KEGG   PATHWAY: masi04137
Entry
masi04137                   Pathway                                
Name
Mitophagy - animal - Myxocyprinus asiaticus (Chinese sucker)
Description
Mitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process called reactive oxidative species (ROS) lead to mitochondrial dysfunction. If the damage is too excessive to be repaired, such mitochondria are selectively recognized and targeted for degradation by a specific mode of autophagy, termed mitophagy. The loss of the mitochondrial membrane potential can induce mitophagy, involving the kinase PINK1 and the E3 ligase Parkin. PINK1 serves as the sensor for the mitochondrial depolarization and recruits Parkin, followed by ubiquitin-dependent recruitment of mitophagy receptors. There are also several PINK1/Parkin-independent mitophagy pathways, in which a group of LIR-containing receptors are required in response to different stimuli. Mitophagy contributes to the maintenance of a healthy mitochondrial network and the prevention of programmed cell death.
Class
Cellular Processes; Transport and catabolism
Pathway map
masi04137  Mitophagy - animal
masi04137

Other DBs
GO: 0000422
Organism
Myxocyprinus asiaticus (Chinese sucker) [GN:masi]
Gene
127437586  activating molecule in BECN1-regulated autophagy protein 1B-like [KO:K17985]
127432968  activating molecule in BECN1-regulated autophagy protein 1A-like isoform X1 [KO:K17985]
127416633  activating molecule in BECN1-regulated autophagy protein 1A isoform X1 [KO:K17985]
127436085  activating molecule in BECN1-regulated autophagy protein 1B [KO:K17985]
127418777  serine/threonine-protein kinase PINK1, mitochondrial-like [KO:K05688] [EC:2.7.11.1]
127425536  mitochondrial import receptor subunit TOM7 homolog [KO:K17771]
127420906  mitochondrial import receptor subunit TOM7 homolog [KO:K17771]
127425020  mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
127426936  mitochondrial import receptor subunit TOM40B-like [KO:K11518]
127421470  mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
127439895  mitochondrial import receptor subunit TOM40B-like [KO:K11518]
127452878  mitochondrial import receptor subunit TOM40 homolog isoform X1 [KO:K11518]
127453821  mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
127411997  mitochondrial import receptor subunit TOM20 homolog [KO:K17770]
127426521  mitochondrial import receptor subunit TOM20 homolog B [KO:K17770]
127414400  translocase of outer mitochondrial membrane 20 [KO:K17770]
127427562  mitochondrial import receptor subunit TOM20 homolog B-like [KO:K17770]
127449650  mitochondrial import receptor subunit TOM70-like [KO:K17768]
127446355  mitochondrial import receptor subunit TOM70-like [KO:K17768]
127412044  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
127413705  E3 ubiquitin-protein ligase parkin-like [KO:K04556] [EC:2.3.2.31]
127412203  E3 ubiquitin-protein ligase MARCHF5-like [KO:K10660] [EC:2.3.2.27]
127432933  E3 ubiquitin-protein ligase MARCHF5 [KO:K10660] [EC:2.3.2.27]
127414419  E3 ubiquitin-protein ligase MARCHF5 isoform X1 [KO:K10660] [EC:2.3.2.27]
127433890  E3 ubiquitin-protein ligase MARCHF5 [KO:K10660] [EC:2.3.2.27]
127418979  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
127439016  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
127440016  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
127433991  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
127428703  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
127423392  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
127450018  E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
127450180  E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
127451259  E3 ubiquitin-protein ligase SMURF1-like isoform X1 [KO:K04678] [EC:2.3.2.26]
127452325  E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
127437456  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
127436293  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
127420432  mitochondrial ubiquitin ligase activator of NFKB 1 isoform X1 [KO:K15688] [EC:2.3.2.27]
127440436  mitochondrial ubiquitin ligase activator of nfkb 1-A [KO:K15688] [EC:2.3.2.27]
