KEGG   PATHWAY: msam04912
Entry
msam04912                   Pathway                                
Name
GnRH signaling pathway - Micropterus salmoides (largemouth bass)
Description
Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its signal to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kinase C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasionally observed in a cell-specific fashion. Signaling downstream of protein kinase C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kinases (MAPKs), including extracellular-signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes.
Class
Organismal Systems; Endocrine system
Pathway map
msam04912  GnRH signaling pathway
msam04912

Organism
Micropterus salmoides (largemouth bass) [GN:msam]
Gene
119917553  gnrh3; gonadotropin-releasing hormone 3 [KO:K05252]
119891650  progonadoliberin-1-like isoform X1 [KO:K05252]
119885988  gnrh2; progonadoliberin-2 [KO:K05252]
119904853  gonadotropin-releasing hormone II receptor-like [KO:K04280]
119898246  gonadotropin-releasing hormone II receptor-like [KO:K04280]
119893929  gnrhr4; LOW QUALITY PROTEIN: gonadotropin releasing hormone receptor 4 [KO:K04280]
119889694  putative gonadotropin-releasing hormone II receptor [KO:K04280]
119889728  putative gonadotropin-releasing hormone II receptor [KO:K04280]
119905691  gnas; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
119886579  guanine nucleotide-binding protein G(s) subunit alpha-like isoform X1 [KO:K04632]
119900267  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
119902050  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
119897894  adcy2a; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
119907366  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
119896893  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
119904436  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
119905272  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
119905502  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
119889811  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
119915897  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
119908444  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
119908457  si:dkey-206f10.1; LOW QUALITY PROTEIN: adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
119901661  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
119899433  adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
119889816  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
119896511  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
119899469  prkacab; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
119900632  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
119902028  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
119898630  atf4a; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
119885408  atf4b; activating transcription factor 4b [KO:K04374]
119884166  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
119914811  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
119900765  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04635]
119889655  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04635]
119910939  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
119911817  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
119908521  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
119913412  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
119908913  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
119885618  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
119886455  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
119886483  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
119893420  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
119905085  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
119890067  calmodulin-like protein 4 [KO:K02183]
119903821  plastin-2-like [KO:K02183]
119882859  calm3a; calmodulin 3a (phosphorylase kinase, delta) isoform X1 [KO:K02183]
119917346  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
119917396  calmodulin-A isoform X1 [KO:K02183]
119893131  calml4b; calmodulin-like protein 4 [KO:K02183]
119886349  calglandulin-like [KO:K02183]
119909333  calm1b; calmodulin-1b [KO:K02183]
119909805  calm1a; calmodulin-1a [KO:K02183]
119915852  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
119891232  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
119912136  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
119899100  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
119895357  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
119914912  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
119899340  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
119889216  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
119898769  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
119885905  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
119886414  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
119918210  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
119905703  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
119886716  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a [KO:K04851]
119905055  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
119905094  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
119905492  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
119886874  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
119900363  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
119893582  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
119910267  map3k22; mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
119917295  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
119890456  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
119915650  map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
119891584  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
119905572  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
119918284  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
119906000  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
119918532  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
119886184  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
119915355  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
119915935  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
119882257  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
119900432  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
119896422  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
119896596  pld1b; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
119884573  phospholipase D2-like [KO:K01115] [EC:3.1.4.4]
119895767  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
119910183  pld1a; phospholipase D1a [KO:K01115] [EC:3.1.4.4]
119905139  src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
119886292  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
119897425  cdc42l; cell division cycle 42, like [KO:K04393]
119905238  cell division control protein 42 homolog isoform X1 [KO:K04393]
119885487  cell division control protein 42 homolog [KO:K04393]
119907070  cell division control protein 42 homolog [KO:K04393]
119894592  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
119915646  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
119899297  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
119917030  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119888580  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
119915031  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
119915573  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119901002  jun; transcription factor AP-1 isoform X1 [KO:K04448]
119902398  transcription factor AP-1-like [KO:K04448]
119915034  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
119911326  gonadotropin subunit beta-2 [KO:K08521]
119909832  cga; glycoprotein hormones alpha chain [KO:K08522]
119887582  LOW QUALITY PROTEIN: protein-tyrosine kinase 2-beta-like [KO:K05871] [EC:2.7.10.2]
119908914  ptk2bb; LOW QUALITY PROTEIN: protein tyrosine kinase 2 beta, b [KO:K05871] [EC:2.7.10.2]
119902997  protein-tyrosine kinase 2-beta-like isoform X1 [KO:K05871] [EC:2.7.10.2]
119890137  mmp2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
119912139  mmp14a; matrix metalloproteinase-14a [KO:K07763] [EC:3.4.24.80]
119902498  mmp14b; matrix metalloproteinase-14b [KO:K07763] [EC:3.4.24.80]
119888537  proheparin-binding EGF-like growth factor [KO:K08523]
119913984  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
119901961  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
119883760  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
119899870  son of sevenless homolog 1-like isoform X1 [KO:K03099]
119910225  sos2; son of sevenless homolog 2 [KO:K03099]
119893575  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
119893343  kras; GTPase KRas [KO:K07827]
119886647  zgc:55558 [KO:K07827]
119905315  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
119893612  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
119900881  map2k2a; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
119902918  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
119891295  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119886325  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119905054  elk1; LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1 [KO:K04375]
119888785  egr1; early growth response protein 1 [KO:K09203]
119895561  early growth response protein 1-like [KO:K09203]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00416  Phosphatidate
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:15350605
  Authors
Ruf F, Sealfon SC.
