KEGG   PATHWAY: msam04020
Entry
msam04020                   Pathway                                
Name
Calcium signaling pathway - Micropterus salmoides (largemouth bass)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
msam04020  Calcium signaling pathway
msam04020

Other DBs
GO: 0019722
Organism
Micropterus salmoides (largemouth bass) [GN:msam]
Gene
119882059  [KO:K04358]
119882195  [KO:K04142]
119882385  [KO:K22642]
119882387  [KO:K00871] [EC:2.7.11.19]
119882485  [KO:K04856]
119882580  stim1a; stromal interaction molecule 1a isoform X1 [KO:K16059]
119882696  [KO:K05219]
119882859  calm3a; calmodulin 3a (phosphorylase kinase, delta) isoform X1 [KO:K02183]
119883085  slc8a2b; sodium/calcium exchanger 2b [KO:K05849]
119883119  pdgfd; platelet-derived growth factor D [KO:K05450]
119883137  [KO:K04258]
119883157  [KO:K04992]
119883493  ryr1b; ryanodine receptor 1b isoform X1 [KO:K04961]
119883508  grm5b; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5b [KO:K04604]
119883529  [KO:K05857] [EC:3.1.4.11]
119883585  itpkcb; LOW QUALITY PROTEIN: inositol-trisphosphate 3-kinase Cb [KO:K00911] [EC:2.7.1.127]
119884033  [KO:K05448]
119884166  [KO:K04634]
119884188  [KO:K05210]
119884449  [KO:K05211]
119884981  [KO:K08774]
119885402  hrh1; histamine H1 receptor [KO:K04149]
119885536  drd5a; D(1B) dopamine receptor [KO:K05840]
119885618  [KO:K04958]
119885638  [KO:K05100] [EC:2.7.10.1]
119885780  [KO:K08794] [EC:2.7.11.17]
119885823  tfeb; transcription factor EB isoform X1 [KO:K15590]
119885905  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
119885928  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
119885945  camk1b; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
119886005  grin2aa; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
119886016  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04855]
119886066  [KO:K04718] [EC:2.7.1.91]
119886134  [KO:K13755] [EC:3.1.4.17]
119886295  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
119886344  mst1; hepatocyte growth factor-like protein [KO:K23441]
119886349  [KO:K02183]
119886455  [KO:K04958]
119886483  [KO:K04958]
119886484  [KO:K05100] [EC:2.7.10.1]
119886579  [KO:K04632]
119886614  [KO:K17332]
119886713  [KO:K08794] [EC:2.7.11.17]
119886716  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a [KO:K04851]
119886746  mst1rb; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
119886804  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
119886809  erbb3a; receptor tyrosine-protein kinase erbB-3a [KO:K05084] [EC:2.7.10.1]
119886869  oxtr; oxytocin receptor [KO:K04229]
119886874  [KO:K04857]
119886904  [KO:K05850] [EC:7.2.2.10]
119886942  ngfb; nerve growth factor [KO:K02582]
119886980  camk1a; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
119887241  [KO:K04994]
119887406  [KO:K06856]
119887582  [KO:K05871] [EC:2.7.10.2]
119887893  cacna1aa; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
119887933  [KO:K05218]
119888036  cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
119888130  [KO:K04809]
119888197  drd1a; D(1) dopamine receptor [KO:K04144]
119888221  vegfba; vascular endothelial growth factor A [KO:K05448]
119888301  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
119888322  si:ch73-22a13.3; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
119888332  grin3bb; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
119888415  p2rx3a; P2X purinoceptor 3a [KO:K05217]
119888480  [KO:K05869] [EC:2.7.11.17]
119888532  [KO:K05097] [EC:2.7.10.1]
119888559  egf; pro-epidermal growth factor [KO:K04357]
119888610  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
119888663  [KO:K04198]
119888705  adrb2a; adrenoceptor beta 2, surface a [KO:K04142]
119888759  slc25a5; ADP/ATP translocase 2 [KO:K05863]
119888860  si:ch73-60h1.1; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
119889001  fgf20b; fibroblast growth factor 20b [KO:K04358]
119889019  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
119889029  [KO:K18496]
119889114  fgf2; fibroblast growth factor 2 [KO:K18497]
119889133  fgf24; fibroblast growth factor 24 isoform X1 [KO:K04358]
119889152  fgf18a; fibroblast growth factor 18a isoform X1 [KO:K04358]
119889180  htr4; 5-hydroxytryptamine receptor 4 [KO:K04160]
119889191  [KO:K04160]
119889209  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
119889216  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
119889289  hrh2a; histamine receptor H2a [KO:K04150]
119889336  [KO:K04358]
