Entry Name Systemic lupus erythematosus - Lynx rufus (bobcat)
Description Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and certain cytoplasmic components, in association with a diverse array of clinical manifestations. The primary pathological findings in patients with SLE are those of inflammation, vasculitis, immune complex deposition, and vasculopathy. Immune complexes comprising autoantibody and self-antigen is deposited particulary in the renal glomeruli and mediate a systemic inflammatory response by activating complement or via Fc{gamma}R-mediated neutrophil and macrophage activation. Activation of complement (C5) leads to injury both through formation of the membrane attack complex (C5b-9) or by generation of the anaphylatoxin and cell activator C5a. Neutrophils and macrophages cause tissue injury by the release of oxidants and proteases.
Class Human Diseases; Immune diseaseBRITE hierarchy
Pathway map Ortholog table Organism Lynx rufus (bobcat) [GN:
lruf ]
Gene 124503675 small nuclear ribonucleoprotein-associated proteins B and B' isoform X1 [KO:K11086 ]
124525552 LOW QUALITY PROTEIN: small nuclear ribonucleoprotein Sm D1-like [KO:K11087 ]
124527968 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
124527969 HLA class II histocompatibility antigen, DR alpha chain [KO:K06752 ]
124527970 HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752 ]
124528564 DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752 ]
124528600 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
124528621 HLA class II histocompatibility antigen, DM beta chain-like [KO:K06752 ]
124528730 HLA class II histocompatibility antigen, DO beta chain-like isoform X1 [KO:K06752 ]
124528769 HLA class II histocompatibility antigen, DO alpha chain-like [KO:K06752 ]
124528840 HLA class II histocompatibility antigen, DM alpha chain-like isoform X1 [KO:K06752 ]
124529193 HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752 ]
124529194 LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752 ]
124504027 tumor necrosis factor receptor superfamily member 5-like [KO:K03160 ]
124515442 high affinity immunoglobulin gamma Fc receptor I-like isoform X1 [KO:K06498 ]
124509902 low affinity immunoglobulin gamma Fc region receptor III-A-like [KO:K06463 ]
Compound Reference Authors Rahman A, Isenberg DA.
Title Systemic lupus erythematosus.
Journal Reference Authors Mok CC, Lau CS.
Title Pathogenesis of systemic lupus erythematosus.
Journal Reference Authors Clatworthy MR, Smith KG.
Title B cells in glomerulonephritis: focus on lupus nephritis.
Journal Reference Authors Couser WG.
Title New insights into mechanisms of immune glomerular injury.
Journal West J Med 160:440-6 (1994)
Reference Authors Cook HT, Botto M.
Title Mechanisms of Disease: the complement system and the pathogenesis of systemic lupus erythematosus.
Journal Reference Authors Carroll MC.
Title A protective role for innate immunity in systemic lupus erythematosus.
Journal Reference Authors Sturfelt G, Truedsson L.
Title Complement and its breakdown products in SLE.
Journal Reference Authors Lu L, Kaliyaperumal A, Boumpas DT, Datta SK.
Title Major peptide autoepitopes for nucleosome-specific T cells of human lupus.
Journal Reference Authors Zieve GW, Khusial PR.
Title The anti-Sm immune response in autoimmunity and cell biology.
Journal Reference Authors Scofield RH, Farris AD, Horsfall AC, Harley JB.
Title Fine specificity of the autoimmune response to the Ro/SSA and La/SSB ribonucleoproteins.
Journal Reference Authors Hoffman RW.
Title T cells in the pathogenesis of systemic lupus erythematosus.
Journal Related lruf04060 Cytokine-cytokine receptor interaction
lruf04610 Complement and coagulation cascades
lruf04612 Antigen processing and presentation
lruf04670 Leukocyte transendothelial migration
KO pathway LinkDB All DBs
