KEGG   PATHWAY: msam04060
Entry
msam04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Micropterus salmoides (largemouth bass)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
msam04060  Cytokine-cytokine receptor interaction
msam04060

Organism
Micropterus salmoides (largemouth bass) [GN:msam]
Gene
119882122  [KO:K05425]
119882270  il16; pro-interleukin-16 isoform X1 [KO:K22628]
119882337  smtla; somatolactin alpha [KO:K05438]
119882467  [KO:K05439]
119882495  [KO:K05439]
119882507  [KO:K05439]
119882583  [KO:K04723]
119882604  il10ra; interleukin-10 receptor subunit alpha [KO:K05134]
119882881  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
119882892  [KO:K04190]
119882943  epor; erythropoietin receptor [KO:K05079]
119883096  tnfrsf19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
119883176  bmp16; bone morphogenetic protein 16 [KO:K21283]
119883275  il12a; interleukin-12 subunit alpha [KO:K05406]
119883369  il15l; interleukin 15, like isoform X1 [KO:K05433]
119883447  relt; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
119883767  [KO:K05424]
119883985  [KO:K14625]
119884429  [KO:K14625]
119884889  [KO:K05439]
119884986  [KO:K22672]
119884992  [KO:K05414]
119884993  [KO:K05414]
119884994  [KO:K05414]
119885295  il2rb; interleukin-2 receptor subunit beta [KO:K05069]
119885479  il19l; interleukin 19 like [KO:K22667]
119885508  csf2rb; cytokine receptor common subunit beta [KO:K04738]
119885515  [KO:K16621]
119885672  si:ch73-361p23.3; tumor necrosis factor receptor superfamily member 4 [KO:K05142]
119885694  tnfrsf1b; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
119885701  [KO:K13567] [EC:2.7.11.30]
119885912  il10; interleukin-10 [KO:K05443]
119885930  [KO:K22687]
119886677  gdf5; growth/differentiation factor 5 [KO:K04664]
119886691  il17rc; uncharacterized protein il17rc isoform X1 [KO:K05166]
119886881  gdf11; growth/differentiation factor 11 isoform X1 [KO:K22679]
119886942  ngfb; nerve growth factor [KO:K02582]
119887085  [KO:K05150]
119887126  [KO:K14625]
119887137  [KO:K05164]
119887503  [KO:K04666]
119887768  [KO:K10030]
119887928  gdf9; LOW QUALITY PROTEIN: growth/differentiation factor 9 [KO:K22673]
119888093  [KO:K05425]
119888129  il12ba; interleukin 12Ba isoform X1 [KO:K05425]
119888180  clcf1; LOW QUALITY PROTEIN: uncharacterized protein clcf1 [KO:K05421]
119888331  il12rb2l; interleukin 12 receptor, beta 2a, like [KO:K05060]
119888383  eda; ectodysplasin-A isoform X1 [KO:K05480]
119888421  [KO:K05155]
119888531  cd40lg; CD40 ligand [KO:K04389]
119888609  [KO:K05090] [EC:2.7.10.1]
119888863  il21; interleukin-21 [KO:K05434]
119888864  cxcl14; C-X-C motif chemokine 14 [KO:K10033]
119889077  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
119889120  rell2; RELT-like protein 2 isoform X1 [KO:K26541]
119890596  [KO:K05491]
119890614  il17a/f1; interleukin 17a/f1 [KO:K05494]
119890680  il17a/f2; interleukin 17a/f2 [KO:K05489]
119890718  [KO:K05071]
119890844  [KO:K05173]
119890845  [KO:K05174]
119891157  lifra; LIF receptor subunit alpha a [KO:K05058]
119891270  [KO:K22670]
119891347  bmpr1ba; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
119891872  [KO:K05060]
119891900  spaw; southpaw [KO:K04666]
119891963  [KO:K05478]
119892005  bmp3; bone morphogenetic protein 3 [KO:K05496]
119892024  [KO:K10032]
119892131  hdr; hematopoietic death receptor isoform X1 [KO:K04722]
119892481  ghra; growth hormone receptor a [KO:K05080]
119892504  [KO:K05425]
119892518  ccl27a; C-C motif chemokine 27a [KO:K05513]
119893437  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
119893507  il17c; interleukin-17C [KO:K05491]
119893526  il34; interleukin-34 [KO:K22633]
119894132  [KO:K12964]
119894277  [KO:K12964]
119894313  [KO:K12964]
119894902  [KO:K22629]
119894956  [KO:K05070]
119895082  csf1rb; macrophage colony-stimulating factor 1 receptor 2 [KO:K05090] [EC:2.7.10.1]
119895157  il12bb; interleukin-12 subunit beta [KO:K05425]
119895880  il22; interleukin-22 [KO:K05445]
119895930  il13ra2; interleukin-13 receptor subunit alpha-2 isoform X1 [KO:K05077]
119896148  gh1; somatotropin [KO:K05438]
119896309  [KO:K22670]
119896417  [KO:K05050]
119896618  [KO:K05423]
119896887  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
119897052  inhbaa; inhibin subunit beta Aa [KO:K04667]