119889380  flt4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
119889387  [KO:K04322]
119889410  fgf16; fibroblast growth factor 16 isoform X1 [KO:K04358]
119889568  [KO:K04157]
119889655  [KO:K04635]
119889692  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
119889787  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
119889811  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
119889816  [KO:K08049] [EC:4.6.1.1]
119889995  tacr2; substance-K receptor [KO:K04223]
119890017  tpcn2; two pore calcium channel protein 2 [KO:K14077]
119890067  [KO:K02183]
119890242  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
119890292  phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
119890430  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
119890485  fgf4; fibroblast growth factor 4 [KO:K04358]
119890522  grpr; gastrin-releasing peptide receptor [KO:K04169]
119890560  fgf3; fibroblast growth factor 3 [KO:K04358]
119890754  ntrk3b; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
119890757  chrna7a; neuronal acetylcholine receptor subunit alpha-7a [KO:K04809]
119890789  fgf19; fibroblast growth factor 19 [KO:K22603]
119890793  fgf7; fibroblast growth factor 7 [KO:K04358]
119891086  adra1aa; adrenoceptor alpha 1Aa [KO:K04135]
119891118  [KO:K05452]
119891173  fgf10b; fibroblast growth factor 10b [KO:K04358]
119891181  p2rx2; P2X purinoceptor 2 [KO:K05216]
119891196  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
119891232  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
119891353  gna14a; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
119891535  grin1b; glutamate receptor ionotropic, NMDA 1b isoform X1 [KO:K05208]
119891640  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
119891660  tacr1a; tachykinin receptor 1a [KO:K04222]
119891746  adora2aa; adenosine A2a receptor a [KO:K04266]
119891749  p2rx4b; P2X purinoceptor 4b isoform X1 [KO:K05218]
119891891  [KO:K05220]
119891930  [KO:K05220]
119891958  [KO:K16056]
119891967  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
119891975  f2r; proteinase-activated receptor 1 [KO:K03914]
119891995  adrb3a; adrenoceptor beta 3a [KO:K04143]
119892041  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a isoform X1 [KO:K04360] [EC:2.7.10.1]
119892109  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a [KO:K04849]
119892185  nos1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
119892186  fgf5; fibroblast growth factor 5 [KO:K04358]
119892195  tpcn1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
119892236  mylk5; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
119892413  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
119892428  atp2a2a; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
119892462  htr7c; 5-hydroxytryptamine receptor 7 [KO:K04163]
119893052  [KO:K04130]
119893078  trhr2; LOW QUALITY PROTEIN: thyrotropin releasing hormone receptor 2 [KO:K04282]
119893131  calml4b; calmodulin-like protein 4 [KO:K02183]
119893177  plcd3a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A [KO:K05857] [EC:3.1.4.11]
119893420  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
119893441  [KO:K05850] [EC:7.2.2.10]
119893453  [KO:K05460]
119893498  [KO:K05859] [EC:3.1.4.11]
119893583  [KO:K22428]
119893584  fgf6a; fibroblast growth factor 6a [KO:K04358]
119893678  camk1db; calcium/calmodulin-dependent protein kinase 1Db isoform X1 [KO:K08794] [EC:2.7.11.17]
119894173  avpr1aa; arginine vasopressin receptor 1Aa [KO:K04226]
119894195  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
119894204  [KO:K05861] [EC:3.1.4.11]
119894335  [KO:K04809]
119894713  [KO:K05853] [EC:7.2.2.10]
119894765  slc8a4a; LOW QUALITY PROTEIN: solute carrier family 8 member 4a [KO:K05849]
119894774  grin2ca; glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca [KO:K05211]
119894813  [KO:K05215]
119894974  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
119895086  [KO:K00476] [EC:1.14.11.16]
119895120  si:dkey-251i10.1; ADP/ATP translocase 2 [KO:K05863]
119895152  fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
119895154  [KO:K04142]
119895299  p2rx5; P2X purinoceptor 5 [KO:K05219]
119895301  adora2b; adenosine receptor A2b [KO:K04267]
119895333  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
119895357  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
119895394  [KO:K00476] [EC:1.14.11.16]
119895609  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
