KEGG   PATHWAY: morg04144
Entry
morg04144                   Pathway                                
Name
Endocytosis - Microtus oregoni (creeping vole)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
morg04144  Endocytosis
morg04144

Other DBs
GO: 0006897
Organism
Microtus oregoni (creeping vole) [GN:morg]
Gene
121452281  Arf6; ADP-ribosylation factor 6 [KO:K07941]
121459372  Pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
121453833  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
121450461  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
121437835  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
121462998  Pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
121456999  Pld2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
121452721  Pld1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
121454962  Dnm3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
121462610  Dnm1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
121451922  Dnm2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
121458420  Clta; clathrin light chain A isoform X1 [KO:K04644]
121453235  Cltb; clathrin light chain B isoform X1 [KO:K04645]
121456200  Cltc; clathrin heavy chain 1 isoform X1 [KO:K04646]
121457529  Ap2a2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
121440717  Ap2a1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
121456888  Ap2b1; AP-2 complex subunit beta isoform X1 [KO:K11825]
121466494  AP-2 complex subunit beta-like [KO:K11825]
121464793  Ap2m1; AP-2 complex subunit mu [KO:K11826]
121449571  Ap2s1; AP-2 complex subunit sigma [KO:K11827]
121449707  Ehd2; EH domain-containing protein 2 [KO:K12469]
121458328  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
121464335  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
121455766  Zfyve16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
121448100  Zfyve9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
121466108  Pml; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
121438761  Smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
121466030  Smad3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
121461766  Tfrc; transferrin receptor protein 1 [KO:K06503]
121459895  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
121460639  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
121457506  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
121459483  fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
121436445  fibroblast growth factor receptor 3-like isoform X1 [KO:K05094] [EC:2.7.10.1]
121444101  LOW QUALITY PROTEIN: fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
121445397  LOW QUALITY PROTEIN: fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
121445442  LOW QUALITY PROTEIN: fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
121445462  LOW QUALITY PROTEIN: fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
121445490  LOW QUALITY PROTEIN: fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
121445507  LOW QUALITY PROTEIN: fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
121445523  LOW QUALITY PROTEIN: fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
121453266  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
121453621  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
121438406  Cbl; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
121461747  Cblb; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
121450183  Cblc; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
121441178  Sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
121441312  SH3 domain-containing kinase-binding protein 1-like [KO:K12470]
121459739  Sh3gl1; endophilin-A2 [KO:K11247]
121451553  Sh3gl3; endophilin-A3 isoform X1 [KO:K11247]
121448563  Sh3gl2; endophilin-A1 [KO:K11247]
121448664  Sh3glb1; endophilin-B1 isoform X1 [KO:K11248]
121462797  Sh3glb2; endophilin-B2 isoform X1 [KO:K21269]
121453245  Bin1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
121443931  Amph; amphiphysin isoform X1 [KO:K12562]
121456473  Epn2; epsin-2 isoform X1 [KO:K12471]
121457058  Epn3; epsin-3 [KO:K12471]
121437244  epsin-1-like [KO:K12471]
121449674  Epn1; epsin-1 isoform X1 [KO:K12471]
121462690  Eps15l1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
121448057  Eps15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
121452862  Spart; spartin isoform X1 [KO:K19366]
121465993  Nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
121438846  Nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
121440679  E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
121460179  Mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
121465651  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
121440550  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
121461500  Rnf41; E3 ubiquitin-protein ligase NRDP1 isoform X1 [KO:K11981] [EC:2.3.2.27]
121460097  Itch; E3 ubiquitin-protein ligase Itchy homolog [KO:K05632] [EC:2.3.2.26]
121464863  Smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
121436046  Smurf2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
121451494  Wwp1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
