factor beta-1
K13376 transforming growth factor beta-2
K13377 transforming growth factor beta-3
K03997 complement component 8 subunit alpha
K03998 complement component 8 subunit beta
K03999 complement component 8 subunit gamma
K23602 serine-threonine-isoleucine rich protein
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C18287 Monocyte locomotion inhibitory factor
Reference
Authors
Stanley SL
Title
Pathophysiology of amoebiasis.
Journal
Reference
Authors
Espinosa-Cantellano M, Martinez-Palomo A
Title
Pathogenesis of intestinal amebiasis: from molecules to disease.
Journal
Reference
Authors
Huston CD, Petri WA Jr
Title
Host-pathogen interaction in amebiasis and progress in vaccine development.
Journal
Reference
Authors
Huston CD
Title
Parasite and host contributions to the pathogenesis of amebic colitis.
Journal
Reference
Authors
Campos-Rodriguezp R, Jarillo-Luna A
Title
The pathogenicity of Entamoeba histolytica is related to the capacity of evading innate immunity.
Journal
Reference
Authors
Lejeune M, Rybicka JM, Chadee K
Title
Recent discoveries in the pathogenesis and immune response toward Entamoeba histolytica.
Journal
Reference
Authors
Carrero JC, Cervantes-Rebolledo C, Aguilar-Diaz H, Diaz-Gallardo MY, Laclette JP, Morales-Montor J
Title
The role of the secretory immune response in the infection by Entamoeba histolytica.
Journal
Reference
Authors
Stanley SL Jr
Title
Amoebiasis.
Journal
Reference
Authors
Stauffer W, Ravdin JI
Title
Entamoeba histolytica: an update.
Journal
Reference
Authors
Petri WA Jr, Haque R, Mann BJ
Title
The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica.
Journal
Reference
Authors
Baxt LA, Singh U
Title
New insights into Entamoeba histolytica pathogenesis.
Journal
Reference
Authors
Petri WA Jr
Title
Pathogenesis of amebiasis.
Journal
Reference
Authors
Guo X, Houpt E, Petri WA Jr
Title
Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies.
Journal
Reference
Authors
Mortimer L, Chadee K
Title
The immunopathogenesis of Entamoeba histolytica.
Journal
Reference
Authors
Meza I, Talamas-Rohana P, Vargas MA
Title
The cytoskeleton of Entamoeba histolytica: structure, function, and regulation by signaling pathways.
Journal
Reference
Authors
Meza I
Title
Extracellular matrix-induced signaling in Entamoeba histolytica: its role in invasiveness.
Journal
Reference
Authors
Stanley SL Jr, Reed SL
Title
Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions.
Journal
Reference
Authors
Wong-Baeza I, Alcantara-Hernandez M, Mancilla-Herrera I, Ramirez-Saldivar I, Arriaga-Pizano L, Ferat-Osorio E, Lopez-Macias C, Isibasi A
Title
The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica.
Journal
Related pathway
ko00330 Arginine and proline metabolism
ko00590 Arachidonic acid metabolism
ko04610 Complement and coagulation cascades
ko04612 Antigen processing and presentation
ko04620 Toll-like receptor signaling pathway
ko04672 Intestinal immune network for IgA production
ko04810 Regulation of actin cytoskeleton
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