Entry
Name
B cell receptor signaling pathway - Microtus oregoni (creeping vole)
Description
B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Microtus oregoni (creeping vole) [GN:
morg ]
Gene
121450124 Cd79a; B-cell antigen receptor complex-associated protein alpha chain [KO:K06506 ]
121436263 Cd79b; B-cell antigen receptor complex-associated protein beta chain [KO:K06507 ]
121450820 Dapp1; dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide [KO:K12229 ]
121462677 Vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730 ]
121450228 Vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730 ]
121444055 ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
121444624 ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
121461739 Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
121453244 Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
121438600 Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
121440145 Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
121460203 Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332 ]
121447567 Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
121465050 caspase recruitment domain-containing protein 11-like [KO:K07367 ]
121438805 Malt1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369 ] [EC:3.4.22.-]
121440582 mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog isoform X1 [KO:K07369 ] [EC:3.4.22.-]
121450269 Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
121455952 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
121462841 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
121448002 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
121464321 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
121453059 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
121448116 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
121441780 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
121455099 low affinity immunoglobulin gamma Fc region receptor II-like [KO:K12560 ]
121442022 low affinity immunoglobulin gamma Fc region receptor II-like [KO:K12560 ]
121449333 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
121449556 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
121449695 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
121449800 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
121449803 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily B member 3-like [KO:K06512 ]
121449810 leukocyte immunoglobulin-like receptor subfamily B member 3A [KO:K06512 ]
121449811 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
121449812 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
121449813 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
121449814 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
121449816 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
121449818 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
121449819 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
121449820 leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
121449821 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
121449823 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily B member 4 [KO:K06512 ]
121450161 leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
121449822 leukocyte immunoglobulin-like receptor subfamily B member 4 [KO:K06512 ]
121449804 leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
121449381 leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
121449806 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily B member 3-like [KO:K06512 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Niiro H, Clark EA.
Title
Regulation of B-cell fate by antigen-receptor signals.
Journal
Reference
Authors
Kurosaki T.
Title
Genetic analysis of B cell antigen receptor signaling.
Journal
Reference
Authors
Nitschke L.
Title
The role of CD22 and other inhibitory co-receptors in B-cell activation.
Journal
Reference
Authors
Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
Title
Complement: central to innate immunity and bridging to adaptive responses.
Journal
Reference
Authors
Kurosaki T.
Title
Regulation of B-cell signal transduction by adaptor proteins.
Journal
Reference
Authors
Nitschke L, Tsubata T.
Title
Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
Journal
Reference
Authors
Jumaa H, Hendriks RW, Reth M.
Title
B cell signaling and tumorigenesis.
Journal
Reference
Authors
Rickert RC.
Title
Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
Journal
Reference
Authors
Zouali M, Sarmay G
Title
B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
Journal
Reference
Authors
Chiles TC.
Title
Regulation and function of cyclin D2 in B lymphocyte subsets.
Journal
Reference
Authors
Allam A, Marshall AJ
Title
Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
Journal
Reference
Authors
Gold MR
Title
To make antibodies or not: signaling by the B-cell antigen receptor.
Journal
Reference
Authors
Fu C, Turck CW, Kurosaki T, Chan AC
Title
BLNK: a central linker protein in B cell activation.
Journal
Reference
Authors
Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
Title
BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
Journal
Reference
Authors
Shinohara H, Maeda S, Watarai H, Kurosaki T
Title
IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
Journal
Related pathway
morg04610 Complement and coagulation cascades
KO pathway
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