119895725  slc8a2a; sodium/calcium exchanger 2a isoform X1 [KO:K05849]
119895744  orai2; protein orai-2 [KO:K16057]
119895754  grm5a; glutamate receptor, metabotropic 5a [KO:K04604]
119895815  itpkca; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
119895825  [KO:K05089] [EC:2.7.10.1]
119895837  [KO:K04961]
119895858  [KO:K16059]
119895886  [KO:K18496]
119896086  [KO:K05215]
119896109  [KO:K04226]
119896191  [KO:K04150]
119896210  drd1b; dopamine receptor D1b [KO:K04144]
119896222  [KO:K04136]
119896511  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
119896513  ptger1c; prostaglandin E receptor 1c (subtype EP1) [KO:K04258]
119896891  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
119896893  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
119897108  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
119897496  prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
119897497  [KO:K05212]
119897529  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
119897578  [KO:K04809]
119897676  [KO:K04633]
119897894  adcy2a; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
119897990  [KO:K04446]
119898005  trhra; thyrotropin-releasing hormone receptor [KO:K04282]
119898457  [KO:K05861] [EC:3.1.4.11]
119898476  [KO:K04994]
119898483  [KO:K04962]
119898542  [KO:K04160]
119898562  fgf8b; fibroblast growth factor 8b [KO:K04358]
119898592  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b isoform X1 [KO:K04344]
119898635  si:ch211-79m20.1; G-box-binding factor isoform X1 [KO:K17386]
119898647  [KO:K04359]
119898769  [KO:K19662] [EC:2.7.11.13]
119898797  [KO:K04856]
119898853  ednraa; endothelin receptor type Aa [KO:K04197]
119898962  tacr3l; tachykinin receptor 3-like [KO:K04224]
119898968  slc25a4; ADP/ATP translocase 1 [KO:K05863]
119899000  tacr3a; tachykinin receptor 3a [KO:K04224]
119899012  adra1d; alpha-1D adrenergic receptor [KO:K04137]
119899064  [KO:K04144]
119899100  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
119899119  [KO:K18196]
119899163  grin2bb; glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b isoform X1 [KO:K05210]
119899290  [KO:K04992]
119899308  [KO:K04718] [EC:2.7.1.91]
119899340  [KO:K02677] [EC:2.7.11.13]
119899385  [KO:K04358]
119899433  adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
119899469  prkacab; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
119899640  ptger1a; prostaglandin E receptor 1a (subtype EP1) [KO:K04258]
119899673  chrna8; CHRNA7-FAM7A fusion protein isoform X1 [KO:K04809]
119899827  vegfc; vascular endothelial growth factor C [KO:K05449]
119899851  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
119899947  slc8a1a; sodium/calcium exchanger 1a isoform X1 [KO:K05849]
119900105  [KO:K03916]
119900106  [KO:K03916]
119900107  [KO:K03916]
119900255  [KO:K01116] [EC:3.1.4.11]
119900267  [KO:K08041] [EC:4.6.1.1]
119900283  mylk4b; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
119900375  mcoln3b; LOW QUALITY PROTEIN: mucolipin-3 [KO:K04994]
119900549  tbxa2r; thromboxane A2 receptor isoform X1 [KO:K04264]
119900597  [KO:K04157]
119900617  ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
119900632  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
119900645  mcoln2; mucolipin-2 isoform X1 [KO:K04993]
119900716  [KO:K04852]
119900764  [KO:K04637]
119900765  [KO:K04635]
119900826  ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
119900909  fgf22; fibroblast growth factor 22 [KO:K04358]
119901062  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
119901064  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
119901491  [KO:K23445]
119901499  [KO:K03916]
119901661  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
119901758  [KO:K04297]
119901774  cckbra; cholecystokinin receptor [KO:K04194]
119901776  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
119901777  ltb4r2b; leukotriene B4 receptor 2b [KO:K04297]
119901803  [KO:K04633]
119901921  pde1cb; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
119901961  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
119902018  cacna1eb; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
119902028  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
119902037  mylk4a; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
119902050  [KO:K08041] [EC:4.6.1.1]
119902436  ednrba; endothelin receptor Ba [KO:K04198]
119902454  [KO:K04189]
119902482  [KO:K05857] [EC:3.1.4.11]
119902491  casq1a; calsequestrin-1a [KO:K23468]
119902612  [KO:K00476] [EC:1.14.11.16]