  Title
Genomics view of gonadotrope signaling circuits.
  Journal
Trends Endocrinol Metab 15:331-8 (2004)
DOI:10.1016/j.tem.2004.07.008
Reference
PMID:15613448
  Authors
Harrison GS, Wierman ME, Nett TM, Glode LM.
  Title
Gonadotropin-releasing hormone and its receptor in normal and malignant cells.
  Journal
Endocr Relat Cancer 11:725-48 (2004)
DOI:10.1677/erc.1.00777
Reference
PMID:15982836
  Authors
Pawson AJ, McNeilly AS.
  Title
The pituitary effects of GnRH.
  Journal
Anim Reprod Sci 88:75-94 (2005)
DOI:10.1016/j.anireprosci.2005.05.010
Reference
  Authors
DeGroot LJ, Jameson JL (ed).
  Title
Endocrinology (Fifth edition)
  Journal
Elsevier Saunders (2006)
Reference
PMID:10707049
  Authors
Naor Z, Benard O, Seger R.
  Title
Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor.
  Journal
Trends Endocrinol Metab 11:91-9 (2000)
DOI:10.1016/S1043-2760(99)00232-5
Reference
PMID:14596811
  Authors
Ruf F, Fink MY, Sealfon SC.
  Title
Structure of the GnRH receptor-stimulated signaling network: insights from genomics.
  Journal
Front Neuroendocrinol 24:181-99 (2003)
DOI:10.1016/S0091-3022(03)00027-X
Reference
PMID:12943720
  Authors
Farshori PQ, Shah BH, Arora KK, Martinez-Fuentes A, Catt KJ.
  Title
Activation and nuclear translocation of PKCdelta, Pyk2 and ERK1/2 by gonadotropin releasing hormone in HEK293 cells.
  Journal
J Steroid Biochem Mol Biol 85:337-47 (2003)
DOI:10.1016/S0960-0760(03)00226-7
Reference
PMID:15080147
  Authors
Shah BH, Catt KJ.
  Title
Matrix metalloproteinases in reproductive endocrinology.
  Journal
Trends Endocrinol Metab 15:47-9 (2004)
DOI:10.1016/j.tem.2004.01.004
Reference
PMID:12963732
  Authors
Roelle S, Grosse R, Aigner A, Krell HW, Czubayko F, Gudermann T.
  Title
Matrix metalloproteinases 2 and 9 mediate epidermal growth factor receptor transactivation by gonadotropin-releasing hormone.
  Journal
J Biol Chem 278:47307-18 (2003)
DOI:10.1074/jbc.M304377200
Reference
PMID:18708085
  Authors
Naor Z
  Title
Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor.
  Journal
Front Neuroendocrinol 30:10-29 (2009)
DOI:10.1016/j.yfrne.2008.07.001
Related
pathway
msam04010  MAPK signaling pathway
msam04020  Calcium signaling pathway
msam04060  Cytokine-cytokine receptor interaction
msam04080  Neuroactive ligand-receptor interaction
KO pathway
ko04912   
LinkDB

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