127440962  mitochondrial ubiquitin ligase activator of nfkb 1-A-like [KO:K15688] [EC:2.3.2.27]
127441969  mitochondrial ubiquitin ligase activator of nfkb 1-A-like [KO:K15688] [EC:2.3.2.27]
127419154  E3 ubiquitin-protein ligase HUWE1-like isoform X1 [KO:K10592] [EC:2.3.2.26]
127420128  E3 ubiquitin-protein ligase HUWE1-like [KO:K10592] [EC:2.3.2.26]
127456508  E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
127417412  E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
127455998  E3 ubiquitin-protein ligase arih1-like isoform X1 [KO:K11968] [EC:2.3.2.31]
127445591  E3 ubiquitin-protein ligase arih1l-like [KO:K11968] [EC:2.3.2.31]
127450887  E3 ubiquitin-protein ligase arih1l [KO:K11968] [EC:2.3.2.31]
127426479  mitofusin-1-like [KO:K21356] [EC:3.6.5.-]
127428041  LOW QUALITY PROTEIN: mitofusin-1b [KO:K21356] [EC:3.6.5.-]
127441240  mitofusin-1-like [KO:K21356] [EC:3.6.5.-]
127424402  mitofusin-2 [KO:K06030] [EC:3.6.5.-]
127414472  mitofusin-2-like [KO:K06030] [EC:3.6.5.-]
127450095  mitochondrial Rho GTPase 1-A isoform X1 [KO:K07870] [EC:3.6.5.-]
127451103  mitochondrial Rho GTPase 1-A-like isoform X1 [KO:K07870] [EC:3.6.5.-]
127446450  mitochondrial Rho GTPase 1-A-like isoform X1 [KO:K07870] [EC:3.6.5.-]
127449006  mitochondrial Rho GTPase 1b isoform X1 [KO:K07870] [EC:3.6.5.-]
127431559  mitochondrial Rho GTPase 2 [KO:K07871] [EC:3.6.5.-]
127434133  mitochondrial Rho GTPase 2-like [KO:K07871] [EC:3.6.5.-]
127440431  ubiquitin-60S ribosomal protein L40 [KO:K02927]
127442693  ubiquitin-60S ribosomal protein L40 [KO:K02927]
127446240  ubiquitin-40S ribosomal protein S27a [KO:K02977]
127448705  ubiquitin-40S ribosomal protein S27a [KO:K02977]
127432600  polyubiquitin-B isoform X1 [KO:K08770]
127433340  polyubiquitin-C isoform X1 [KO:K08770]
127427487  polyubiquitin-B [KO:K08770]
127440157  polyubiquitin-C-like [KO:K08770]
127425288  tax1-binding protein 1 homolog A-like [KO:K21347]
127421585  tax1-binding protein 1 homolog A isoform X1 [KO:K21347]
127452849  tax1-binding protein 1 homolog B-like isoform X1 [KO:K21347]
127453780  tax1-binding protein 1 homolog B isoform X1 [KO:K21347]
127412849  sequestosome-1-like isoform X1 [KO:K14381]
127417868  sequestosome-1 [KO:K14381]
127427053  calcium-binding and coiled-coil domain-containing protein 2-like [KO:K21348]
127423318  calcium-binding and coiled-coil domain-containing protein 2-like [KO:K21348]
127436657  optineurin-like isoform X1 [KO:K19946]
127435256  optineurin-like [KO:K19946]
127450159  next to BRCA1 gene 1 protein-like isoform X1 [KO:K17987]
127426985  next to BRCA1 gene 1 protein-like isoform X1 [KO:K17987]
127452284  next to BRCA1 gene 1 protein-like isoform X1 [KO:K17987]
127423312  next to BRCA1 gene 1 protein-like isoform X1 [KO:K17987]
127435182  serine/threonine-protein kinase TBK1-like [KO:K05410] [EC:2.7.11.10]
127436432  serine/threonine-protein kinase TBK1-like isoform X1 [KO:K05410] [EC:2.7.11.10]
127412280  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
127437265  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
127438320  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
127439886  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
127452986  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
127422605  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
127453973  gamma-aminobutyric acid receptor-associated protein-like 1 isoform X1 [KO:K08341]
127435780  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
127412617  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
127437836  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
127426240  microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
127426522  microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
127427617  microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
127428199  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
127435920  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
127417739  microtubule-associated proteins 1A/1B light chain 3C-like isoform X1 [KO:K10435]
127427122  beclin-1 [KO:K08334]
127423004  beclin-1 [KO:K08334]