119897116  il21r.1; interleukin 21 receptor, tandem duplicate 1 isoform X1 [KO:K05075]
119897144  [KO:K03156]
119897253  ifnlr1; interferon lambda receptor 1 isoform X1 [KO:K05136]
119897268  [KO:K13596] [EC:2.7.11.30]
119897290  csf3r; granulocyte colony-stimulating factor receptor [KO:K05061]
119897350  cxcr3.2; C-X-C chemokine receptor type 3-2 [KO:K04188]
119897352  [KO:K04188]
119897353  [KO:K04188]
119897409  [KO:K06454]
119897434  [KO:K03160]
119897443  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
119897444  cd27; tumor necrosis factor receptor superfamily member 6 [KO:K05144]
119897475  il11a; uncharacterized protein il11a [KO:K05417]
119897606  si:dkey-92i15.4; uncharacterized protein si:dkey-92i15.4 [KO:K22628]
119897611  il6r; interleukin-6 receptor subunit alpha [KO:K05055]
119897709  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
119897866  [KO:K05143]
119897868  [KO:K05148]
119897898  cabz01093075.1; C-C chemokine receptor type 5 [KO:K04179]
119897899  si:cabz01093077.1; C-C chemokine receptor type 2 [KO:K04179]
119897901  [KO:K04180]
119898009  gdf6a; growth/differentiation factor 6-A [KO:K20012]
119898112  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
119898181  [KO:K04188]
119898250  [KO:K05132]
119898260  [KO:K05132]
119898467  [KO:K05147]
119898625  [KO:K05069]
119898874  [KO:K05433]
119899104  [KO:K10030]
119899106  [KO:K10030]
119899424  cxcl12b; chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) [KO:K10031]
119899450  [KO:K05477]
119899781  ccr7; C-C chemokine receptor type 7 [KO:K04182]
119900058  [KO:K05082]
119900150  [KO:K05080]
119900382  mpl; thrombopoietin receptor isoform X1 [KO:K05082]
119900412  lepr; leptin receptor [KO:K05062]
119900530  il12rb1; interleukin-12 receptor subunit beta-1 [KO:K05063]
119900535  mstna; myostatin a [KO:K05497]
119900611  [KO:K05065]
119900738  ccl25b; C-C motif chemokine 25b [KO:K13072]
119900743  ccl44; chemokine (C-C motif) ligand 44 [KO:K21083]
119900804  [KO:K04193]
119900870  amh; muellerian-inhibiting factor [KO:K04665]
119900964  il23r; interleukin-23 receptor isoform X1 [KO:K05064]
119900965  il12rb2; interleukin-12 receptor subunit beta-2 [KO:K05064]
119901000  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
119901066  bmpr2b; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
119901828  [KO:K13596] [EC:2.7.11.30]
119901851  ccl25a; C-C motif chemokine 20 [KO:K13072]
119901888  ackr4a; atypical chemokine receptor 4 [KO:K04186]
119901924  [KO:K04193]
119901925  [KO:K04193]
119901926  xcr1b.1; chemokine XC receptor 1 [KO:K04193]
119902099  thpo; thrombopoietin isoform X1 [KO:K06854]
119902142  [KO:K05406]
119902196  ccl20l; C-C motif chemokine 26 isoform X1 [KO:K14625]
119902237  [KO:K05504]
119902454  [KO:K04189]
119902549  [KO:K04179]
119902635  crfb16; cytokine receptor family member B16 [KO:K05137]
119902753  inhbab; inhibin subunit beta Ab [KO:K04667]
119902769  ccr9a; C-C chemokine receptor type 9a [KO:K04184]
119902881  ccl20a.3; C-C motif chemokine 20a.3 [KO:K14625]
119903030  [KO:K21283]
119903250  [KO:K05405]
119903412  mstnb; growth/differentiation factor 8 [KO:K05497]
119903469  inhbb; inhibin beta B chain [KO:K22687]
119903520  [KO:K05135]
119903523  [KO:K05135]
119903610  [KO:K04671] [EC:2.7.11.30]
119903646  [KO:K05050]
119903741  acvr2aa; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
119903766  tgfbr2l; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
119903849  [KO:K05050]
119903907  [KO:K04189]
119903949  edar; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
119904031  [KO:K13568] [EC:2.7.11.30]
119904033  [KO:K04675] [EC:2.7.11.30]
119904177  ackr3a; atypical chemokine receptor 3a [KO:K04304]
119904227  tnfsf13b; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476]
119904387  [KO:K05050]
119904413  [KO:K22672]
119904443  inha; inhibin alpha chain [KO:K05500]
119904450  [KO:K04387]
119904452  [KO:K05172]
119904454  [KO:K05172]
119904455  [KO:K04386]
119904457  il1rl1; interleukin-1 receptor-like 1 [KO:K05171]
119904478  il17d; interleukin-17D [KO:K05492]
119904788  [KO:K04390]
119905141  cd40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
119905232  [KO:K05146]
119905275  acvr2ab; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