119902997  [KO:K05871] [EC:2.7.10.2]
119903404  [KO:K04157]
119903462  pln; cardiac phospholamban [KO:K05852]
119903476  [KO:K04194]
119903482  ednrbb; endothelin receptor type B [KO:K04198]
119903502  fgf9; fibroblast growth factor 4A [KO:K04358]
119903747  [KO:K00907] [EC:2.7.11.18]
119903805  [KO:K05857] [EC:3.1.4.11]
119903821  [KO:K02183]
119903907  [KO:K04189]
119903962  erbb4b; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
119904020  [KO:K05449]
119904187  casq2; calsequestrin-2 isoform X1 [KO:K23445]
119904250  [KO:K04169]
119904608  [KO:K05085] [EC:2.7.10.1]
119904614  pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
119905055  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
119905085  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
119905094  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
119905133  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
119905368  camk1gb; calcium/calmodulin-dependent protein kinase IGb isoform X1 [KO:K08794] [EC:2.7.11.17]
119905411  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
119905434  [KO:K13755] [EC:3.1.4.17]
119905492  [KO:K04857]
119905691  gnas; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
119905703  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
119905765  atp2b3b; plasma membrane calcium-transporting ATPase 3b isoform X1 [KO:K05850] [EC:7.2.2.10]
119905833  tnnc1b; troponin C type 1b (slow) [KO:K05865]
119906034  erbb3b; receptor tyrosine-protein kinase erbB-3b [KO:K05084] [EC:2.7.10.1]
119906109  [KO:K04282]
119906156  ngfa; neurotrophin-7 [KO:K02582]
119906157  htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
119906163  ntsr1; neurotensin receptor type 1 [KO:K04211]
119906174  [KO:K12042]
119906175  tnnc2; troponin C, skeletal muscle [KO:K12042]
119906275  tnnc1a; troponin C type 1a (slow) [KO:K05865]
119907292  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
119907366  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
119907881  grin2da; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
119908126  trhrb; thyrotropin-releasing hormone receptor b [KO:K04282]
119908152  chrna11; cholinergic receptor, nicotinic, alpha 11 [KO:K04809]
119908385  [KO:K04282]
119908408  grm1a; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
119908444  [KO:K08048] [EC:4.6.1.1]
119908457  si:dkey-206f10.1; LOW QUALITY PROTEIN: adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
119908463  itpkb; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
119908507  [KO:K04133]
119908509  ryr3; ryanodine receptor 3 [KO:K04963]
119908521  [KO:K05858] [EC:3.1.4.11]
119908556  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
119908913  [KO:K05858] [EC:3.1.4.11]
119908914  ptk2bb; LOW QUALITY PROTEIN: protein tyrosine kinase 2 beta, b [KO:K05871] [EC:2.7.10.2]
119909104  si:dkey-63b1.1; B2 bradykinin receptor [KO:K03916]
119909215  [KO:K23449]
119909333  calm1b; calmodulin-1b [KO:K02183]
119909684  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
119909775  [KO:K04279]
119909805  calm1a; calmodulin-1a [KO:K02183]
119909820  grin3ba; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
119909833  [KO:K03916]
119910102  fgfr3; LOW QUALITY PROTEIN: fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
119910227  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
119910244  [KO:K05857] [EC:3.1.4.11]
119910354  itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
119910417  agtr1b; type-1 angiotensin II receptor [KO:K04166]
119910541  [KO:K04279]
119910543  [KO:K04279]
119910545  [KO:K04279]
119910706  [KO:K04963]
119910708  htr5ab; 5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate b [KO:K04161]
119910728  [KO:K03916]
119910797  [KO:K10785]
119910801  [KO:K04603]
119910824  [KO:K03916]
119910883  chrm5a; muscarinic acetylcholine receptor M5a [KO:K04133]
119910939  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
119911009  [KO:K00911] [EC:2.7.1.127]
119911205  [KO:K05853] [EC:7.2.2.10]
119911555  [KO:K04348] [EC:3.1.3.16]
119911608  cysltr3; cysteinyl leukotriene receptor 2 [KO:K04322]
119911817  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
119911902  [KO:K05849]
119911942  [KO:K04197]
119912040  [KO:K01242] [EC:3.2.2.6 2.4.99.20]
119912049  [KO:K01242] [EC:3.2.2.6 2.4.99.20]
119912136  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
119912584  phka1a; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
119912924  cckar; cholecystokinin receptor type A [KO:K04194]