127455930  ubiquitin carboxyl-terminal hydrolase 8-like [KO:K11839] [EC:3.4.19.12]
127417431  ubiquitin carboxyl-terminal hydrolase 8-like [KO:K11839] [EC:3.4.19.12]
127436993  ubiquitin carboxyl-terminal hydrolase 15-like isoform X1 [KO:K21343] [EC:3.4.19.12]
127435309  ubiquitin carboxyl-terminal hydrolase 15-like isoform X1 [KO:K21343] [EC:3.4.19.12]
127418723  ubiquitin carboxyl-terminal hydrolase 30 isoform X1 [KO:K11851] [EC:3.4.19.12]
127439637  ubiquitin carboxyl-terminal hydrolase 30-like isoform X1 [KO:K11851] [EC:3.4.19.12]
127418980  bcl-2-like protein 1 [KO:K04570]
127418805  serine/threonine-protein phosphatase PGAM5, mitochondrial-like isoform X1 [KO:K15637] [EC:3.1.3.16]
127432351  serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
127425545  casein kinase II subunit alpha-like isoform X1 [KO:K03097] [EC:2.7.11.1]
127437792  casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
127420879  casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
127452825  casein kinase II subunit alpha-like isoform X1 [KO:K03097] [EC:2.7.11.1]
127454281  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
127435919  casein kinase II subunit alpha'-like isoform X1 [KO:K03097] [EC:2.7.11.1]
127454799  casein kinase II subunit alpha'-like isoform X1 [KO:K03097] [EC:2.7.11.1]
127436113  casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
127425584  casein kinase II subunit beta [KO:K03115]
127420917  casein kinase II subunit beta-like [KO:K03115]
127418784  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
127419990  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
127430581  serine/threonine-protein kinase ULK1-like isoform X1 [KO:K21357] [EC:2.7.11.1]
127414762  serine/threonine-protein kinase ULK1-like [KO:K21357] [EC:2.7.11.1]
127428822  serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
127424131  serine/threonine-protein kinase ULK1-like [KO:K21357] [EC:2.7.11.1]
127445797  FUN14 domain-containing protein 1-like [KO:K17986]
127447460  FUN14 domain-containing protein 1-like [KO:K17986]
127447688  FUN14 domain-containing protein 1 isoform X1 [KO:K17986]
127455481  BCL2 interacting protein 4 isoform X1 [KO:K15464]
127427330  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
127440056  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
127411405  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
127423647  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
127423692  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
127432785  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X1 [KO:K15465]
127433345  BCL2 interacting protein 3 like b [KO:K15465]
127415425  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15465]
127423760  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X1 [KO:K15465]
127455665  bcl-2-like protein 13 isoform X1 [KO:K15485]
127416864  bcl-2-like protein 13 [KO:K15485]
127456101  peptidyl-prolyl cis-trans isomerase FKBP8-like [KO:K09574] [EC:5.2.1.8]
127437921  peptidyl-prolyl cis-trans isomerase FKBP8-like [KO:K09574] [EC:5.2.1.8]
127439299  peptidyl-prolyl cis-trans isomerase FKBP8-like isoform X1 [KO:K09574] [EC:5.2.1.8]
127417422  peptidyl-prolyl cis-trans isomerase FKBP8-like [KO:K09574] [EC:5.2.1.8]
127437595  sorting and assembly machinery component 50 homolog A [KO:K07277]
127435258  sorting and assembly machinery component 50 homolog B-like isoform X1 [KO:K07277]
127435648  sorting and assembly machinery component 50 homolog A-like [KO:K07277]
127436394  sorting and assembly machinery component 50 homolog B [KO:K07277]
127449659  prohibitin-2-like isoform X1 [KO:K17081]
127445619  prohibitin-2-like [KO:K17081]
127441257  prohibitin-2-like [KO:K17081]
127442028  prohibitin-2-like [KO:K17081]
127421728  NLR family member X1 [KO:K12653]
127429867  NLR family member X1-like isoform X1 [KO:K12653]
127420924  metaxin-1b isoform X1 [KO:K17776]
127446482  metaxin-2-like [KO:K17776]
127439826  metaxin-3 isoform X1 [KO:K17776]
127428200  metaxin-3-like isoform X1 [KO:K17776]
127453486  metaxin-1a [KO:K17776]
127454211  metaxin-1-like [KO:K17776]
127448940  metaxin-2-like [KO:K17776]
