KEGG   PATHWAY: mrv00230
Entry
mrv00230                    Pathway                                
Name
Purine metabolism - Mauremys reevesii (Reeves's turtle)
Class
Metabolism; Nucleotide metabolism
Pathway map
mrv00230  Purine metabolism
mrv00230

Module
mrv_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mrv00230]
mrv_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mrv00230]
mrv_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mrv00230]
mrv_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:mrv00230]
mrv_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:mrv00230]
mrv_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:mrv00230]
Other DBs
GO: 0006163 0042278
Organism
Mauremys reevesii (Reeves's turtle) [GN:mrv]
Gene
120406251  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
120383222  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
120395231  NUDT5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
120370663  PGM1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
120406452  PGM2; phosphoglucomutase-2 isoform X1 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
120371535  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
120384698  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
120405756  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
120371872  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
120388475  trifunctional purine biosynthetic protein adenosine-3-like isoform X1 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
120381394  PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
120372343  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
120374663  ATIC; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
120384172  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
120383379  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
120373860  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial isoform X1 [KO:K01081] [EC:3.1.3.5]
120405363  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
120389151  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
120408137  LOW QUALITY PROTEIN: NAD 5'-nucleotidase-like [KO:K01081] [EC:3.1.3.5]
120369549  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
120400685  cytosolic 5'-nucleotidase 1A-like isoform X1 [KO:K01081] [EC:3.1.3.5]
120399064  cytosolic purine 5'-nucleotidase-like isoform X1 [KO:K01081] [EC:3.1.3.5]
120402136  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
120381318  purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
120396121  LACC1; purine nucleoside phosphorylase LACC1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
120371813  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
120394855  inosine-5'-monophosphate dehydrogenase 2-like isoform X1 [KO:K00088] [EC:1.1.1.205]
120395658  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
120409206  IMPDH2; LOW QUALITY PROTEIN: inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
120383351  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
120383352  NME1; nucleoside diphosphate kinase A isoform X1 [KO:K00940] [EC:2.7.4.6]
120373172  NME4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
120395700  NME6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
120374109  NME3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
120399313  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
120400510  AK9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
120386571  ectonucleoside triphosphate diphosphohydrolase 8-like isoform X1 [KO:K01510] [EC:3.6.1.5]
120386589  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
120386878  ectonucleoside triphosphate diphosphohydrolase 8-like isoform X1 [KO:K01510] [EC:3.6.1.5]
120398094  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
120369439  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
120383780  CANT1; soluble calcium-activated nucleotidase 1 isoform X1 [KO:K12304] [EC:3.6.1.6]
120398378  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
120403093  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 isoform X1 [KO:K01511] [EC:3.6.1.6]
120400964  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
120388497  NUDT16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
120403202  ITPA; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
120400858  XDH; LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120408480  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
120371550  GMPS; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
120396504  GMPR; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
120381018  GMPR2; GMP reductase 2 [KO:K00364] [EC:1.7.1.7]
120407759  GDA; guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
120398039  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
120395561  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
120398588  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
120399984  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
120401571  HDDC2; 5'-deoxynucleotidase HDDC2 isoform X1 [KO:K07023] [EC:3.1.3.89]
120399019  DGUOK; LOW QUALITY PROTEIN: deoxyguanosine kinase, mitochondrial [KO:K00904] [EC:2.7.1.113]
120405638  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
120373466  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
120390214  PRUNE1; exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
120398088  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
120397653  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
120401447  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
120380361  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
120374831  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
120391118  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
120384768  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
120399258  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
120373164  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
120370427  ADCY10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
120405152  adenylate cyclase type 10-like isoform X1 [KO:K11265] [EC:4.6.1.1]
120395944  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
120405517  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X1 [KO:K12318] [EC:4.6.1.2]
120372715  guanylate cyclase soluble subunit beta-2-like isoform X1 [KO:K12319] [EC:4.6.1.2]
120373856  guanylate cyclase soluble subunit beta-2-like isoform X1 [KO:K12319] [EC:4.6.1.2]
120407050  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
120373686  heat-stable enterotoxin receptor-like [KO:K12320] [EC:4.6.1.2]
120374311  heat-stable enterotoxin receptor-like [KO:K12320] [EC:4.6.1.2]
120381502  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
120369188  guanylate cyclase 2G-like isoform X1 [KO:K22600] [EC:4.6.1.2]
120390152  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
120407255  atrial natriuretic peptide receptor 2-like [KO:K12324] [EC:4.6.1.2]
120408252  NPR2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
120374419  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like isoform X1 [KO:K13755] [EC:3.1.4.17]
120397877  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
120391195  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
120405770  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
120407962  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
120403719  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
120405966  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
120408039  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
120368651  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1 [KO:K13757] [EC:3.1.4.35]
120372119  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
120374249  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X1 [KO:K13760]
120396009  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
120400772  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
120374623  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X1 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
120402197  adenylosuccinate synthetase isozyme 1 A [KO:K01939] [EC:6.3.4.4]
120400589  ADSS2; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
120409331  adenylosuccinate synthetase isozyme 2-like isoform X1 [KO:K01939] [EC:6.3.4.4]
120402782  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
120403868  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
120404273  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
120409283  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
120380750  adenosine deaminase-like [KO:K01488] [EC:3.5.4.4]
120380751  adenosine deaminase-like [KO:K01488] [EC:3.5.4.4]
120388435  ADA2; adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
120370813  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
120403293  AK7; adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
120386726  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
120386809  AK8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
120379411  adenylate kinase 8-like [KO:K00939] [EC:2.7.4.3]
120389317  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
120369643  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
120391012  adenylate kinase isoenzyme 1-like [KO:K00939] [EC:2.7.4.3]
120408332  AK6; adenylate kinase isoenzyme 6 isoform X1 [KO:K18532] [EC:2.7.4.3]
120407693  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
120386768  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 isoform X1 [KO:K01509] [EC:3.6.1.-]
120400583  NTPCR; cancer-related nucleoside-triphosphatase isoform X1 [KO:K06928] [EC:3.6.1.15]
120401704  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
120401731  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
120370327  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
120391812  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
120407520  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
120390948  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
120398047  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
120400690  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
120373131  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
120407320  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
120368943  FHIT; bis(5'-adenosyl)-triphosphatase isoform X1 [KO:K01522] [EC:3.6.1.29]
120402222  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
120406219  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
120369103  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
120370462  uricase-like isoform X1 [KO:K00365] [EC:1.7.3.3]
120370465  uricase-like [KO:K00365] [EC:1.7.3.3]
120372609  allantoinase, mitochondrial-like isoform X1 [KO:K01466] [EC:3.5.2.5]
120401261  ALLC; probable allantoicase isoform X1 [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mrv00030  Pentose phosphate pathway
mrv00220  Arginine biosynthesis
mrv00250  Alanine, aspartate and glutamate metabolism
mrv00260  Glycine, serine and threonine metabolism
mrv00340  Histidine metabolism
mrv00630  Glyoxylate and dicarboxylate metabolism
mrv00730  Thiamine metabolism
mrv00740  Riboflavin metabolism
mrv00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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