121451746  Ldlr; low-density lipoprotein receptor isoform X1 [KO:K12473]
121448097  Ldlrap1; low density lipoprotein receptor adapter protein 1 [KO:K12474]
121433060  Dab2; disabled homolog 2 isoform X1 [KO:K12475]
121464452  C-C chemokine receptor type 5 [KO:K04180]
121447562  C-X-C chemokine receptor type 1-like [KO:K04175]
121447623  Cxcr2; C-X-C chemokine receptor type 2 [KO:K05050]
121446134  Cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
121462291  Grk1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
121454366  Grk2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
121446010  Grk3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
121453996  Grk5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
121459367  G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
121453371  Grk6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
121436435  G protein-coupled receptor kinase 4-like isoform X1 [KO:K08291] [EC:2.7.11.16]
121445804  G protein-coupled receptor kinase 6-like [KO:K08291] [EC:2.7.11.16]
121455237  beta-arrestin-1 isoform X1 [KO:K04439]
121456412  Arrb2; beta-arrestin-2 [KO:K04439]
121458738  beta-arrestin-1-like isoform X1 [KO:K04439]
121463328  Wasl; neural Wiskott-Aldrich syndrome protein [KO:K23612]
121459418  Actr2; actin-related protein 2 isoform X1 [KO:K17260]
121446270  Actr3; actin-related protein 3 [KO:K18584]
121439980  Actr3b; actin-related protein 3B isoform X1 [KO:K18584]
121464770  Arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
121465138  Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
121447106  Arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
121446239  Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
121433088  Arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
121455432  Arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
121463173  Arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
121456275  WAS/WASL-interacting protein family member 2 [KO:K19475]
121439324  WAS/WASL-interacting protein family member 1 [KO:K19475]
121439766  Wipf3; WAS/WASL-interacting protein family member 3 isoform X1 [KO:K19475]
121433297  WAS/WASL-interacting protein family member 1 [KO:K19475]
121442371  Wipf2; WAS/WASL-interacting protein family member 2 [KO:K19475]
121436877  heat shock cognate 71 kDa protein-like [KO:K03283]
121451608  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
121437229  heat shock cognate 71 kDa protein-like [KO:K03283]
121434806  heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
121435244  Hspa1l; heat shock 70 kDa protein 1-like [KO:K03283]
121435245  heat shock 70 kDa protein 1A [KO:K03283]
121435246  Hspa1a; heat shock 70 kDa protein 1A [KO:K03283]
121448155  Dnajc6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
121461857  Washc4; WASH complex subunit 4 [KO:K18465]
121461111  Washc5; WASH complex subunit 5 [KO:K18464]
121435404  Washc2c; WASH complex subunit 2C isoform X1 [KO:K18462]
121433445  Washc1; WASH complex subunit 1 isoform X1 [KO:K18461]
121460839  Washc3; WASH complex subunit 3 isoform X1 [KO:K18463]
121463369  Capza2; F-actin-capping protein subunit alpha-2 [KO:K10364]
121465583  Capza3; F-actin-capping protein subunit alpha-3 [KO:K10364]
121437972  Capza1; F-actin-capping protein subunit alpha-1 [KO:K10364]
121463023  F-actin-capping protein subunit beta-like [KO:K10365]
121448466  Capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
121446007  Vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
121451782  Vps26b; vacuolar protein sorting-associated protein 26B [KO:K18466]
121451000  Vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
121447192  Vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
121444967  sorting nexin-12 [KO:K17918]
121441692  sorting nexin-3-like [KO:K17918]
121449442  Snx3; sorting nexin-3 [KO:K17918]
121443303  sorting nexin-12-like isoform X1 [KO:K17918]
121465596  Usp8; ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
121461712  STAM-binding protein-like [KO:K11866] [EC:3.4.19.12]
121443221  STAM-binding protein [KO:K11866] [EC:3.4.19.12]
121466233  Rab7a; ras-related protein Rab-7a [KO:K07897]
121444100  hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
121444608  hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
121432583  Stam; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
121433210  Stam2; signal transducing adapter molecule 2 [KO:K04705]
121448160  Tsg101; tumor susceptibility gene 101 protein isoform X1 [KO:K12183]
121462944  Mvb12b; multivesicular body subunit 12B [KO:K12186]
121463151  Mvb12a; multivesicular body subunit 12A [KO:K12186]
121461303  Vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
121454679  Vps37c; vacuolar protein sorting-associated protein 37C isoform X1 [KO:K12185]
121444567  Vps37d; vacuolar protein sorting-associated protein 37D isoform X1 [KO:K12185]
121446348  Vps37b; vacuolar protein sorting-associated protein 37B [KO:K12185]
121442817  Vps37a; vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
121456247  Snf8; vacuolar-sorting protein SNF8 [KO:K12188]
121462293  Vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