127414221  eukaryotic translation initiation factor 2-alpha kinase 3-like isoform X1 [KO:K08860] [EC:2.7.11.1]
127411854  eukaryotic translation initiation factor 2-alpha kinase 3-like [KO:K08860] [EC:2.7.11.1]
127409719  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
127416341  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
127411266  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
127454931  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
127449999  activating transcription factor 4b [KO:K04374]
127451404  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
127446203  LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
127412122  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127430781  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
127431115  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
127413972  mitogen-activated protein kinase 8B isoform X1 [KO:K04440] [EC:2.7.11.24]
127426968  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
127428642  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
127428709  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
127423091  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127416105  transcription factor Jun-like [KO:K04448]
127410395  transcription factor Jun-like [KO:K04448]
127423532  transcription factor Jun-like [KO:K04448]
127433363  transcription factor Jun-like [KO:K04448]
127410534  transcription factor p65 [KO:K04735]
127443565  GTPase HRas-like [KO:K02833]
127437085  GTPase HRas-like [KO:K02833]
127452252  GTPase HRas [KO:K02833]
127436084  GTPase HRas-like isoform X1 [KO:K02833]
127437280  GTPase KRas isoform X1 [KO:K07827]
127450507  GTPase HRas-like [KO:K07827]
127451777  GTPase HRas-like [KO:K07827]
127436201  GTPase KRas [KO:K07827]
127415059  GTPase NRas [KO:K07828]
127423940  GTPase NRas [KO:K07828]
127437989  ras-related protein M-Ras-like [KO:K07831]
127438798  ras-related protein M-Ras-like [KO:K07831]
127447145  ras-related protein M-Ras-like isoform X1 [KO:K07831]
127447810  ras-related protein M-Ras [KO:K07831]
127450475  ras-related protein R-Ras-like [KO:K07830]
127451767  ras-related protein R-Ras [KO:K07830]
127452046  ras-related protein R-Ras2-like [KO:K07830]
127415070  ras-related protein R-Ras2 [KO:K07830]
127418794  transcription factor E2F1-like [KO:K17454]
127419645  transcription factor E2F1 [KO:K17454]
127412159  hypoxia-inducible factor 1-alpha-like isoform X1 [KO:K08268]
127414184  hypoxia-inducible factor 1-alpha-like isoform X1 [KO:K08268]
127409787  hypoxia inducible factor 1 subunit alpha b [KO:K08268]
127422553  hypoxia-inducible factor 1-alpha-like isoform X1 [KO:K08268]
127416406  hypoxia-inducible factor 1-alpha-like isoform X1 [KO:K08268]
127430261  hypoxia-inducible factor 1-alpha-like isoform X1 [KO:K08268]
127426577  transcription factor Sp1 [KO:K04684]
127428316  transcription factor Sp1-like [KO:K04684]
127412460  cellular tumor antigen p53-like [KO:K04451]
127439189  cellular tumor antigen p53-like isoform X1 [KO:K04451]
127423032  cellular tumor antigen p53-like isoform X1 [KO:K04451]
127415916  forkhead box protein O3-like [KO:K09408]
127410441  forkhead box protein O3B [KO:K09408]
127410675  forkhead box protein O3a [KO:K09408]
127454801  forkhead box protein O3-like [KO:K09408]
127456691  cbp/p300-interacting transactivator 2 [KO:K21361]
127416184  cbp/p300-interacting transactivator 2-like [KO:K21361]
127418914  microphthalmia-associated transcription factor-like isoform X1 [KO:K09455]
127420039  microphthalmia-associated transcription factor-like isoform X1 [KO:K09455]
127445881  microphthalmia-associated transcription factor-like isoform X1 [KO:K09455]
127449117  microphthalmia-associated transcription factor-like [KO:K09455]
127426146  transcription factor EB-like [KO:K15590]
127428046  transcription factor EB-like isoform X1 [KO:K15590]
127424430  transcription factor E3-like isoform X1 [KO:K09105]
127426203  transcription factor E3-like [KO:K09105]
127415031  microphthalmia-associated transcription factor-like isoform X1 [KO:K09105]
127427750  transcription factor E3-like [KO:K09105]