119905306  bmp7b; bone morphogenetic protein 7b isoform X1 [KO:K16621]
119905633  acvr1ba; activin A receptor type 1Ba [KO:K13567] [EC:2.7.11.30]
119905705  [KO:K05165]
119905744  [KO:K05152]
119905745  [KO:K05152]
119905746  [KO:K05152]
119905747  [KO:K05152]
119905834  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
119906008  acvrl1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
119906018  [KO:K05152]
119906075  [KO:K05168]
119906143  wu:fl23c11; uncharacterized protein wu:fl23c11 [KO:K05166]
119906156  ngfa; neurotrophin-7 [KO:K02582]
119906171  si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A [KO:K05160]
119906688  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
119906712  gdf6b; growth/differentiation factor 6-B [KO:K20012]
119906838  bmp8a; bone morphogenetic protein 8A [KO:K16622]
119907257  [KO:K04388] [EC:2.7.11.30]
119907944  [KO:K05143]
119907990  bmp6; bone morphogenetic protein 6 [KO:K16620]
119908523  bmp2b; bone morphogenetic protein 2b [KO:K21283]
119908529  tnfrsf11a; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
119908939  tnfrsf21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
119909065  [KO:K22687]
119909133  [KO:K13377]
119909155  il20ra; interleukin-20 receptor subunit alpha [KO:K05136]
119909268  il17a/f3; interleukin 17a/f3 [KO:K05494]
119909281  ackr3b; atypical chemokine receptor 3b [KO:K04304]
119909408  ccr6a; C-C chemokine receptor type 6a isoform X1 [KO:K04181]
119909596  [KO:K22630]
119909826  ccr6b; C-C chemokine receptor type 6 [KO:K04181]
119910406  bmp4; bone morphogenetic protein 4 [KO:K04662]
119910425  [KO:K05060]
119910587  ackr4b; atypical chemokine receptor 4b [KO:K04186]
119910592  ebi3; interleukin-27 subunit beta [KO:K24476]
119910627  acvr1l; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
119910740  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
119910909  [KO:K04721]
119911155  [KO:K10031]
119911183  [KO:K05438]
119911295  cxcl19; C-X-C motif chemokine 19 [KO:K10030]
119911452  [KO:K04673] [EC:2.7.11.30]
119911521  epoa; erythropoietin isoform X1 [KO:K05437]
119911735  tnfsf12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
119911870  [KO:K05408]
119911914  [KO:K04184]
119912333  [KO:K10030]
119912404  [KO:K05076]
119912547  ccl20b; C-C motif chemokine 20b [KO:K14625]
119912587  bmp15; LOW QUALITY PROTEIN: bone morphogenetic protein 15 [KO:K05498]
119912931  [KO:K04180]
119912960  [KO:K04721]
119913270  rell1; RELT-like protein 1 [KO:K26541]
119913317  [KO:K05498]
119914032  prlra; prolactin receptor a [KO:K05081]
119914107  [KO:K22670]
119914185  tnfrsfa; tumor necrosis factor receptor superfamily, member a isoform X1 [KO:K04722]
119914293  bmpr1bb; bone morphogenetic protein receptor, type IBb isoform X1 [KO:K13578] [EC:2.7.11.30]
119914509  cntfr; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
119914787  il11ra; interleukin-11 receptor subunit alpha [KO:K05056]
119914826  [KO:K04666]
119914838  [KO:K05058]
119914859  [KO:K05072]
119914860  [KO:K05072]
119915103  [KO:K05080]
119915140  il6st; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
119915539  [KO:K05075]
119915945  ccr10; C-C chemokine receptor type 10 [KO:K04182]
119916133  [KO:K21283]
119916205  [KO:K05414]
119916217  [KO:K05414]
119916225  [KO:K05414]
119916226  ngfrb; nerve growth factor receptor b [KO:K02583]
119916231  [KO:K05414]
119916279  [KO:K05149]
119916280  gdf2; growth/differentiation factor 2 [KO:K05503]
119916375  [KO:K22674]
119916538  [KO:K05414]
119916580  [KO:K05150]
119916870  [KO:K05416]
119916915  ifngr1l; interferon gamma receptor 1-like isoform X1 [KO:K05132]
119917025  bmp5; bone morphogenetic protein 5 [KO:K04663]
119917251  cxcl12a; chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) [KO:K10031]
119917367  [KO:K04390]
119917542  [KO:K05414]
119917642  gdf10a; growth/differentiation factor 10 [KO:K22674]
119918085  il17ra1a; interleukin 17 receptor A1a [KO:K05164]
119918320  [KO:K05439]
119918395  lepb; leptin b [KO:K05424]
119918544  il15ra; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
119918589  [KO:K05090] [EC:2.7.10.1]
119918688  [KO:K04722]
119918788  [KO:K05061]
119918936  [KO:K05498]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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