119912925  stim2b; stromal interaction molecule 2 isoform X1 [KO:K18196]
119913184  htr2cl1; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 [KO:K04157]
119913392  [KO:K05840]
119913412  [KO:K05858] [EC:3.1.4.11]
119913446  [KO:K05840]
119913458  casq1b; calsequestrin-1b isoform X1 [KO:K23468]
119913984  [KO:K04361] [EC:2.7.10.1]
119913994  [KO:K04135]
119914020  atp2a2b; sarcoplasmic/endoplasmic reticulum calcium ATPase 2b [KO:K05853] [EC:7.2.2.10]
119914353  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b isoform X1 [KO:K04360] [EC:2.7.10.1]
119914377  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
119914452  [KO:K05217]
119914465  [KO:K05217]
119914512  [KO:K04362] [EC:2.7.10.1]
119914515  gdnfa; glial cell line-derived neurotrophic factor [KO:K05452]
119914522  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
119914530  tacr1b; tachykinin receptor 1b isoform X1 [KO:K04222]
119914585  orai1b; calcium release-activated calcium channel protein 1 [KO:K16056]
119914647  [KO:K03914]
119914811  [KO:K04634]
119914812  [KO:K04636]
119914832  [KO:K05208]
119914912  [KO:K04515] [EC:2.7.11.17]
119915029  fgf10a; fibroblast growth factor 10a [KO:K04358]
119915035  si:dkey-247m21.3; 5-hydroxytryptamine receptor 4 [KO:K04160]
119915040  adora2ab; adenosine A2a receptor b [KO:K04266]
119915078  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
119915108  grin3a; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
119915120  zgc:56235; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15041]
119915424  [KO:K05211]
119915441  [KO:K04131]
119915526  [KO:K00907] [EC:2.7.11.18]
119915537  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
119915637  [KO:K05857] [EC:3.1.4.11]
119915647  [KO:K05857] [EC:3.1.4.11]
119915749  [KO:K23450]
119915776  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
119915852  [KO:K04515] [EC:2.7.11.17]
119915897  [KO:K08048] [EC:4.6.1.1]
119915987  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
119916007  ryr2a; ryanodine receptor 2 [KO:K04962]
119916040  [KO:K09565] [EC:5.2.1.8]
119916049  [KO:K15040]
119916353  [KO:K05840]
119916362  fgf21; fibroblast growth factor 21 [KO:K22429]
119916493  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
119916614  adrb1; beta-1 adrenergic receptor [KO:K04141]
119916758  [KO:K04604]
119916885  fgf8a; fibroblast growth factor 8 [KO:K04358]
119916902  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
119917090  lhcgr; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
119917102  mcu; calcium uniporter protein, mitochondrial [KO:K20858]
119917327  slc8a1b; sodium/calcium exchanger 1b isoform X1 [KO:K05849]
119917346  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
119917358  ppifa; peptidylprolyl isomerase Fa isoform X1 [KO:K09565] [EC:5.2.1.8]
119917368  ryr2b; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
119917396  [KO:K02183]
119917456  chrm3a; muscarinic acetylcholine receptor M3 [KO:K04131]
119917516  [KO:K04248]
119917586  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
119917613  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
119917717  [KO:K06268]
119917871  [KO:K15041]
119918027  camk1da; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
119918194  atp2b1a; plasma membrane calcium-transporting ATPase 1a isoform X1 [KO:K05850] [EC:7.2.2.10]
119918210  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
119918229  chrm2a; muscarinic acetylcholine receptor M2a [KO:K04130]
119918297  hgfa; hepatocyte growth factor a isoform X1 [KO:K05460]
119918424  [KO:K04358]
119918427  fgf23; fibroblast growth factor 23 [KO:K22428]
119918588  [KO:K05089] [EC:2.7.10.1]
119918941  [KO:K05840]
119919396  [KO:K04136]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
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Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
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J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
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J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
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Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
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Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
msam04010  MAPK signaling pathway
msam04070  Phosphatidylinositol signaling system
msam04210  Apoptosis
KO pathway
ko04020   

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