127432905  rab5 GDP/GTP exchange factor-like isoform X1 [KO:K20131]
127433720  rab5 GDP/GTP exchange factor-like isoform X1 [KO:K20131]
127421947  RAB guanine nucleotide exchange factor (GEF) 1, like [KO:K20131]
127429605  rab5 GDP/GTP exchange factor-like [KO:K20131]
127424906  ras-related protein Rab-5A-like [KO:K07887]
127421416  RAB5A, member RAS oncogene family, a [KO:K07887]
127453220  ras-related protein Rab-5A-like [KO:K07887]
127454174  ras-related protein Rab-5A-like [KO:K07887]
127447146  ras-related protein Rab-5B-like [KO:K07888]
127448130  ras-related protein Rab-5B-like [KO:K07888]
127450506  ras-related protein Rab-5C [KO:K07889]
127451136  ras-related protein Rab-5C-like [KO:K07889]
127426193  vacuolar fusion protein MON1 homolog B-like [KO:K20195]
127426578  vacuolar fusion protein MON1 homolog A [KO:K20195]
127427585  vacuolar fusion protein MON1 homolog B [KO:K20195]
127427285  vacuolar fusion protein CCZ1 homolog [KO:K27045]
127423440  vacuolar fusion protein CCZ1 homolog [KO:K27045]
127425839  si:dkey-13a21.4; ras-related protein Rab-7a isoform X1 [KO:K07897]
127426289  ras-related protein rab7 [KO:K07897]
127432850  ras-related protein rab7-like [KO:K07897]
127414841  ras-related protein rab7-like [KO:K07897]
127433761  ras-related protein rab7-like [KO:K07897]
127428073  ras-related protein rab7-like [KO:K07897]
127423981  ras-related protein Rab-7a-like [KO:K07897]
127456392  TBC1 domain family member 15-like [KO:K20168]
127416894  TBC1 domain family member 15 [KO:K20168]
127449933  TBC1 domain family member 17-like [KO:K19945]
127451386  TBC1 domain family member 17 [KO:K19945]
127446893  mitochondrial fission 1 protein [KO:K17969]
127434170  mitochondrial fission 1 protein-like [KO:K17969]
127432163  autophagy-related protein 9A-like [KO:K17907]
127446264  autophagy-related protein 9A [KO:K17907]
127434116  autophagy-related protein 9B isoform X1 [KO:K17907]
127445711  dynamin-like 120 kDa protein, mitochondrial isoform X1 [KO:K17079] [EC:3.6.5.5]
127448732  dynamin-like 120 kDa protein, mitochondrial isoform X1 [KO:K17079] [EC:3.6.5.5]
127418036  transitional endoplasmic reticulum ATPase-like [KO:K13525]
127444267  transitional endoplasmic reticulum ATPase-like [KO:K13525]
127444712  transitional endoplasmic reticulum ATPase-like [KO:K13525]
127434435  transitional endoplasmic reticulum ATPase [KO:K13525]
Compound
C00035  GDP
C00044  GTP
Reference
PMID:25611507
  Authors
Pickrell AM, Youle RJ
  Title
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
  Journal
Neuron 85:257-73 (2015)
DOI:10.1016/j.neuron.2014.12.007
Reference
PMID:25995186
  Authors
Durcan TM, Fon EA
  Title
The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications.
  Journal
Genes Dev 29:989-99 (2015)
DOI:10.1101/gad.262758.115
Reference
PMID:25999423
  Authors
Shirihai OS, Song M, Dorn GW 2nd
  Title
How mitochondrial dynamism orchestrates mitophagy.
  Journal
Circ Res 116:1835-49 (2015)
DOI:10.1161/CIRCRESAHA.116.306374
Reference
PMID:26611876
  Authors
Hamacher-Brady A, Brady NR
  Title
Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy.
  Journal
Cell Mol Life Sci 73:775-95 (2016)
DOI:10.1007/s00018-015-2087-8
Reference
PMID:26882551
  Authors
Yamano K, Matsuda N, Tanaka K
  Title
The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation.
  Journal
EMBO Rep 17:300-16 (2016)
DOI:10.15252/embr.201541486
Reference
PMID:27021519
  Authors
Yamaguchi O, Murakawa T, Nishida K, Otsu K
  Title
Receptor-mediated mitophagy.
  Journal
J Mol Cell Cardiol 95:50-6 (2016)
DOI:10.1016/j.yjmcc.2016.03.010
Reference
PMID:27443527
  Authors
Roberts RF, Tang MY, Fon EA, Durcan TM
  Title
Defending the mitochondria: The pathways of mitophagy and mitochondrial-derived vesicles.
  Journal
Int J Biochem Cell Biol 79:427-436 (2016)
DOI:10.1016/j.biocel.2016.07.020
Reference
PMID:27701735
  Authors
Arena G, Valente EM
  Title
PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease.
  Journal
J Pathol 241:251-263 (2017)
DOI:10.1002/path.4815
Related
pathway
masi04140  Autophagy - animal
masi04210  Apoptosis
KO pathway
ko04137   
LinkDB

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