121438705  vacuolar protein-sorting-associated protein 25-like [KO:K12189]
121442446  Vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
121444049  charged multivesicular body protein 6 [KO:K12195]
121444630  charged multivesicular body protein 6 [KO:K12195]
121460532  Chmp4b; charged multivesicular body protein 4b [KO:K12194]
121434910  Chmp4a; LOW QUALITY PROTEIN: charged multivesicular body protein 4a [KO:K12194]
121458360  charged multivesicular body protein 4c [KO:K24782]
121432375  Chmp4c; charged multivesicular body protein 4c [KO:K24782]
121466360  charged multivesicular body protein 3 isoform X1 [KO:K12193]
121449763  charged multivesicular body protein 3-like [KO:K12193]
121449395  Chmp2a; charged multivesicular body protein 2a [KO:K12191]
121465414  Chmp2b; charged multivesicular body protein 2b [KO:K12192]
121459329  Chmp7; charged multivesicular body protein 7 [KO:K15053]
121446275  Vps4b; vacuolar protein sorting-associated protein 4B [KO:K12196]
121446872  Vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
121466447  Vta1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
121445096  charged multivesicular body protein 1b-2 [KO:K12197]
121438848  Chmp1b; charged multivesicular body protein 1b [KO:K12197]
121447602  Chmp1a; charged multivesicular body protein 1a [KO:K12197]
121442731  charged multivesicular body protein 1b-2 [KO:K12197]
121458341  Chmp5; charged multivesicular body protein 5 [KO:K12198]
121447333  Ist1; IST1 homolog [KO:K19476]
121464215  programmed cell death 6-interacting protein isoform X1 [KO:K12200]
121466112  Spg21; maspardin [KO:K19367]
121466371  Igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564]
121453288  sorting nexin-2 isoform X1 [KO:K17917]
121466150  Snx1; sorting nexin-1 isoform X1 [KO:K17917]
121441954  sorting nexin-2 isoform X1 [KO:K17917]
121454071  Snx32; sorting nexin-32 [KO:K17920]
121452436  Snx6; sorting nexin-6 [KO:K17920]
121460331  Snx5; sorting nexin-5 isoform X1 [KO:K17920]
121460112  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
121458090  Hras; GTPase HRas [KO:K02833]
121432686  Il2ra; interleukin-2 receptor subunit alpha [KO:K05068]
121461444  Il2rb; interleukin-2 receptor subunit beta [KO:K05069]
121444965  cytokine receptor common subunit gamma-like isoform X1 [KO:K05070]
121443322  cytokine receptor common subunit gamma-like [KO:K05070]
121464173  Rhoa; transforming protein RhoA [KO:K04513]
121439342  transforming protein RhoA-like isoform X1 [KO:K04513]
121435269  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435270  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435271  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435272  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435273  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435274  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435275  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435277  RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751]
121435283  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435313  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
121435364  class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like isoform X1 [KO:K06751]
121435376  class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like isoform X1 [KO:K06751]
121435377  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435378  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
121435379  H-2 class I histocompatibility antigen, D-37 alpha chain-like [KO:K06751]
121435380  H-2 class I histocompatibility antigen, L-D alpha chain-like [KO:K06751]
121435381  H-2 class I histocompatibility antigen, L-D alpha chain-like isoform X1 [KO:K06751]
121435382  H-2 class I histocompatibility antigen, D-37 alpha chain-like isoform X1 [KO:K06751]
121435464  class I histocompatibility antigen, B alpha chain-like [KO:K06751]
121435500  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
121435594  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
121435668  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
121435669  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
121435693  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
121435695  putative HLA class I histocompatibility antigen, alpha chain H [KO:K06751]
121435698  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
121463900  folate receptor beta-like [KO:K13649]
121463906  folate receptor alpha [KO:K13649]
121463465  Cav1; caveolin-1 [KO:K06278]
121463515  Cav2; caveolin-2 isoform X1 [KO:K12958]
121438590  Cav3; caveolin-3 [KO:K12959]
121442699  caveolin-3 [KO:K12959]
121432979  Ehd3; EH domain-containing protein 3 [KO:K12476]
121465696  Ehd4; EH domain-containing protein 4 [KO:K12477]
121457873  Eea1; early endosome antigen 1 isoform X1 [KO:K12478]
121450580  Rab5a; ras-related protein Rab-5A [KO:K07887]
121459215  Rab5b; ras-related protein Rab-5B [KO:K07888]
121442499  Rab5c; ras-related protein Rab-5C [KO:K07889]
121456512  Rabep1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
121440321  Rbsn; rabenosyn-5 isoform X1 [KO:K12481]
121446797  Rab4a; ras-related protein Rab-4A [KO:K07879]
121456978  Rufy1; RUN and FYVE domain-containing protein 1 [KO:K12482]
121450810  Rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
121454338  Ehd1; EH domain-containing protein 1 [KO:K12483]
121439507  EH domain-containing protein 1-like [KO:K12483]
121450719  vacuolar protein sorting-associated protein 45 [KO:K12479]
121437932  vacuolar protein sorting-associated protein 45 [KO:K12479]
121461986  Snx4; sorting nexin-4 [KO:K17919]
121440783  Rab22a; ras-related protein Rab-22A isoform X1 [KO:K07891]
121433469  Rab31; ras-related protein Rab-31 [KO:K07891]
121439640  ras-related protein Rab-10 [KO:K07903]
121439645  ras-related protein Rab-10 [KO:K07903]
121463115  Rab8a; ras-related protein Rab-8A [KO:K07901]
121445828  Rab35; ras-related protein Rab-35 isoform X1 [KO:K07876]
121466181  Rab11a; ras-related protein Rab-11A [KO:K07904]
121459350  Rab11b; ras-related protein Rab-11B [KO:K07905]
121454084  Rab11fip2; rab11 family-interacting protein 2 isoform X1 [KO:K12484]
121462250  Rab11fip1; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
121435070  Rab11fip5; rab11 family-interacting protein 5 isoform X1 [KO:K12484]
121453906  Zfyve27; protrudin isoform X1 [KO:K19368]
121455924  Kif5a; kinesin heavy chain isoform X1 [KO:K10396]
121433144  Kif5c; kinesin heavy chain [KO:K10396]
121440697  Kif5b; kinesin-1 heavy chain isoform X1 [KO:K10396]
121456288  Rab11fip4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
121463676  Rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
121446866  Pard3; partitioning defective 3 homolog isoform X1 [KO:K04237]
121460470  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
121440114  Pard6g; partitioning defective 6 homolog gamma [KO:K06093]
121447227  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
121448043  protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
121443525  protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
121452820  Prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
121448012  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
121450547  Smap1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
121448615  Smap2; stromal membrane-associated protein 2 [KO:K12486]
121456472  Git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
121445189  Git2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
121461057  Asap1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
121438893  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
121432362  Asap2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
121448158  Asap3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
121461657  Acap2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
121456845  Acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
121443592  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 [KO:K12489]
121448048  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 [KO:K12489]
121463693  Arap1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
121460757  Arap2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
121453343  Arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
121439955  Agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
121447185  Agap1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
121463950  Agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
121440851  Arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
121461245  Arfgap3; ADP-ribosylation factor GTPase-activating protein 3 isoform X1 [KO:K12493]
121437595  Arfgap2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
121462734  Psd3; PH and SEC7 domain-containing protein 3 isoform X1 [KO:K12494]
121462889  Psd4; PH and SEC7 domain-containing protein 4 isoform X1 [KO:K12494]
121453282  PH and SEC7 domain-containing protein 2-like isoform X1 [KO:K12494]
121453850  Psd; PH and SEC7 domain-containing protein 1 [KO:K12494]
121442979  PH and SEC7 domain-containing protein 2 isoform X1 [KO:K12494]
121445558  Iqsec2; IQ motif and SEC7 domain-containing protein 2 isoform X1 [KO:K12495]
121439627  Iqsec1; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
121433814  Iqsec3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
121443079  LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 2-like [KO:K12495]
121461140  Cyth4; cytohesin-4 [KO:K18441]
121464962  Cyth3; cytohesin-3 [KO:K18441]
121436131  Cyth1; cytohesin-1 isoform X1 [KO:K18441]
121446088  Cyth2; cytohesin-2 [KO:K18441]
121458286  Arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
121460079  Arfgef2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
121453903  Gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
121456128  Arf1; ADP-ribosylation factor 1 [KO:K07937]
121436311  ADP-ribosylation factor 2 [KO:K07937]
121441467  Arf3; ADP-ribosylation factor 3 [KO:K07938]
121455416  Arf4; ADP-ribosylation factor 4 [KO:K07939]
121463348  Arf5; ADP-ribosylation factor 5 [KO:K07940]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
morg04060  Cytokine-cytokine receptor interaction
morg04070  Phosphatidylinositol signaling system
morg04130  SNARE interactions in vesicular transport
morg04142  Lysosome
morg04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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